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Research Article

Functional Characterization of a Non-AUUUA AU-Rich Element from the c-jun Proto-Oncogene mRNA: Evidence for a Novel Class of AU-Rich Elements

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Pages 1490-1499 | Received 18 Aug 1995, Accepted 16 Jan 1996, Published online: 29 Mar 2023

REFERENCES

  • Aharon, T., and R. J. Schneider. 1993. Selective destabilization of short-lived mRNAs with the granulocyte-macrophage colony-stimulating factor AU-rich noncoding region is mediated by a cotranslational mechanism. Mol. Cell. Biol. 13:1971–1980.
  • Akashi, M., G. Shaw, M. Hachiya, E. Elstner, G. Suzuki, and P. Koeffler. 1994. Number and location of AUUUA motifs: Role in regulating transiently expressed RNAs. Blood 83:3182–3187.
  • Caput, D., B. Beutler, K. Hartog, R. Thayer, S. Brown-Shimer, and A. Cerami. 1986. Identification of a common nucleotide sequence in the 3′-untranslated regions of mRNA molecules specifying inflammatory mediators. Proc. Natl. Acad. Sci. USA 83:1670–1674.
  • Chen, C.-Y. A., T.-M. Chen, and A.-B. Shyu. 1994. Interplay of two functionally and structurally distinct domains of the c-fos AU-rich element specifies its mRNA-destabilizing function. Mol. Cell. Biol. 14:416–426.
  • Chen, C.-Y. A., N. Xu, and A.-B. Shyu. 1995. mRNA decay mediated by two distinct AU-rich elements from c-fos and granulocyte-macrophage colony-stimulating factor transcripts: different deadenylation kinetics and uncoupling from translation. Mol. Cell. Biol. 15:5777–5788.
  • Chen, C.-Y. A., and A.-B. Shyu. 1995. AU-rich elements: characterization and importance in mRNA degradation. Trends Biochem. Sci. 20:465–470.
  • Chen, C.-Y. A., and A.-B. Shyu. 1994. Selective degradation of early-response-gene mRNAs: functional analyses of sequence features of the AU-rich elements. Mol. Cell. Biol. 14:8471–8482.
  • Curatola, A. M., M. S. Nadal, and R. J. Schneider. 1995. Rapid degradation of AU-rich element (ARE) mRNAs is activated by ribosome transit and blocked by secondary structure at any position 5′ to the ARE. Mol. Cell. Biol. 15:6331–6340.
  • Higuchi, R. 1990. Recombinant PCR, p. 177–183. In M. A. Innis, D. H. Gelfand, J. J. Sninsky, and T. J. White (ed.), PCR protocols: a guide to methods and applications. Academic Press, Inc., San Diego, Calif.
  • Hirsch, H. H., P. K. Asha, V. Backenstoss, and C. Moroni. 1995. Interleu-kin-3 mRNA stabilization by a trans-acting mechanism in autocrine tumors lacking interleukin-3 gene rearrangements. J. Biol. Chem. 270:20629–20635.
  • Koeller, D. M., J. A. Horowitz, J. L. Casey, R. D. Klausner, and J. B. Harford. 1991. Translation and the stability of mRNAs encoding the transferrin receptor and c-fos. Proc. Natl. Acad. Sci. USA 88:7778–7782.
  • Kozak, M. 1989. Circumstances and mechanisms of inhibition of translation by secondary structure in eucaryotic mRNAs. Mol. Cell. Biol. 9:5134–5142.
  • Lagnado, C. A., C. Y. Brown, and G. J. Goodall. 1994. AUUUA is not sufficient to promote poly(A) shortening and degradation of an mRNA: the functional sequence within AU-rich elements may be UUAUUUA(U/A)(U/ A). Mol. Cell. Biol. 14:7984–7995.
  • Ross, J. 1995. mRNA stability in mammalian cells. Microbiol. Rev. 59:16–95.
  • Savant-Bhonsale, S., and D. W. Cleveland. 1992. Evidence for instability of mRNAs containing AUUUA motifs mediated through translation-dependent assembly of a >20S degradation complex. Genes Dev. 6:1927–1939.
  • Shaw, G., and R. Kamen. 1986. A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 46:659–667.
  • Shyu, A.-B., J. G. Belasco, and M. E. Greenberg. 1991. Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay. Genes Dev. 5:221–231.
  • Shyu, A.-B., M. E. Greenberg, and J. G. Belasco. 1989. The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways. Genes Dev. 3:60–72.
  • Stoecklin, G., S. Hahn, and C. Moroni. 1994. Functional hierarchy of AUUUA motifs in mediating rapid interleukin-3 mRNA decay. J. Biol. Chem. 269:28591–28597.
  • Winstall, E., M. Gamache, and V. Raymond. 1995. Rapid mRNA degradation mediated by the c-fos 3′ AU-rich element and that mediated by the granulocyte-macrophage colony-stimulating factor 3′ AU-rich element occur through similar polysome-associated mechanisms. Mol. Cell. Biol. 15:3796–3804.
  • Zubiaga, A. M., J. G. Belasco, and M. E. Greenberg. 1995. The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation. Mol. Cell. Biol. 15:2219–2230.

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