21
Views
204
CrossRef citations to date
0
Altmetric
Research Article

Protein Kinase C-θ Isoenzyme Selective Stimulation of the Transcription Factor Complex AP-1 in T Lymphocytes

, , , , , , , & show all
Pages 1842-1850 | Received 10 Jul 1995, Accepted 04 Jan 1996, Published online: 29 Mar 2023

REFERENCES

  • Angel, P., and M. Karin. 1991. The role of Jun, Fos and the AP-1 complex in cell proliferation and transformation. Biochim. Biophys. Acta 1072:129–157.
  • Baier, G. Unpublished observations.
  • Baier, G., G. Baier-Bitterlich, C. Couture, D. Telford, L. Giampa, and A. Altman. 1994. An efficient expression, purification and immunodetection system for recombinant gene products. BioTechniques 17:94–99.
  • Baier, G., G. Baier-Bitterlich, D. Looney, and A. Altman. 1995. Immunogenic targeting of synthetic human immunodeficiency virus type 1 peptide vaccines to antigen-presenting cells by chimeric anti-major histocompatibility complex class II and anti-secretory immunoglobulin D antibodies in vitro. J. Virol. 69:2357–2365.
  • Baier, G., G. Baier-Bitterlich, N. Meller, K. M. Coggeshall, D. Telford, L. Giampa, N. Isakov, and A. Altman. 1994. Expression and biochemical characterization of PKC-θ. Eur. J. Biochem. 225:195–203.
  • Baier, G., D. Telford, L. Giampa, K. M. Coggeshall, G. Baier-Bitterlich, N. Isakov, and A. Altman. 1993. Molecular cloning and characterization of PKC-θ, a novel member of the PKC gene family expressed predominantly in hematopoietic cells. J. Biol. Chem. 268:4997–5004.
  • Baldari, C. T., A. Heguy, and J. L. Telford. 1993. Ras protein activity is essential for T-cell antigen receptor signal transduction. J. Biol. Chem. 268:2693–2698.
  • Baldari, C. T., A. Heguy, and J. L. Telford. 1993. Calcium-dependent cyclosporin A-sensitive activation by the IL-2 promoter by p56lck. Biol. Chem. 268:8406–8409.
  • Binetruy, B., T. Smeal, and M. Karin. 1991. Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. Nature (London) 351:122–127.
  • Boyle, W. J., T. Smeal, L. H. K. Defize, P. Angel, J. R. Woodgett, M. Karin, and T. Hunter. 1991. Activation of PKC decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity. Cell 64:573–584.
  • Chang, J. D., Y. Xu, M. K. Raychowdhury, and A. Ware. 1993. Molecular cloning and expression of a cDNA encoding a novel isoenzyme of PKC (nPKC). J. Biol. Chem. 268:14208–14214.
  • Crabtree, G. R. 1989. Contingent genetic regulatory events in T lymphocyte activation. Science 243:355–361.
  • Dekker, L. V., P. McIntyre, and P. J. Parker. 1993. Mutagenesis of the regulatory domain of rat PKC-η. J. Biol. Chem. 268:19498–19504.
  • Diaz-Meco, M. T., E. Berra, M. M. Municio, L. Sanz, J. Lozano, I. Dominguez, V. Diaz-Golpe, M. T. Lain de Lera, J. Alcami, C. V. Paya, F. Arenzana-Seisdedos, J. L. Virelizier, and J. Moscat. 1993. A dominat negative protein kinase C ζ subspecies blocks NF-κB activation. Mol. Cell. Biol. 13:4770–1775.
  • Durand, D. B., J. P. Shaw, M. R. Bush, R. E. Replogle, R. Belagaje, and G. R. Crabtree. 1988. Characterization of antigen receptor response elements within the interleukin-2 enhancer. Mol. Cell. Biol. 8:1715–1724.
  • Erdel, M., G. Baier-Bitterlich, C. Duba, N. Isakov, A. Altman, G. Utermann, and G. Baier. 1995. Mapping of human PKC-θ gene locus to the short arm of chromosome 10 (10p15) by FISH. Genomics 25:595–597.
  • Genot, E. M., P. J. Parker, and D. A. Cantrell. 1995. Analysis of the role of PKC-α, -ε and -ξ in T cell activation. J. Biol. Chem. 270:9833–9839.
  • Goode, N. T., and P. J. Parker. 1994. A PMA-responsive PKC-ξ generated by fusion with the regulatory domain of PKC-δ. FEBS Lett. 340:145–150.
  • Granelli-Piperno, A., and P. Nolan. 1991. Nuclear transcription factor that binds to elements of the IL-2 promoter: induction requirements in primary human T cells. J. Immunol. 147:2734–2740.
  • Gulbins, E., R. Bissonnette, A. Mahboubi, G. Baier, G. Baier-Bitterlich, C. Byrd, R. Kolesnick, D. Green, and A. Altman. 1995. The Ras signaling pathway mediates Fas-induced apoptosis in T cells. Immunity 2:341–351.
  • Hata, A., Y. Akita, K. Suzuki, and S. Ohno. 1993. Functional divergence of PKC family members. J. Biol. Chem. 268:9122–9129.
  • Hirai, S., Y. Izumi, K. Higa, K. Kaibuchi, K. Mizuno, S. Osada, K. Suzuki, and S. Ohno. 1994. Ras-dependent signal transduction is indispensable but not sufficient for the activation of AP-1/Jun by PKC-δ. EMBO J. 13:2331–2340.
  • House, C., and B. E. Kemp. 1987. PKC contains a pseudosubstrate prototype in its regulatory domain. Science 238:1726–1728.
  • Howe, L. R., S. J. Leevers, N. Gomez, S. Nakielny, P. Cohen, and C. J. Marshall. 1992. Activation of the MAP kinase pathway by the protein kinase raf. Cell 71:335–342.
  • Ioannides, C. G., R. S. Freedman, R. M. Liskamp, N. E. Ward, and C. A. O’Brian. 1990. Inhibition of IL-2 receptor induction and IL-2 production in Jurkat cells by a novel peptide inhibitor of PKC. Cell. Immunol. 131:242–248.
  • Jain, J., V. E. Valge-Archer, and A. Rao. 1992. Analysis of the AP-1 sites in the IL-2 promoter. J. Immunol. 148:1240–1250.
  • Jain, J., V. E. Valge-Archer, A. J. Sinskey, and A. Rao. 1992. The AP-1 site at —150 bp, but not the NFkB site, is likely to represent the major target of PKC in the IL-2 promoter. J. Exp. Med. 175:853–862.
  • Kang, S. M., B. Bart, A. C. Tran, K. Brorson, R. H. Schwartz, and M. J. Lenardo. 1992. Transactivation by AP-1 is a molecular target of T cell clonal anergy. Science 257:1134–1138.
  • Kvanta, A., E. Kontny, M. Jondal, S. Okret, and B. B. Fredholm. 1992. Mitogen stimulation of T-cells increases c-Fos and c-Jun protein levels, AP-1 binding and AP-1 transcriptional activity. Cell. Signalling 4:275–282.
  • Leung, K., and G. J. Nabel. 1988. HTLV-1 transactivator induces IL-2 receptor expression through a NFκB-like factor. Nature (London) 333:776–778.
  • Lin, A., J. Frost, T. Dend, N. Al-Alawi, T. Smeal, U. Kikkawa, T. Hunter, D. Brenner, and M. Karin. 1992. Casein kinase II is a negative regulator of cJun DNA binding and AP-1 activity. Cell 70:777–789.
  • Macchia, G., C. T. Baldari, A. Massone, and J. L. Telford. 1990. A role for PKC activity in interleukin-1 (IL-1) induction of IL-2 gene expression but not in IL-1 signal transduction. Mol. Cell. Biol. 10:2731–2737.
  • Maramutsu, M., K. Kaibuchi, and K. Arai. 1992. PKC mutants in the autoinhibitory region exhibit two distinct properties. FEBS Lett. 311:75–79.
  • Meugge, K., T. M. Williams, J. Kant, M. Karin, R. Chiu, A. Schmidt, U. Siebenlist, H. A. Young, and S. K. Durum. 1989. IL-1 costimulatory activity on the IL-2 promoter via AP-1. Science 246:249–251.
  • Mischak, H., J. Goodnight, D. W. Henderson, S. Osada, S. Ohno, and J. F. Mushinski. 1993. Unique expression pattern of protein kinase C-θ: high mRNA levels in normal mouse testes and in T-lymphocytic cells and neoplasms. FEBS Lett. 326:51–55.
  • Mizushima, S., and S. Nagata. 1990. pEF-BOS, a powerful mammalian expression vector. Nucleic Acids Res. 18:5322.
  • Nishizuka, Y. 1992. Intracellular signaling by hydrolysis of phospholipids and activation of PKC. Science 258:607–614.
  • Northrop, J. P., K. S. Ullman, and G. R. Crabtree. 1993. Characterization of the nuclear and cytoplasmic components of the lymphoid-specific NF-AT complex. J. Biol. Chem. 268:2917–2923.
  • Ohno, S., Y. Konno, Y. Akita, A. Yano, and K. Suzuki. 1990. A point mutation at the putative ATP-binding site of PKC-α abolishes the kinase activity. J. Biol. Chem. 265:6296–6300.
  • Osada, S., K. Mizuno, T. C. Saido, K. Suzuki, T. Kuroki, and S. Ohno. 1992. A new member of the PKC family, nPKC-θ, predominantly expressed in skeletal muscle. Mol. Cell. Biol. 12:3930–3938.
  • Paliogianni, F., A. Raptis, S. S. Ahuja, S. M. Najjar, and D. T. Boumpas. 1993. Negative transcriptional regulation of human IL-2 gene by glucocorticoids through intereference with nuclear transcription factors AP-1 and NF-AT. J. Clin. Invest. 91:1481–1490.
  • Pears, C. J., G. Kour, C. House, B. E. Kemp, and P. J. Parker. 1990. Mutagenesis of the pseudosubstrate site of PKC leads to activation. Eur. J. Biochem. 194:89–94.
  • Perkins, N. D., R. M. Schmid, C. Duckett, K. Leung, N. R. Rice, and G. J. Nabel. 1992. Distinct combinations of NFkB subunits determine the specificity of transcriptional activation. Proc. Natl. Acad. Sci. USA 89:1529–1533.
  • Pulverer, B. J., J. M. Kyriakis, J. Avruch, E. Nikolakaki, and J. R. Woodgett. 1991. Phosphorylation of c-Jun mediated by MAP-kinases. Nature (London) 353:670–674.
  • Rayter, S. I., M. Woodrow, S. C. Lucas, D. A. Cantrell, and J. Downward. 1992. p21ras mediates control of IL-2 gene promoter function in T cell activation. EMBO J. 11:4549–4556.
  • Schreiber, S. L., and G. R. Crabtree. 1992. The mechanism of action of cyclosporin A and FK506. Immunol. Today 13:136–142.
  • Schwartz, R. H. 1990. A cell culture model for T lymphocyte clonal anergy. Science 248:1349–1356.
  • Serfling, E., R. Barthelmas, I. Pfeuffer, B. Schenk, S. Zarius, R. Swoboda, F. Mercurio, and M. Karin. 1989. Ubiquitous and lymphocyte-specific factors are involved in the induction of the moue IL-2 gene in T-lymphocytes. EMBO J. 8:465–473.
  • Smeal, T., B. Binetruy, D. A. Mercola, M. Birrer, and M. Karin. 1991. Phosphorylation of c-Jun on serines 63 and 73 is required for oncogenic and transcriptional cooperation with Ha-Ras. Nature (London) 354:494–496.
  • Su, B., E. Jacinto, M. Hibi, T. Kallunki, M. Karin, and Y. Ben-Neriah. 1994. JNK is involved in signal integration during costimulation of T lymphocytes. Cell 77:727–736.
  • Ullman, K., J. Northrop, A. Admon, and G. Crabtree. 1993. Jun family members are controlled by a calcium-regulated, cyclosporin A-sensitive signalling pathway in activated T lymphocytes. Genes Dev. 7:188–196.
  • Ullman, K., J. Northrop, C. L. Verweij, and G. Crabtree. 1990. Transmission of signals from the TCR to the genes responsible for cell proliferation and immune function: the missing link. Annu. Rev. Immunol. 8:421–435.
  • Valge, V. E., J. G. P. Wong, B. M. Datlof, A. J. Sinskey, and A. Rao. 1988. PKC is required for responses to TCR ligands but not to IL-2 in T cells. Cell 55:101–109.
  • Wang, F., U. P. Naik, Y. H. Ehrlich, Z. Freyberg, S. Osada, S. Ohno, T. Kuroki, K. Suzuki, and E. Kornecki. 1993. Anew protein kinase C, nPKCη, and nPKCθ are expressed in human platelets: involvement of nPKCη and nPKCθ in signal transduction by PAF. Biochem. Biophys. Res. Commun. 191:240–246.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.