REFERENCES
- Alemà, S., P. Casalbore, E. Agostini, and F. Tatò. 1985. Differentiation of PC12 phaeochromocytoma cells induced by v-src oncogene. Nature (London) 316:557–559.
- Bar-Sagi, D., and J. R. Feramisco. 1985. Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation. Cell 42:841–848.
- Baybis, M., and S. R. J. Salton. 1992. Nerve growth factor rapidly regulates VGF gene transcription through cycloheximide sensitive and insensitive pathways. FEBS Lett. 308:202–206.
- Binetruy, B., T. Smeal, and M. Karin. 1991. Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. Nature (London) 351:122–127.
- Bonni, A., D. D. Ginty, H. Dudek, and M. E. Greenberg. 1995. Serine 133-phosphorylated CREB induces transcription via a cooperative mechanism that may confer specificity to neurotrophin signals. Mol. Cell. Neurosci. 6:168–183.
- Bruder, J. T., G. Heidecker, and U. R. Rapp. 1992. Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase. Genes Dev. 6:545–556.
- Cho, K.-O., W. C. Skarnes, B. Minsk, S. Palmieri, L. Jackson-Grusby, and J. A. Wagner. 1989. Nerve growth factor regulates gene expression by several distinct mechanisms. Mol. Cell. Biol. 9:135–143.
- Chrivia, J. C., R. P. Kwok, N. Lamb, M. Hagiwara, M. R. Montminy, and R. H. Goodman. 1993. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature (London) 365:855–859.
- Crosby, S. D., J. J. Puetz, K. S. Simburger, T. J. Fahrner, and J. Milbrandt. 1991. The early response gene NGFI-C encodes a zinc finger transcriptional activator and is a member of the GCGGGGGCG (GSG) element-binding protein family. Mol. Cell. Biol. 11:3835–3841.
- Danielson, P. E., S. Forss-Petter, M. A. Brau, L. Calavetta, J. Douglass, R. J. Milner, and J. G. Sutcliffe. 1988. pIB15: a cDNA clone of the rat RNA encoding cyclophilin. DNA 7:261–267.
- D’Arcangelo, G., and S. Halegoua. 1993. A branched signaling pathway for nerve growth factor is revealed by Src-, Ras-, and Raf-mediated gene inductions. Mol. Cell. Biol. 13:3146–3155.
- D’Arcangelo, G., and S. Salton. Unpublished data.
- Der, C. J., T. Finkel, and G. M. Cooper. 1986. Biological and biochemical properties of human rasH genes mutated at codon 61. Cell 44:167–176.
- Dignam, J. D., R. M. Lebovitz, and R. G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475–1489.
- Feig, L. A., and G. M. Cooper. 1988. Inhibition of NIH/3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP. Mol. Cell. Biol. 8:3235–3243.
- Freter, R. R., J.-C. Irminger, J. A. Porter, S. D. Jones, and C. D. Stiles. 1992. A novel 7-nucleotide motif located in 3′ untranslated sequences of the immediate-early gene set mediates platelet-derived growth factor induction of the Je gene. Mol. Cell. Biol. 12:5288–5300.
- Ginty, D. D., A. Bonni, and M. E. Greenberg. 1994. Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB. Cell 77:713–725.
- Green, S. H., R. E. Rydel, J. L. Connolly, and L. A. Greene. 1986. PC12 cell mutants that possess low- but not high-affinity nerve growth factor receptors neither respond to nor internalize nerve growth factor. J. Cell Biol. 102:830–843.
- Greene, L. A., and A. S. Tischler. 1976. Establishment of a noradrenergic clonal cell line of rat pheochromocytoma cells which respond to nerve growth factor. Proc. Natl. Acad. Sci. USA 73:2424–2428.
- Greene, L. A., and A. S. Tischler. 1982. PC12 pheochromocytoma cultures in neurobiological research. Adv. Cell. Neurobiol. 3:373–414.
- Gutman, A., and B. Wasylyk. 1991. Nuclear targets for transcription regulation by oncogenes. Trends Genet. 7:49–54.
- Habas, R., and S. Salton. Unpublished data.
- Hagag, N., S. Halegoua, and M. Viola. 1986. Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibodies to ras p21. Nature (London) 319:680–682.
- Hai, T., and T. Curran. 1991. Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity. Proc. Natl. Acad. Sci. USA 88:3720–3724.
- Halegoua, S., R. C. Armstrong, and N. E. Kremer. 1991. Dissecting the mode of action of a neuronal growth factor. Curr. Top. Microbiol. Immunol. 165:119–170.
- Hawley, R. J., R. J. Scheibe, and J. A. Wagner. 1992. NGF induces the expression of the VGF gene through a cAMP response element. J. Neurosci. 12:2573–2581.
- Hempstead, B. L., D. Martin-Zanca, D. R. Kaplan, L. F. Parada, and M. V. Chao. 1991. High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor. Nature (London) 350:678–683.
- Johnson, P. F. 1993. Identification of C/EBP basic region residues involved in DNA sequence recognition and half-site spacing preference. Mol. Cell. Biol. 13:6919–6930.
- Kaplan, D. R., B. L. Hempstead, D. Martin-Zanca, M. V. Chao, and L. F. Parada. 1991. The trk proto-oncogene product: a signal transducing receptor for nerve growth factor. Science 252:554–558.
- Keegan, K., and S. Halegoua. 1993. Signal transduction pathways in neuronal differentiation. Curr. Opin. Neurobiol. 3:14–19.
- Klein, R., S. Jing, V. Nanduri, E. O’Rourke, and M. Barbacid. 1991. The trk proto-oncogene encodes a receptor for nerve growth factor. Cell 65:189–197.
- Kremer, N. E., G. D’Arcangelo, S. M. Thomas, M. DeMarco, J. S. Brugge, and S. Halegoua. 1991. Signal transduction by nerve growth factor and fibroblast growth factor in PC12 cells requires a sequence of src and ras actions. J. Cell Biol. 115:809–819.
- Lemaire, P., C. Vesque, J. Schmitt, H. Stunnenberg, R. Frank, and P. Charnay. 1990. The serum-inducible mouse gene Krox-24 encodes a sequence-specific transcriptional activator. Mol. Cell. Biol. 10:3456–3467.
- Levi, A., J. D. Eldridge, and B. M. Paterson. 1985. Molecular cloning of a gene sequence regulated by nerve growth factor. Science 229:3469–3473.
- Loeb, D. M., R. M. Stephens, T. Copeland, D. R. Kaplan, and L. A. Greene. 1994. A Trk nerve growth factor (NGF) receptor point mutation affecting interaction with phospholipase C-gamma 1 abolishes NGF-promoted pe-ripherin induction but not neurite outgrowth. J. Biol. Chem. 269:8901–8910.
- Marshall, C. J. 1995. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80:179–185.
- McCormick, F. 1993. How receptors turn Ras on. Nature (London) 363:15–16.
- McKnight, S. L. 1992. CCAAT/enhancer binding protein, p. 771–795. In S. L. McKnight and K. R. Yamamoto (ed.), Transcriptional regulation. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
- Milbrandt, J. 1987. A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. Science 238:797–799.
- Milbrandt, J. Personal communication.
- Mobley, W. C., A. Schenker, and E. M. Shooter. 1976. Characterization and isolation of proteolytically modified nerve growth factor. Biochemistry 15:5543–5552.
- Moodie, S. A., B. M. Willumsen, M. J. Weber, and A. Wolfman. 1993. Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase. Science 260:1658–1661.
- Noda, M., M. Ko, A. Ogura, D. G. Liu, T. Amano, T. Takano, and Y. Ikawa. 1985. Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line. Nature (London) 318:73–75.
- Oshima, M., G. Sithanandam, U. R. Rapp, and G. Guroff. 1991. The phos-phorylation and activation of B-raf in PC12 cells stimulated by nerve growth factor. J. Biol. Chem. 266:23753–23760.
- Owen, R. D., and M. C. Ostrowski. 1990. Transcriptional activation of a conserved sequence element by ras requires a nuclear factor distinct from c-fos or c-jun. Proc. Natl. Acad. Sci. USA 87:3866–3870.
- Possenti, R., G. Di Rocco, S. Nasi, and A. Levi. 1992. Regulatory elements in the promoter region of vgf, a nerve growth factor-inducible gene. Proc. Natl. Acad. Sci. USA 89:3815–3819.
- Prendergast, G. C., and E. B. Ziff. 1992. A new bind for Myc. Trends Genet. 8:91–96.
- Rausch, D. M., G. Dickens, S. Doll, K. Fujita, S. Koizumi, B. B. Rudkin, M. Tocco, L. E. Eiden, and G. Guroff. 1989. Differentiation of PC12 cells with v-src: comparison with nerve growth factor. J. Neurosci. Res. 24:49–58.
- Rauscher, F. J. Personal communication.
- Rozakis-Adcock, A., J. McGlade, G. Mbamalu, G. Pelicci, R. Daly, W. Li, A. Batzer, S. Thomas, J. Brugge, P. Pelicci, J. Schlessinger, and T. Pawson. 1992. Association of the SHC and GRB2/sem-5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases. Nature (London) 360:689–692.
- Salton, S. R., G. Prendergast, and E. B. Ziff. Unpublished data.
- Salton, S. R., C. Volonte, and G. D’Arcangelo. 1995. Stimulation of vgf gene expression by NGF is mediated through multiple signal transduction pathways involving protein phosphorylation. FEBS Lett. 360:106–110.
- Salton, S. R. J. 1991. Nucleotide sequence and regulatory studies of VGF, a nervous system-specific mRNA that is rapidly and relatively selectively induced by nerve growth factor. J. Neurochem. 57:991–996.
- Salton, S. R. J., M. Blum, J. A. Jonassen, R. N. Clayton, and J. L. Roberts. 1988. Stimulation of pituitary luteinizing hormone secretion by gonado-tropin-releasing hormone is not coupled to beta-luteinizing hormone gene transcription. Mol. Endocrinol. 2:1033–1042.
- Salton, S. R. J., D. J. Fischberg, and K. W. Dong. 1991. Structure of the gene encoding VGF, a nervous system-specific mRNA that is rapidly and selectively induced by nerve growth factor in PC12 cells. Mol. Cell. Biol. 11:2335–2349.
- Schlessinger, J. 1993. How receptor tyrosine kinases activate Ras. Trends Biochem. Sci. 18:273–275.
- Singh, H., R. Sen, D. Baltimore, and P. A. Sharp. 1986. A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes. Nature (London) 319:154–158.
- Steffan, N. H., H. D. Hunt, and L. R. Pease. 1989. Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77:51–59.
- Stephens, R. M., D. M. Loeb, T. D. Copeland, T. Pawson, L. A. Greene, and D. R. Kaplan. 1994. Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses. Neuron 12:691–705.
- Szeberenyi, J., H. Cai, and G. M. Cooper. 1990. Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells. Mol. Cell. Biol. 10:5324–5332.
- Tatarowicz, W. A., et al. Submitted for publication.
- Thomas, S. M., M. DeMarco, G. D’Arcangelo, S. Halegoua, and J. Brugge. 1992. Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases. Cell 68:1031–1040.
- Thomas, S. M., M. Hayes, G. D’Arcangelo, R. C. Armstrong, B. E. Meyer, A. Zilberstein, J. Brugge, and S. Halegoua. 1991. Induction of neurite outgrowth by v-src mimics critical aspects of nerve growth factor-induced differentiation. Mol. Cell. Biol. 11:4739–4750.
- Troppmair, J., J. T. Bruder, H. App, H. Cai, L. Liptak, J. Szeberenyi, G. M. Cooper, and U. R. Rapp. 1992. Ras controls coupling of growth factors receptors and protein kinase C in the membrane to Raf-1 and B-Raf protein serine kinases in the cytosol. Oncogene 7:1867–1873.
- Van Aesle, L., M. Barr, S. Marcus, A. Polverino, and M. Wigler. 1993. Complex formation between RAS and RAF and other protein kinases. Proc. Natl. Acad. Sci. USA 90:6213–6217.
- Van Buskirk, R., T. Corcoran, and J. A. Wagner. 1985. Clonal variants of PC12 pheochromocytoma cells with defects in cAMP-dependent protein kinases induce ornithine decarboxylase in response to nerve growth factor but not adenosine agonists. Mol. Cell. Biol. 5:1984–1992.
- Vojtek, A. B., S. M. Hollenberg, and J. A. Cooper. 1993. Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell 74:205–214.
- Westin, G., T. Gerster, M. M. Muller, G. Schaffner, and W. Schaffner. 1987. OVEC., a versatile system to study transcription in mammalian cells and cell-free extracts. Nucleic Acids Res. 15:6787–6798.
- Wood, K. W., H. Qi, G. D’Arcangelo, R. C. Armstrong, T. M. Roberts, and S. Halegoua. 1993. The cytoplasmic raf oncogene induces the neuronal differentiation of PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transduction. Proc. Natl. Acad. Sci. USA 90:5016–5020.
- Wood, K. W., C. Sarnecki, T. M. Roberts, and J. Blenis. 1992. ras mediates nerve growth factor receptor modulation of three signal transduction protein kinases: MAP kinase, Raf-1 and RSK. Cell 68:1041–1050.
- Yamamoto, K. K., G. A. Gonzales, W. H. I. Biggs, and M. R. Montminy. 1988. Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB. Nature (London) 334:494–498.