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Research Article

Localization of BRCA1 and a Splice Variant Identifies the Nuclear Localization Signal

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Pages 444-452 | Received 03 Jun 1996, Accepted 11 Sep 1996, Published online: 29 Mar 2023

REFERENCES

  • Abel, K. J., J. Xu, G.-Y. Yin, R. H. Lyons, M. H. Meisler, and B. L. Weber. 1995. Mouse BRCA1: localization, sequence analysis and identification of evolutionarily conserved domains. Hum. Mol. Genet. 4:2265–2273.
  • Beckmann, H., L.-K. Su, and T. Kadesch. 1990. TFE3: a helix-loop-helix protein that activates transcription through the immunoglobulin enhancer uE3 motif. Genes Dev. 4:167–179.
  • Bennett, L. M., A. Haugen-Strano, C. Cochran, H. A. Brownlee, F. T. Fiedorek, Jr., and R. W. Weisman. 1995. Isolation of the mouse homologue of BRCA1 and genetic mapping to mouse chromosome 11. Genomics 29:576–581.
  • Boulikas, T. 1993. Nuclear localization signals (NLS). Crit. Rev. Eukaryot. Gene Expr. 3:193–227.
  • Castilla, L. H., F. J. Couch, M. R. Erdos, K. F. Hoskins, K. Calzone, J. E. Garber, J. Boyd, M. B. Lubin, M. L. Deshano, L. C. Brody et al. 1994. Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer. Nat. Genet. 8:387–391.
  • Chen, Y., C.-F. Chen, D. J. Riley, D. C. Allred, P.-L. Chen, D. Von Hoff, C. K. Osborne, and W.-H. Lee. 1995. Aberrant subcellular localization of BRCA1 in breast cancer. Science 270:789–791.
  • Chen, Y., P.-L. Chen, D. J. Riley, and W.-H. Lee. 1996. Location of BRCA1 in human breast and ovarian cancer cells. Science 272:125–126.
  • Couch, F. J., B. L. Weber, and Breast Cancer Information Core. 1996. Mutations and polymorphisms in the familial early onset breast cancer (BRCA1) gene. Hum. Mutat. 8:8–18.
  • Easton, D. F., D. T. Bishop, G. P. Crockford, and The International Breast Cancer Linkage Consortium. 1993. Genetic analysis in familial breast and ovarian cancer: results from 214 families. Am. J. Hum. Genet. 52:678–701.
  • Feinberg, A. P., and B. Vogelstein. 1984. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 137:266–267.
  • Freemont, P. S. 1993. The RING finger: a novel protein sequence motif related to zinc finger. Ann. N. Y. Acad. Sci. 684:174–192.
  • Futreal, P. A., Q. Liu, D. Shattuck-Eidens, C. Cochran et al. 1994. BRCA1 mutations in primary breast and ovarian carcinomas. Science 266:120–122.
  • Graham, F. L., and A. J. van der Eb. 1973. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52:456–467.
  • Gudas, J. M., H. Nguyen, T. Li, and K. H. Cowan. 1995. Hormone-dependent regulation of BRCA1 in human breast cancer cells. Cancer Res. 55:4561–4565.
  • Hannink, M., and H. M. Temin. 1989. Transactivation of gene expression by nuclear and cytoplasmic rel proteins. Mol. Cell. Biol. 9:4323–4336.
  • Holt, J. T., M. E. Thompson, C. Szabo, C. Robinson-Benion, C. L. Arteaga, M.-C. King, and R. A. Jensen. 1996. Growth retardation and tumor inhibition by BRCA1. Nat. Genet. 12:298–302.
  • Jensen, R. A., M. E. Thompson, T. L. Jetton, C. Szabo, R. van der Meer, B. Helou, S. R. Tronick, D. L. Page, M.-C. King, and J. T. Holt. 1996. BRCA1 is a secreted protein and exhibits properties of a granin. Nat. Genet. 12:303–308.
  • Kalderon, D., W. D. Richardson, A. F. Markham, and A. E. Smith. 1984. Sequence requirements for nuclear location of simian virus 40 large-T antigen. Nature 311:33–38.
  • Kiledjian, M., L.-K. Su, and T. Kadesch. 1988. Identification and characterization of two functional domains within the murine heavy-chain enhancer. Mol. Cell. Biol. 8:145–152.
  • Marquis, S. T., J. V. Rajan, A. Wynshaw-Boris, J. Xu, G.-Y. Yin, K. Abel, B. L. Weber, and L. A. Chodosh. 1995. The developmental pattern of BRCA1 expression implies a role in differentiation of the breast and other tissues. Nat. Genet. 11:17–26.
  • Miki, Y., J. Swensen, E. D. Shattuck-Eidens, P. A. Futreal, K. Harshman, S. Tavtigian, Q. Liu, C. Cochran, L. M. Bennett, W. Ding et al. 1994. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266:66–71.
  • Morin, N., C. Delsert, and D. F. Klessig. 1989. Nuclear localization of the adenovirus DNA-binding protein: requirement for two signals and complementation during viral infection. Mol. Cell. Biol. 9:4372–4380.
  • Rao, V. N., N. Shao, M. Ahmad, and E. S. P. Reddy. 1996. Antisense RNA to the putative tumor suppressor gene BRCA1 transforms mouse fibroblasts. Oncogene. 12:523–528.
  • Rexach, M., and G. Blobel. 1995. Protein import into nuclei: association and dissociation reactions involving transport substrate. Cell 83:683–692.
  • Scully, R., S. Ganesan, M. Brown, J. A. DiCaprio, S. A. Cannistra, J. Feunteun, S. Schnitt, and D. M. Livingston. 1996. Location of BRCA1 in human breast and ovarian cancer cells. Science 272:123–125.
  • Sharan, S. K., M. Nims, and A. Bradley. 1995. Murine BRCA1: sequence and significance for human mutations. Hum. Mol. Genet. 4:2275–2278.
  • Slavicek, J. M., N. C. Jones, and J. D. Richter. 1989. A karyophilic signal sequence in adenovirus type 5 E1A is functional in Xenopus oocytes but not in somatic cells. J. Virol. 63:4047–4050.
  • Thompson, M. E., R. A. Jensen, P. S. Obermiller, D. L. Page, and J. T. Holt. 1995. Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression. Nat. Genet. 9:444–450.
  • Van Etten, R. A., P. Jackson, and D. Baltimore. 1989. The mouse type IV c-abl product is a nuclear protein, and activation of transforming ability is associated with cytoplasmic localization. Cell 58:669–678.

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