14
Views
201
CrossRef citations to date
0
Altmetric
Research Article

Hepatocyte Nuclear Factor 3β is Involved in Pancreatic β-Cell-Specific Transcription of the pdx-1 Gene

, , , , , , , , & show all
Pages 6002-6013 | Received 27 Jan 1997, Accepted 30 Jun 1997, Published online: 29 Mar 2023

REFERENCES

  • Ahlgren, U., J. Jonsson, and H. Edlund. 1996. The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice. Development 122:1409–1416.
  • Alpert, S., D. Hanahan, and G. Teitelman. 1988. Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons. Cell 53:295–308.
  • Ang, S.-L., A. Wierda, D. Wong, K. A. Stevens, S. Cascio, J. Rossant, and K. S. Zaret. 1993. The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of the HNF3/fork head proteins. Development 119:1301–1315.
  • Ang, S.-L., and J. Rossant. 1994. HNF-3þ is essential for node and notochord formation in mouse development. Cell 78:561–574.
  • Becker, P. B. 1994. The establishment of active promoters in chromatin. Bioessays 16:541–547.
  • Bonnerot, C., and J.-L. Nicolas. 1993. Application of LacZ gene fusions to postimplantation development. Methods Enzymol. 225:451–469.
  • Byrne, M. M., J. Sturis, S. Menzel, K. Yamagata, S. S. Fajans, M. J. Dronsfield, S. C. Bain, A. T. Hattersley, G. Velho, P. Groguel, G. I. Bell, and K. S. Polonsky. 1996. Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY3 on chromosome 12. Diabetes 45:1503–1510.
  • Clark, K. L., E. D. Halay, E. Lai, and S. K. Burley. 1993. Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5. Nature (London) 364:412–420.
  • Cockell, M., D. Stolarczyk, S. Frutiger, G. J. Hughes, O. Hagenbuchle, and P. K. Wellauer. 1995. Binding sites for hepatocyte nuclear factor 3þ or 3μ and pancreas transcription factor 1 are required for efficient expression of the gene encoding pancreatic a-amylase. Mol. Cell. Biol. 15:1933–1941.
  • De Wet, J. R., K. V. Wood, M. DeLuca, D. R. Helinski, and S. Subramani. 1987. Firefly luciferase gene: structure and expression in mammalian cells. Mol. Cell. Biol. 7:725–737.
  • Elgin, S. C. R. 1988. The formation and function of DNase 1 hypersensitive sites in the process of gene activation. J. Biol. Chem. 263:19259–19262.
  • Fernandes, A., L. C. King, Y. Guz, R. Stein, C. V. E. Wright, and G. Teitelman. 1997. Differentiation of new insulin-producing cells is induced by injury in adult pancreatic islets. Endocrinology 138:1750–1762.
  • Finegood, D. T., L. Scaglia, and S. Bonner-Weir. 1995. Perspectives in diabetes. Dynamics of þ-cell mass in the growing rat pancreas: estimation with a simple mathematical model. Diabetes 44:249–256.
  • Fire, A., S. W. Harrison, and D. Dixon. 1990. A modular set of lacZ fusion vectors for studying gene expression in Caenorhabditis elegans. Gene 93:189–198.
  • Gittes, G. K., and W. J. Rutter. 1992. Onset of cell-specific gene expression in the developing mouse pancreas. Proc. Natl. Acad. Sci. USA 89:1128–1132.
  • Gregor, P. D., M. Sawadogo, and R. G. Roeder. 1990. The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer. Genes Dev. 4:1730–1740.
  • Gross, D. S., and W. T. Garrard. 1988. Nuclease hypersensitive sites in chromatin. Annu. Rev. Biochem. 57:159–197.
  • Guz, Y., M. R. Montminy, R. Stein, J. Leonard, L. W. Gamer, C. V. E. Wright, and G. Teitelman. 1995. Expression of murine STF-1, a putative insulin gene transcription factor, in þ-cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny. Development 121:11–18.
  • Herrmann, B. G., and A.-M. Frischauf. 1987. Isolation of genomic DNA. Methods Enzymol. 152:180–193.
  • Hogan, B., R. Beddington, F. Constantini, and E. Lacy. 1994. Manipulating the mouse embryo: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
  • Ip, Y. T., D. K. Granner, and R. Chalkley. 1989. Hormonal regulation of phosphoenolpyruvate carboxykinase gene expression is mediated through an already disrupted chromatin structure. Mol. Cell. Biol. 9:1289–1297.
  • Ip, Y. T., M. Levine, and E. Bier. 1994. Neurogenic expression of snail is controlled by separable CNS and PNS promoter elements. Development 120:199–207.
  • Jacoby, D. B., N. D. Zilz, and H. C. Towle. 1989. Sequences within the 5′-flanking region of the S14 gene confer responsiveness to glucose in primary hepatocytes. J. Biol. Chem. 264:17623–17626.
  • Jetton, T. L., Y. Liang, C. C. Pettipher, E. C. Zimmerman, F. G. Cox, K. Horvath, F. M. Matschinsky, and M. Magnuson. 1994. Analysis of upstream glucokinase promoter activity in transgenic mice and identification of glucokinase in rare neuroendocrine cells in the brain and gut. J. Biol. Chem. 269:3641–3654.
  • Jonsson, J., L. Carlsson, T. Edlund, and H. Edlund. 1994. Insulin-promoterfactor 1 is required for pancreas development in mice. Nature 371:606–609.
  • Krapp, A., M. Knofler, S. Frutiger, G. J. Hughes, O. Hagenbuchle, and P. K. Wellauer. 1996. The p48 DNA-binding subunit of transcription factor PTF1 is a new exocrine pancreas-specific basic helix-loop-helix protein. EMBO J. 15:4317–4329.
  • Kruse, F., S. D. Rose, G. H. Swift, R. H. Hammer, and R. J. MacDonald. 1995. Cooperation between elements of an organ-specific transcriptional enhancer in animals. Mol. Cell. Biol. 15:4385–4394.
  • Lee, J. E., S. M. Hollenberg, L. Snider, D. L. Turner, N. Lipnick, and H. Weintraub. 1995. Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein. Science 268:836–844.
  • Leonard, J., B. Peers, T. Johnson, K. Ferrere, S. Lee, and M. Montminy. 1993. Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells. Mol. Endocrinol. 7:1275–1283.
  • Marti, E., R. Takada, D. A. Bumcrot, H. Sasaki, and A. P. McMahon. 1995. Distribution of sonic hedgehog peptides in the developing chick and mouse embryo. Development 121:2537–2547.
  • Miller, C. P., R. E. McGehee, Jr., and J. F. Habener. 1994. IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene. EMBO J. 13:1145–1156.
  • Monaghan, A. P., K. H. Kaestner, E. Grau, and G. Schutz. 1994. Postimplantation expression patterns indicate a role for the mouse fork head/ HNF-3 a, þ, and μ genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm. Development 119:567–578.
  • Naya, F. J., C. M. M. Stellrecht, and M.-J. Tsai. 1995. Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor. Genes Dev. 9:1009–1019.
  • Nordeen, S. K., P. P. Green III, and D. M. Fowles. 1987. Laboratory methods. A rapid, sensitive, and inexpensive assay for chloramphenicol acetyltransferase. DNA 6:173–178.
  • Offield, M. F., T. L. Jetton, R. Stein, T. Labosky, M. Ray, M. Magnuson, B. Hogan, and C. V. E. Wright. 1996. PDX-1 is required for development of the pancreas and differentiation of the rostral duodenum. Development 122:983–995.
  • Ohlsson, H., K. Karlsson, and T. Edlund. 1993. IPF-1, a homeodomaincontaining transactivator of the insulin gene. EMBO J. 12:4251–4259.
  • Overdier, D. G., A. Porcella, and R. H. Costa. 1994. The DNA-binding specificity of the hepatocyte nuclear factor 3/forkhead domain is influenced by amino acid residues adjacent to the recognition helix. Mol. Cell. Biol. 14:2755–2766.
  • Peers, B., J. Leonard, S. Sharma, G. Teitelman, and M. R. Montiminy. 1995. Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1. Mol. Endocrinol. 8:1798–1806.
  • Peshavaria, M., L. Gamer, E. Henderson, G. Teitelman, C. V. E. Wright, and R. Stein. 1994. XIHbox 8, an endoderm-specific Xenopus homeodomain protein, is closely related to a mammalian insulin gene transcription factor. Mol. Endocrinol. 8:806–816.
  • Petersen, H. V., P. Serup, J. Leonard, B. K. Michelsen, and O. D. Madsen. 1994. Transcriptional regulation of the human insulin gene is dependent of the homeodomain proteins STF1/IPF1 acting through the CT boxes. Proc. Natl. Acad. Sci. USA 91:10465–10469.
  • Pictet, R., and W. J. Rutter. 1972. Development of the embryonic endocrine pancreas, p. 25–66. In D. F. Steiner and M. Frenkel (ed.), Handbook of physiology. American Physiology Society, Washington, D.C.
  • Robinson, G. L. W. G., M. Peshavaria, E. Henderson, S.-Y. Shieh, M.-J. Tsai, G. Teitelman, and R. Stein. 1994. Expression of the trans-active factors that stimulate insulin control element mediated activity precedes insulin transcription. J. Biol. Chem. 269:2452–2460.
  • Sadowski, H. B., and M. Z. Gilman. 1993. Cell-free activation of a DNA- binding protein by epidermal growth factor. Nature (London) 362:79–82.
  • Saiki, R. K., D. H. Gelfand, S. Stoffel, J. J. Scharf, R. Higuchi, G. T. Horn, K. B. Mullis, and H. A. Erlich. 1988. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239:487–491.
  • Sasaki, H., and B. L. M. Hogan. 1993. Differential expression of multiple fork head related genes during gastrulation and pattern formation in the mouse embryo. Development 118:47–59.
  • Sasaki, H., and B. L. M. Hogan. 1996. Enhancer analysis of the mouse HNF-3þ gene: regulatory elements for node/notochord and floor plate are independent and consist of multiple sub-elements. Genes Cells 1:59–72.
  • Schreiber, E., P. Matthias, M. M. Muller, and W. Schaffner. 1989. Rapid detection of octamer binding proteins with ‘mini-extracts’ prepared from a small number of cells. Nucleic Acids Res. 17:6419.
  • Sharma, S., J. Leonard, H. Chapman, E. Leiter, and M. Montminy. 1996. Pancreatic islet restricted expression of the homeobox factor STF-1 relies on an E-box motif which binds USF. J. Biol. Chem. 271:2294–2299.
  • Sharma, S., U. S. Jhala, T. Johnson, K. Ferreri, J. Leonard, and M. Montminy. 1997. Hormonal regulation of an islet-specific enhancer in the pancreatic homeobox gene STF-1. Mol. Cell. Biol. 17:2598–2604.
  • Sosa-Pineda, B., K. Chowdhury, M. Torres, G. Oliver, and P. Gruss. 1997. The Pax4 gene is essential for differentiation of insulin-producing þ cells in the mammalian pancreas. Nature (London) 386:399–402.
  • Steger, D. J., and J. L. Workman. 1996. Remodeling chromatin structures for transcription: what happens to the histones? Bioessays 18:875–884.
  • Stoffers, D. A., N. T. Zinkin, V. Stanojevec, W. L. Clarke, and J. F. Habener. 1997. Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence. Nat. Genet. 15:107–110.
  • Wang, J.-C., P.-E. Stromstedt, R. M. O’Brien, and D. K. Granner. 1996. Hepatic nuclear factor 3 is an accessory factor required for the stimulation of phosphoenolpyruvate carboxykinase gene transcription by glucocorticoids. Mol. Endocrinol. 10:794–800.
  • Weinstein, D. C., A. Ruiz, I. Altaba, W. S. Chen, P. Hoodless, V. R. Prezioso, T. M. Jessell, and J. E. Darnell, Jr. 1994. The winged-helix transcription factor HNF-3þ is required for notochord development in the mouse embryo. Cell 78:575–599.
  • Wessels, N. K., and J. H. Cohen. 1968. Ultrastructural studies of early morphogenesis and cytodifferentiation in the embryonic pancreas. Dev. Biol. 17:413–446.
  • Whelan, J., D. Poon, P. A. Weil, and R. Stein. 1989. Pancreatic þ-cell-typespecific expression of the rat insulin II gene is controlled by positive and negative transcriptional elements. Mol. Cell. Biol. 9:3253–3259.
  • Whelan, J., S. R. Cordle, E. Henderson, P. A. Weil, and R. Stein. 1990. Identification of a pancreatic þ-cell insulin gene transcription factor that binds to and appears to activate cell-type-specific expression: its possible relationship to other cellular factors that bind to a common insulin gene sequence. Mol. Cell. Biol. 10:1564–1572.
  • Wolffe, A. P. 1992. New insights into chromatin function in transcriptional control. FASEB J. 6:3354–3361.
  • Wright, C. V. E. Unpublished observations.
  • Yamagata, K., H. Furuta, N. Oda, P. J. Kaisaki, S. Menzel, N. J. Cox, S. S. Fajans, S. Signorini, M. Stoffel, and G. I. Bell. 1996. Mutations in the hepatocyte nuclear factor-4a gene in maturity-onset diabetes of the young (MODY1). Nature (London) 384:458–460.
  • Yamagata, K., N. Oda, P. J. Kaisaki, S. Menzel, H. Furuta, M. Vaxillaire, L. Southam, R. D. Cox, G. M. Lathrop, V. V. Boriraj, Z. Chen, N. J. Cox, Y. Oda, H. Yano, M. M. Le Beau, S. Yamada, N. Nishigori, J. Tekeda, S. S. Fajans, A. T. Hattersley, N. Iwasaki, T. Hansen, O. Pedersen, K. S. Polonsky, R. C. Turner, G. Velho, J.-C. Chevre, P. Froguel, and G. I. Bell. 1996. Mutations in the hepatocyte nuclear factor-1a gene in maturity-onset diabetes of the young (MODY3). Nature (London) 384:455–458.
  • Zaret, K. S. 1996. Molecular genetics of early liver development. Annu. Rev. Physiol. 58:231–251.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.