REFERENCES
- Ahmad, M., S. M. Srinivasula, L. J. Wang, R. V. Talanian, G. Litwack, T. Fernandes-Alnemri, and E. S. Alnemri. 1997. CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL tumor necrosis factor receptor-interacting protein RIP. Cancer Res. 57:615–619.
- Alnemri, E. S. 1997. Mammalian cell death proteases—a family of highly conserved aspartate specific cysteine proteases. J. Cell. Biochem. 64:33–42.
- Boldin, M. P., E. E. Varfolomeev, Z. Pancer, I. L. Mett, J. H. Camonis, and D. Wallach. 1995. A novel protein that interacts with the death domain of fas/apo1 contains a sequence motif related to the death domain. J. Cell. Biochem. 270:7795–7798.
- Chinnaiyan, A. M., K. O’Rourke, M. Tewari, and V. M. Dixit. 1995. FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis. Cell 81:505–512.
- Chinnaiyan, A. M., K. O’Rourke, B. R. Lane, and V. M. Dixit. 1997. Interaction of ced-4 with ced-3 and ced-9—a molecular framework for cell death. Science 275:1122–1126.
- Chow, S. C., M. Weis, G. Kass, T. H. Holmstrom, J. E. Eriksson, and S. Orrenius. 1995. Involvement of multiple proteases during fas-mediated apoptosis in T lymphocytes. FEBS Lett. 364:134–138.
- Deiss, L. P., H. Galinka, H. Berissi, O. Cohen, and A. Kimchi. 1996. Cathepsin d protease mediates programmed cell death induced by interferongamma, Fas/APO-1 and TNF-alpha. EMBO J. 15:3861–3870.
- Drexler, H. 1997. Activation of the cell death program by inhibition of proteasome function. Proc. Natl. Acad. Sci. USA 94:855–860.
- Duan, H., and V. M. Dixit. 1997. RAIDD is a new death adaptor molecule. Nature 385:86–89.
- Fernandes-Alnemri, T., A. Takahashi, R. Armstrong, J. Krebs, L. Fritz, K. J. Tomaselli, L. Wang, Z. Yu, C. M. Croce, G. Salveson, W. C. Earnshaw, G. Litwack, and E. S. Alnemri. 1995. Mch3, a novel human apoptotic cysteine protease highly related to CPP32. Cancer Res. 55:6045–6052.
- Fernandes-Alnemri, T., G. Litwack, and E. S. Alnemri. 1995. Mch2, a new member of the apoptotic ced-3/ICE cysteine protease gene family. Cancer Res. 55:2737–2742.
- Fujita, E., T. Mukasa, T. Tsukahara, K. Arahata, S. Omura, and T. Momoi. 1996. Enhancement of CPP32-like activity in the TNF-treated U937 cells by the proteasome inhibitors. Biochem. Biophys. Res. Commun. 224:74–79.
- Grimm, L. M., A. L. Goldberg, G. G. Poirier, L. M. Schwartz, and B. A. Osborne. 1996. Proteasomes play an essential role in thymocyte apoptosis. EMBO J. 15:3835–3844.
- Katunuma, N., and E. Kominami. 1995. Structure, properties, mechanisms, and assays of cysteine protease inhibitors: cystatins and E-64 derivatives. Methods Enzymol. 251:382–397.
- Lazebnik, Y. A., S. Cole, C. A. Cooke, W. G. Nelson, and W. C. Earnshaw. 1993. Nuclear events of apoptosis in vitro in cell free mitotic extracts—a model system for analysis of the active phase of apoptosis. J. Cell Biol. 123:7–22.
- Lazebnik, Y. A., A. Takahashi, R. D. Moir, R. D. Goldman, G. G. Poirier, S. H. Kaufmann, and W. C. Earnshaw. 1995. Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution. Proc. Natl. Acad. Sci. USA 92:9042–9046.
- Liu, X. S., H. Zou, C. Slaughter, and X. D. Wang. 1997. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell 89:175–184.
- Lugasi, H., S. Hajos, J. R. Murphy, T. B. Strom, J. Nichols, C. Penarroja, and D. Naor. 1990. Murine spontaneous T-cell leukemia constitutively expressing IL-2 receptor—a model for human T-cell malignancies expressing IL-2 receptor. Int. J. Cancer 45:163–167.
- Nagata, S. 1997. Apoptosis by death factor. Cell 88:355–365.
- Nicholson, D. W., A. Ali, N. A. Thornberry, J. P. Vaillancourt, C. K. Ding, M. Gallant, Y. Gareau, P. R. Griffin, M. Labelle, Y. A. Lazebnik, N. A. Munday, S. M. Raju, M. E. Smulson, T. T. Yamin, V. L. Yu, and D. K. Miller. 1995. Identification and inhibition of the ICE/ced-3 protease necessary for mammalian apoptosis. Nature 376:37–43.
- Rawlings, N. D., and A. J. Barrett. 1994. Families of cysteine peptidases. Methods Enzymol. 244:461–486.
- Sarin, A., D. H. Adams, and P. A. Henkart. 1993. Protease inhibitors selectively block T cell receptor-triggered programmed cell death in a murine T cell hybridoma and activated peripheral T cells. J. Exp. Med. 178:1693–1700.
- Shinohara, K., M. Tomioka, H. Nakano, S. Tone, H. Ito, and S. Kawashima. 1996. Apoptosis induction resulting from proteasome inhibition. Biochem. J. 317:385–388.
- Squier, M., and J. J. Cohen. 1997. Calpain, an upstream regulator of thymocyte apoptosis. J. Immunol. 158:3690–3697.
- Ucker, D. S., P. S. Obermiller, W. Eckhart, J. R. Apgar, N. A. Berger, and J. Meyers. 1992. Genome digestion is a dispensable consequence of physiological cell death mediated by cytotoxic T lymphocytes. Mol. Cell. Biol. 12:3060–3069.
- Williams, M. S., and P. A. Henkart. 1994. Apoptotic cell death induced by intracellular proteolysis. J. Immunol. 153:4247–4255.
- Wyllie, A. H. 1980. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284:555–556.
- Yoshida, A., R. Takauji, M. Inuzuka, T. Ueda, and T. Nakamura. 1996. Role of serine and ICE-like proteases in induction of apoptosis by etoposide in human leukemia HL-60 cells. Leukemia 10:821–824.
- Yuan, J. Y., S. Shaham, S. Ledoux, H. M. Ellis, and H. R. Horvitz. 1993. The C. elegans cell death gene ced 3 encodes a protein similar to mammalian interleukin 1 beta converting enzyme. Cell 75:641–652.