Expression of Wild-Type α-Catenin Protein in Cells with a Mutant α-Catenin Gene Restores Both Growth Regulation and Tumor Suppressor Activities

REFERENCES

• Aberle, H., S. Butz, J. Stappert, H. Weissig, R. Kemler, and H. Hoschuetzky. 1994. Assembly of the cadherin-catenin complex in vitro with recombinant proteins. J. Cell Sci. 107:3655–3663.
   PubMed Web of Science ®Google Scholar
• Ewing, C. M., N. Ru, R. A. Morton, J. C. Robinson, M. J. Wheelock, K. R. Johnson, J. C. Barrett, and W. B. Isaacs. 1995. Chromosome 5 suppresses tumorigenicity of PC3 prostate cancer cells: correlation with re-expression of a-catenin and restoration of E-cadherin function. Cancer Res. 55:4813–4817.
   PubMed Web of Science ®Google Scholar
• Herrenknecht, K., M. Ozawa, S. C. Ecker, F. Lottspeich, M. Lenter, and R. Kemler. 1991. The uvomorulin-anchorage protein alpha catenin is a vinculin homologue. Proc. Natl. Acad. Sci. USA 88:9156–9160.
   PubMed Web of Science ®Google Scholar
• Hinck, L., I. S. Nathke, J. Papkoff, and W. J. Nelson. 1994. Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly. J. Cell Biol. 125:1327–1340.
   PubMed Web of Science ®Google Scholar
• Innis, M. A., D. H. Gelfand, J. J. Sninsky, and T. J. White. 1990. PCR protocols—a guide to methods and applications. Academic Press, Inc., San Diego, Calif.
   Google Scholar
• Jou, T.-S., D. B. Stewart, J. Stappert, W. J. Nelson, and J. A. Marrs. 1995. Genetic and biochemical dissection of protein linkages in the cadherin-catenin complex. Proc. Natl. Acad. Sci. USA 92:5067–5071.
   PubMed Web of Science ®Google Scholar
• Kadowaki, T., H. Shiozaki, M. Inoue, S. Tamura, H. Oka, Y. Doki, K. Iihara, S. Matsui, T. Iwazawa, A. Nagafuchi, S. Tsukita, and T. Mori. 1994. E-cadherin and a-catenin expression in human esophageal cancer. Cancer Res. 54:291–296.
   PubMed Web of Science ®Google Scholar
• Kintner, C. 1992. Regulation of embryonic cell adhesion by the cadherin cytoplasmic domain. Cell 69:225–236.
   PubMed Web of Science ®Google Scholar
• Kozak, M. 1984. Selection of initiation sites by eukaryotic ribosomes: effect of inserting AUG triplets upstream from the coding sequence for preproinsulin. Nucleic Acids Res. 12:3873–3893.
   PubMed Web of Science ®Google Scholar
• Kozak, M. 1992. Regulation of translation in eukaryotic systems. Annu. Rev. Cell Biol. 8:197–225.
   PubMedGoogle Scholar
• Kozyraki, R., J.-Y. Scoazec, J.-F. Flejou, A. D’errico, P. Bedossa, B. Terris, M. Fiorentino, A.-F. Bringuier, W. Grigioni, and G. Feldmann. 1996. Expression of cadherins and a-catenin in primary epithelial tumors of the liver. Gastroenterology 110:1137–1149.
   PubMedGoogle Scholar
• Liu, C.-C., C. Simnsen, and A. Levinson. 1984. Initiation of translation at internal AUG codons in mammalian cells. Nature 309:82–85.
   PubMed Web of Science ®Google Scholar
• Mader, S., and J. H. White. 1993. A steroid-inducible promoter for the controlled overexpression of cloned genes in eukaryotic cells. Proc. Natl. Acad. Sci. USA 90:5603–5607.
   PubMed Web of Science ®Google Scholar
• Magee, A. I., and R. S. Buxton. 1991. Transmembrane molecular assemblies regulated by the greater cadherin family. Curr. Opin. Cell Biol. 3:854–861.
   PubMed Web of Science ®Google Scholar
• Matsui, S., H. Shiozaki, M. Inoue, S. Tamura, Y. Doki, T. Kadowaki, T. Iwazawa, K. Shimaya, A. Nagafuchi, S. Tsukita, and T. Mori. 1994. Immunohistochemical evaluation of alpha-catenin expression in human gastric cancer. Virchows Arch. 424:375–381.
   PubMedGoogle Scholar
• Moll, R., M. Mitze, U. H. Frixen, and W. Birchmeir. 1993. Differential loss of E-cadherin expression in infiltrating ductal and lobal breast carcinomas. Am. J. Pathol. 143:1731–1742.
   PubMed Web of Science ®Google Scholar
• Morton, R. A., C. M. Ewing, A. Nagafuchi, S. Tsukita, and W. B. Isaacs. 1993. Reduction of E-cadherin levels and deletion of the a-catenin gene in human prostate cancer cells. Cancer Res. 53:3585–3590.
   PubMed Web of Science ®Google Scholar
• Nagafuchi, A., and M. Takeichi. 1988. Cell binding function of E-cadherin is regulated by the cytoplasmic domain. EMBO J. 7:3679–3684.
   PubMed Web of Science ®Google Scholar
• Nagafuchi, A., and M. Takeichi. 1989. Transmembrane control of cadherin-mediated cell adhesion: a 94-kD protein functionally associates with a specific region of the cytoplasmic domain of E-cadherin. Cell Regul. 1:37–44.
   PubMedGoogle Scholar
• Nagafuchi, A., M. Takeichi, and S. Tsukita. 1991. The 102-kD cadherin-associated protein: similarity to vinculin and posttranslational regulation of expression. Cell 65:849–857.
   PubMed Web of Science ®Google Scholar
• Ochiai, A., S. Akimoto, Y. Shimoyama, A. Nagafuchi, S. Tsukita, and S. Hirohashi. 1994. Frequent loss of a-catenin expression in scirrhous carcinomas with scattered cell growth. Jpn. J. Cancer Res. 85:266–273.
   PubMedGoogle Scholar
• Oda, T., Y. Kanai, Y. Shimoyama, A. Nagafuchi, S. Tsukita, and S. Hirohashi. 1993. Cloning of the human a-catenin cDNA and its aberrant mRNA in a human cancer cell line. Biochem. Biophys. Res. Commun. 193:897–904.
   PubMed Web of Science ®Google Scholar
• Oyama, T., Y. Kanai, A. Ochiai, S. Akimoto, T. Oda, K. Yanagihara, A. Nagafuchi, S. Tsukita, S. Shibamoto, F. Ito, M. Takeichi, H. Matsuda, and S. Hirohashi. 1994. A truncated b-catenin disrupts the interaction between E-cadherin and a-catenin: a cause of loss of intercellular adhesiveness in human cancer cell lines. Cancer Res. 54:6282–6287.
   PubMed Web of Science ®Google Scholar
• Ozawa, M., H. Baribault, and R. Kemler. 1989. The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J. 8:1711–1717.
   PubMed Web of Science ®Google Scholar
• Ozawa, M., M. Ringwals, and R. Kemler. 1990. Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule. Proc. Natl. Acad. Sci. USA 87:4246–4250.
   PubMed Web of Science ®Google Scholar
• Peabody, D., S. Subramani, and P. Berg. 1986. Effect of upstream reading frames on translation efficiency in simian virus 40 recombinants. Mol. Cell. Biol. 6:2704–2711.
   PubMedGoogle Scholar
• Pierceall, W. E., A. S. Woodard, J. S. Morrow, D. Rimm, and E. R. Fearon. 1995. Frequent alteration in E-cadherin and a-catenin expression in human breast cancer cell lines. Oncogene 11:1319–1325.
   PubMed Web of Science ®Google Scholar
• Reynolds, A. B., J. Daniel, P. D. McCrea, M. J. Wheelock, J. Wu, and Z. Zhang. 1994. Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes. Mol. Cell. Biol. 14:8333–8342.
   PubMed Web of Science ®Google Scholar
• Rimm, D. L., J. H. Sinard, and J. S. Morrow. 1995. Reduced a-catenin and E-cadherin expression in breast cancer. Lab. Invest. 72:506–512.
   PubMed Web of Science ®Google Scholar
• Schipper, J. H., U. H. Frixen, J. Behrens, A. Unger, K. Jahnke, and W. Birchmeier. 1991. E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis. Cancer Res. 51:6328–6337.
   PubMed Web of Science ®Google Scholar
• Shimazui, T., J. Schalken, L. Giroldi, C. Jansen, H. Akaza, K. Koiso, F. Debruyne, and P. Bringuier. 1996. Prognostic value of cadherin-associated molecules (a-, b-, and g-catenins and p120cas) in bladder tumors. Cancer Res. 56:4154–4158.
   PubMed Web of Science ®Google Scholar
• Shiozaki, H., K. Iihara, H. Oka, T. Kadowaki, S. Matsui, J. Gofuku, M. Inoue, A. Nagafuchi, S. Tsukita, and T. Mori. 1994. Immunohistochemical detection of a-catenin expression in human cancers. Am. J. Pathol. 144:667–674.
   PubMedGoogle Scholar
• Takayama, T., H. Shiozaki, M. Inoue, S. Tamura, H. Oka, and T. Kadowaki. 1994. Expression of E-cadherin and a-catenin molecules in human breast cancer tissues and association with clinicopathological features. Int. J. Oncol. 5:775–780.
   PubMed Web of Science ®Google Scholar
• Takayama, T., H. Shiozaki, S. Shibamoto, H. Oka, Y. Kimura, S. Tamura, M. Inoue, T. Monden, F. Ito, and M. Monden. 1996. b-Catenin expression in human cancers. Am. J. Pathol. 148:39–46.
   PubMed Web of Science ®Google Scholar
• Takeichi, M. 1990. Cadherins: a molecular family important in selective cell-cell adhesion. Annu. Rev. Biochem. 59:237–252.
   PubMed Web of Science ®Google Scholar
• Tanaka, M., and W. Herr. 1990. Differential transcriptional activation of oct-1 and oct-2: independent activation domains induce oct-2 phosphorylation. Cell 60:375–386.
   PubMedGoogle Scholar
• Tsukita, S., A. Nagafuchi, and S. Yonemura. 1992. Molecular linkage between cadherins and actin filaments in cell-cell adherens junctions. Curr. Opin. Cell Biol. 4:834–839.
   PubMedGoogle Scholar
• Vermeulen, S. J., E. A. Bruyneel, M. E. Bracke, G. K. De Bruyne, K. M. Vennekens, K. L. Vleminckx, G. J. Berx, F. M. van Roy, and M. M. Mareel. 1995. Transition from the noninvasive to the invasive phenotype and loss of a-catenin in human colon cancer cells. Cancer Res. 55:4722–4728.
   PubMed Web of Science ®Google Scholar
• Vleminckx, K., L. Vakaet, M. Marell, W. Fiers, and F. Van Roy. 1991. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell 66:107–119.
   PubMed Web of Science ®Google Scholar
• Watabe, M., A. Nagafuchi, S. Tsukita, and M. Takeichi. 1994. Induction of polarized cell-cell association and retardation of growth by activation of the E-cadherin-catenin adhesion system in a dispersed carcinoma line. J. Cell Biol. 127:247–256.
   PubMed Web of Science ®Google Scholar