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Research Article

Control of Thrombopoietin-Induced Megakaryocytic Differentiation by the Mitogen-Activated Protein Kinase Pathway

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Pages 4991-5000 | Received 08 Apr 1997, Accepted 21 Jun 1997, Published online: 29 Mar 2023

REFERENCES

  • Alexander, W. S., A. B. Maurer, U. Novak, and M. Harrison-Smith. 1996. Tyrosine-599 of the c-mpl receptor is required for Shc phosphorylation and the induction of cellular differentiation. EMBO. J. 15:6531–6540.
  • Bartley, D. T., J. Bogenberger, P. Hunt, Y. S. Li, H. S. Lu, F. Martin, M. S. Chang, B. Samal, J. L. Nichol, S. Swift, M. J. Johnson, R. Y. Hsu, V. P. Parker, S. Suggs, J. D. Skrine, L. A. Merewether, C. Clogston, E. Hsu, M. M. Hokom, A. Hornkohl, E. Choi, M. Pangelinan, Y. Sun, V. Mar, J. McNinch, L. Simonet, F. Jacobsen, C. Xie, J. Shuter, H. Chute, R. Basu, L. Selander, D. Trollinger, L. Sieu, D. Padilla, G. Trail, G. Elliot, R. Izumi, T. Covey, J. Crouse, A. Garcia, W. Xu, J. Del Castillo, J. Biron, S. Cole, M. C. T. Hu, R. Pacifici, I. Ponting, C. Saris, D. Wen, Y. P. Yung, H. Lin, and R. A. Bosselman. 1994. Identification and cloning of a megakaryocyte growth and development factor, that is a ligand for the cytokine receptor MPL. Cell 77:1117–1124.
  • Beadling, C., J. Ng, J. W. Babbage, and D. A. Cantrell. 1996. Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway. EMBO. J. 15:1902–1913.
  • Brunet, A., G. Pagès, and J. Pouysségur. 1994. Constitutively active mutantsof MAP kinase kinase (MEK1) induce growth factor-relaxation and oncogenicity when expressed in fibroblasts. Oncogene 9:3379–3387.
  • Burgering, B. M. T., A. M. M. de Vries-Smits, R. H. Medema, P. C. van Weeren, L. G. J. Tertoolen, and J. L. Bos. 1993. Epidermal growth factor induces phosphorylation of extracellular signal-regulated kinase 2 via multiple pathways. Mol. Cell. Biol. 13:7248–7256.
  • Büscher, D., R. A. Hipskind, S. Krautwald, T. Reimann, and M. Baccarini. 1995. Ras-dependent and -independent pathways target the mitogen-activated protein kinase network in macrophages. Mol. Cell. Biol. 15:466–475.
  • Corcoran, A. E., F. M. Smart, R. J. Cowling, T. Crompton, M. J. Owen, and A. R. Venkitaraman. 1996. The interleukin-7 receptor a chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis. EMBO. J. 15:1924–1932.
  • Cowley, S., H. Paterson, P. Kemp, and C. J. Marshall. 1994. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 77:841–852.
  • Crompton, T., K. C. Gilmour, and M. J. Owen. 1996. The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte. Cell 86:243–251.
  • Damen, J. E., L. Liu, P. Rosten, R. K. Humphries, A. B. Jefferson, P. W. Majerus, and G. Krystal. 1996. The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5,-triphosphate 5-phosphatase. Proc. Natl. Acad. Sci. USA 93:1689–1693.
  • Debili, N., F. Wendling, D. Cosman, M. Titeux, C. Florindo, I. Dusanter-Fourt, K. Schooley, N. Methia, M. Charon, R. Nador, A. Bettaieb, and W. Vainchenker. 1995. The Mpl receptor is expressed in the megakaryocytic lineage from late progenitors to platelets. Blood 85:391–401.
  • De Sauvage, F. J., P. E. Hass, S. D. Spencer, B. E. Malloy, A. L. Gurney, S. A. Spencer, W. C. Darbonne, W. J. Henzel, S. C. Wong, W. J. Kuang, K. J. Oles, B. Hultgren, L. A. Solberg, Jr., D. V. Goeddel, and D. L. Eaton. 1994. Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-mpl ligand. Nature 369:533–538.
  • Downward, J., J. D. Graves, P. H. Warne, S. Rayter, and D. A. Cantrell. 1990. Stimulation of p21ras upon T-cell activation. Nature 346:719–723.
  • Drachman, J. G., J. D. Griffin, and K. Kaushansky. 1995. The c-mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c- mpl. J. Biol. Chem. 270:4979–4982.
  • Drachman, J. G., and K. Kaushansky. 1997. Dissecting the thrombopoietin receptor: functional elements of the Mpl cytoplasmic domain. Proc. Natl. Acad. Sci. USA 94:2350–2355.
  • Dudley, D. T., L. Pang, S. J. Decker, A. J. Bridges, and A. R. Saltiel. 1995. A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc. Natl. Acad. Sci. USA 92:7686–7689.
  • Eychène, A., I. Dusanter-Fourt, J. Vianney Barnier, C. Papin, M. Charon, S. Gisselbrecht, and G. Calothy. 1995. Expression and activation of B-Raf kinase isoforms in human and murine leukemia cell lines. Oncogene 10:1159–1165.
  • Fabian, J. R., I. O. Daar, and D. K. Morrison. 1993. Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase. Mol. Cell. Biol. 13:7170–7179.
  • Fukanaga, R., E. Ishizaka-Ikeda, and S. Nagata. 1993. Growth and differentiation signals mediated by different regions in the cytoplasmic domain of granulocyte colony-stimulating factor receptor. Cell 74:1079–1087.
  • Gobert, S., V. Duprez, C. Lacombe, S. Gisselbrecht, and P. Mayeux. 1995. The signal transduction pathway involves three forms of mitogen-activated protein (MAP) kinase in UT7 erythroleukemia cells. Eur. J. Biochem. 234:75–83.
  • Gurney, A. L., S. C. Wong, W. J. Henzel, and F. J. de Sauvage. 1995. Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylation. Proc. Natl. Acad. Sci. USA 92:5292–5296.
  • Hankins, W. D., and E. M. Scolnick. 1981. Harvey and Kirsten sarcoma viruses promote growth and differentiation of erythroid precursor cells in vitro. Cell 26:91–97.
  • Hill, R. J., S. Zozulya, Y.-L. Lu, P. W. Hollenbach, B. Joyce-Shaikh, J. Bogenberger, and M. L. Gishizky. 1996. Differentiation induced by the c-mpl cytokine receptor is blocked by mutant Shc adaptor protein. Cell Growth Differ. 7:1125–1134.
  • Hong, Y., J. F. Martin, W. Vainchenker, and J. D. Erusalimsky. 1996. Inhibition of protein kinase C suppresses megakaryocytic differentiation and stimulates erythroid differentiation in HEL cells. Blood 87:123–131.
  • Ihle, J. N. 1996. Signaling by the cytokine receptor superfamily in normal and transformed hematopoietic cells. Adv. Cancer Res. 68:23–65.
  • Izquierdo, M., J. Downward, J. D. Graves, and D. A. Cantrell. 1992. Role of protein kinase C in T-cell antigen receptor regulation of p21ras: evidence that two p21ras regulatory pathways coexist in T cells. Mol. Cell. Biol. 12:3305–3312.
  • Kaushansky, K., S. Lok, R. D. Holly, V. C. Broudy, N. Lin, M. C. Balley, J. W. Forstrom, M. D. Buddie, P. J. Oort, F. S. Hagen, G. J. Roth, T. Papayannopoulou, and D. C. Foster. 1994. Promotion of megakaryocyte progenitor expansion and differentiation by the c-mpl ligand thrombopoietin. Nature 369:568–571.
  • Kinoshita, T., T. Yokota, K.-I. Arai, and A. Miyajima. 1995. Suppression of apoptotic death in hematopoietic cells by signaling through the IL-3/GM- CSF receptors. EMBO J. 14:266–275.
  • Kolch, W., G. Heidecker, G. Kochs, R. Hummel, H. Vahidi, H. Mischak, G. Finkenzeller, D. Marme, and U. R. Rapp. 1993. Protein kinase Ca activates RAF-1 by direct phosphorylation. Nature 364:249–252.
  • Komatsu, N., H. Nakauchi, A. Miwa, T. Ishihara, M. Eguchi, M. Moroi, M. Okada, Y. Sato, H. Wada, Y. Yawata, T. Suda, and Y. Miura. 1991. Establishment and characterization of a human leukemic cell line with megakaryo- cytic features: dependency on granulocyte-macrophage colony-stimulating factor, interleukin 3, or erythropoietin for growth and survival. Cancer Res. 51:341–348.
  • Ku, H., Y. Yonemura, K. Kaushansky, and M. Ogawa. 1996. Thrombopoietin, the ligand for the Mpl receptor, synergizes with steel factor and other early acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice. Blood 87:4544–4551.
  • Li, W., R. Nishimura, A. Kashishian, A. G. Batzer, W. J. H. Kim, J. A. Cooper, and J. Schlessinger. 1994. A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase. Mol. Cell. Biol. 14:509–517.
  • Lok, S., K. Kaushansky, R. D. Holly, J. L. Kuijiper, C. E. Lofton-Day, P. J. Oort, F. J. Grant, M. D. Heipel, S. K. Burkhead, J. M. Kramer, L. A. Bell, C. A. Sprecher, H. Blumberg, R. Johnson, D. Prunckard, A. F. T. Ching, S. L. Mathewes, M. C. Bailey, J. W. Forstrom, M. M. Buddle, S. G. Osborn, S. J. Evans, P. O. Sheppard, S. R. Presnell, P. J. O’Hara, F. S. Hagen, G. J. Roth, and D. C. Foster. 1994. Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 369:565–568.
  • Lowy, D. R., and B. M. Willumsen. 1993. Function and regulation of Ras. Annu. Rev. Biochem. 62:851–891.
  • Mansour, S. J., W. T. Matten, A. S. Hermann, J. M. Candia, S. Rong, K. Fukasawa, G. F. Vande Woude, and N. G. Ahn. 1994. Transformation of mammalian cells by constitutively active MAP kinase kinase. Science 265:966–970.
  • Minami, M., M. Inoue, S. Wei, K. Takeda, M. Matsumoto, T. Kishimoto, and S. Akira. 1996. STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line. Proc. Natl. Acad. Sci. USA 93:3963–3966.
  • Morita, H., T. Tahara, A. Matsumoto, T. Kato, H. Miyazaki, and H. Ohashi. 1996. Functional analysis of the cytoplasmic domain of the human Mpl receptor for tyrosine-phosphorylation of the signaling molecules, proliferation and differentiation. FEBS Lett. 395:228–234.
  • Mu, S. X., M. Xia, G. Elliot, J. Bogenberger, S. Swift, L. Bennett, D. L. Lappinga, R. Hetch, R. Lee, and C. J. M. Charis. 1995. Megakaryocyte growth and development factor and interleukin-3 induce patterns of protein tyrosine-phosphorylation that correlate with dominant differentiation over proliferation of mpl-transfected 32D cells. Blood 86:4532–4543.
  • Pages, G., A. Brunet, G. L’Allemain, and J. Pouyssegur. 1994. Constitutive mutant and putative regulatory serine phosphorylation site of mammalian MAP kinase kinase (MEK1). EMBO J. 13:3003–3010.
  • Palacios, R., and M. Steinmetz. 1985. IL3-dependent mouse clones that express B-220 surface antigen, contain Ig genes in germ line configuration and generate B lymphocytes. Cell 41:727–734.
  • Pallard, C., F. Gouilleux, L. Benit, L. Cocault, M. Souyri, D. Levy, B. Groner, S. Gisselbrecht, and I. Dusanter-Fourt. 1995. Thrombopoietin activates a STAT5-like factor in hematopoietic cells. EMBO. J. 14:2847–2856.
  • Pelicci, G., L. Lanfrancone, F. Grignani, J. McGlade, F. Cavallo, G. Forni, I. Nocoletti, T. Pawson, and P. G. Pelicci. 1992. A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell 70:93–104.
  • Pierce, J. H., and S. A. Aaronson. 1985. Myeloid cell transformation by ras-containing murine sarcoma viruses. Mol. Cell. Biol. 5:667–674.
  • Porteu, F., M.-C. Rouyez, L. Cocault, L. Benit, M. Charon, F. Picard, S. Gisselbrecht, M. Souyri, and I. Dusanter-Fourt. 1996. Functional regions of the mouse thrombopoietin receptor cytoplasmic domain: evidence for a critical region which is involved in differentiation and can be complemented by erythropoietin. Mol. Cell. Biol. 16:2473–2482.
  • Porteu, F., and M. C. Rouyez. Unpublished data.
  • Qiu, M., and S. H. Green. 1992. PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged Erk activity. Neuron 9:705–717.
  • Ryan, J. J., L. J. McReynolds, A. Keegan, L.-H. Wang, E. Garfein, P. Rothman, K. Nelms, and W. E. Paul. 1996. Growth and gene expression are predominantly controlled by distinct regions of the human IL-4 receptor. Cell 4:123–132.
  • Satoh, T., W. J. Fantl, J. A. Escobedo, L. T. Williams, and Y. Kaziro. 1993. Platelet-derived growth factor receptor mediates activation of Ras through different signaling pathways in different cell types. Mol. Cell. Biol. 13:3706–3713.
  • Schlessinger, J. 1993. How receptor tyrosine kinases activate ras. Trends Biochem. Sci. 18:273–275.
  • Skoda, R. C., D. C. Seldin, M. K. Chiang, C. L. Peichel, T. F. Vogt, and P. Leder. 1993. Murine c-mpl: a member of the hematopoietic growth factor superfamily that transduces a proliferative signal. EMBO. J. 12:2645–2653.
  • Souyri, M., I. Vigon, J. F. Penciolelli, J. M. Heard, P. Tambourin, and F. Wendling. 1990. A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors. Cell 63:1137–1147.
  • Takata, K., and S. J. Singer. 1988. Detection of high concentrations of phosphotyrosine-modified proteins in mouse megakaryocytes. Blood 71:818–821.
  • Traverse, S., N. Gomez, H. Paterson, C. Marshall, and P. Cohen. 1992. Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor. Biochem. J. 288:351–355.
  • Traverse, S., K. Seedorf, H. Paterson, C. J. Marshall, P. Cohen, and A. Ullrich. 1995. EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor. Curr. Biol. 4:694–701.
  • Treisman, R. 1996. Regulation of transcription by MAP kinase cascades. Curr. Biol. 8:205–215.
  • Vigon, I., J. P. Mornon, L. Cocault, M. T. Mitjavila, P. Tambourin, S. Gisselbrecht, and M. Souyri. 1992. Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor superfamily. Proc. Natl. Acad. Sci. USA 89:5640–5644.
  • Vigon, I., C. Florindo, S. Fichelson, J. L. Guenet, M. G. Mattei, M. Souyri, D. Cosman, and S. Gisselbrecht. 1993. Characterization of the murine Mpl proto-oncogene, a member of the hematopoietic cytokine receptor family: molecular cloning, chromosomal location and evidence for a function in cell growth. Oncogene 8:2607–2615.
  • Waskiewicz, A. J., and J. A. Cooper. 1995. Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast. Curr. Biol. 7:798–805.
  • Wen, Z., Z. Zhong, and J. E. Darnell, Jr. 1995. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 82:241–250.
  • Yamada, M., N. Komatsu, K. Okada, T. Kato, H. Miyazaki, and Y. Miura. 1995. Thrombopoietin induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in human thrombopoietin-dependent cell lines. Biochem. Biophys. Res. Commun. 217:230–237.
  • Yamanaka, Y., K. Nakajima, T. Fukada, M. Hibi, and T. Hirano. 1996. Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for STAT3 activation. EMBO J. 15:1557–1565.

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