Pex19p, a Farnesylated Protein Essential for Peroxisome Biogenesis

REFERENCES

• Albertini, M., P. Rehling, R. Erdmann, W. Girzalsky, J. A. K. W. Kiel, M. Veenhuis, and W.-H. Kunau 1997. Pex14p, a peroxisomal membrane protein binding both receptors of the two PTS-dependent import pathways. Cell 89: 1–20.
   PubMedGoogle Scholar
• Ausubel, F. J., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl 1989. Current protocols in molecular biology. Greene Publishing Associates and Wiley-Interscience, New York, N.Y.
   Google Scholar
• Baerends, R. J. S., S. W. Rasmussen, R. E. Hilbrands, M. van der Heide, K. N. Faber, P. T. W. Reuvekamp, J. A. K. W. Kiel, J. M. Cregg, I. J. van der Klei, and M. Veenhuis 1996. The Hansenula polymorpha PER9 gene encodes a peroxisomal membrane protein essential for peroxisome assembly and integrity. J. Biol. Chem. 271: 8887–8894.
   PubMedGoogle Scholar
• Balch, W. E. 1990. Low molecular weight GTP-binding proteins (LMGPs) involved in vesicular transport: binary switches or biological transducers? Trends Biochem. Sci. 15: 469–472.
   PubMedGoogle Scholar
• Baumgart, E. 1994. Morphology of peroxisomes in light- and electron microscopy Peroxisomes: biochemistry, molecular biology and genetic diseases. In: Bugaut, M., and N. Latruffe37–57Springer-Verlag, Heidelberg, Germany.
   Google Scholar
• Bhattacharya, S., L. Chen, J. R. Broach, and S. Powers 1995. Ras membrane targeting is essential for glucose signaling but not for viability in yeast. Proc. Natl. Acad. Sci. USA 92: 2984–2988.
   PubMedGoogle Scholar
• Blobel, F., and R. Erdmann 1996. Identification of a peroxisomal member of the AMP-binding protein family. Eur. J. Biochem. 240: 468–476.
   PubMedGoogle Scholar
• Bloecker, H., and P. Brandt. Unpublished data.
   Google Scholar
• Braun, A., S. Kammerer, W. Weissenhorn, E. H. Weis, and H. Cleve 1994. Sequence of a putative human housekeeping gene (HK33) localized on chromosome 1. Gene 146: 291–295.
   PubMedGoogle Scholar
• Brocard, C., F. Kragler, M. M. Simon, T. Schuster, and A. Hartig 1994. The tetratricopeptide repeat-domain of the Pas10 protein of Saccharomyces cerevisiae is essential for binding the peroxisomal targeting signal SKL. Biochem. Biophys. Res. Commun. 204: 1016–1022.
   PubMedGoogle Scholar
• Brunelli, J. P., and M. L. Pall 1993. A series of yeast vectors for expression of cDNAs and other DNA sequences. Yeast 9: 1299–1308.
   PubMedGoogle Scholar
• Butt, T. R., E. J. Sternberg, J. A. Gorman, P. Clark, D. Hamer, M. Rosenberg, and S. T. Crooke 1984. Copper metallothionein of yeast, structure of the gene, and regulation of expression. Proc. Natl. Acad. Sci. USA 81: 3332–3336.
   PubMed Web of Science ®Google Scholar
• Caplan, A. J., J. Tsai, P. J. Casey, and M. G. Douglas 1992. Farnesylation of YDJ1p is required for function at elevated growth temperatures in Saccharomyces cerevisiae. J. Biol. Chem. 267: 18890–18895.
   PubMed Web of Science ®Google Scholar
• Chevray, P. M., and D. Nathans 1992. Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun. Proc. Natl. Acad. Sci. USA 89: 5789–5793.
   PubMed Web of Science ®Google Scholar
• Chien, C. T., P. L. Bartel, R. Sternglanz, and S. Fields 1991. The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest. Proc. Natl. Acad. Sci. USA 88: 9578–9582.
   PubMed Web of Science ®Google Scholar
• De Hoop, H. J., and G. Ab 1992. Import of proteins into peroxisomes and other microbodies. Biochem. J. 286: 657–669.
   PubMed Web of Science ®Google Scholar
• Distel, B., R. Erdmann, S. J. Gould, G. Blobel, D. I. Crane, J. M. Cregg, G. Dodt, Y. Fujiki, J. M. Goodman, W. W. Just, J. A. K. W. Kiel, W.-H. Kunau, P. B. Lazarow, G. P. Mannaerts, H. W. Moser, T. Osumi, R. A. Rachubinski, A. Roscher, S. Subramani, H. F. Tabak, T. Tsukamoto, D. Valle, I. van der Klei, P. P. van Veldhoven, and M. Veenhuis 1996. A unified nomenclature for peroxisome biogenesis. J. Cell Biol. 135: 1–3.
   PubMedGoogle Scholar
• Dodt, G., and S. J. Gould 1996. Multiple PEX genes are required for proper subcellular distribution and stability of Pex5p, the PTS1 receptor: evidence that PTS1 protein import is mediated by a cycling receptor. J. Cell Biol. 135: 1763–1774.
   PubMed Web of Science ®Google Scholar
• Dyer, J. M., J. A. McNew, and M. Goodman 1996. The sorting sequence of the peroxisomal integral membrane protein PMP47 is contained within a short hydrophilic loop. J. Cell Biol. 133: 269–280.
   PubMedGoogle Scholar
• Elgersma, Y., L. Kwast, A. Klein, T. Voorn-Brouwer, M. van den Berg, B. Metzig, T. America, H. F. Tabak, and B. Distel 1996. The SH3 domain of the Saccharomyces cerevisiae peroxisomal membrane protein Pex13p functions as a docking site for Pex5p, a mobile receptor for the import of PTS1 containing proteins. J. Cell Biol. 135: 97–109.
   PubMedGoogle Scholar
• Elgersma, Y., and H. F. Tabak 1996. Proteins involved in peroxisome biogenesis and functioning. Biochim. Biophys. Acta 1286: 269–283.
   PubMedGoogle Scholar
• Erdmann, R. 1994. The peroxisomal targeting signal of 3-oxoacyl-CoA thiolase from Saccharomyces cerevisiae. Yeast 10: 935–944.
   PubMedGoogle Scholar
• Erdmann, R., M. Veenhuis, D. Mertens, and W.-H. Kunau 1989. Isolation of peroxisome-deficient mutants of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 86: 5419–5423.
   PubMedGoogle Scholar
• Erdmann, R., and W.-H. Kunau 1992. A genetic approach to the biogenesis of peroxisomes in the yeast Saccharomyces cerevisiae. Cell Biochem. Funct. 10: 167–174.
   PubMedGoogle Scholar
• Erdmann, R., and W.-H. Kunau 1994. Purification and immunolocalization of the peroxisomal 3-oxoacyl-CoA thiolase from Saccharomyces cerevisiae. Yeast 10: 1173–1182.
   PubMed Web of Science ®Google Scholar
• Erdmann, R., and G. Blobel 1995. Giant peroxisomes in oleic acid-induced Saccharomyces cerevisiae lacking the peroxisomal membrane protein Pmp27p. J. Cell Biol. 128: 509–523.
   PubMed Web of Science ®Google Scholar
• Erdmann, R., and G. Blobel 1996. Identification of a peroxisomal membrane receptor for the C-terminal tripeptide signal recognition factor. J. Cell Biol. 135: 111–121.
   PubMed Web of Science ®Google Scholar
• Erdmann, R., M. Veenhuis, and W.-H. Kunau 1997. Peroxisomes: organelles at the cross-roads. Trends Cell Biol. 7: 400–407.
   PubMedGoogle Scholar
• Evan, G. I., G. K. Lewis, G. Ramsay, and J. M. Bishop 1985. Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol. Cell. Biol. 5: 3610–3616.
   PubMed Web of Science ®Google Scholar
• Fields, S., and O. K. Song 1989. A novel genetic system to detect protein-protein interactions. Nature 340: 245–246.
   PubMed Web of Science ®Google Scholar
• Gietz, R. D., and A. Sugino 1988. New yeast-E. coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. Gene 74: 527–534.
   PubMed Web of Science ®Google Scholar
• Glomset, J. A., M. H. Gelb, and C. C. Farnsworth 1990. Prenyl proteins in eukaryotic cells: a new type of membrane anchor. Trends Biochem. Sci. 15: 139–142.
   PubMed Web of Science ®Google Scholar
• Glover, J. R., D. W. Andrews, and R. A. Rachubinski 1994. Saccharomyces cerevisiae peroxisomal thiolase is imported as a dimer. Proc. Natl. Acad. Sci. USA 91: 10541–10545.
   PubMed Web of Science ®Google Scholar
• Goldstein, L. J., and M. S. Brown 1990. Regulation of the mevalonate pathway. Nature 343: 425–430.
   PubMed Web of Science ®Google Scholar
• Gould, S. J., G. A. Keller, and S. Subramani 1987. Identification of a peroxisomal targeting signal at the carboxy terminus of firefly luciferase. J. Cell Biol. 105: 2923–2931.
   PubMedGoogle Scholar
• Gould, S. J., J. E. Kalish, J. E. Morrell, J. Bjorkman, A. J. Urquhart, and D. I. Crane 1996. An SH3 protein in the peroxisome membrane is a docking factor for the PTS1 receptor. J. Cell Biol. 135: 85–95.
   PubMed Web of Science ®Google Scholar
• Harlow, E., and D. Lane 1988. Antibodies—a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
   Google Scholar
• Häusler, T., Y. D. Stierhof, E. Wirtz, and C. Clayton 1996. Import of a DHFR hybrid protein into glycosomes in vivo is not inhibited by the folate-analogue aminopterin. J. Cell Biol. 132: 311–324.
   PubMedGoogle Scholar
• Hill, J. E., A. M. Myers, T. J. Koerner, and A. Tzagaloff 1986. Yeast E. coli shuttle vectors with multiple unique restriction sites. Yeast 2: 163–167.
   PubMedGoogle Scholar
• Höhfeld, J., M. Veenhuis, and W.-H. Kunau 1991. PAS3, a Saccharomyces cerevisiae gene encoding a peroxisomal integral membrane protein essential for peroxisome biogenesis. J. Cell Biol. 114: 1167–1178.
   PubMedGoogle Scholar
• Horton, R. M., H. D. Hunt, S. N. Ho, J. K. Pullen, and L. R. Pease 1989. Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension. Gene 77: 61–68.
   PubMed Web of Science ®Google Scholar
• James, G. L., J. L. Goldstein, R. K. Pathak, R. G. W. Anderson, and M. S. Brown 1994. PxF, a prenylated protein of peroxisomes. J. Biol. Chem. 269: 14182–14190.
   PubMed Web of Science ®Google Scholar
• Jones, J. S., and L. Prakash 1990. Yeast Saccharomyces cerevisiae selectable markers in pUC18 polylinkers. Yeast 6: 363–366.
   PubMedGoogle Scholar
• Köhl, R., and W.-H. Kunau. Unpublished data.
   Google Scholar
• Krause, T. 1995. Investigation on membrane proteins of Saccharomyces cerevisiae with the focus on Pas3p. Ph.D. thesis. Ruhr-Universität Bochum, Bochum, Germany.
   Google Scholar
• Kyte, J., and R. F. Doolittle 1982. A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157: 105–132.
   PubMed Web of Science ®Google Scholar
• Lamb, J. R., W. A. Michaud, R. S. Sikorski, and P. A. Hieter 1994. Cdc16p, Cdc23p and Cdc27p form a complex for mitosis. EMBO J. 13: 4321–4328.
   PubMedGoogle Scholar
• Lazarow, P. B. 1993. Genetic approaches to study peroxisome biogenesis. Trends Cell Biol. 175: 105–132.
   Google Scholar
• Lazarow, P. B., and Y. Fujiki 1985. Biogenesis of peroxisomes. Annu. Rev. Cell Biol. 1: 489–530.
   PubMedGoogle Scholar
• Lazarow, P. B., and H. W. Moser Disorders in peroxisome biogenesis The metabolic and molecular bases of inherited disease7th ed.Scriver, C. R., C. R. Beaudet, W. S. Sly, and D. Valle219952287–2324McGraw-Hill Book Co., New York, N.Y.
   Google Scholar
• Maniatis, T., E. F. Fritsch, and J. Sambrook 1982. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
   Google Scholar
• Marshall, P. A., Y. I. Krimkevich, R. H. Lark, J. M. Deyer, M. Veenhuis, and J. M. Goodman 1995. PMP27 promotes peroxisome proliferation. J. Cell Biol. 129: 345–355.
   PubMed Web of Science ®Google Scholar
• Marzioch, M., R. Erdmann, M. Veenhuis, and W.-H. Kunau 1994. PAS7 encodes a novel yeast member of the WD-40 protein family essential for import of 3-oxoacyl-CoA thiolase, a PTS2-containing protein, into peroxisomes. EMBO J. 13: 4908–4918.
   PubMed Web of Science ®Google Scholar
• McCollum, D., E. Monosov, and S. Subramani 1993. The pas8 mutant of Pichia pastoris exhibits the peroxisomal protein deficiencies of Zellweger syndrome cells—the PAS8 protein binds to the COOH-terminal tripeptide peroxisomal targeting signal, and is a member of the TPR protein family. J. Cell Biol. 121: 761–774.
   PubMed Web of Science ®Google Scholar
• McNew, J. A., and J. M. Goodman 1994. An oligomeric protein is imported into peroxisomes in vivo. J. Cell Biol. 127: 1245–1257.
   PubMed Web of Science ®Google Scholar
• McNew, J. A., and J. M. Goodman 1996. The targeting and assembly of peroxisomal proteins: some old rules do not apply. Trends Biochem. Sci. 21: 54–58.
   PubMedGoogle Scholar
• Moreno de la Garza, M., U. Schultz-Borchardt, J. W. Crabb, and W.-H. Kunau 1985. Peroxisomal β-oxidation system of Candida tropicalis. Eur. J. Biochem. 148: 285–291.
   PubMedGoogle Scholar
• Omer, C. A., and J. B. Gibbs 1994. Protein prenylation in eukaryotic microorganisms: genetics, biology and biochemistry. Mol. Microbiol. 11: 219–225.
   PubMed Web of Science ®Google Scholar
• Osumi, T., T. Tsukamoto, S. Hata, S. Yokota, S. Miura, Y. Fujiki, M. Hijikata, S. Miyazawa, and T. Hashimoto 1991. Amino-terminal presequence of the precursor of peroxisomal 3-ketoacyl-CoA thiolase is a cleavable signal peptide for peroxisomal targeting. Biochem. Biophys. Res. Commun. 181: 947–954.
   PubMedGoogle Scholar
• Powers, S., S. Michaelis, D. Broek, S. Santa Anna, J. Field, I. Herskowitz, and M. Wigler 1986. RAM1, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor. Cell 47: 413–422.
   PubMedGoogle Scholar
• Rachubinski, R. A., and S. Subramani 1995. How proteins penetrate peroxisomes. Cell 83: 525–528.
   PubMedGoogle Scholar
• Rehling, P., M. Marzioch, F. Niesen, E. Wittke, M. Veenhuis, and W.-H. Kunau 1996. The import receptor for the peroxisomal targeting signal 2 (PTS2) in Saccharomyces cerevisiae is encoded by the PAS7 gene. EMBO J. 15: 2901–2913.
   PubMedGoogle Scholar
• Rose, M. D., P. Novick, J. H. Thomas, D. Bothstein, and G. R. Fink 1987. A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector. Gene 60: 237–243.
   PubMed Web of Science ®Google Scholar
• Rose, M. D., L. M. Misra, and J. P. Vogel 1989. KAR2, a karyogamy gene, is the yeast homolog of the mammalian BiP/GRP78 gene. Cell 57: 1211–1221.
   PubMed Web of Science ®Google Scholar
• Rout, M. P., and J. V. Kilmartin 1990. Components of the yeast spindle pole body. J. Cell Biol. 111: 1913–1927.
   PubMed Web of Science ®Google Scholar
• Rüther, U., and B. Müller-Hill 1983. Easy identification of cDNA clones. EMBO J. 2: 1791–1794.
   PubMedGoogle Scholar
• Sanger, F., S. Nicklen, and A. R. Coulson 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74: 5463–5467.
   PubMed Web of Science ®Google Scholar
• Schafer, W. R., and J. Rine 1992. Protein prenylation: genes, enzymes, targets and functions. Annu. Rev. Genet. 30: 209–237.
   Google Scholar
• Sherman, F., G. R. Fink, and J. Hicks 1986. Methods in yeast genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
   Google Scholar
• Sikorski, R. S., and P. Hieter 1989. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122: 19–27.
   PubMed Web of Science ®Google Scholar
• Smith, M., D. W. Leung, S. Gillam, C. R. Astell, D. L. Montgomery, and B. D. Hall 1979. Sequence of the gene for iso-1-cytochrome c in Saccharomyces cerevisiae. Cell 16: 753–761.
   PubMed Web of Science ®Google Scholar
• Subramani, S. 1996. Protein translocation into peroxisomes. J. Biol. Chem. 271: 32483–32486.
   PubMed Web of Science ®Google Scholar
• Subramani, S. 1997. PEX genes on the rise. Nat. Genet. 15: 331–333.
   PubMedGoogle Scholar
• Swinkels, B. W., S. J. Gould, A. G. Bodnar, R. A. Rachubinski, and S. Subramani 1991. A novel, cleavable peroxisomal targeting signal at the amino-terminus of the rat 3-ketoacyl-CoA thiolase. EMBO J. 10: 3255–3262.
   PubMedGoogle Scholar
• Szilard, K. R., V. I. Titorenko, M. Veenhuis, and R. A. Rachubinski 1995. Pay32p of the yeast Yarrowia lipolytica is an intraperoxisomal component of the matrix protein translocation machinery. J. Cell Biol. 131: 1453–1469.
   PubMedGoogle Scholar
• Veenhuis, M., M. Mateblowski, W.-H. Kunau, and W. Harder 1987. Proliferation of microbodies in Saccharomyces cerevisiae. Yeast 3: 77–84.
   PubMedGoogle Scholar
• Walton, P. A., P. E. Hill, and S. Subramani 1995. Import of stably folded proteins into peroxisomes. Mol. Biol. Cell 6: 675–683.
   PubMed Web of Science ®Google Scholar
• Walworth, N. C., B. Goud, A. Kastan Kabcenell, and P. J. Novick 1989. Mutational analysis of SEC4 suggests a cyclical mechanism for the regulation of vesicular traffic. EMBO J. 8: 1685–1693.
   PubMedGoogle Scholar
• Wiemer, E. A. C., G. H. Luers, K. N. Faber, T. Wenzel, M. Veenhuis, and S. Subramani 1996. Isolation and characterization of Pas2p, a peroxisomal membrane protein essential for peroxisome biogenesis in the methylotrophic yeast Pichia pastoris. J. Biol. Chem. 271: 18973–18980.
   PubMedGoogle Scholar
• Wilson, K. L., and I. Herskowitz 1987. STE16, a new gene required for pheromone production by cells of Saccharomyces cerevisiae. Genetics 115: 441–449.
   PubMedGoogle Scholar
• Zhang, J. W., and P. B. Lazarow 1995. PEB1(PAS7) in Saccharomyces cerevisiae encodes a hydrophilic, intra-peroxisomal protein that is a member of the WD repeat family and is essential for the import of thiolase into peroxisomes. J. Cell Biol. 129: 65–80.
   PubMedGoogle Scholar
• Zhang, J. W., and P. B. Lazarow 1996. PEB1(PAS7) is an intraperoxisomal receptor for the NH2-terminal, type 2, peroxisomal targeting sequence of thiolase: Peb1p itself is targeted to peroxisomes by an NH2-terminal peptide. J. Cell Biol. 132: 325–334.
   PubMedGoogle Scholar