17
Views
155
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Activation of p38 Mitogen-Activated Protein Kinase by Sodium Salicylate Leads to Inhibition of Tumor Necrosis Factor-Induced IκBα Phosphorylation and Degradation

, , &
Pages 78-84 | Received 07 Aug 1997, Accepted 06 Oct 1997, Published online: 28 Mar 2023

REFERENCES

  • Abramson, S. B., and G. Weissmann 1989. The mechanisms of action of nonsteroidal antiinflammatory drugs. Arthritis Rheum. 32: 1–9.
  • Baeuerle, P. A., and D. Baltimore 1996. NF-κB: ten years after. Cell 87: 13–20.
  • Baldwin, A. S.Jr. 1996. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14: 649–683.
  • Beauparlant, P., and J. Hiscott 1996. Biological and biochemical inhibitors of the NF-κB/Rel proteins and cytokine synthesis. Cytokine Growth Factor Rev. 7: 175–190.
  • Beg, A. A., and D. Baltimore 1996. An essential role for NF-κB in preventing TNF-α-induced cell death. Science 274: 782–784.
  • Beg, A. A., T. S. Finco, P. V. Nantermet, Baldwin A. S., Jr. 1993. Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of IκBα: a mechanism for NF-κB activation. Mol. Cell. Biol. 13: 3301–3310.
  • Bertrand, F., C. Philippe, P. J. Antoine, L. Baud, A. Groyer, J. Capeau, and G. Cherqui 1995. Insulin activates nuclear factor kappa B in mammalian cells through a Raf-1-mediated pathway. J. Biol. Chem. 270: 24435–24441.
  • Beyaert, R., A. Cuenda, W. Vanden Berghe, S. Plaisance, J. C. Lee, G. Haegeman, P. Cohen, and W. Fiers 1996. The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis in response to tumour necrosis factor. EMBO J. 15: 1914–1923.
  • Bitko, V., A. Velazquez, L. Yang, Y. C. Yang, and S. Barik 1997. Transcriptional induction of multiple cytokines by human respiratory syncytial virus requires activation of NF-κB and is inhibited by sodium salicylate and aspirin. Virology 232: 369–378.
  • Cano, E., and L. C. Mahadevan 1995. Parallel signal processing among mammalian MAPKs. Trends Biochem. Sci. 20: 117–122.
  • Chalasani, N., J. Roman, and R. L. Jurado 1996. Systemic inflammatory response syndrome caused by chronic salicylate intoxication. South. Med. J. 89: 479–482.
  • Connelly, M. A., and K. B. Marcu 1995. CHUK, a new member of the helix-loop-helix and leucine zipper families of interacting proteins, contains a serine-threonine kinase catalytic domain. Cell. Mol. Biol. Res. 41: 537–549.
  • Cuenda, A., P. Cohen, V. Buee-Scherrer, and M. Goedert 1997. Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38). EMBO J. 16: 295–305.
  • Cuenda, A., J. Rouse, Y. N. Doza, R. Meier, P. Cohen, T. F. Gallagher, P. R. Young, and J. C. Lee 1995. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett. 364: 229–233.
  • Demarchi, F., F. d’Adda di Fagagna, A. Falaschi, and M. Giacca 1996. Activation of transcription factor NF-κB by the Tat protein of human immunodeficiency virus type 1. J. Virol. 70: 4427–4437.
  • Gautam, S. C., K. R. Pindolia, C. J. Noth, N. Janakiraman, Y. X. Xu, and R. A. Chapman 1995. Chemokine gene expression in bone marrow stromal cells: downregulation with sodium salicylate. Blood 86: 2541–2550.
  • Graves, J. D., K. E. Draves, A. Craxton, J. Saklatvala, E. G. Krebs, and E. A. Clark 1996. Involvement of stress-activated protein kinase and p38 mitogen-activated protein kinase in mlgM-induced apoptosis of human B lymphocytes. Proc. Natl. Acad. Sci. USA 93: 13814–13818.
  • Grilli, M., M. Pizzi, M. Memo, and P. Spano 1996. Neuroprotection by aspirin and sodium salicylate through blockade of NF-κB activation. Science 274: 1383–1385.
  • Gupta, S., T. Barrett, A. J. Whitmarsh, J. Cavanagh, H. K. Sluss, B. Dérijard, and R. J. Davis 1996. Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J. 15: 2760–2770.
  • Hsu, H., H.-B. Shu, M.-G. Pan, and D. V. Goeddel 1996. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 84: 299–308.
  • Jiang, Y., C. Chen, Z. Li, W. Guo, J. A. Gegner, S. Lin, and J. Han 1996. Characterization of the structure and function of a new mitogen-activated protein kinase (p38β). J. Biol. Chem. 271: 17920–17926.
  • Juo, P., C. J. Kuo, S. E. Reynolds, R. F. Konz, J. Raingeaud, R. J. Davis, H. P. Biemann, and J. Blenis 1997. Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases. Mol. Cell. Biol. 17: 24–35.
  • Kawasaki, H., T. Morooka, S. Shimohama, J. Kimura, T. Hirano, Y. Gotoh, and E. Nishida 1997. Activation and involvement of p38 mitogen-activated protein kinase in glutamate-induced apoptosis in rat cerebellar granule cells. J. Biol. Chem. 272: 18518–18521.
  • Kinoshita, T., T. Yokota, K. Arai, and A. Miyajima 1995. Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors. EMBO J. 14: 266–275.
  • Kopp, E., and S. Ghosh 1994. Inhibition of NF-κB by sodium salicylate and aspirin. Science 265: 956–959.
  • Kumar, S., P. C. McDonnell, R. J. Gum, A. T. Hand, J. C. Lee, and P. R. Young 1997. Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. Biochem. Biophys. Res. Commun. 235: 533–538.
  • Kyriakis, J. M., P. Banerjee, E. Nikolakaki, T. Dai, E. A. Rubie, M. F. Ahmad, J. Avruch, and J. R. Woodgett 1994. The stress-activated protein kinase subfamily of c-Jun kinases. Nature 369: 156–160.
  • Lechner, C., M. A. Zahalka, J. F. Giot, N. P. Moller, and A. Ullrich 1996. ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation. Proc. Natl. Acad. Sci. USA 93: 4355–4359.
  • Lee, J. C., J. T. Laydon, P. C. McDonnell, T. F. Gallagher, S. Kumar, D. Green, D. McNulty, M. J. Blumenthal, J. R. Heys, S. W. Landvatter, J. E. Strickler, M. M. McLaughlin, I. R. Siemens, S. M. Fisher, G. P. Livi, J. R. White, J. L. Adams, and P. R. Young 1994. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372: 739–746.
  • Li, Z., Y. Jiang, R. J. Ulevitch, and J. Han 1996. The primary structure of p38 gamma: a new member of p38 group of MAP kinases. Biochem. Biophys. Res. Commun. 228: 334–340.
  • Lin, A., A. Minden, H. Martinetto, F. X. Claret, C. Lange-Carter, F. Mercurio, G. L. Johnson, and M. Karin 1995. Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. Science 268: 286–290.
  • Liu, Z.-G., H. Hsu, D. V. Goeddel, and M. Karin 1996. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death. Cell 87: 565–576.
  • Malinin, N. L., M. P. Boldin, A. V. Kovalenko, and D. Wallach 1997. MAP3K-related kinase involved in NF-κB induction by TNF, CD95 and IL-1. Nature 385: 540–544.
  • Marshall, C. J. 1995. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80: 179–185.
  • Minden, A., A. Lin, M. McMahon, C. Lange-Carter, B. Dérijard, R. J. Davis, G. L. Johnson, and M. Karin 1994. Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science 266: 1719–1723.
  • Minden, A., A. Lin, T. Smeal, B. Dérijard, M. Cobb, R. Davis, and M. Karin 1994. c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases. Mol. Cell. Biol. 14: 6683–6688.
  • Mitchell, J. A., P. Akarasereenont, C. Thiemermann, R. J. Flower, and J. R. Vane 1993. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc. Natl. Acad. Sci. USA 90: 11693–11697.
  • Miyamoto, S., M. Maki, M. J. Schmitt, M. Hatanaka, and I. M. Verma 1994. Tumor necrosis factor α-induced phosphorylation of IκBα is a signal for its degradation but not dissociation from NF-κB. Proc. Natl. Acad. Sci. USA 91: 12740–12744.
  • Miyamoto, S., and I. M. Verma 1995. Rel/NF-κB/IκB story. Adv. Cancer Res. 66: 255–292.
  • Oeth, P., and N. Mackman 1995. Salicylates inhibit lipopolysaccharide-induced transcriptional activation of the tissue factor gene in human monocytic cells. Blood 86: 4144–4152.
  • Palombella, V. J., O. J. Rando, A. L. Goldberg, and T. Maniatis 1994. The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB. Cell 78: 773–785.
  • Pierce, J. W., M. A. Read, H. Ding, F. W. Luscinskas, and T. Collins 1996. Salicylates inhibit IκB-α phosphorylation, endothelial-leukocyte adhesion molecule expression, and neutrophil transmigration. J. Immunol. 156: 3961–3969.
  • Raingeaud, J., S. Gupta, J. S. Rogers, M. Dickens, J. Han, R. J. Ulevitch, and R. J. Davis 1995. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J. Biol. Chem. 270: 7420–7426.
  • Regnier, C. H., H. Y. Song, X. Gao, D. V. Goeddel, Z. Cao, and M. Rothe 1997. Identification and characterization of an IκB kinase. Cell 90: 373–383.
  • Robinson, M. J., and M. H. Cobb 1997. Mitogen-activated protein kinase pathways. Curr. Opin. Cell Biol. 9: 180–186.
  • Sanchez, I., R. T. Hughes, B. J. Mayer, K. Yee, J. R. Woodgett, J. Avruch, J. M. Kyriakis, and L. I. Zon 1994. Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature 372: 794–798.
  • Schwenger, P., P. Bellosta, I. Vietor, C. Basilico, E. Y. Skolnik, and J. Vilcek 1997. Sodium salicylate induces apoptosis via p38 mitogen-activated protein kinase but inhibits tumor necrosis factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activation. Proc. Natl. Acad. Sci. USA 94: 2869–2873.
  • Schwenger, P., E. Y. Skolnik, and J. Vilcek 1996. Inhibition of tumor necrosis factor-induced p42/p44 mitogen-activated protein kinase by sodium salicylate. J. Biol. Chem. 271: 8089–8094.
  • Sun, S. C., P. A. Ganchi, C. Beraud, D. W. Ballard, and W. C. Greene 1994. Autoregulation of the NF-κB transactivator RelA (p65) by multiple cytoplasmic inhibitors containing ankyrin motifs. Proc. Natl. Acad. Sci. USA 91: 1346–1350.
  • Thompson, J. E., R. J. Phillips, H. Erdjument-Bromage, P. Tempst, and S. Ghosh 1995. IκB-β regulates the persistent response in a biphasic activation of NF-κB. Cell 80: 573–582.
  • Ting, A. T., F. X. Pimentel-Muinos, and B. Seed 1996. RIP mediates tumor necrosis factor receptor 1 activation of NF-κB but not Fas/APO-1-initiated apoptosis. EMBO J. 15: 6189–6196.
  • Van Antwerp, D. J., S. J. Martin, T. Kafri, D. R. Green, and I. M. Verma 1996. Suppression of TNF-α-induced apoptosis by NF-κB. Science 274: 787–789.
  • Van Lint, J., P. Agostinis, V. Vandevoorde, G. Haegeman, W. Fiers, W. Merlevede, and J. R. Vandenheede 1992. Tumor necrosis factor stimulates multiple serine/threonine protein kinases in Swiss 3T3 and L929 cells. Implication of casein kinase-2 and extracellular signal-regulated kinases in the tumor necrosis factor signal transduction pathway. J. Biol. Chem. 267: 25916–25921.
  • Vietor, I., P. Schwenger, W. Li, J. Schlessinger, and J. Vilcek 1993. Tumor necrosis factor-induced activation and increased tyrosine phosphorylation of mitogen-activated protein (MAP) kinase in human fibroblasts. J. Biol. Chem. 268: 18994–18999.
  • Wang, C.-Y., M. W. Mayo, Baldwin A. S., Jr. 1996. TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB. Science 274: 784–787.
  • Wang, X. Z., and D. Ron 1996. Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP kinase. Science 272: 1347–1349.
  • Weissmann, G. 1991. Aspirin. Sci. Am. 264: 84–90.
  • Whitmarsh, A. J., S.-H. Yang, M. S.-S. Su, A. D. Sharrocks, and R. J. Davis 1997. Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors. Mol. Cell. Biol. 17: 2360–2371.
  • Xia, Z., M. Dickens, J. Raingeaud, R. J. Davis, and M. E. Greenberg 1995. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270: 1326–1331.
  • Young, P. R., M. M. McLaughlin, S. Kumar, S. Kassis, M. L. Doyle, D. McNulty, T. F. Gallagher, S. Fisher, P. C. McDonnell, S. A. Carr, M. J. Huddleston, G. Seibel, T. G. Porter, G. P. Livi, J. L. Adams, and J. C. Lee 1997. Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site. J. Biol. Chem. 272: 12116–12121.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.