11
Views
101
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Biased Suppression of Hematopoiesis and Multiple Developmental Defects in Chimeric Mice Containing Shp-2 Mutant Cells

, , , , &
Pages 6075-6082 | Received 12 May 1998, Accepted 16 Jul 1998, Published online: 28 Mar 2023

REFERENCES

  • Bash, R. O., S. Hall, C. F. Timmons, W. M. Crist, M. Amylon, R. G. Smith, and R. Baer 1995. Does activation of the TAL1 gene occur in a majority of patients with T-cell acute lymphoblastic leukemia? A pediatric oncology group study. Blood 86: 666–676.
  • Cooper, S., and H. E. Broxmeyer. 1996. Measurement of interleukin-3 and other hematopoietic growth factors, such as GM-CSF, G-CSF, M-CSF, erythropoietin and the other potent co-stimulating cytokines steel factor and Flt-3 ligand. Curr. Protocols Immunol. 18(Suppl.):6.4.1–6.4.12.
  • Deng, C. X., A. Wynshaw-Boris, M. M. Shen, C. Daugherty, D. M. Ornitz, and P. Leder 1994. Murine FGFR-1 is required for early postimplantation growth and axial organization. Genes Dev. 8: 3045–3057.
  • de Vries, C., J. A. Escobedo, H. Ueno, K. Houck, N. Ferrara, and L. T. Williams 1992. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255: 989–991.
  • Feng, G. S., C. C. Hui, and T. Pawson 1993. SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases. Science 259: 1607–1611.
  • Feng, G. S., and T. Pawson 1994. Phosphotyrosine phosphatases with SH2 domains: regulators of signal transduction. Trends Genet. 10: 54–58.
  • Furuta, Y., D. Ilic, S. Kanazawa, N. Takeda, T. Yamamoto, and S. Aizawa 1995. Mesodermal defect in late phase of gastrulation by a targeted mutation of focal adhesion kinase, FAK. Oncogene 11: 1989–1995.
  • Georgopoulos, K., M. Bigby, J. H. Wang, A. Molnar, P. Wu, S. Winandy, and A. Sharpe 1994. The Ikaros gene is required for the development of all lymphoid lineages. Cell 79: 143–156.
  • Ilic, D., Y. Furuta, S. Kanazawa, N. Takeda, K. Sobue, N. Nakatsuji, S. Nomura, J. Fujimoto, M. Okada, T. Yamamoto, et al. 1995. Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature 377: 539–544.
  • Johnson, R. L., and C. J. Tabin 1997. Molecular models for vertebrate limb development. Cell 90: 979–990.
  • Keller, G. M. 1995. In vitro differentiation of embryonic stem cells. Curr. Opin. Cell. Biol. 7: 862–869.
  • Kessel, M., and P. Gruss 1991. Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid. Cell 67: 89–104.
  • Matthews, W., C. T. Jordan, G. W. Wiegand, D. Pardoll, and I. R. Lemischka 1991. A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations. Cell 65: 1143–1152.
  • Milarski, K. L., and A. R. Saltiel 1994. Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin. J. Biol. Chem. 269: 21239–21243.
  • Mortensen, R. M., D. A. Conner, S. Chao, A. A. T. Geisterfer-Lowrance, and J. G. Seidman 1992. Production of homozygous mutant ES cells with a single targeting construct. Mol. Cell. Biol. 12: 2391–2395.
  • Mucenski, M. L., K. McLain, A. B. Kier, S. H. Swerdlow, C. M. Schreiner, T. A. Miller, D. W. Pietryga, Scott W. J., Jr., and S. S. Potter 1991. A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis. Cell 65: 677–689.
  • Nagy, A., J. Rossant, R. Nagy, W. Abramow-Newerly, and J. C. Roder 1993. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc. Natl. Acad. Sci. USA 90: 8424–8428.
  • Neel, B. G., and N. K. Tonks 1997. Protein tyrosine phosphatases in signal transduction. Curr. Opin. Cell Biol. 9: 193–204.
  • Noguchi, T., T. Matozaki, K. Horita, Y. Fujioka, and M. Kasuga 1994. Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation. Mol. Cell. Biol. 14: 6674–6682.
  • Oh, W., and L. Stern 1987. Respiratory diseases of the newborn Neonatal medicine. In: Stern, L., and P. Vert395Masson Publishing USA, Inc., New York, N.Y.
  • Okuda, T., J. van Deursen, S. W. Hiebert, G. Grosveld, and J. R. Downing 1996. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell 84: 321–330.
  • Orkin, S. H. 1995. Hematopoiesis: how does it happen? Curr. Opin. Cell Biol. 7: 870–877.
  • Pevny, L., M. C. Simon, E. Robertson, W. H. Klein, S. F. Tsai, V. D’Agati, S. H. Orkin, and F. Costantini 1991. Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature 349: 257–260.
  • Porcher, C., W. Swat, K. Rockwell, Y. Fujiwara, F. W. Alt, and S. H. Orkin 1996. The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages. Cell 86: 47–57.
  • Qu, C. K., and G. S. Feng 1998. Shp-2 has a positive regulatory role in ES cell differentiation and proliferation. Oncogene 17: 433–440.
  • Qu, C.-K., Z.-Q. Shi, R. Shen, F.-Y. Tsai, S. H. Orkin, and G.-S. Feng 1997. A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development. Mol. Cell. Biol. 17: 5499–5507.
  • Robb, L., N. J. Elwood, A. G. Elefanty, F. Kontgen, R. Li, L. D. Barnett, and C. G. Begley 1996. The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse. EMBO J. 15: 4123–4129.
  • Roche, S., J. McGlade, M. Jones, G. D. Gish, T. Pawson, and S. A. Courtneidge 1996. Requirement of phospholipase C gamma, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF-induced DNA synthesis: evidence for the existence of Ras-dependent and Ras-independent pathways. EMBO J. 15: 4940–4948.
  • Saxton, T. M., M. Henkemeyer, S. Gasca, R. Shen, F. Shalaby, G. S. Feng, and T. Pawson 1997. Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2. EMBO J. 16: 2352–2364.
  • Scott, E. W., M. C. Simon, J. Anastasi, and H. Singh 1994. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science 265: 1573–1577.
  • Shalaby, F., J. Ho, W. L. Stanford, K. D. Fischer, A. C. Schuh, L. Schwartz, A. Bernstein, and J. Rossant 1997. A requirement for Flk1 in primitive and definitive hematopoiesis and vasculogenesis. Cell 89: 981–990.
  • Shalaby, F., J. Rossant, T. P. Yamaguchi, M. Gertsenstein, X. F. Wu, M. L. Breitman, and A. C. Schuh 1995. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 376: 62–66.
  • Shi, Z. Q., W. Lu, and G. S. Feng 1998. The Shp-2 tyrosine phosphatase has opposite effects in mediating the activation of extracellular signal-regulated and c-Jun NH2-terminal mitogen-activated protein kinases. J. Biol. Chem. 273: 4892–4896.
  • Tang, T. L., Freeman, R.Jr., A. M. O’Reilly, B. G. Neel, and S. Y. Sokol 1995. The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development. Cell 80: 473–483.
  • Tauchi, T., G. S. Feng, M. S. Marshall, R. Shen, C. Mantel, T. Pawson, and H. E. Broxmeyer 1994. The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells. J. Biol. Chem. 269: 25206–25211.
  • Tauchi, T., G. S. Feng, R. Shen, M. Hoatlin, Bagby G., Jr., D. Kabat, L. Lu, and H. E. Broxmeyer 1995. Involvement of SH2-containing phosphotyrosine phosphatase Syp in erythropoietin receptor signal transduction pathways. J. Biol. Chem. 270: 5631–5635.
  • Tsai, F. Y., G. Keller, F. C. Kuo, M. Weiss, J. Chen, M. Rosenblatt, F. W. Alt, and S. H. Orkin 1994. An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature 371: 221–226.
  • Weiss, M. J., G. Keller, and S. H. Orkin 1994. Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells. Genes Dev. 8: 1184–1197.
  • Weiss, M. J., and S. H. Orkin 1995. Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis. Proc. Natl. Acad. Sci. USA 92: 9623–9627.
  • Yamaguchi, T. P., K. Harpal, M. Henkemeyer, and J. Rossant 1994. FGFR-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation. Genes Dev. 8: 3032–3044.
  • Yu, D. H., C. K. Qu, O. Henegariu, X. Lu, and G. S. Feng 1998. Protein tyrosine phosphatase Shp-2 regulates cell spreading, migration and focal adhesion. J. Biol. Chem. 273: 21125–21131.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.