Akt-Dependent and -Independent Survival Signaling Pathways Utilized by Insulin-Like Growth Factor I

REFERENCES

• Berra, E., M. T. Diaz-Meco, I. Dominguez, M. M. Municio, L. Sanz, J. Lozano, R. S. Chapkin, and J. Moscat 1998. Protein kinase C zeta isoform is critical for mitogenic signal transduction. Cell 74: 555–563.
   Google Scholar
• Berra, E., M. M. Municio, L. Sanz, S. Frutos, M. T. Diaz-Meco, and J. Moscat 1997. Positioning atypical protein kinase C isoforms in the UV-induced apoptotic signaling cascade. Mol. Cell. Biol. 17: 4346–4544.
   PubMed Web of Science ®Google Scholar
• Bertollini, L., M. T. Ciotti, E. Cherubini, and A. Cattaneo 1997. Neurotrophin-3 promotes the survival of oligodendrocyte precursors in embryonic hippocampal cultures under chemically defined conditions. Brain Res. 746: 19–24.
   PubMedGoogle Scholar
• Blakesley, V. A., B. S. Stannard, T. Kalebic, L. J. Helman, and D. LeRoith 1997. Role of the IGF-I receptor in mutagenesis and tumor promotion. J. Endocrinol. 152: 339–344.
   PubMed Web of Science ®Google Scholar
• Cardone, M. H., G. S. Salvesen, C. Widmann, G. Johnson, and S. M. Frisch 1997. The regulation of anoikis: MEKK-1 activation requires cleavage by caspases. Cell 90: 315–323.
   PubMed Web of Science ®Google Scholar
• Chen, Y. R., X. Wang, D. Templeton, R. J. Davis, and T. H. Tan 1996. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation. J. Biol. Chem. 271: 31929–31936.
   PubMed Web of Science ®Google Scholar
• Darnay, B. G., and B. B. Aggarwal 1997. Early events in TNF signaling: a story of associations and dissociations. J. Leukoc. Biol. 61: 559–566.
   PubMed Web of Science ®Google Scholar
• Datta, S. R., H. Dudek, X. Tao, S. Masters, H. Fu, Y. Gotoh, and M. E. Greenberg 1997. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91: 231–241.
   PubMed Web of Science ®Google Scholar
• Delpeso, L., M. Gonzalez-Garcia, C. Page, R. Herrera, and G. Nunez 1997. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 278: 687–689.
   PubMedGoogle Scholar
• Diaz-Meco, M. T., M. M. Municio, S. Frutos, P. Sanchez, J. Lozano, L. Sanz, and J. Moscat 1996. The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C. Cell 86: 777–786.
   PubMed Web of Science ®Google Scholar
• Dudek, H., S. R. Datta, T. F. Franke, M. J. Birnbaum, R. Yao, G. M. Cooper, R. A. Segal, D. R. Kaplan, and M. E. Greenberg 1997. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275: 661–665.
   PubMed Web of Science ®Google Scholar
• Franke, T. F., D. R. Kaplan, and L. C. Cantley 1997. PI3K: downstream AKTion blocks apoptosis. Cell 88: 435–437.
   PubMed Web of Science ®Google Scholar
• Hack, N., H. Hidaka, M. J. Wakefield, and R. Balazs 1993. Promotion of granule cell survival by high K+ or excitatory amino acid treatment and Ca2+/calmodulin-dependent protein kinase activity. Neuroscience 57: 9–20.
   PubMed Web of Science ®Google Scholar
• Heidenreich, K. A., and J. L. Kummer 1996. Inhibition of p38 mitogen-activated protein kinase by insulin in cultured fetal neurons. J. Biol. Chem. 271: 9891–9894.
   PubMed Web of Science ®Google Scholar
• Ichijo, H., E. Nishida, K. Irie, P. ten Dijke, M. Saitoh, T. Moriguchi, M. Takagi, K. Matsumoto, K. Miyazono, and Y. Gotoh 1997. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science 275: 90–94.
   PubMed Web of Science ®Google Scholar
• Ikizawa, K., K. Kajiwara, Y. Basaki, T. Koshio, and Y. Yanagihara 1996. Evidence for a role of phosphatidylinositol 3-kinase in IL-4-induced germline C epsilon transcription. Cell. Immunol. 170: 134–140.
   PubMedGoogle Scholar
• Kauffmann-Zeh, A., P. Rodriguez-Viciana, E. Ulrich, C. Gilbert, P. Coffer, J. Downward, and G. Evan 1997. Suppression of c-Myc-induced apoptosis by Ras signaling through PI(3)K and PKB. Nature 385: 544–548.
   PubMed Web of Science ®Google Scholar
• Kennedy, S. G., A. J. Wagner, S. D. Conzen, J. Jordan, A. Bellacosa, P. N. Tsichlis, and N. Hay 1997. The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes Dev. 11: 701–713.
   PubMed Web of Science ®Google Scholar
• Khwaja, A., P. Rodriguez-Viciana, S. Wennstrom, P. H. Warne, and J. Downward 1997. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J. 16: 2783–2793.
   PubMed Web of Science ®Google Scholar
• Klippel, A., C. Reinhard, W. M. Kavanaugh, G. Apell, M. A. Escobedo, and L. T. Williams 1996. Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways. Mol. Cell. Biol. 16: 4117–4127.
   PubMed Web of Science ®Google Scholar
• Konishi, H., H. Matsuzaki, M. Tanaka, Y. Ono, C. Tokunaga, S. Kuroda, and U. Kikkawa 1996. Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of phosphatidylinositol 3-kinase. Proc. Natl. Acad. Sci. USA 93: 7639–7643.
   PubMed Web of Science ®Google Scholar
• Konishi, H., H. Matsuzaki, M. Tanaka, Y. Takemura, S. Kuroda, Y. Ono, and U. Kikkawa 1997. Activation of protein kinase B (Akt/RAC-protein kinase) by cellular stress and its association with heat shock protein Hsp27. FEBS Lett. 410: 493–498.
   PubMed Web of Science ®Google Scholar
• Koumenis, C., and A. Giaccia 1997. Transformed cells require continuous activity of RNA polymerase II to resist oncogene-induced apoptosis. Mol. Cell. Biol. 17: 7306–7316.
   PubMed Web of Science ®Google Scholar
• Kulik, G., A. Klippel, and M. J. Weber 1997. Antiapoptotic signaling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol. Cell. Biol. 17: 1595–1606.
   PubMed Web of Science ®Google Scholar
• Kulik, G., and Weber, M. J. 1997. Unpublished data.
   Google Scholar
• LeRoith, D., H. Werner, S. Neuenschwander, T. Kalebic, and L. J. Helman 1995. The role of the insulin-like growth factor-I receptor in cancer. Ann. N. Y. Acad. Sci. 766: 402–408.
   PubMedGoogle Scholar
• Lozano, J., E. Berra, M. M. Municio, M. T. Diaz-Meco, I. Dominguez, L. Sanz, and J. Moscat 1994. Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase. J. Biol. Chem. 269: 19200–19202.
   PubMed Web of Science ®Google Scholar
• Marte, B. M., and J. Downward 1997. PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond. Trends Biochem. Sci. 22: 355–358.
   PubMed Web of Science ®Google Scholar
• Mayo, M. W., C. Y. Wang, P. C. Cogswell, K. S. Rogersgraham, S. W. Lowe, C. J. Der, and A. S. Baldwin 1997. Requirement of NF-kappa-B activation to suppress p53-independent apoptosis induced by oncogenic ras. Science 278: 1812–1815.
   PubMed Web of Science ®Google Scholar
• Minshall, C., S. Arkins, G. G. Freund, and K. W. Kelley 1996. Requirement for phosphatidylinositol 3′-kinase to protect hemopoietic progenitors against apoptosis depends upon the extracellular survival factor. J. Immunol. 156: 939–947.
   PubMedGoogle Scholar
• Mizukami, Y., T. Hirata, and K. Yoshida 1997. Nuclear translocation of PKC zeta during ischemia and its inhibition by wortmannin, an inhibitor of phosphatidylinositol 3-kinase. FEBS Lett. 401: 247–251.
   PubMedGoogle Scholar
• Nakanishi, H., K. A. Brewer, and J. H. Exton 1993. Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 268: 13–16.
   PubMed Web of Science ®Google Scholar
• Nishina, H., K. D. Fischer, L. Radvanyi, A. Shahinian, R. Hakem, E. A. Rubie, A. Bernstein, T. W. Mak, J. R. Woodgett, and J. M. Penninger 1997. Stress-signaling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3. Nature 385: 350–353.
   PubMedGoogle Scholar
• Parizzas, M., A. R. Saltiel, and D. LeRoth 1997. Insulin-like growth factor inhibits apoptosis using the phosphatidylinositol 3′-kinase and mitogen-activated protein kinase pathways. J. Biol. Chem. 272: 154–161.
   PubMedGoogle Scholar
• Peterson, J. E., G. Kulik, T. Jelinek, C. W. Reuter, J. A. Shannon, and M. J. Weber 1996. Src phosphorylates the insulin-like growth factor type I receptor on the autophosphorylation sites. J. Biol. Chem. 271: 31562–31571.
   PubMedGoogle Scholar
• Philpott, K. L., M. J. McCarthy, A. Klippel, and L. L. Rubin 1997. Activated phosphatidylinositol 3-kinase and Akt kinase promote survival of superior cervical neurons. J. Cell Biol. 139: 809–815.
   PubMed Web of Science ®Google Scholar
• Railo, M. J., S. K. von Smitten, and F. Pekonen 1994. The prognostic value of insulin-like growth factor-I in breast cancer patients. Results of a follow-up study on 126 patients. Eur. J. Cancer 30A: 307–311.
   PubMed Web of Science ®Google Scholar
• Resnik, J. L., D. B. Reichart, K. Huey, N. J. Webster, and B. L. Seely 1998. Elevated insulin-like growth factor I receptor autophosphorylation and kinase activity in human breast cancer. Cancer Res. 58: 1159–1164.
   PubMed Web of Science ®Google Scholar
• Sable, C. L., N. Filippa, B. Hemmings, and O. E. VanObbergen 1997. cAMP stimulates protein kinase B in a wortmannin-insensitive manner. FEBS Lett. 409: 253–257.
   PubMed Web of Science ®Google Scholar
• Schultz, R. M., R. L. Merriman, S. L. Andis, R. Bonjouklian, G. B. Grindey, P. G. Rutherford, A. Gallegos, K. Massey, and G. Powis 1995. In vitro and in vivo antitumor activity of the phosphatidylinositol-3-kinase inhibitor, wortmannin. Anticancer Res. 15: 1135–1139.
   PubMed Web of Science ®Google Scholar
• Toker, A., M. Meyer, K. K. Reddy, J. R. Falck, R. Aneja, S. Aneja, A. Parra, D. J. Burns, L. M. Ballas, and L. C. Cantley 1994. Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3. J. Biol. Chem. 269: 32358–32367.
   PubMed Web of Science ®Google Scholar
• Tombes, R. M., S. Grant, E. H. Westin, and G. Krystal 1995. G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase). Cell Growth Differ. 6: 1063–1070.
   PubMedGoogle Scholar
• Wang, H. G., U. R. Rapp, and J. C. Reed 1996. Bcl-2 targets the protein kinase Raf-1 to mitochondria. Cell 87: 629–638.
   PubMed Web of Science ®Google Scholar
• Weber, M. J. 1994. Unpublished data.
   Google Scholar
• Xia, Z., M. Dickens, J. Raingeaud, R. J. Davis, and M. E. Greenberg 1995. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270: 1326–1331.
   PubMed Web of Science ®Google Scholar
• Yao, R., and G. M. Cooper 1995. Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 267: 2003–2006.
   PubMed Web of Science ®Google Scholar
• Yao, R., and G. M. Cooper 1996. Growth factor-dependent survival of rodent fibroblasts requires phosphatidylinositol 3-kinase but is independent of pp70S6K activity. Oncogene 13: 343–351.
   PubMedGoogle Scholar
• Zamorano, J., H. Y. Wang, L.-M. Wang, J. H. Pierce, and A. D. Keegan 1996. IL-4 protects cells from apoptosis via the insulin receptor substrate pathway and a second independent signaling pathway. J. Immunol. 157: 4926–4933.
   PubMedGoogle Scholar
• Zha, J., H. Harada, E. Yang, J. Jockel, and S. J. Korsmeyer 1996. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L). Cell 87: 619–628.
   PubMed Web of Science ®Google Scholar