15
Views
66
CrossRef citations to date
0
Altmetric
Transcriptional Regulation

The Notch Pathway Intermediate HES-1 Silences CD4 Gene Expression

&
Pages 7166-7175 | Received 24 Apr 1998, Accepted 10 Sep 1998, Published online: 28 Mar 2023

REFERENCES

  • Adlam, M., D. D. Duncan, D. K. Ng, and G. Siu 1997. Positive selection induces CD4 promoter and enhancer function. Int. Immunol. 9: 877–887.
  • Artavanis-Tsakonas, S., K. Matsuno, and M. E. Fortini 1995. Notch signaling. Science 268: 225–232.
  • Bailey, A. M., and J. W. Posakony 1995. Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity. Genes Dev. 9: 2609–2622.
  • Cooper, J. P., S. Y. Roth, and R. T. Simpson 1994. The global transcriptional regulators, SSN6 and TUP1, play distinct roles in the establishment of a repressive chromatin structure. Genes Dev. 8: 1400–1410.
  • Dawson, S. R., D. L. Turner, H. Weintraub, and S. M. Parkhurst 1995. Specificity for the hairy/enhancer of split basic helix-loop-helix (bHLH) proteins maps outside the bHLH domain and suggests two separable modes of transcriptional repression. Mol. Cell. Biol. 15: 6923–6931.
  • de Celis, J. F., J. de Celis, P. Ligoxygakis, A. Preiss, C. Delidakis, and S. Bray 1996. Functional relationships between Notch, Su(H) and the bHLH genes of the E(spl) complex: the E(spl) genes mediate only a subset of Notch activities during imaginal development. Development 122: 2719–2728.
  • Del Amo, F. F., D. E. Smith, P. J. Swiatek, M. Gendron-Maguire, R. J. Greenspan, A. P. McMahon, and T. Gridley 1992. Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development. Development 115: 737–744.
  • Delidakis, C., and S. Artavanis-Tsakonas 1992. The Enhancer of split [E(spl)] locus of Drosophila encodes seven independent helix-loop-helix proteins. Proc. Natl. Acad. Sci. USA 89: 8731–8735.
  • Donda, A., M. Schulz, K. Burki, G. De Libero, and Y. Uematsu 1996. Identification and characterization of a human CD4 silencer. Eur. J. Immunol. 26: 493–500.
  • Duncan, D. D., M. Adlam, and G. Siu 1996. Asymmetric redundancy in CD4 silencer function. Immunity 4: 301–311.
  • Duncan, D. D., A. Stupakoff, S. M. Hedrick, K. B. Marcu, and G. Siu 1995. A Myc-associated zinc-finger protein (MAZ) binding site is one of four important functional regions in the CD4 promoter. Mol. Cell. Biol. 15: 3179–3186.
  • Edmondson, D. G., M. M. Smith, and S. Y. Roth 1996. Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4. Genes Dev. 10: 1247–1259.
  • Ellisen, L. W., J. Bird, D. C. West, A. L. Soreng, T. C. Reynolds, S. D. Smith, and J. Sklar 1991. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 66: 649–661.
  • Fisher, A. L., S. Ohsako, and M. Caudy 1996. The WRPW motif of the Hairy-related basic-helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain. Mol. Cell. Biol. 16: 2670–2677.
  • Fortini, M. E., I. Rebay, L. A. Caron, and S. Artavanis-Tsakonas 1993. An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye. Nature 365: 555–557.
  • Fowlkes, B. J., and D. Pardoll 1989. Molecular and cellular events of T cell development. Adv. Immunol. 44: 207–264.
  • Furukawa, T., Y. Kobayakawa, K. Tamura, K. Kimura, M. Kawaichi, T. Tanimura, and T. Honjo 1995. Suppressor of hairless, the Drosophila homologue of RBP-J kappa, transactivates the neurogenic gene E(spl)m8. Jpn. J. Genet. 70: 505–524.
  • Girard, L., Z. Hanna, N. Beaulieu, C. D. Hoemann, C. Simard, C. A. Kozak, and P. Jolicoeur 1996. Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesis. Genes Dev. 10: 1930–1944.
  • Greenwald, I. 1994. Structure/function studies of lin-12/Notch proteins. Curr. Opin. Genet. Dev. 4: 556–562.
  • Greenwald, I., and G. M. Rubin 1992. Making a difference: the role of cell-cell interactions in establishing separate identities for equivalent cells. Cell 68: 271–281.
  • Guan, E., J. Wang, J. Laborda, M. Norcross, P. A. Baeuerle, and T. Hoffman 1996. T cell leukemia-associated human Notch/translocation-associated Notch homologue has IκB-like activity and physically interacts with Nuclear Factor-κB proteins in T cells. J. Exp. Med. 183: 2025–2032.
  • Hasserjian, R., J. Aster, D. Davi, D. Weinberg, and J. Sklar 1996. Modulated expression of Notch1 during thymocyte development. Blood 88: 970–976.
  • Jarriault, S., C. Brou, F. Logeat, E. H. Schroeter, R. Kopan, and A. Israel 1995. Signalling downstream of activated mammalian Notch. Nature 377: 355–358.
  • Jennings, B., A. Preiss, C. Delidakis, and S. Bray 1994. The Notch signalling pathway is required for Enhancer of split bHLH protein expression during neurogenesis in the Drosophila embryo. Development 120: 3537–3548.
  • Kageyama, R., Y. Sasai, C. Akazawa, M. Ishibashi, K. Takebayashi, C. Shimizu, K. Tomita, and S. Nakanishi 1995. Regulation of mammalian neural development by helix-loop-helix transcription factors. Crit. Rev. Neurobiol. 9: 177–188.
  • Kim, H. K., and G. Siu. Unpublished data.
  • Kim, H. K., M. Caudy, and G. Siu. Unpublished data.
  • Knust, E., H. Schrons, F. Grawe, and J. A. Campos-Ortega 1992. Seven genes of the Enhancer of split complex of Drosophila melanogaster encode helix-loop-helix proteins. Genetics 132: 505–518.
  • Kopan, R., J. S. Nye, and H. Weintraub 1994. The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD. Development 120: 2385–2396.
  • Lardelli, M., J. Dahlstrand, and U. Lendahl 1994. The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium. Mech. Dev. 46: 123–136.
  • Lardelli, M., and U. Lendahl 1993. Motch A and motch B—two mouse Notch homologues coexpressed in a wide variety of tissues. Exp. Cell Res. 204: 364–372.
  • Lardelli, M., R. Williams, and U. Lendahl 1995. Notch-related genes in animal development. Int. J. Dev. Biol. 39: 769–780.
  • Lecourtois, M., and F. Schweisguth 1995. The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling. Genes Dev. 9: 2598–2608.
  • Littman, D. R., C. B. Davis, N. Killeen, and H. Xu 1994. Signal transduction during T cell development. Adv. Exp. Med. Biol. 365: 63–71.
  • Mallo, M., F. Franco del Amo, and T. Gridley 1993. Cloning and developmental expression of Grg, a mouse gene related to the groucho transcript of the Drosophila Enhancer of split complex. Mech. Dev. 42: 67–76.
  • Miyasaka, H., B. K. Choudhury, E. W. Hou, and S. S. Li 1993. Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein. Eur. J. Biochem. 216: 343–352.
  • Murre, C., G. Bain, M. A. van Dijk, I. Engel, B. A. Furnari, M. E. Massari, J. R. Matthews, M. W. Quong, R. R. Rivera, and M. H. Stuiver 1994. Structure and function of helix-loop-helix proteins. Biochim. Biophys. Acta 1218: 129–135.
  • Oellers, N., M. Dehio, and E. Knust 1994. bHLH proteins encoded by the Enhancer of split complex of Drosophila negatively interfere with transcriptional activation mediated by proneural genes. Mol. Gen. Genet. 244: 465–473.
  • Ordentlich, P., A. Lin, C. P. Shen, C. Blaumueller, K. Matsuno, S. Artavanis-Tsakonis, and T. Kadesch 1998. Notch inhibition of E47 supports the existence of a novel signaling pathway. Mol. Cell. Biol. 18: 2230–2239.
  • Paroush, Z., Finley, R. L.Jr., T. Kidd, S. M. Wainwright, P. W. Ingham, R. Brent, and D. Ish-Horowicz 1994. Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins. Cell 79: 805–815.
  • Pear, W. S., J. C. Aster, M. L. Scott, R. P. Hasserjian, B. Soffer, J. Sklar, and D. Baltimore 1996. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J. Exp. Med. 183: 2283–2291.
  • Perlmutter, R. M., J. D. Marth, S. F. Ziegler, A. M. Garvin, S. Pawar, M. P. Cooke, and K. M. Abraham 1988. Specialized protein tyrosine kinase proto-oncogenes in hematopoietic cells. Biochim. Biophys. Acta 948: 245–262.
  • Robey, E., D. Chang, A. Itano, D. Cado, H. Alexander, D. Lane, G. Weinmaster, and P. Salmon 1996. An activated form of Notch influences the choice between CD4 and CD8 T cell lineages. Cell 87: 483–492.
  • Salmon, P., O. Boyer, P. Lores, J. Jami, and D. Klatzmann 1996. Characterization of an intronless CD4 minigene expressed in mature CD4 and CD8 T cells, but not expressed in immature thymocytes. J. Immunol. 156: 1873–1879.
  • Salmon, P., A. Giovane, B. Wasylyk, and D. Klatzmann 1993. Characterization of the human CD4 gene promoter: transcription from the CD4 gene core promoter is tissue-specific and is activated by Ets proteins. Proc. Natl. Acad. Sci. USA 90: 7739–7743.
  • Sasai, Y., R. Kageyama, Y. Tagawa, R. Shigemoto, and S. Nakanishi 1992. Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split. Genes Dev. 6: 2620–2634.
  • Sawada, S., and D. R. Littman 1993. A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines. Mol. Cell. Biol. 13: 5620–5628.
  • Sawada, S., J. D. Scarborough, N. Killeen, and D. R. Littman 1994. A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development. Cell 77: 917–929.
  • Schmidt, C. J., and T. E. Sladek 1993. A rat homolog of the Drosophila enhancer of split (groucho) locus lacking WD-40 repeats. J. Biol. Chem. 268: 25681–25686.
  • Shawber, C., D. Nofziger, J. J. Hsieh, C. Lindsell, O. Bogler, D. Hayward, and G. Weinmaster 1996. Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway. Development 122: 3765–3773.
  • Shore, D. 1995. Telomere position effects and transcriptional silencing in the yeast Saccharomyces cerevisiae Telomeres. In: Blackburn, E. H., and C. W. Greider139–191Cold Spring Harbor Press, Plainview, N.Y.
  • Siu, G., A. L. Wurster, D. D. Duncan, T. M. Soliman, and S. M. Hedrick 1994. A transcriptional silencer controls the developmental expression of the CD4 gene. EMBO J. 13: 3570–3579.
  • Siu, G., A. L. Wurster, J. S. Lipsick, and S. M. Hedrick 1992. Expression of the CD4 gene requires a Myb transcription factor. Mol. Cell. Biol. 12: 1592–1604.
  • Stifani, S., C. M. Blaumueller, N. J. Redhead, R. E. Hill, and S. Artavanis-Tsakonas 1992. Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins. Nature Genet. 2: 119–127.
  • Strom, A., P. Castella, J. Rockwood, J. Wagner, and M. Caudy 1997. Mediation of NGF signaling by post-translational inhibition of HES-1, a basic helix-loop-helix repressor of neuronal differentiation. Genes Dev. 11: 3168–3181.
  • Struhl, G., and A. Adachi 1998. Nuclear access and action of Notch in vivo. Cell 93: 649–660.
  • Struhl, G., K. Fitzgerald, and I. Greenwald 1993. Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo. Cell 74: 331–345.
  • Tata, F., and D. A. Hartley. 1993. The role of the enhancer of split complex during cell fate determination in Drosophila. Development 1993(Suppl.):139–148.
  • Uematsu, Y., A. Donda, and G. De Libero 1997. Thymocytes control the CD4 gene differently from mature T lymphocytes. Int. Immunol. 9: 179–187.
  • Uyttendaele, H., G. Marazzi, G. Wu, Q. Yan, D. Sassoon, and J. Kitajewski 1996. Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene. Development 122: 2251–2259.
  • Wainwright, S. M., and D. Ish-Horowicz 1992. Point mutations in the Drosophila hairy gene demonstrate in vivo requirements for basic, helix-loop-helix, and WRPW domains. Mol. Cell. Biol. 12: 2475–2483.
  • Washburn, T., E. Schweighoffer, T. Gridley, D. Chang, B. J. Fowlkes, D. Cado, and E. Robey 1997. Notch activity influences the α/β versus γ/δ T cell lineage decision. Cell 88: 833–843.
  • Waterman, M. L., and K. A. Jones 1990. Purification of TCF-1α, a T-cell-specific transcription factor that activates the T-cell receptor Cα gene enhancer in a context-dependent manner. New Biol. 2: 621–636.
  • Weinmaster, G., V. J. Roberts, and G. Lemke 1991. A homolog of Drosophila Notch expressed during mammalian development. Development 113: 199–205.
  • Weinmaster, G., V. J. Roberts, and G. Lemke 1992. Notch2: a second mammalian Notch gene. Development 116: 931–941.
  • Wettstein, D. A., D. L. Turner, and C. Kintner 1997. The Xenopus homolog of Drosophila Suppressor of Hairless mediates Notch signaling during primary neurogenesis. Development 124: 693–702.
  • Wurster, A. L., G. Siu, J. Leiden, and S. M. Hedrick 1994. Elf-1 binds to a critical element in a second CD4 enhancer. Mol. Cell. Biol. 14: 6452–6463.
  • Zenke, M., T. Grundstrom, H. Matthes, M. Wintzerith, C. Schatz, A. Wildeman, and P. Chambon 1986. Multiple sequence motifs are involved in SV40 enhancer function. EMBO J. 5: 387–397.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.