Strain-Dependent Myeloid Hyperplasia, Growth Deficiency, and Accelerated Cell Cycle in Mice Lacking the Rb-Related p107 Gene

REFERENCES

• Asimakopoulos, F. A., N. J. White, E. Nacheva, and A. R. Green 1994. Molecular analysis of chromosome 20q deletions associated with myeloproliferative disorders and myelodysplastic syndromes. Blood 84: 3086–3094.
   PubMed Web of Science ®Google Scholar
• Baker, J., J. P. Liu, E. J. Robertson, and A. Efstratiadis 1993. Role of insulin-like growth factors in embryonic and postnatal growth. Cell 75: 73–82.
   PubMed Web of Science ®Google Scholar
• Bang, O. S., F. W. Ruscetti, M. H. Lee, S. J. Kim, and M. C. Birchenall-Roberts 1996. Transforming growth factor-beta1 modulates p107 function in myeloid cells: correlation with cell cycle progression. J. Biol. Chem. 271: 7811–7819.
   PubMedGoogle Scholar
• Beijersbergen, R. L., E. M. Hijmans, L. Zhu, and R. Bernards 1994. Interaction of c-Myc with the pRb-related protein p107 results in inhibition of c-Myc-mediated transactivation. EMBO J. 13: 4080–4086.
   PubMedGoogle Scholar
• Bignon, Y. J., Y. Chen, C. Y. Chang, D. J. Riley, J. J. Windle, P. L. Mellon, and W. H. Lee 1993. Expression of a retinoblastoma transgene results in dwarf mice. Genes Dev. 7: 1654–1662.
   PubMedGoogle Scholar
• Bonyadi, M., S. A. Rusholme, F. M. Cousins, H. C. Su, C. A. Biron, M. Farrall, and R. J. Akhurst 1997. Mapping of a major genetic modifier of embryonic lethality in TGF beta 1 knockout mice. Nature Genet. 15: 207–211.
   PubMedGoogle Scholar
• Botz, J., K. Zerfass-Thome, D. Spitkovsky, H. Delius, B. Vogt, M. Eilers, A. Hatzigeorgiou, and P. Jansen-Durr 1996. Cell cycle regulation of the murine cyclin E gene depends on an E2F binding site in the promoter. Mol. Cell. Biol. 16: 3401–3409.
   PubMed Web of Science ®Google Scholar
• Brehm, A., E. A. Miska, D. J. McCance, J. L. Reid, A. J. Bannister, and T. Kouzarides 1998. Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature 391: 597–601.
   PubMed Web of Science ®Google Scholar
• Bremner, R., B. L. Cohen, M. Sopta, P. A. Hamel, C. J. Ingles, B. L. Gallie, and R. A. Phillips 1995. Direct transcriptional repression by pRB and its reversal by specific cyclins. Mol. Cell. Biol. 15: 3256–3265.
   PubMedGoogle Scholar
• Cao, L., B. Faha, M. Dembski, L. H. Tsai, E. Harlow, and N. Dyson 1992. Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F. Nature 355: 176–179.
   PubMedGoogle Scholar
• Chellappan, S. P., S. Hiebert, M. Mudryj, J. M. Horowitz, and J. R. Nevins 1991. The E2F transcription factor is a cellular target for the RB protein. Cell 65: 1053–1061.
   PubMed Web of Science ®Google Scholar
• Chittenden, T., D. M. Livingston, and J. A. DeCaprio 1993. Cell cycle analysis of E2F in primary human T cells reveals novel E2F complexes and biochemically distinct forms of free E2F. Mol. Cell. Biol. 13: 3975–3983.
   PubMedGoogle Scholar
• Clarke, A. R., E. R. Maandag, M. van Roon, N. M. van der Lugt, M. van der Valk, M. L. Hooper, A. Berns, and H. te Riele 1992. Requirement for a functional Rb-1 gene in murine development. Nature 359: 328–330.
   PubMed Web of Science ®Google Scholar
• Cobrinik, D., M. H. Lee, G. Hannon, G. Mulligan, R. T. Bronson, N. Dyson, E. Harlow, D. Beach, R. A. Weinberg, and T. Jacks 1996. Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev. 10: 1633–1644.
   PubMed Web of Science ®Google Scholar
• DeGregori, J., T. Kowalik, and J. R. Nevins 1995. Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes. Mol. Cell. Biol. 15: 4215–4224.
   PubMed Web of Science ®Google Scholar
• Fantl, V., G. Stamp, A. Andrews, I. Rosewell, and C. Dickson 1995. Mice lacking cyclin D1 are small and show defects in eye and mammary gland development. Genes Dev. 9: 2364–2372.
   PubMed Web of Science ®Google Scholar
• Geng, Y., E. N. Eaton, M. Picon, J. M. Roberts, A. S. Lundberg, A. Gifford, C. Sardet, and R. A. Weinberg 1996. Regulation of cyclin E transcription by E2Fs and retinoblastoma protein. Oncogene 12: 1173–1180.
   PubMed Web of Science ®Google Scholar
• George, E. L., E. N. Georges-Labouesse, R. S. Patel-King, H. Rayburn, and R. O. Hynes 1993. Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin. Development 119: 1079–1091.
   PubMed Web of Science ®Google Scholar
• Gu, W., K. Bhatia, I. T. Magrath, C. V. Dang, and R. Dalla-Favera 1994. Binding and suppression of the Myc transcriptional activation domain by p107. Science 264: 251–254.
   PubMedGoogle Scholar
• Herrera, R. E., V. P. Sah, B. O. Williams, T. P. Makela, R. A. Weinberg, and T. Jacks 1996. Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts. Mol. Cell. Biol. 16: 2402–2407.
   PubMedGoogle Scholar
• Hiebert, S. W., S. P. Chellappan, J. M. Horowitz, and J. R. Nevins 1992. The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F. Genes Dev. 6: 177–185.
   PubMed Web of Science ®Google Scholar
• Hoang, A. T., B. Lutterbach, B. C. Lewis, T. Yano, T. Y. Chou, J. F. Barrett, M. Raffeld, S. R. Hann, and C. V. Dang 1995. A link between increased transforming activity of lymphoma-derived MYC mutant alleles, their defective regulation by p107, and altered phosphorylation of the c-Myc transactivation domain. Mol. Cell. Biol. 15: 4031–4042.
   PubMed Web of Science ®Google Scholar
• Huet, X., J. Rech, A. Plet, A. Vie, and J. M. Blanchard 1996. Cyclin A expression is under negative transcriptional control during the cell cycle. Mol. Cell. Biol. 16: 3789–3798.
   PubMedGoogle Scholar
• Hurford, R. K.Jr., D. Cobrinik, M. H. Lee, and N. Dyson 1997. pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes. Genes Dev. 11: 1447–1463.
   PubMed Web of Science ®Google Scholar
• Jacks, T., A. Fazeli, E. M. Schmitt, R. T. Bronson, M. A. Goodell, and R. A. Weinberg 1992. Effects of an Rb mutation in the mouse. Nature 359: 295–300.
   PubMed Web of Science ®Google Scholar
• Johnson, D. G., and R. Schneider-Broussard 1998. Role of E2F in cell cycle control and cancer. Front. Biosci. 3: d447–d448.
   PubMedGoogle Scholar
• Johnson, D. G., J. K. Schwarz, W. D. Cress, and J. R. Nevins 1993. Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature 365: 349–352.
   PubMed Web of Science ®Google Scholar
• Kablar, B., K. Krastel, C. Ying, A. Asakura, S. J. Tapscott, and M. A. Rudnicki 1997. MyoD and Myf-5 differentially regulate the development of limb versus trunk skeletal muscle. Development 124: 4729–4738.
   PubMed Web of Science ®Google Scholar
• Kim, K. K., M. H. Soonpaa, H. Wang, and L. J. Field 1995. Developmental expression of p107 mRNA and evidence for alternative splicing of the p107 (RBL1) gene product. Genomics 28: 520–529.
   PubMedGoogle Scholar
• LeCouter, J. E., and M. A. Rudnicki. Unpublished observation.
   Google Scholar
• LeCouter, J. E., P. F. Whyte, and M. A. Rudnicki 1996. Cloning and expression of the Rb-related mouse p130 mRNA. Oncogene 12: 1433–1440.
   PubMedGoogle Scholar
• LeCouter, J. E., B. Kablar, P. F. M. Whyte, C. Ying, and M. A. Rudnicki. Strain-dependent embryonic lethality in mice lacking the retinoblastoma-related p130 gene. Development, in press.
   Google Scholar
• Lee, E. Y., C. Y. Chang, N. Hu, Y. C. Wang, C. C. Lai, K. Herrup, W. H. Lee, and A. Bradley 1992. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature 359: 288–294.
   PubMed Web of Science ®Google Scholar
• Lee, M. H., B. O. Williams, G. Mulligan, S. Mukai, R. T. Bronson, N. Dyson, E. Harlow, and T. Jacks 1996. Targeted disruption of p107: functional overlap between p107 and Rb. Genes Dev. 10: 1621–1632.
   PubMed Web of Science ®Google Scholar
• Li, E., T. H. Bestor, and R. Jaenisch 1992. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69: 915–926.
   PubMed Web of Science ®Google Scholar
• Liu, J. P., J. Baker, A. S. Perkins, E. J. Robertson, and A. Efstratiadis 1993. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 75: 59–72.
   PubMed Web of Science ®Google Scholar
• Lukas, J., B. O. Petersen, K. Holm, J. Bartek, and K. Helin 1996. Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression. Mol. Cell. Biol. 16: 1047–1057.
   PubMed Web of Science ®Google Scholar
• Luo, R. X., A. A. Postigo, and D. C. Dean 1998. Rb interacts with histone deacetylase to repress transcription. Cell 92: 463–473.
   PubMed Web of Science ®Google Scholar
• Magnaghi-Jaulin, L., R. Groisman, I. Naguibneva, P. Robin, S. Lorain, J. P. Le Villain, F. Troalen, D. Trouche, and A. Harel-Bellan 1998. Retinoblastoma protein represses transcription by recruiting a histone deacetylase. Nature 391: 601–605.
   PubMed Web of Science ®Google Scholar
• Maniatis, T., E. F. Fritsch, and J. Sambrook 1982. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
   Google Scholar
• McBurney, M. W., L. C. Sutherland, C. N. Adra, B. Leclair, M. A. Rudnicki, and K. Jardine 1991. The mouse Pgk-1 gene promoter contains an upstream activator sequence. Nucleic Acids Res. 19: 5755–5761.
   PubMedGoogle Scholar
• Megeney, L. A., B. Kablar, K. Garrett, J. E. Anderson, and M. A. Rudnicki 1996. MyoD is required for myogenic stem cell function in adult skeletal muscle. Genes Dev. 10: 1173–1183.
   PubMed Web of Science ®Google Scholar
• Muller, R. 1995. Transcriptional regulation during the mammalian cell cycle. Trends Genet. 11: 173–178.
   PubMedGoogle Scholar
• Mulligan, G., and T. Jacks 1998. The retinoblastoma gene family: cousins with overlapping interests. Trends Genet. 14: 223–229.
   PubMed Web of Science ®Google Scholar
• Nevins, J. R., G. Leone, J. DeGregori, and L. Jakoi 1997. Role of the Rb/E2F pathway in cell growth control. J. Cell Physiol. 173: 233–236.
   PubMed Web of Science ®Google Scholar
• Ohtani, K., J. DeGregori, and J. R. Nevins 1995. Regulation of the cyclin E gene by transcription factor E2F1. Proc. Natl. Acad. Sci. USA 92: 12146–12150.
   PubMed Web of Science ®Google Scholar
• Porcu, P., X. Grana, S. Li, J. Swantek, A. De Luca, A. Giordano, and R. Baserga 1994. An E2F binding sequence negatively regulates the response of the insulin-like growth factor 1 (IGF-I) promoter to simian virus 40T antigen and to serum. Oncogene 9: 2125–2134.
   PubMed Web of Science ®Google Scholar
• Proetzel, G., S. A. Pawlowski, M. V. Wiles, M. Yin, G. P. Boivin, P. N. Howles, J. Ding, M. W. Ferguson, and T. Doetschman 1995. Transforming growth factor-beta 3 is required for secondary palate fusion. Nature Genet. 11: 409–414.
   PubMed Web of Science ®Google Scholar
• Qin, X. Q., D. M. Livingston, M. Ewen, W. R. Sellers, Z. Arany, Kaelin W. G., Jr. 1995. The transcription factor E2F-1 is a downstream target of RB action. Mol. Cell. Biol. 15: 742–755.
   PubMedGoogle Scholar
• Robertson, E. J. 1987. Embryo-derived stem cells Teratomas and embryonic stem cells: a practical approach. In: Robertson, E. J.71–112IRL Press, Oxford, United Kingdom.
   Google Scholar
• Rohrer, D. K., K. H. Desai, J. R. Jasper, M. E. Stevens, Regula D. P., Jr., G. S. Barsh, D. Bernstein, and B. K. Kobilka 1996. Targeted disruption of the mouse beta 1-adrenergic receptor gene: developmental and cardiovascular effects. Proc. Natl. Acad. Sci. USA 93: 7375–7380.
   PubMed Web of Science ®Google Scholar
• Rozmahel, R., M. Wilschanski, A. Matin, S. Plyte, M. Oliver, W. Auerbach, A. Moore, J. Forstner, P. Durie, J. Nadeau, C. Bear, and L. C. Tsui 1996. Modulation of disease severity in cystic fibrosis transmembrane conductance regulator deficient mice by a secondary genetic factor. Nature Genet. 12: 280–287.
   PubMed Web of Science ®Google Scholar
• Rudnicki, M. A., T. Braun, S. Hinuma, and R. Jaenisch 1992. Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development. Cell 71: 383–390.
   PubMed Web of Science ®Google Scholar
• Schulze, A., K. Zerfass, D. Spitkovsky, S. Middendorp, J. Berges, K. Helin, P. Jansen-Durr, and B. Henglein 1995. Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site. Proc. Natl. Acad. Sci. USA 92: 11264–11268.
   PubMed Web of Science ®Google Scholar
• Sellers, W. R., J. W. Rodgers, Kaelin W. G., Jr. 1995. A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites. Proc. Natl. Acad. Sci. USA 92: 11544–11548.
   PubMed Web of Science ®Google Scholar
• Shan, B., and W. H. Lee 1994. Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol. Cell. Biol. 14: 8166–8173.
   PubMedGoogle Scholar
• Shirodkar, S., M. Ewen, J. A. DeCaprio, J. Morgan, D. M. Livingston, and T. Chittenden 1992. The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner. Cell 68: 157–166.
   PubMed Web of Science ®Google Scholar
• Sibilia, M., and E. F. Wagner 1995. Strain-dependent epithelial defects in mice lacking the EGF receptor. Science 269: 234–238.
   PubMed Web of Science ®Google Scholar
• Sladek, T. L. 1997. E2F transcription factor action, regulation and possible role in human cancer. Cell Prolif. 30: 97–105.
   PubMedGoogle Scholar
• Testa, J. R., A. Kinnealey, J. D. Rowley, D. W. Golde, and D. Potter 1978. Deletion of the long arm of chromosome 20 [del(20)(q11)] in myeloid disorders. Blood 52: 868–877.
   PubMed Web of Science ®Google Scholar
• Threadgill, D. W., A. A. Dlugosz, L. A. Hansen, T. Tennenbaum, U. Lichti, D. Yee, C. LaMantia, T. Mourton, K. Herrup, R. C. Harris, et al. 1995. Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science 269: 230–234.
   PubMed Web of Science ®Google Scholar
• Watanabe, S., S. Ishida, K. Koike, and K. Arai 1995. Characterization of cis-regulatory elements of the c-myc promoter responding to human GM-CSF or mouse interleukin 3 in mouse proB cell line BA/F3 cells expressing the human GM-CSF receptor. Mol. Biol. Cell 6: 627–636.
   PubMedGoogle Scholar
• Weinberg, R. A. 1995. The retinoblastoma protein and cell cycle control. Cell 81: 323–330.
   PubMed Web of Science ®Google Scholar
• Whyte, P. 1995. The retinoblastoma protein and its relatives. Semin. Cancer Biol. 6: 83–90.
   PubMed Web of Science ®Google Scholar
• Williams, B. O., L. Remington, D. M. Albert, S. Mukai, R. T. Bronson, and T. Jacks 1994. Cooperative tumorigenic effects of germline mutations in Rb and p53. Nature Genet. 7: 480–484.
   PubMed Web of Science ®Google Scholar
• Zerfass-Thome, K., A. Schulze, W. Zwerschke, B. Vogt, K. Helin, J. Bartek, B. Henglein, and P. Jansen-Durr 1997. p27KIP1 blocks cyclin E-dependent transactivation of cyclin A gene expression. Mol. Cell. Biol. 17: 407–415.
   PubMedGoogle Scholar