15
Views
26
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Sequence Divergence in the 3′ Untranslated Regions of Human ζ- and α-Globin mRNAs Mediates a Difference in Their Stabilities and Contributes to Efficient α-to-ζ Gene Developmental Switching

, , &
Pages 2173-2183 | Received 27 Oct 1997, Accepted 20 Jan 1998, Published online: 27 Mar 2023

REFERENCES

  • Albitar, M., C. Peschle, and S. A. Liebhaber 1989. Theta, zeta, and epsilon globin messenger RNAs are expressed in adults. Blood 74: 629–637.
  • Aviv, H., Z. Volloch, R. Bastos, and S. Levy 1976. Biosynthesis and stability of globin mRNA in erythroleukemic Friend cells. Cell 8: 495–503.
  • Baer, B. W., and R. D. Kornberg 1983. The protein responsible for the repeating structure of cytoplasmic poly(A)-ribonucleoprotein. J. Cell Biol. 96: 717–721.
  • Baer, B. W., and R. D. Kornberg 1980. Repeating structure of cytoplasmic poly(A)-ribonucleoprotein. Proc. Natl. Acad. Sci. USA 77: 1890–1892.
  • Bastos, R. N., and H. Aviv 1977. Theoretical analysis of a model for globin messenger RNA accumulation during erythropoiesis. J. Mol. Biol. 110: 205–218.
  • Beelman, C. A., and R. Parker 1995. Degradation of mRNA in eukaryotes. Cell 81: 179–183.
  • Chui, D. H. K., S. C. Wong, S.-W. Chung, M. Patterson, S. Bhargava, and M.-C. Poon 1986. Embryonic ζ-globin chains in adults: a marker for α-thalassemia-1 haplotype due to a >17.5 kb deletion. N. Engl. J. Med. 314: 76–79.
  • Decker, C. J., and R. Parker 1994. Mechanisms of mRNA degradation in eucaryotes. Trends Biochem. Sci. 19: 336–340.
  • Decker, C. J., and R. Parker 1993. A turnover pathway for both stable and unstable mRNAs in yeast: evidence for a requirement for deadenylation. Genes Dev. 7: 1632–1643.
  • Feldman, H. A. 1972. Mathematical theory of complex ligand-binding systems at equilibrium: some methods for parameter fitting. Anal. Biochem. 48: 317–338.
  • Gau, G. T., V. F. Fairbanks, J. E. Maldonado, J. B. Bassingthwaighte, and R. G. Tancredi 1974. Cardiac dysfunction in a patient with hemoglobin Malmo treated with repeated transfusions. Clin. Res. 22: 276A.
  • Goodman, M., M. L. Weiss, and J. Czelusniak 1982. Molecular evolution above the species level: branching pattern, rates, and mechanisms. Syst. Zool. 31: 376.
  • Hamalainen, L., J. Oikarinen, and K. Kivirikko 1985. Synthesis and degradation of type 1 procollagen mRNA in cultured human skin fibroblasts and the effects of cortisol. J. Biol. Chem. 260: 720–726.
  • Hofmann, O., R. Mould, and Y. Brittain 1995. Allosteric modulation of oxygen binding to the three human embryonic hemoglobins. Biochem. J. 306: 367–370.
  • Holcik, M., and S. A. Liebhaber 1997. Four highly stable eukaryotic mRNAs assemble 3′UTR RNA-protein complexes sharing cis- and trans-components. Proc. Natl. Acad. Sci. USA 94: 2410–2414.
  • Jacobson, A., and S. W. Peltz 1996. Interrelationships of the pathways of mRNA decay and translation in eukaryotic cells. Annu. Rev. Biochem. 65: 693–739.
  • Jones, T. R., and M. D. Cole 1987. Rapid cytoplasmic turnover of c-myc mRNA: requirement of the 3′ untranslated sequences. Mol. Cell. Biol. 7: 4513–4521.
  • Kabnick, K. S., and D. E. Housman 1988. Determinants that contribute to cytoplasmic stability of human c-fos and β-globin mRNAs are located at several sites in each mRNA. Mol. Cell. Biol. 8: 3244–3250.
  • Kiledjian, M., X. Wang, and S. A. Liebhaber 1995. Identification of two KH domain proteins in the alpha-globin mRNP stability complex. EMBO J. 14: 4357–4364.
  • Klausner, R. D., T. A. Rouault, and J. B. Harford 1993. Regulating the fate of mRNA: the control of cellular iron metabolism. Cell 72: 19–28.
  • Krowczynska, A., R. Yenofsky, and G. Brawerman 1985. Regulation of messenger RNA stability in mouse erythroleukemia cells. J. Mol. Biol. 181: 231–239.
  • Li, X. A., and D. C. Beebe 1991. Messenger RNA stabilization in chicken lens development: a reexamination. Dev. Biol. 146: 239–241.
  • Liebhaber, S. A., Z. Wang, F. E. Cash, B. Monks, and J. E. Russell 1996. Developmental silencing of the embryonic ζ-globin gene: synergistic action of the promoter and 3′-flanking region combined with stage-specific silencing by the transcribed segment. Mol. Cell. Biol. 16: 2637–2646.
  • Lodish, H. F., and B. Small 1976. Different lifetimes of reticulocyte messenger RNA. Cell 7: 59–65.
  • Maata, A., E. Elkholm, and R. P. Penttinen 1995. Effect of the 3′-untranslated region on the expression levels and mRNA stability of alpha1(1) collagen gene. Biochim. Biophys. Acta 1260: 294–300.
  • Morales, J., J. E. Russell, and S. A. Liebhaber 1997. Destabilization of human α-globin mRNA by translation anti-termination is controlled during erythroid differentiation and paralleled by phased shortening of the poly(A) tail. J. Biol. Chem. 272: 6607–6613.
  • Mullner, E. W., and L. C. Kuhn 1988. A stem-loop in the 3′ untranslated region mediates iron-dependent regulation of transferrin receptor mRNA stability in the cytoplasm. Cell 53: 815–825.
  • Peltz, S. W., G. Brewer, P. Bernstein, P. Hart, and J. Ross 1991. Regulation of mRNA turnover in eukaryotic cells. Crit. Rev. Eukaryot. Gene Expr. 1: 99–126.
  • Pondel, M. D., N. J. Proudfoot, C. Whitelaw, and E. Whitelaw 1992. The developmental regulation of the human ζ-globin gene in transgenic mice employing β-galactosidase as a reporter gene. Nucleic Acids Res. 20: 5655–5660.
  • Ross, J. 1995. mRNA stability in mammalian cells. Microbiol. Rev. 59: 423–450.
  • Ross, J., and A. Pizarro 1983. Human beta and delta globin messenger RNAs turn over at different rates. J. Mol. Biol. 167: 607–617.
  • Ross, J., and T. D. Sullivan 1985. Half-lives of beta and gamma globin messenger RNAs and of protein synthetic capacity in cultured human reticulocytes. Blood 66: 1149–1154.
  • Russell, J. E., and S. A. Liebhaber 1993. Molecular genetics of thalassemia. Adv. Genome Biol. 2: 283–353.
  • Russell, J. E., and S. A. Liebhaber 1996. The stability of human β-globin mRNA is dependent on structural determinants positioned within its 3′ untranslated region. Blood 87: 5314–5323.
  • Russell, J. E., J. Morales, and S. A. Liebhaber 1997. The role of globin mRNA stability in the control of globin gene expression. Prog. Nucleic Acid Res. Mol. Biol. 57: 249–287.
  • Sabath, D. E., K. M. Koehler, W. Q. Yang, K. Patton, and G. Stamatoyannopoulos 1995. Identification of a major positive regulatory element located 5′ to the human ζ-globin gene. Blood 85: 2587–2597.
  • Sabath, D. E., E. A. Spangler, E. M. Rubin, and G. Stamatoyannopoulos 1993. Analysis of the human ζ-globin gene promoter in transgenic mice. Blood 82: 2899–2905.
  • Sharpe, J. A., P. S. Chan-Thomas, J. Lida, H. Ayyub, W. G. Wood, and D. R. Higgs 1992. Analysis of the human alpha globin upstream regulatory element (HS-40) in transgenic mice. EMBO J. 11: 4565–4572.
  • Shyu, A. B., M. E. Greenberg, and J. G. Belasco 1989. The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways. Genes Dev. 3: 60–72.
  • Shyu, A. B., J. G. Belasco, and M. E. Greenberg 1991. Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay. Genes Dev. 5: 221–234.
  • Talbot, D., P. Collis, M. Antoniou, M. Vidal, F. Grosveld, and D. Greaves 1989. A dominant control region for human β-globin locus conferring integration site-independent gene expression. Nature 33: 352–355.
  • Tang, W., H.-Y. Luo, M. Albitar, M. Patterson, B. Eng, J. S. Waye, S. A. Liebhaber, D. R. Higgs, and D. H. K. Chui 1992. Human embryonic ζ-globin chain expression in deletional α-thalassemias. Blood 80: 517–522.
  • Wang, X., M. Kiledjian, I. M. Weiss, and S. A. Liebhaber 1995. Detection and characterization of a 3′ untranslated region ribonucleoprotein complex associated with human α-globin mRNA stability. Mol. Cell. Biol. 15: 1769–1777.
  • Wang, X., and S. A. Liebhaber 1996. Complementary change in cis determinants and trans factors in the evolution of an mRNP stability complex. EMBO J. 15: 5040–5051.
  • Wang, Z., and S. A. Liebhaber. Unpublished data.
  • Weiss, I. M., and S. A. Liebhaber 1995. Erythroid cell-specific mRNA stability elements in the α2-globin 3′ nontranslated region. Mol. Cell. Biol. 15: 2457–2465.
  • Weiss, I. M., and S. A. Liebhaber 1994. Erythroid cell-specific determinants of α-globin mRNA stability. Mol. Cell. Biol. 14: 8123–8132.
  • Whittemore, L.-A., and T. Maniatis 1990. Postinduction turnover of beta-interferon gene expression. Mol. Cell. Biol. 10: 1329–1337.
  • Wisdom, R., and W. M. F. Lee 1991. The protein coding region of c-myc mRNA contains a sequence that specifies rapid mRNA turnover and induction by protein synthesis inhibitors. Genes Dev. 5: 232–243.
  • Yagi, M., R. Gelinas, J. T. Elder, M. Peretz, T. Papayannopoulou, G. Stamatoyannopoulos, and M. Groudine 1986. Chromatin structure and developmental expression of the human α-globin cluster. Mol. Cell. Biol. 6: 1108–1116.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.