7
Views
96
CrossRef citations to date
0
Altmetric
Gene Expression

Differential Transcriptional Activation by Human T-Cell Leukemia Virus Type 1 Tax Mutants Is Mediated by Distinct Interactions with CREB Binding Protein and p300

, , &
Pages 2392-2405 | Received 30 Jul 1997, Accepted 23 Jan 1998, Published online: 27 Mar 2023

REFERENCES

  • Arany, Z., W. R. Sellers, D. M. Livingston, and R. Eckner 1994. E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators. Cell 77: 799–800.
  • Arany, Z., D. Newsome, E. Oldread, D. M. Livingston, and R. Eckner 1995. A family of transcriptional adaptor proteins targeted by the E1A oncoprotein. Nature 374: 81–84.
  • Armstrong, A. P., A. A. Franklin, M. N. Henbogaard, H. A. Giebler, and J. K. Nyborg 1993. Pleiotropic effect of the human T-cell leukemia virus TAX protein on the DNA binding activity of eukaryotic transcription factors. Proc. Natl. Acad. Sci. USA 90: 7303–7307.
  • Avantaggiati, M. L., V. Ogryzko, K. Gardner, A. Giordano, A. S. Levine, and K. Kelly 1997. Recruitment of p300/CBP in p53-dependent signal pathways. Cell 89: 1175–1184.
  • Ballard, D. W., E. Bohnlein, J. W. Lowenthal, Y. Wano, B. R. Franza, and W. C. Greene 1988. HTLV-1 Tax induces cellular proteins that activate the κB element in the IL-2 receptor α gene. Science 241: 1652–1655.
  • Bannister, A. J., and T. Kouzarides 1996. The CBP co-activator is a histone acetyltransferase. Nature 384: 641–643.
  • Baranger, A. M., C. R. Palmer, M. K. Hamm, H. A. Glebler, A. Brauweiler, J. K. Nyborg, and A. Schepartz 1995. Mechanism of DNA-binding enhancement by the human T-cell leukaemia virus transactivator Tax. Nature 376: 606–608.
  • Beraud, C., S.-C. Sun, P. Ganchi, D. W. Ballard, and W. C. Greene 1994. Human T-cell leukemia virus type I Tax associates with and is negatively regulated by the NF-κB2 p100 gene product: implication for viral latency. Mol. Cell. Biol. 14: 1374–1382.
  • Berglund, P., M. Sjöberg, H. Garoff, G. J. Atkins, B. J. Sheahan, and P. Liljeström 1993. Semliki Forest virus expression system: production of conditionally infectious recombinant particles. Bio/Technology 11: 916–920.
  • Bex, F., A. McDowall, A. Burny, and R. B. Gaynor 1997. The human T-cell leukemia virus transactivator protein Tax colocalizes with NF-κB proteins in unique nuclear bodies. J. Virol. 71: 3484–3497.
  • Borrow, J., Stanton, V. P.Jr., J. M. Andersen, R. Becher, F. G. Behm, R. S. Chaganti, C. I. Civin, C. Disteche, I. Dube, A. M. Frichauf, D. Horsman, F. Mitelman, S. Volinia, A. E. Watmore, and D. E. Housman 1996. The translocation t(8;16) (p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein. Nat. Genet. 14: 33–41.
  • Brady, J., K. T. Jeang, J. Duvall, and G. Khoury 1987. Identification of p40x-responsive regulatory sequences within the human T-cell leukemia virus type I long terminal repeat. J. Virol. 61: 2175–2181.
  • Brauweiler, A., P. Garl, A. A. Franklin, H. A. Giebler, and J. K. Nyborg 1995. A molecular mechanism for human T-cell leukemia virus latency and Tax transactivation. J. Biol. Chem. 270: 12814–12822.
  • Brockman, J. A., D. C. Scherer, T. A. McKinsey, S. M. Hall, X. Qi, W. Y. Lee, and D. W. Ballard 1995. Coupling of a signal response domain in IκBα to multiple pathways for NF-κB activation. Mol. Cell. Biol. 15: 2809–2818.
  • Cann, A. J., J. D. Rosenblatt, W. Wachsman, N. P. Shah, and I. S. Y. Chen 1985. Identification of the gene responsible for human T-cell leukemia virus transcriptional regulation. Nature 318: 571–574.
  • Chakravarti, D., V. J. LaMorte, M. C. Nelson, T. Nakajima, I. G. Schulman, H. Juguilon, M. Montminy, and R. M. Evans 1996. Role of CBP/p300 in nuclear receptor signaling. Nature 383: 99–103.
  • Chen, Z., J. Hagler, V. J. Palombella, F. Melandri, D. Scherer, D. Ballard, and T. Maniatis 1995. Signal-induced site-specific phosphorylation targets IκBα to the ubiquitin-proteasome pathway. Genes Dev. 9: 1586–1597.
  • Chrivia, J. C., R. P. S. Kwok, N. Lamb, M. Hagiwara, M. R. Montminy, and R. H. Goodman 1993. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365: 855–859.
  • Dai, P., H. Akimaru, Y. Tanaka, D.-X. Hou, T. Yasukawa, C. Kanei-Ishii, T. Takahashi, and S. Ishii 1996. CBP as a transcriptional coactivator of c-Myb. Genes Dev. 10: 528–540.
  • Eckner, R., M. E. Ewen, D. Newsome, M. Gerdes, J. A. DeCaprio, J. B. Lawrence, and D. M. Livingston 1994. Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. Genes Dev. 8: 869–884.
  • Eckner, R., J. W. Ludlow, N. L. Lill, E. Oldread, Z. Arany, N. Modjtahedi, J. A. DeCaprio, D. M. Livingston, and J. A. Morgan 1996. Association of p300 and CBP with simian virus 40 large T antigen. Mol. Cell. Biol. 16: 3454–3464.
  • Felber, B. K., H. Paskalis, D. Kleinman-Ewing, F. Wong-Staal, and G. N. Pavlakis 1985. The pX protein of HTLV-1 is a transcriptional activator of its long terminal repeats. Science 229: 54–58.
  • Fujii, M., P. Sassone-Corsi, and I. M. Verma 1988. c-fos promoter trans-activation by the tax1 protein of human T-cell leukemia virus type I. Proc. Natl. Acad. Sci. USA 85: 8526–8530.
  • Fujii, M., H. Tsuchiya, T. Chuhjo, T. Akizawa, and M. Seiki 1992. Interaction of HTLV-I Tax1 with p67SRF causes the aberrant induction of cellular immediate early genes through CArG boxes. Genes Dev. 6: 2066–2076.
  • Fujisawa, J., M. Seiki, M. Sato, and M. Yoshida 1986. A transcriptional enhancer sequence of HTLV-I is responsible for trans-activation mediated by p40x of HTLV-I. EMBO J. 5: 713–718.
  • Fujisawa, J.-I., M. Toita, and M. Yoshida 1994. Tax of HTLV-1 interacts with cAMP-responsive element (CRE) binding and CRE modulator proteins that bind to the 21 base-pair enhancer of HTLV-1. Proc. Natl. Acad. Sci. USA 90: 610–614.
  • Gerritsen, M. E., A. J. Williams, A. S. Neish, S. Moore, Y. Shi, and T. Collins 1997. CREB-binding protein/p300 are transcriptional coactivators of p65. Proc. Natl. Acad. Sci. USA 94: 2927–2932.
  • Giebler, H. A., J. E. Loring, K. van Orden, M. A. Colgin, J. E. Garrus, K. W. Escudero, A. Brauweiler, and J. K. Nyborg 1997. Anchoring of CREB binding protein to the human T-cell leukemia virus type 1 promoter: a molecular mechanism of Tax transactivation. Mol. Cell. Biol. 17: 5156–5164.
  • Gonzalez, G. A., P. Menzel, J. Leonard, W. H. Fischer, and M. R. Montminy 1991. Characterization of motifs which are critical for activity of the cyclic AMP-responsive transcription factor CREB. Mol. Cell. Biol. 11: 1306–1312.
  • Grassmann, R., C. Dengler, I. Muller-Fleckenstein, B. Fleckenstein, K. McGuire, M. Dokhelar, J. Sodroski, and W. Haseltine 1989. Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a Herpesvirus saimiri vector. Proc. Natl. Acad. Sci. USA 86: 3351–3355.
  • Grossman, W. J., J. T. Kimata, F.-H. Wong, M. Zutter, T. J. Ley, and L. Ratner 1995. Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I. Proc. Natl. Acad. Sci. USA 92: 1057–1061.
  • Gu, W., X.-L. Shl, and R. G. Roeder 1997. Synergistic activation of transcription by CBP and p53. Nature 387: 819–823.
  • Hai, T. W., F. Liu, W. J. Coukos, and M. R. Green 1989. Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. Genes Dev. 3: 2083–2090.
  • Harrich, D., J. Garcia, R. Mitsuyasu, and R. Gaynor 1990. TAR independent activation of the human immunodeficiency virus in phorbol ester stimulated T lymphocytes. EMBO J. 9: 4417–4423.
  • Haugland, R. P. 1996. Handbook of fluorescent probes and research chemicals. Molecular Probes, Inc., Eugene, Oreg.
  • Hinuma, Y., H. Komoda, T. Chosa, T. Kondo, M. Kohakura, T. Takenaka, M. Kikuchi, M. Ichimaru, K. Yunoki, I. Sato, R. Matsuo, Y. Takiuchi, H. Uchino, and M. Hanaoka 1982. Antibodies to adult T-cell leukemia-virus-associated antigen (ATLA) in sera from patients with ATL and controls in Japan: a nation-wide seroepidemiologic study. Int. J. Cancer 29: 631–635.
  • Hiscott, J., L. Petropoulos, and J. Lacoste 1995. Molecular interactions between HTLV-1 Tax protein and the NF-kappa B/kappa B transcription complex. Virology 214: 3–11.
  • Hoshino, H., H. Esumi, and M. Miwa 1983. Establishment and characterization of 10 cell lines derived from patients with adult T-cell leukemia. Proc. Natl. Acad. Sci. USA 80: 6061–6065.
  • Janknecht, R., and T. Hunter 1996. Transcription. A growing coactivator network. Nature 383: 22–23.
  • Kamei, Y., L. Xu, T. Heinzel, J. Torchia, R. Kurokawa, B. Gloss, S.-C. Lin, R. A. Heyman, D. W. Rose, C. K. Glass, and M. G. Rosenfeld 1996. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85: 403–414.
  • Kanno, T., K. Brown, G. Franzoso, and U. Siebenlist 1994. Kinetic analysis of human T-cell leukemia virus type I tax-mediated activation of NF-κB. Mol. Cell. Biol. 14: 6443–6451.
  • Kanno, T., G. Franzoso, and U. Siebenlist 1994. Human T-cell leukemia virus type I Tax-protein-mediated activation of NF-κB from p100 (NF-κB2)-inhibited reservoirs. Proc. Natl. Acad. Sci. USA 91: 12634–12638.
  • Kwok, R. P. S., J. R. Lundblad, J. C. Chrivia, J. P. Richards, H. P. Bachinger, R. G. Brennan, S. G. E. Roberts, M. R. Green, and R. H. Goodman 1994. Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature 370: 223–226.
  • Kwok, R. P. S., M. E. Laurance, J. R. Lundblad, P. S. Goldman, H.-M. Shih, L. M. Connor, S. J. Marriott, and R. H. Goodman 1996. Control of cAMP-regulated enhancers by the viral transactivator Tax through CREB and the co-activator CBP. Nature 380: 642–646.
  • Lacoste, J., L. Petropoulos, N. Pépin, and J. Hiscott 1995. Constitutive phosphorylation and turnover of IκBα in human T-cell leukemia virus type I-infected and tax-expressing T cells. J. Virol. 69: 564–569.
  • Leung, K., and G. J. Nabel 1988. HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-kappa B-like factor. Nature 333: 776–778.
  • Liljeström, P., and H. Garoff 1991. A new generation of animal cell expression vectors based on the Semliki Forest virus replicon. Bio/Technology 9: 1356–1361.
  • Lill, N. L., S. R. Grossman, D. Ginsberg, J. DeCaprio, and D. M. Livingston 1997. Binding and modulation of p53 by p300/CBP coactivators. Nature 387: 823–827.
  • Lundblad, J. R., R. P. S. Kwok, M. E. Laurance, M. L. Harter, and R. H. Goodman 1995. Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP. Nature 374: 85–88.
  • McKinsey, T. A., J. A. Brockman, D. C. Scherer, S. W. Al-Murrani, P. L. Green, and D. W. Ballard 1996. Inactivation of IκBβ by the Tax protein of human T-cell leukemia virus type 1: a potential mechanism for constitutive induction of NF-κB. Mol. Cell. Biol. 16: 2083–2090.
  • Miyoshi, I., I. Kubonishi, S. Yoshimoto, T. Akagi, Y. Ohtsuki, Y. Shiraishi, K. Nagata, and Y. Hinuma 1981. Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukeamic T-cells. Nature 294: 770–771.
  • Moran, E. 1993. DNA tumor virus transforming proteins and the cell cycle. Curr. Opin. Genet. Dev. 3: 63–70.
  • Muraoka, M., M. Konishi, R. Yanoshita, K. Tanaka, N. Shitara, J. M. Chong, T. Iwama, and M. Miyaki 1996. p300 gene alterations in colorectal and gastric carcinomas. Oncogene 12: 1565–1569.
  • Nerenberg, M., S. H. Hinrichs, R. K. Reynolds, G. Khoury, and G. Jay 1987. The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice. Science 237: 1324–1329.
  • Oelgeschlager, M., R. Janknecht, J. Krieg, S. Schreek, and B. Luscher 1996. Interaction of the co-activator CBP with Myb proteins: effects on Myb-specific transactivation and on the cooperativity with NF-M. EMBO J. 15: 2771–2780.
  • Ogryzko, V. V., R. L. Schiltz, V. Russanova, B. H. Howard, and Y. Nakatani 1996. The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 87: 953–959.
  • Oliner, J. D., J. M. Andresen, S. K. Hansen, S. Zhou, and R. Tjian 1996. SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein. Genes Dev. 10: 2903–2911.
  • Paca-Uccaralertkun, S., L. J. Zhao, N. Adya, J. V. Cross, B. R. Cullen, I. M. Boros, and C. Giam 1994. In vitro selection of DNA elements highly responsive to the human T-cell lymphotropic virus type I transcriptional activator, Tax. Mol. Cell. Biol. 14: 456–462.
  • Parker, D., K. Ferreri, T. Nakajima, V. J. LaMorte, R. Evans, S. C. Koerber, C. Hoeger, and M. R. Montminy 1996. Phosphorylation of CREB at Ser-133 induces complex formation with CREB-binding protein via a direct mechanism. Mol. Cell. Biol. 16: 694–703.
  • Paskalis, H., B. K. Felber, and G. N. Pavlakis 1986. cis-acting sequences responsible for the transcriptional activation of a human T-cell leukemia virus type I constitute a conditional enhancer. Proc. Natl. Acad. Sci. USA 83: 6558–6562.
  • Pepin, N., A. Roulston, J. Lacoste, R. Lin, and J. Hiscott 1994. Subcellular redistribution of HTLV-I Tax protein by NF-κB/Rel transcription factors. Virology 204: 706–716.
  • Perini, G., S. Wagner, and M. B. Green 1995. Recognition of bZIP proteins by the human T-cell leukemia virus transactivator Tax. Nature 376: 602–605.
  • Perkins, N. D., L. K. Felzien, J. C. Betts, K. Leung, D. H. Beach, and G. J. Nabel 1997. Regulation of NF-κB by cyclin-dependent kinases associated with the p300 coactivator. Science 275: 523–527.
  • Pettersson, I., M. Hinterberger, T. Mimori, E. Gottlieb, and J. A. Steitz 1984. The structure of mammalian small nuclear ribonucleoproteins: identification of multiple protein components reactive with (U1) ribonucleoprotein and anti-Sm autoantibodies. J. Biol. Chem. 259: 5907–5914.
  • Poiesz, B. J., R. W. Ruscetti, A. F. Gazdar, P. A. Bunn, J. D. Minna, and R. C. Gallo 1980. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc. Natl. Acad. Sci. USA 77: 7415–7419.
  • Pozzatti, R., J. Vogel, and G. Jay 1990. The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cells. Mol. Cell. Biol. 10: 413–417.
  • Schmitz, M. L., and P. A. Baeuerle 1991. The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B. EMBO J. 10: 3805–3817.
  • Seeler, J. S., C. Muchardt, M. Podar, and R. B. Gaynor 1993. Regulatory elements involved in tax-mediated transactivation of the HTLV-1 LTR. Virology 196: 442–450.
  • Semmes, O. J., and K.-T. Jeang 1992. Mutational analysis of human T-cell leukemia virus type I Tax: regions necessary for function determined with 47 mutant proteins. J. Virol. 66: 7183–7192.
  • Semmes, O. J., and K.-T. Jeang 1996. Localization of human T-cell leukemia virus type 1 Tax to subnuclear compartments that overlap with interchromatin speckles. J. Virol. 70: 6347–6357.
  • Shimotohno, K., M. Takano, T. Teruchi, and M. Miwa 1986. Requirement of multiple copies of a 21-nucleotide sequence in the U3 region of human T-cell leukemia virus type I and type II long terminal repeats for trans-acting activation of transcription. Proc. Natl. Acad. Sci. USA 83: 8112–8116.
  • Siekevitz, M., M. B. Feinberg, N. Holbrook, F. Wong-Staal, and W. C. Greene 1987. Activation of interleukin 2 and interleukin 2 receptor (Tac) promoter expression by the transactivator (tat) gene product of human T-cell leukemia virus type 1. Proc. Natl. Acad. Sci. USA 84: 5389–5393.
  • Smith, D. B., and K. S. Johnson 1988. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 67: 31–40.
  • Smith, C. L., S. A. Onate, M. J. Tsai, and B. W. O’Malley 1996. CREB binding protein acts synergistically with steroid receptor coactivator-1 to enhance steroid receptor-dependent transcription. Proc. Natl. Acad. Sci. USA 93: 8884–8888.
  • Smith, M. R., and W. C. Greene 1990. Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes. Genes Dev. 4: 1875–1885.
  • Smith, M. R., and W. C. Greene 1991. Type I human T-cell leukemia tax protein transforms rat fibroblasts through the cyclic adenosine monophosphate response element binding protein/activating transcription factor pathway. J. Clin. Invest. 88: 1038–1042.
  • Sodroski, J., C. Rosen, W. C. Goh, and W. Haseltine 1985. A transcriptional activator protein encoded by the x-lor region of the human T-cell leukemia virus. Science 228: 1430–1434.
  • Suzuki, T., J. I. Fujisawa, M. Toita, and M. Yoshida 1993. The trans-activator tax of human T-cell leukemia virus type 1 (HTLV-I) interacts with cAMP-responsive element (CRE) binding and CRE modulator proteins that bind to the 21-base-pair enhancer of HTLV-I. Proc. Natl. Acad. Sci. USA 90: 610–614.
  • Tanaka, A., C. Takahashi, S. Yamaoka, T. Nosaka, M. Maki, and M. Hatanaka 1990. Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro. Proc. Natl. Acad. Sci. USA 87: 1071–1075.
  • Wagner, S., and M. R. Green 1993. HTLV-I Tax protein stimulation of DNA binding of bZIP proteins by enhancing dimerization. Science 262: 395–399.
  • Yamaoka, S., H. Inoue, M. Sakurai, T. Sugiyama, M. Hazama, T. Yamada, and M. Hatanaka 1996. Constitutive activation of NF-κB is essential for transformation of rat fibroblasts by the human T-cell leukemia virus type I Tax protein. EMBO J. 15: 873–887.
  • Yang, X.-J., V. V. Ogryzko, J.-I. Nishikawa, B. H. Howard, and Y. Nakatani 1996. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature 382: 319–324.
  • Yin, M., E. Paulssen, J. Seeler, and R. Gaynor 1995. Chimeric proteins comprised of Jun and CREB define domains required for interaction with the HTLV-I Tax protein. J. Virol. 69: 6209–6218.
  • Yin, M.-J., and R. B. Gaynor 1996. HTLV-I 21bp repeat sequences facilitate stable association between Tax and CREB to increase CREB binding affinity. J. Mol. Biol. 264: 20–31.
  • Yoshida, M., I. Miyoshi, and Y. Hinuma 1982. Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease. Proc. Natl. Acad. Sci. USA 79: 2031–2035.
  • Zhao, L. J., and C. Z. Giam 1991. Interaction of the human T-cell lymphotropic virus type I (HTLV-I) transcriptional activator Tax with cellular factors that bind specifically to the 21-base-pair repeats in the HTLV-I enhancer. Proc. Natl. Acad. Sci. USA 88: 11445–11449.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.