Negative Regulation of DNA Replication by the Retinoblastoma Protein Is Mediated by Its Association with MCM7

REFERENCES

• Bergemann, A. D., and E. M. Johnson 1992. The HeLa Pur factor binds single-stranded DNA at a specific element conserved in gene flanking regions and origins of DNA replication. Mol. Cell. Biol. 12: 1257–1265.
   PubMed Web of Science ®Google Scholar
• Bergemann, A. D., Z.-W. Ma, and E. M. Johnson 1992. Sequence of cDNA comprising the human pur gene and sequence-specific single-stranded-DNA-binding properties of the encoded protein. Mol. Cell. Biol. 12: 5673–5682.
   PubMed Web of Science ®Google Scholar
• Blow, J. J. 1993. Preventing re-replication of DNA in a single cell cycle: evidence for a replication licensing factor. J. Cell. Biol. 120: 993–1002.
   Google Scholar
• Blow, J. J., and R. A. Laskey 1986. Initiation of DNA replication in nuclei and purified DNA by a cell-free extract of Xenopus eggs. Cell 47: 577–587.
   PubMed Web of Science ®Google Scholar
• Blow, J. J., and R. A. Laskey 1988. A role for the nuclear envelope in controlling DNA replication within the cell cycle. Nature (London) 332: 546–548.
   PubMed Web of Science ®Google Scholar
• Blow, J. J., and J. V. Watson 1987. Nuclei act as independent and integrated units of replication in a Xenopus cell-free DNA replication system. EMBO J. 6: 1997–2002.
   PubMedGoogle Scholar
• Buchkovich, K., L. A. Duffy, and E. Harlow 1989. The retinoblastoma protein is phosphorylated during specific phases of the cell cycle. Cell 58: 1097–1105.
   PubMed Web of Science ®Google Scholar
• Chen, P.-L., P. Scully, J.-Y. Shew, J. Y. J. Wang, and W.-H. Lee 1989. Phosphorylation of the retinoblastoma gene product is modified during the cell cycle and cellular differentiation. Cell 58: 1193–1198.
   PubMed Web of Science ®Google Scholar
• Chong, J. P. J., H. M. Mahbubani, C.-Y. Khoo, and J. J. Blow 1995. Purification of an MCM-containing complex as a component of the DNA replication licensing system. Nature (London) 375: 418–421.
   PubMed Web of Science ®Google Scholar
• Chong, J. P. J., P. Thommes, and J. J. Blow 1996. The role of MCM/P1 proteins in the licensing of DNA replication. Trends Biochem. Sci. 21: 102–106.
   PubMed Web of Science ®Google Scholar
• Clarke, A. R., E. R. Maandag, M. Van Roon, N. M. T. Van Der Lugt, M. Van Der Valk, M. L. Hooper, A. Berns, and H. Te Riele 1992. Requirement for a functional Rb-1 gene in murine development. Nature (London) 359: 328–333.
   PubMed Web of Science ®Google Scholar
• Cobrinik, D., M.-H. Lee, G. Hannon, G. Mulligan, R. T. Bronson, N. Dyson, E. Harlow, D. Beach, R. A. Weinberg, and T. Jacks 1996. Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev. 10: 1633–1644.
   PubMed Web of Science ®Google Scholar
• Cox, L. S., T. Hupp, C. A. Midgley, and D. P. Lane 1995. A direct effect of activated human p53 on nuclear DNA replication. EMBO J. 14: 2099–2105.
   PubMed Web of Science ®Google Scholar
• Datta, P. K., P. Raychaudhuri, and S. Bagchi 1995. Association of p107 with Sp1: genetically separable regions of p107 are involved in regulation of E2F- and Sp1-dependent transcription. Mol. Cell. Biol. 15: 5444–5452.
   PubMedGoogle Scholar
• DeCaprio, J. A., Y. Furukawa, F. Ajchenbaum, J. D. Griffin, and D. M. Livingston 1992. The retinoblastoma-susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression. Proc. Natl. Acad. Sci. USA 89: 1795–1798.
   PubMed Web of Science ®Google Scholar
• DeCaprio, J. A., J. W. Ludlow, J. Figge, J.-Y. Shew, C.-M. Huang, W.-H. Lee, E. Marsilio, E. Paucha, and D. M. Livingston 1988. SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell 54: 275–282.
   PubMed Web of Science ®Google Scholar
• Dowdy, S. F., P. W. Hinds, K. Louie, S. I. Reed, A. Arnold, and R. A. Weinberg 1993. Physical interaction of the retinoblastoma protein with human D cyclins. Cell 73: 499–511.
   PubMed Web of Science ®Google Scholar
• Dryja, T. P., J. Rapaport, T. L. McGee, T. M. Nork, and T. L. Schwartz 1993. Molecular etiology of low-penetrance retinoblastoma in two pedigrees. Am. J. Hum. Genet. 52: 1122–1128.
   PubMedGoogle Scholar
• Durfee, T., K. Becherer, P.-L. Chen, S.-H. Yeh, Y. Yang, A. E. Kilburn, W.-H. Lee, and S. J. Elledge 1993. The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. Genes Dev. 7: 555–569.
   PubMed Web of Science ®Google Scholar
• Durfee, T., M. A. Mancini, D. Jones, S. J. Elledge, and W.-H. Lee 1994. The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing. J. Cell. Biol. 127: 609–622.
   PubMed Web of Science ®Google Scholar
• Dutta, A., J. M. Ruppert, J. C. Aster, and E. Winchester 1993. Inhibition of DNA replication factor RPA by p53. Nature (London) 365: 79–82.
   PubMed Web of Science ®Google Scholar
• Dyson, N., R. Bernards, S. H. Friend, L. R. Gooding, J. A. Hassell, E. O. Major, J. M. Pipas, T. Vandyke, and E. Harlow 1990. Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein. J. Virol. 64: 1353–1356.
   PubMed Web of Science ®Google Scholar
• Dyson, N., P. M. Howley, K. Munger, and E. Harlow 1989. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 243: 934–937.
   PubMed Web of Science ®Google Scholar
• Ewen, M. E., H. K. Sluss, C. J. Sherr, H. Matsushime, J.-Y. Kato, and D. M. Livingston 1993. Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell 73: 487–497.
   PubMed Web of Science ®Google Scholar
• Ewen, M. E., Y. Xing, J. B. Lawrence, and D. M. Livingston 1991. Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein. Cell 66: 1155–1164.
   PubMed Web of Science ®Google Scholar
• Fang, F., and J. W. Newport 1991. Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes. Cell 66: 731–742.
   PubMed Web of Science ®Google Scholar
• Friedrich, T. D., J. Laffin, and J. M. Lehman 1993. Hypophosphorylated retinoblastoma gene product accumulates in SV40-infected CV-1 cells acquiring a tetraploid DNA content. Oncogene 8: 1673–1677.
   PubMedGoogle Scholar
• Fujita, M., T. Kiyono, Y. Hayashi, and M. Ishibashi 1996. hCDC47, a human member of the MCM family. J. Biol. Chem. 271: 4349–4354.
   PubMedGoogle Scholar
• Goodrich, D. W., and W.-H. Lee 1992. Abrogation by c-myc of G1 phase arrest induced by RB protein but not by p53. Nature (London) 360: 177–179.
   PubMedGoogle Scholar
• Goodrich, D. W., N. P. Wang, Y. Qian, E. Y.-H. P. Lee, and W.-H. Lee 1991. The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle. Cell 67: 293–302.
   PubMed Web of Science ®Google Scholar
• Hamel, P. A., B. L. Cohen, L. M. Sorce, B. L. Gallie, and R. A. Phillips 1990. Hyperphosphorylation of the retinoblastoma gene product is determined by domains outside the simian virus 40 large-T-antigen-binding regions. Mol. Cell. Biol. 10: 6586–6595.
   PubMed Web of Science ®Google Scholar
• Hannon, G. J., D. Demetrick, and D. Beach 1993. Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins. Genes Dev. 7: 2378–2391.
   PubMed Web of Science ®Google Scholar
• Hensey, C. E., F. Hong, T. Durfee, Y.-W. Qian, E. Y.-H. P. Lee, and W.-H. Lee 1994. Identification of discrete structural domains in the retinoblastoma protein. J. Biol. Chem. 269: 1380–1387.
   PubMedGoogle Scholar
• Hinds, P. W., S. Mittnacht, V. Dulic, A. Arnold, S. I. Reed, and R. A. Weinberg 1992. Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell 70: 993–1006.
   PubMed Web of Science ®Google Scholar
• Hogg, A., B. Bia, Z. Onadim, and J. K. Cowell 1993. Molecular mechanisms of oncogenic mutations in tumors from patients with bilateral and unilateral retinoblastoma. Proc. Natl. Acad. Sci. USA 90: 7351–7355.
   PubMed Web of Science ®Google Scholar
• Horowitz, J. M., S.-H. Park, E. Bogenmann, J.-C. Cheng, D. W. Yandell, F. J. Kaye, J. D. Minna, T. P. Dryja, and R. A. Weinberg 1990. Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells. Proc. Natl. Acad. Sci. USA 87: 2775–2779.
   PubMed Web of Science ®Google Scholar
• Horowitz, J. M., and A. J. Udvadia 1995. Regulation of transcription by the retinoblastoma (Rb) protein. Mol. Cell. Differ. 3: 275–314.
   Google Scholar
• Horowitz, J. M., D. W. Yandell, S.-H. Park, S. Canning, P. Whyte, K. J. Buchkovich, E. Harlow, R. A. Weinberg, and T. P. Dryja 1989. Point mutational inactivation of the retinoblastoma antioncogene. Science 243: 937–940.
   PubMed Web of Science ®Google Scholar
• Hu, B., R. Burkhart, D. Schulte, C. Musahl, and R. Knippers 1993. The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins. Nucleic Acids Res. 21: 5289–5293.
   PubMedGoogle Scholar
• Hu, Q., C. Bautista, G. M. Edwards, D. Defeo-Jones, R. E. Jones, and E. Harlow 1991. Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides. Mol. Cell. Biol. 11: 5792–5799.
   PubMed Web of Science ®Google Scholar
• Hutchinson, C. J., R. Cox, R. S. Drepaul, M. Gomperts, and C. C. Ford 1987. Periodic DNA synthesis in cell-free extracts of Xenopus eggs. EMBO J. 6: 2003–2010.
   PubMedGoogle Scholar
• Inoue, A., T. Torigoe, K. Sogahata, K. Kamiguchi, S. Takahashi, Y. Sawada, M. Saijo, Y. Taya, S.-i. Ishii, N. Sato, and K. Kikuchi 1995. 70-kDa heat shock cognate protein interacts directly with the N-terminal region of the retinoblastoma gene product pRb. J. Biol. Chem. 270: 22571–22576.
   PubMedGoogle Scholar
• Jacks, T., A. Fazeli, E. M. Schmitt, R. T. Bronson, M. A. Goodell, and R. A. Weinberg 1992. Effects of an Rb mutation in the mouse. Nature (London) 359: 295–300.
   PubMed Web of Science ®Google Scholar
• Jackson, P. K., S. Chevalier, M. Philippe, and M. W. Kirschner 1995. Early events in DNA replication require cyclin E and are blocked by p21CIP1. J. Cell. Biol. 130: 755–769.
   PubMed Web of Science ®Google Scholar
• Johnson, E. M., P.-L. Chen, C. P. Krachmarov, S. M. Barr, M. Kanovsky, Z.-W. Ma, and W.-H. Lee 1995. Association of human Pura with the retinoblastoma protein, Rb, regulates binding to the single-stranded DNA Pura element. J. Biol. Chem. 270: 24352–24360.
   PubMedGoogle Scholar
• Kiyono, T., M. Fujita, Y. Hayashi, and M. Ishibashi 1996. Cloning of a cDNA encoding a human homologue of CDC47, a member of the MCM family. Biochem. Biophys. Acta 1307: 31–34.
   PubMedGoogle Scholar
• Kubota, Y., S. Mimura, S.-i. Nishimoto, T. Masuda, H. Nojima, and H. Takisawa 1997. Licensing of DNA replication by a multi-protein complex of MCM/P1 proteins in Xenopus eggs. EMBO J. 16: 3320–3331.
   PubMedGoogle Scholar
• Kubota, Y., S. Mimura, S.-i. Nishimoto, H. Takisawa, and H. Nojima 1997. Identification of the yeast MCM3-related protein as a component of Xenopus DNA replication licensing factor. Cell 81: 601–609.
   Google Scholar
• Lee, E. Y.-H. P., C. Chang, N. Hu, Y. J. Wang, C. Lai, K. Herrup, W.-H. Lee, and A. Bradley 1992. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature (London) 359: 288–294.
   PubMed Web of Science ®Google Scholar
• Lee, M.-H., B. O. Williams, G. Mulligan, S. Muakai, R. T. Bronson, N. Dyson, E. Harlow, and T. Jacks 1996. Targeted disruption of p107: functional overlap between p107 and Rb. Genes Dev. 10: 1621–1632.
   PubMed Web of Science ®Google Scholar
• Lees, J. A., K. J. Buchkovich, D. R. Marshak, C. W. Anderson, and E. Harlow 1991. The retinoblastoma protein is phosphorylated on multiple sites by human cdc2. EMBO J. 10: 4279–4290.
   PubMed Web of Science ®Google Scholar
• Li, Y., C. Graham, S. Lacy, A. M. V. Duncan, and P. Whyte 1993. The adenovirus E1A-associated 130kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E. Genes Dev. 7: 2366–2377.
   PubMed Web of Science ®Google Scholar
• Ludlow, J. W., J. A. DeCaprio, C.-M. Huang, W.-H. Lee, E. Paucha, and D. M. Livingston 1989. SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family. Cell 56: 57–65.
   PubMed Web of Science ®Google Scholar
• Ludlow, J. W., C. L. Glendening, D. M. Livingston, and J. A. DeCaprio 1993. Specific enzymatic dephosphorylation of the retinoblastoma protein. Mol. Cell. Biol. 13: 367–372.
   PubMed Web of Science ®Google Scholar
• Ludlow, J. W., J. Shon, J. M. Pipas, D. M. Livingston, and J. A. DeCaprio 1990. The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T. Cell 60: 387–396.
   PubMed Web of Science ®Google Scholar
• Macleod, K. F., Y. Hu, and T. Jacks 1996. Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system. EMBO J. 15: 6178–6188.
   PubMed Web of Science ®Google Scholar
• Madine, M. A., C.-Y. Khoo, A. D. Mills, and R. A. Laskey 1995. MCM3 complex required for cell cycle regulation of DNA replication in vertebrate cells. Nature (London) 375: 421–424.
   PubMed Web of Science ®Google Scholar
• Maine, G. T., P. Sinha, and B.-K. Tye 1984. Mutants of S. cerevisiae defective in the maintenance of minichromosomes. Genetics 106: 365–385.
   PubMed Web of Science ®Google Scholar
• Mayol, X., X. Grana, A. Baldi, N. Sang, Q. Hu, and A. Giordano 1993. Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain. Oncogene 8: 2561–2566.
   PubMed Web of Science ®Google Scholar
• Mihara, K., X.-R. Cao, A. Yen, S. Chandler, B. Driscoli, A. L. Murphree, A. T’Ang, and Y.-K. T. Fung 1989. Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product. Science 246: 1300–1303.
   PubMed Web of Science ®Google Scholar
• Morgenbesser, S. D., B. O. Williams, T. Jacks, and R. A. DePinho 1994. p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature (London) 371: 72–75.
   PubMed Web of Science ®Google Scholar
• Moss, B., O. Elroy-Stein, T. Mizukami, W. A. Alexander, and T. R. Fuerst 1990. New mammalian expression vectors. Nature (London) 348: 91–92.
   PubMedGoogle Scholar
• Munger, K., B. A. Werness, N. Dyson, W. C. Phelps, E. Harlow, and P. M. Howley 1989. Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product. EMBO J. 8: 4099–4105.
   PubMed Web of Science ®Google Scholar
• Murata, Y., H. G. Kim, K. T. Rogers, A. J. Udvadia, and J. M. Horowitz 1994. Negative regulation of Sp1 trans-activation is correlated with the binding of cellular proteins to the amino terminus of the Sp1 trans-activation domain. J. Biol. Chem. 269: 20674–20681.
   PubMedGoogle Scholar
• Nelson, D. A., N. A. Krucher, and J. W. Ludlow 1997. High molecular weight protein phosphatase type 1 dephosphorylates the retinoblastoma protein. J. Biol. Chem. 272: 4528–4535.
   PubMed Web of Science ®Google Scholar
• Newmeyer, D. D., and D. J. Forbes 1990. A N-ethylmaleimide-sensitive cytosolic factor necessary for nuclear protein import: requirement in signal-mediated binding to the nuclear pore. J. Cell. Biol. 110: 547–557.
   PubMedGoogle Scholar
• Ornitz, D. M., R. E. Hammer, A. Messing, R. D. Palmiter, and R. L. Brinster 1987. Pancreatic neoplasia induced by SV40 T-antigen expression in acinar cells of transgenic mice. Science 238: 188–193.
   PubMed Web of Science ®Google Scholar
• Pardee, A. B. 1989. G1 events and regulation of cell proliferation. Science 246: 603–608.
   PubMed Web of Science ®Google Scholar
• Qian, Y., C. Luckey, L. Horton, M. Esser, and D. J. Templeton 1992. Biological function of the retinoblastoma protein requires distinct domains for hyperphosphorylation and transcription factor binding. Mol. Cell. Biol. 12: 5363–5372.
   PubMed Web of Science ®Google Scholar
• Riley, D. J., C.-Y. Liu, and W.-H. Lee 1997. Mutations of N-terminal regions render the retinoblastoma protein insufficient for functions in development and tumor suppression. Mol. Cell. Biol. 17: 7342–7352.
   PubMedGoogle Scholar
• Rinehart, C. A., J. P. Mayben, T. D. Butler, J. S. Haskill, and D. G. Kaufman 1992. Alterations of DNA content in human endometrial stromal cells transfected with a temperature-sensitive SV40: tetraploidization and physiological consequences. Carcinogen 13: 63–68.
   PubMedGoogle Scholar
• Romanowski, P., M. A. Madine, and R. A. Laskey 1996. XMCM7, a novel member of the Xenopus MCM family, interacts with XMCM3 and colocalizes with it throughout replication. Proc. Natl. Acad. Sci. USA 93: 10189–10194.
   PubMed Web of Science ®Google Scholar
• Schneider, J. W., W. Gu, V. Mahdavi, and B. Nadal-Ginard 1994. Reversal of terminal differentiation mediated by p107 in Rb−/− muscle cells. Science 264: 1467–1471.
   PubMed Web of Science ®Google Scholar
• Schulte, D., A. Richter, R. Burkhart, C. Musahl, and R. Knippers 1996. Properties of the human nuclear protein p85Mcm. Eur. J. Biochem. 235: 144–151.
   PubMedGoogle Scholar
• Shao, Z., J. L. Siegert, S. Ruppert, and P. D. Robbins 1997. Rb interacts with TAFII250/TFIID through multiple domains. Oncogene 15: 385–392.
   PubMedGoogle Scholar
• Shivji, M. K., S. J. Grey, U. P. Strausfeld, R. D. Wood, and J. J. Blow 1994. Cip1 inhibits DNA replication but not PCNA-dependent nucleotide excision-repair. Curr. Biol. 4: 1062–1068.
   PubMed Web of Science ®Google Scholar
• Smythe, C., and J. W. Newport 1991. Systems for the study of nuclear assembly, DNA replication, and nuclear breakdown in Xenopus laevis egg extracts. Methods Cell Biol. 35: 449–468.
   PubMed Web of Science ®Google Scholar
• Sterner, J. M., Y. Murata, H. G. Kim, S. B. Kennett, D. J. Templeton, and J. M. Horowitz 1995. Characterization of cellular proteins that form complexes with the amino-terminus of the retinoblastoma (Rb) protein: a novel cell-cycle regulated kinase associates with Rb in G2/M phases. J. Biol. Chem. 270: 9281–9288.
   PubMedGoogle Scholar
• Sterner, J. M., Y. Tao, S. B. Kennett, H. G. Kim, and J. M. Horowitz 1996. The amino-terminus of the retinoblastoma (Rb) protein associates with a cdk-like kinase via Rb amino acids required for growth suppression. Cell Growth Differ. 7: 53–64.
   PubMedGoogle Scholar
• Taya, Y., H. Yasuda, M. Kamijo, K. Nakaya, Y. Nakamura, Y. Ohba, and S. Nishimura 1989. In vitro phosphorylation of the tumor suppressor gene RB protein by mitosis-specific histone H1 kinase. Biochem. Biophys. Res. Commun. 164: 580–586.
   PubMedGoogle Scholar
• Thommes, P., Y. Kubota, H. Takisawa, and J. J. Blow 1997. The RLF-M component of the replication licensing system forms complexes containing all six MCM/P1 polypeptides. EMBO J. 16: 3312–3319.
   PubMed Web of Science ®Google Scholar
• Tye, B.-K. 1994. The MCM 2-3-5 proteins: are they replication licensing factors? Trends Cell Biol. 4: 160–166.
   PubMedGoogle Scholar
• Weinberg, R. A. 1995. The retinoblastoma protein and cell cycle control. Cell 81: 323–330.
   PubMed Web of Science ®Google Scholar
• Whitaker, L. L., and M. F. Hansen 1997. Induction of apoptosis in Mv1Lu cells by expression of competitive RB1 mutants. Oncogene 15: 1069–1077.
   PubMedGoogle Scholar
• Whyte, P., K. J. Buchkovich, J. M. Horowitz, S. H. Friend, M. Raybuck, R. A. Weinberg, and E. Harlow 1988. Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma susceptibility gene product. Nature (London) 334: 124–129.
   PubMed Web of Science ®Google Scholar
• Yan, H., S. Gibson, and B. K. Tye 1991. Mcm2 and Mcm3, two proteins important for ARS activity, are related in structure and function. Genes Dev. 5: 944–957.
   PubMed Web of Science ®Google Scholar
• Yan, H., and J. Newport 1995. An analysis of the regulation of DNA synthesis by cdk2, CIP1, and licensing factor. J. Cell. Biol. 129: 1–15.
   PubMedGoogle Scholar
• Zacksenhaus, E., Z. Jiang, D. Chung, J. D. Marth, R. A. Phillips, and B. L. Gallie 1996. pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis. Genes Dev. 10: 3051–3064.
   PubMed Web of Science ®Google Scholar
• Zhu, L., S. van den Heuvel, K. Helin, A. Fattaey, M. Ewen, D. M. Livingston, N. Dyson, and E. Harlow 1993. Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. Genes Dev. 7: 1111–1125.
   PubMed Web of Science ®Google Scholar