38
Views
91
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Increased Expression of Cyclin D2 during Multiple States of Growth Arrest in Primary and Established Cells

, , &
Pages 3163-3172 | Received 10 Dec 1997, Accepted 18 Feb 1998, Published online: 28 Mar 2023

REFERENCES

  • Ajchenbaum, F., K. Ando, J. A. DeCaprio, and J. D. Griffin 1993. Independent regulation of human D-type cyclin gene expression during G1 phase in primary human T lymphocytes. J. Biol. Chem. 268: 4113–4119.
  • Atadja, P., H. Wong, C. Veillette, and K. Riabowol 1995. Overexpression of cyclin D1 blocks proliferation of normal diploid fibroblasts. Exp. Cell Res. 217: 205–216.
  • Atadja, P., H. Wong, I. Garkavtev, C. Veillette, and K. Riabowol 1995. Increased activity of p53 in senescing fibroblasts. Proc. Natl. Acad. Sci. USA 92: 8348–8352.
  • Baldin, V., J. Lukas, M. J. Marcote, M. Pagano, and G. Draetta 1993. Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes Dev. 7: 812–821.
  • Buckley, M. F., K. J. E. Sweeney, J. A. Hamilton, R. L. Sini, D. L. Manning, R. I. Nicholson, A. deFazio, C. W. K. Watts, E. A. Musgrove, and R. L. Sutherland 1993. Expression and amplification of cyclin genes in human breast cancer. Oncogene 8: 2127–2133.
  • Burger, C., M. Wick, and R. Muller 1994. Lineage-specific regulation of cell cycle gene expression in differentiating myeloid cells. J. Cell Sci. 107: 2047–2054.
  • Chen, X., J. Bargonetti, and C. Prives 1995. p53, through p21 (WAF1/CIP1), induces cyclin D1 synthesis. Cancer Res. 55: 4257–4263.
  • Del Sal, G., M. Murphy, E. M. Ruaro, D. Lararevic, A. J. Levine, and C. Schneider 1996. Cyclin D1 and p21/waf1 are both involved in p53 growth suppression. Oncogene 12: 177–185.
  • Dowdy, S. F., P. W. Hinds, K. Louie, S. I. Reed, A. Arnold, and R. A. Weinberg 1993. Physical interaction of the retinoblastoma protein with human D cyclins. Cell 73: 499–511.
  • Dulic, V., L. F. Drullinger, E. Lees, S. I. Reed, and G. H. Stein 1993. Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive E-Cdk2 and cyclin D1-Cdk2 complexes. Proc. Natl. Acad. Sci. USA 90: 11034–11038.
  • El-Deiry, W. S., T. Tokino, V. E. Velculescu, D. B. Levy, R. Parsons, J. M. Trent, D. Lin, E. Mercer, K. W. Kinzler, and B. Vogelstein 1993. WAF1, a potential mediator of p53 tumor suppression. Cell 75: 817–825.
  • Ewen, M., H. K. Sluss, C. J. Sherr, H. Matsushime, J.-Y. Kato, and D. M. Livingston 1993. Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell 73: 487–497.
  • Fantl, V., G. Stamp, A. Andrews, I. Rosewell, and C. Dickson 1995. Mice lacking cyclin D1 are small and show defects in eye and mammary gland development. Genes Dev. 9: 2364–2372.
  • Freeman, R. S., S. Estus, and E. M. Johnson 1994. Analysis of cell cycle-regulated gene expression in post mitotic neurons: selective induction of cyclin D1 during programmed cell death. Neuron 12: 343–355.
  • Gao, C. Y., and P. S. Zelenka 1997. Cyclins, cyclin-dependent kinases and differentiation. Bioessays 19: 307–315.
  • Garkavtsev, I., and K. Riabowol 1997. Extension of the replicative lifespan of human diploid fibroblasts by inhibition of the p33ING1 candidate tumor suppressor. Mol. Cell. Biol. 17: 2014–2019.
  • Goldstein, S. 1990. Replicative senescence: the human fibroblast comes of age. Science 249: 1129–1133.
  • Han, E. K.-H., A. Sgambato, W. Jiang, Y.-J. Zhang, R. M. Santella, Y. Doki, A. M. Cacace, I. Schieren, and I. B. Weinstein 1995. Stable overexpression of cyclin D1 in a human mammary epithelial cell line prolongs the S-phase and inhibits growth. Oncogene 10: 953–961.
  • Han, E. K.-H., M. Begemann, A. Sgambato, J.-W. Soh, Y. Doki, W.-Q. Xing, W. Liu, and I. B. Weinstein 1996. Increased expression of cyclin D1 in murine mammary epithelial cell line induces p27kip1, inhibits growth, and enhances apoptosis. Cell Growth Differ. 7: 699–710.
  • Hanna, Z., M. Jankowski, P. Tremblay, J. Xiaoyan, A. Milatovich, U. Francke, and P. Jolicoeur 1993. The vin-1 gene, identified by proviral insertional mutagenesis, corresponds to the G1-phase cyclin D2. Oncogene 8: 1661–1667.
  • Hara, E., R. Smith, D. Parry, H. Tahara, S. Stone, and G. Peters 1996. Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence. Mol. Cell. Biol. 16: 859–867.
  • Hayflick, L. 1965. The limited in vitro lifetime of human diploid fibroblasts. Exp. Cell Res. 37: 614–636.
  • Horiguchi-Yamada, J., H. Yamada, S. Nakada, K. Ochi, and T. Nemoto 1994. Changes of G1 cyclins, cdk2, and cyclin A during differentiation of HL60 cells induced by TPA. Mol. Cell. Biochem. 132: 31–37.
  • Houldsworth, J., V. Reuter, G. J. Bosl, and R. S. Chaganti 1997. Aberrant expression of cyclin D2 is an early event in human male germ cell tumorigenesis. Cell Growth Differ. 8: 293–299.
  • Inaba, T., H. Matsushime, M. Valentine, M. Roussel, C. J. Sherr, and A. T. Look 1992. Genomic organization, and independent expression of human cyclin D genes. Genomics 13: 565–574.
  • Jiang, Z., E. Zacksenhaus, B. L. Gallie, and R. A. Phillips 1997. The retinoblastoma gene family is differentially expressed during embryogenesis. Oncogene 14: 1789–1797.
  • Kato, J.-Y., H. Matsushime, S. W. Hiebert, M. E. Ewen, and C. J. Sherr 1993. Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. Genes Dev. 7: 331–342.
  • Kerkhoff, E., and E. B. Ziff 1995. Cyclin D2 and Ha-ras transformed rat embryo fibroblasts exhibit a novel deregulation of cell size control and early S phase arrest in low serum. EMBO J. 14: 1892–1903.
  • Kiess, M., R. M. Gill, and P. A. Hamel 1995. Expression of the positive regulator of cell cycle progression, cyclin D3, is induced during differentiation of myoblasts into quiescent myotubes. Oncogene 10: 159–166.
  • Kiyokawa, H., X. Busquets, C. T. Powell, L. Ngo, R. A. Rifkind, and P. A. Marks 1992. Cloning of a D-type cyclin from murine erythroleukemia cells. Proc. Natl. Acad. Sci. USA 89: 2444–2447.
  • Kranenburg, O., R. P. De Groot, A. J. van der Eb, and A. Zantema 1995. Differentiation of P19 EC cells leads to differential modulation of cyclin-dependent kinase activities and to changes in the cell cycle profile. Oncogene 10: 87–95.
  • Levine, A. J. 1993. The tumor suppressor genes. Annu. Rev. Biochem. 62: 623–651.
  • Lew, D. J., V. Dulic, and S. I. Reed 1991. Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. Cell 66: 1197–1206.
  • Lucibello, F. C., A. Sewing, S. Brusselbach, C. Burger, and R. Muller 1993. Deregulation of cyclins D1 and E and suppression of cdk2 and cdk4 in senescent human fibroblasts. J. Cell Sci. 105: 123–133.
  • Lukas, J., M. Pagano, Z. Staskova, G. Draetta, and J. Bartek 1994. Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumor cell lines. Oncogene 9: 707–718.
  • Lukas, J., J. Bartkova, M. Welcker, O. W. Peterson, G. Peters, M. Strauss, and J. Bartek 1995. Cyclin D2 is a moderately oscillating nucleoprotein required for G1 phase progression in specific cell types. Oncogene 10: 2115–2134.
  • Matsushime, H., M. Roussel, R. A. Ashmun, and C. J. Sherr 1991. Colony-stimulating factor regulates novel cyclins during the G1 phase of the cell cycle. Cell 65: 701–713.
  • Matsushime, H., M. E. Ewen, D. K. Strom, J.-Y. Kato, S. K. Hanks, M. Roussel, and C. J. Sherr 1992. Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins. Cell 71: 323–334.
  • Matsushime, H., D. E. Quelle, S. A. Shurtleff, M. Shibuya, C. J. Sherr, and J.-Y. Kato 1994. D-type cyclin-dependent kinase activity in mammalian cells. Mol. Cell. Biol. 14: 2066–2076.
  • Mayol, X., J. Garriga, and X. Grana 1996. G1 cyclin/CDK-independent phosphorylation and accumulation of p130 during the transition from G1 to G0 lead to its association with E2F-4. Oncogene 13: 237–246.
  • Meyerson, M., and E. Harlow 1994. Identification of G1 kinase activity for cdk6, a novel cyclin D partner. Mol. Cell. Biol. 14: 2077–2086.
  • Meyyappan, M., P. W. Atadja, and K. T. Riabowol 1996. Regulation of gene expression and transcription factor binding activity during cellular aging. Biol. Signals 5: 130–138.
  • Motokura, T., and A. Arnold 1993. Cyclin D and oncogenesis. Curr. Opin. Genet. Dev. 3: 5–10.
  • Motokura, T., K. Keyomarsi, H. M. Kronenberg, and A. Arnold 1992. Cloning and characterization of human cyclin D3, a cDNA closely related in sequence to the PRAD1/cyclin D1 proto-oncogene. J. Biol. Chem. 267: 20412–20415.
  • Muller, H., J. Lukas, A. Schneider, P. Warthoe, J. Bartek, M. Eilers, and M. Strauss 1994. Cyclin D1 expression is regulated by the retinoblastoma protein. Proc. Natl. Acad. Sci. USA 91: 2945–2949.
  • Neuman, E., M. H. Ladha, N. Lin, T. M. Upton, S. J. Miller, J. DiRenzo, R. G. Pestell, P. W. Hinds, S. F. Dowdy, M. Brown, and M. E. Ewen 1997. Cyclin D1 stimulation of estrogen receptor transcriptional activity independent of cdk4. Mol. Cell. Biol. 17: 5338–5347.
  • Noda, A., Y. Ning, S. F. Venable, O. M. Pereira-Smith, and J. R. Smith 1994. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp. Cell Res. 211: 90–98.
  • Ohtsubo, M., and J. M. Roberts 1993. Cyclin-dependent regulation of G1 in mammalian fibroblasts. Science 259: 1908–1911.
  • Pagano, M., A. M. Theodoras, S. W. Tam, and G. F. Draetta 1994. Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts. Genes Dev. 8: 1627–1639.
  • Palmero, I., A. Holder, A. J. Sinclair, C. Dickson, and G. Peters 1993. Cyclins D1 and D2 are differentially expressed in human B-lymphoid cell lines. Oncogene 8: 1049–1054.
  • Pardee, A. B. 1989. G1 events and regulation of cell proliferation. Science 246: 603–608.
  • Quelle, D. E., R. A. Ashmun, S. A. Shurtleff, J.-Y. Kato, D. Bar-Sagi, M. F. Roussel, and C. J. Sherr 1993. Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts. Genes Dev. 7: 1559–1571.
  • Resnitzky, D., M. Gossen, H. Bujard, and S. I. Reed 1994. Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system. Mol. Cell. Biol. 14: 1669–1679.
  • Ross, M. E., and M. Risken 1994. MN20, a D2 cyclin found in brain, is implicated in neural differentiation. J. Neurosci. 14: 6394–6391.
  • Ross, M. E., M. L. Carter, and J. H. Lee 1996. MN20, a D2 cyclin, is transiently expressed in selected neural populations during embryogenesis. J. Neurosci. 16: 210–219.
  • Sherr, C. J. 1993. Mammalian G1 cyclins. Cell 73: 1059–1065.
  • Sherr, C. J. 1994. G1 phase progression: cycling on cue. Cell 79: 551–555.
  • Sicinski, P., J. L. Donaher, S. B. Parker, T. Li, A. Fazeli, H. Gardner, S. Z. Haslam, R. T. Bronson, S. J. Elledge, and R. A. Weinberg 1995. Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell 82: 621–630.
  • Sicinski, P., J. L. Donaher, Y. Geng, S. B. Parker, H. Gardner, M. Y. Park, R. L. Robker, J. S. Richards, L. K. McGinnis, J. D. Biggers, J. J. Eppig, R. T. Bronson, S. J. Elledge, and R. A. Weinberg 1996. Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis. Nature 384: 470–474.
  • Spikovsky, D., P. Steiner, R. V. Gopalkrishnan, M. Eilers, and P. Jansen-Durr 1995. The role of p53 in coordinated regulation of cyclin D1 and p21 gene expression by the adenovirus E1A and E1B oncogenes. Oncogene 10: 2421–2425.
  • Stein, G. H., M. Beeson, and L. Gordon 1990. Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts. Science 249: 666–669.
  • Sweeney, K. J., B. Sarcevic, R. L. Sutherland, and E. A. Musgrove 1997. Cyclin D2 activates cdk2 in preference to cdk4 in human breast epithelial cells. Oncogene 14: 1329–1340.
  • Tam, S. W., A. M. Theodoras, J. W. Shay, G. F. Draetta, and M. Pagano 1994. Differential expression and regulation of cyclin D1 protein in normal and tumor human cells: association with Cdk4 is required for cyclin D1 function in G1 progression. Oncogene 9: 2663–2674.
  • Tsai, L. H., E. Lees, B. Faha, E. Harlow, and K. Riabowol 1993. The cdk2 kinase is required for the G1-to-S transition in mammalian cells. Oncogene 8: 1593–1602.
  • Van Grunsven, L. A., A. Thomas, J. L. Urdiales, S. Machenaud, P. Choler, I. Durand, and B. B. Rudkin 1996. Nerve growth factor-induced accumulation of PC12 cells expressing cyclin D1: evidence for a G1 phase block. Oncogene 12: 855–862.
  • Vaziri, H., M. D. West, R. C. Allsopp, T. S. Davison, Y. S. Wu, C. H. Arrowsmith, G. S. Poirier, and S. Benchimol 1997. ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase. EMBO J. 16: 6018–6033.
  • Weinberg, R. A. 1995. The retinoblastoma protein and cell cycle control. Cell 81: 323–330.
  • Weinberg, R. A. 1996. E2F and cell proliferation: a world turned upside down. Cell 85: 457–459.
  • Wheaton, K., P. Atadja, and K. Riabowol 1996. Regulation of transcription factor activity during cellular aging. Biochem. Cell Biol. 74: 523–534.
  • Wilhide, C. C., C. V. Dang, J. Dipersio, A. A. Kenedy, and P. F. Bray 1995. Overexpression of cyclin D1 in the Dami Megakaryocytic cell line causes growth arrest. Blood 86: 294–304.
  • Wong, H., W. D. Anderson, T. Cheng, and K. T. Riabowol 1994. Monitoring mRNA expression by polymerase chain reaction: the “primer-dropping” method. Anal. Biochem. 223: 251–258.
  • Wong, H., and K. T. Riabowol 1996. Differential CDK-inhibitor gene expression in aging human diploid fibroblasts. Exp. Gerontol. 31: 311–325.
  • Wu, F., S. Buckley, K. C. Bui, A. Yee, H. Y. Wu, J. Liu, and D. Warburton 1996. Cell cycle arrest in G0/G1 phase by contact inhibition and TGF-β1 in mink Mv1Lu lung epithelial cells. Am. J. Physiol. 270: L879–L888.
  • Xiong, Y., T. Connolly, B. Futcher, and D. Beach 1991. Human D-type cyclin. Cell 65: 691–699.
  • Xiong, Y., J. Menninger, D. Beach, and D. C. Ward 1992. Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins. Genomics 13: 575–584.
  • Xiong, Y., H. Zhang, and D. Beach 1992. D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell 71: 505–514.
  • Yan, G.-Z., and E. B. Ziff 1995. NGF regulates the PC12 cell cycle machinery through specific inhibition of the Cdk kinases and induction of cyclin D1. J. Neurosci. 15: 6200–6212.
  • Zwijsen, R. M. L., E. Wientjens, R. Klompmaker, J. van der Sman, R. Bernards, and R. J. A. M. Michalides 1997. CDK-independent activation of estrogen receptor by cyclin D1. Cell 88: 405–415.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.