14
Views
77
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Tyrosine Phosphorylation of Cdc2 Is Required for the Replication Checkpoint in Schizosaccharomyces pombe

&
Pages 3782-3787 | Received 13 Feb 1998, Accepted 16 Apr 1998, Published online: 28 Mar 2023

REFERENCES

  • Alfa, C. E., B. Ducommun, D. Beach, and J. S. Hyams 1990. Distinct nuclear and spindle pole body population of cyclin-cdc2 in fission yeast. Nature 347: 680–682.
  • al-Khodairy, F., and A. M. Carr 1992. DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe. EMBO J. 11: 1343–1350.
  • al-Khodairy, F., E. Fotou, K. S. Sheldrick, D. J. Griffiths, A. R. Lehmann, and A. M. Carr 1994. Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast. Mol. Biol. Cell 5: 147–160.
  • Booher, R. N., C. E. Alfa, J. S. Hyams, and D. H. Beach 1989. The fission yeast cdc2/cdc13/suc1 protein kinase: regulation of catalytic activity and nuclear localization. Cell 58: 485–497.
  • Creanor, J., and J. M. Mitchison 1979. Reduction of perturbations in leucine incorporation in synchronous cultures of Schizosaccharomyces pombe. J. Gen. Microbiol. 112: 385–388.
  • Enoch, T., and P. Nurse 1990. Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication. Cell 60: 665–673.
  • Featherstone, C., and P. Russell 1991. Fission yeast p107wee1 mitotic inhibitor is a tyrosine/serine kinase. Nature 349: 808–811.
  • Fisher, D., and P. Nurse 1995. Cyclins of the fission yeast Schizosaccharomyces pombe. Semin. Cell Biol. 6: 73–78.
  • Fisher, D. L., and P. Nurse 1996. A single fission yeast mitotic cyclin B p34cdc2 kinase promotes both S-phase and mitosis in the absence of G1 cyclins. EMBO J. 15: 850–860.
  • Furnari, B., N. Rhind, and P. Russell 1997. Cdc25 mitotic inducer targeted by Chk1 DNA damage checkpoint kinase. Science 277: 1495–1497.
  • Gould, K. L., and P. Nurse 1989. Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis. Nature 342: 39–45.
  • Harlow, E., and D. Lane 1988. Antibodies: a laboratory manual. Cold Spring Harbor Press, Cold Spring Harbor, N.Y.
  • Hayles, J., D. Fisher, A. Woollard, and P. Nurse 1994. Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex. Cell 78: 813–822.
  • Hirano, T., Y. Hiraoka, and M. Yanagida 1988. A temperature-sensitive mutation of the Schizosaccharomyces pombe gene nuc2+ that encodes a nuclear scaffold-like protein blocks spindle elongation in mitotic anaphase. J. Cell Biol. 106: 1171–1183.
  • Jimenez, G., J. Yucel, R. Rowley, and S. Subramani 1992. The rad3+ gene of Schizosaccharomyces pombe is involved in multiple checkpoint functions and in DNA repair. Proc. Natl. Acad. Sci. USA 89: 4952–4956.
  • Knudsen, K. E., E. S. Knudsen, J. Y. Wang, and S. Subramani 1996. p34cdc2 kinase activity is maintained upon activation of the replication checkpoint in Schizosaccharomyces pombe. Proc. Natl. Acad. Sci. USA 93: 8278–8283.
  • Kovelman, R., and P. Russell 1996. Stockpiling of Cdc25 during a DNA replication checkpoint arrest in Schizosaccharomyces pombe. Mol. Cell. Biol. 16: 86–93.
  • Lee, M. S., T. Enoch, and H. Piwnica-Worms 1994. mik1+ encodes a tyrosine kinase that phosphorylates p34cdc2 on tyrosine 15. J. Biol. Chem. 269: 30530–30537.
  • Lundgren, K., N. Walworth, R. Booher, M. Dembski, M. Kirschner, and D. Beach 1991. mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2. Cell 64: 1111–1122.
  • Martin-Castellanos, C., K. Labib, and S. Moreno 1996. B-type cyclins regulate G1 progression in fission yeast in opposition to the p25rum1 cdk inhibitor. EMBO J. 15: 839–849.
  • McGowan, C. H., and P. Russell 1993. Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15. EMBO J. 12: 75–85.
  • Millar, J., C. McGowan, G. Lenaers, R. Jones, and P. Russell 1991. p80cdc25 mitotic inducer is the tyrosine phosphatase that activates p34cdc2 kinase in fission yeast. EMBO J. 10: 4301–4309.
  • Mondesert, O., C. H. McGowan, and P. Russell 1996. Cig2, a B-type cyclin, promotes the onset of S in Schizosaccharomyces pombe. Mol. Cell. Biol. 16: 1527–1533.
  • Moreno, S., J. Hayles, and P. Nurse 1989. Regulation of p34cdc2 protein kinase during mitosis. Cell 58: 361–372.
  • Moreno, S., A. Klar, and P. Nurse 1991. Molecular genetic analysis of fission yeast Schizosaccharomyces pombe. Methods Enzymol. 194: 795–823.
  • Norbury, C., J. Blow, and P. Nurse 1991. Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates. EMBO J. 10: 3321–3329.
  • Parker, L. L., S. Atherton-Fessler, and H. Piwnica-Worms 1992. p107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15. Proc. Natl. Acad. Sci. USA 89: 2917–2921.
  • Parker, L. L., and H. Piwnica-Worms 1992. Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase. Science 257: 1955–1957.
  • Rhind, N., B. Furnari, and P. Russell 1997. Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast. Genes Dev. 11: 504–511.
  • Rhind, N., and P. Russell. Unpublished data.
  • Russell, P., and P. Nurse 1986. cdc25+ functions as an inducer in the mitotic control of fission yeast. Cell 45: 145–153.
  • Russell, P., and P. Nurse 1987. Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog. Cell 49: 559–67.
  • Sheldrick, K. S., and A. M. Carr 1993. Feedback controls and G2 checkpoints: fission yeast as a model system. Bioessays 15: 775–782.
  • Sorger, P. K., and A. W. Murray 1992. S-phase feedback control in budding yeast independent of tyrosine phosphorylation of p34cdc28. Nature 355: 365–368.
  • Stern, B., and P. Nurse 1996. A quantitative model for the cdc2 control of S phase and mitosis in fission yeast. Trends Genet. 12: 345–350.
  • Walworth, N., S. Davey, and D. Beach 1993. Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2. Nature 363: 368–371.
  • Walworth, N. C., and R. Bernards 1996. rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint. Science 271: 353–356.
  • Yamada, H., K. Kumada, and M. Yanagida 1997. Distinct subunit functions and cell cycle regulated phosphorylation of 20S APC/cyclosome required for anaphase in fission yeast. J. Cell Sci. 110: 1793–804.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.