Identification and Characterization of a Constitutively Active STAT5 Mutant That Promotes Cell Proliferation

REFERENCES

• Ahmed, S. A., Gogal, R.Jr., and J. E. Walsh 1994. A new rapid and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes: an alternative to [3H]thymidine incorporation assay. J. Immunol. Methods 170: 211–224.
   PubMed Web of Science ®Google Scholar
• Azam, M., C. Lee, I. Strehlow, and C. Schindler 1997. Functionally distinct isoforms of STAT5 are generated by protein processing. Immunity 6: 691–701.
   PubMedGoogle Scholar
• Cao, X., A. Tay, G. R. Guy, and Y. H. Tan 1996. Activation and association of Stat3 with Src in v-Src-transformed cell lines. Mol. Cell. Biol. 16: 1595–1603.
   PubMed Web of Science ®Google Scholar
• Carlesso, N., D. A. Frank, and J. D. Griffin 1996. Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl. J. Exp. Med. 183: 811–820.
   PubMed Web of Science ®Google Scholar
• Damen, J. E., H. Wakao, A. Miyajima, J. Krosl, R. K. Humphries, R. L. Cutler, and G. Krystal 1995. Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation. EMBO J. 14: 5557–5568.
   PubMed Web of Science ®Google Scholar
• Danial, N. N., A. Pernis, and P. B. Rothman 1995. Jak-STAT signaling by the v-abl oncogene. Science 269: 1875–1877.
   PubMed Web of Science ®Google Scholar
• Friedmann, M. C., T. Migone, S. M. Russell, and W. J. Leonard 1996. Different interleukin 2 receptor b-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation. Proc. Natl. Acad. Sci. USA 93: 2077–2082.
   PubMed Web of Science ®Google Scholar
• Fujii, H., Y. Nakagawa, U. Schindler, A. Kawahara, H. Mori, F. Gouilleux, B. Groner, J. N. Ihle, Y. Minami, T. Miyazaki, and T. Taniguchi 1995. Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor b chain but is not essential for the proliferative signal transmission. Proc. Natl. Acad. Sci. USA 92: 5482–5486.
   PubMed Web of Science ®Google Scholar
• Gobert, S., S. Chretien, F. Gouilleux, O. Muller, C. Pallard, I. Dusanter-Fourt, B. Groner, C. Lacombe, S. Gisselbrecht, and P. Mayeux 1996. Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation. EMBO J. 15: 2434–2441.
   PubMed Web of Science ®Google Scholar
• Gouilleux, F., H. Wakao, M. Mundt, and B. Groner 1994. Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription. EMBO J. 13: 4361–4369.
   PubMed Web of Science ®Google Scholar
• Gouilleux-Gruart, V., F. Gouilleux, C. Desaint, J.-F. Claisse, J.-C. Capiod, J. Delobel, R. Weber-Nordt, I. Dusanter-Fourt, F. Dreyfus, B. Groner, and L. Prin 1996. STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients. Blood 87: 1692–1697.
   PubMed Web of Science ®Google Scholar
• Hawley, T. S., W. A. McLeish, and R. G. Hawley 1991. Establishment of a novel factor-dependent myeloid cell line from primary cultures of mouse bone marrow. Cytokine 3: 60–71.
   PubMedGoogle Scholar
• Hou, J., U. Schindler, W. J. Henzel, T. C. Ho, M. Brasseur, and S. L. McKnight 1994. An interleukin-4-induced transcription factor: IL-4 Stat. Science 265: 1701–1706.
   PubMed Web of Science ®Google Scholar
• Ihle, J. N. 1996. STATs: signal transducers and activators of transcription. Cell 84: 331–334.
   PubMed Web of Science ®Google Scholar
• Jacobson, N. G., S. J. Szabo, R. M. Weber-Nordt, Z. Zhong, R. D. Schreiber, Darnell J., Jr., and K. M. Murphy 1995. Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J. Exp. Med. 181: 1755–1762.
   PubMed Web of Science ®Google Scholar
• Kawakami, Y., T. Miura, R. Bissonnette, D. Hata, W. N. Khan, T. Kitamura, M. Maeda-Yamamoto, S. E. Hartman, L. Yao, F. W. Alt, and T. Kawakami 1997. Bruton’s tyrosine kinase regulates apoptosis and JNK/SAPK kinase activity. Proc. Natl. Acad. Sci. USA 94: 3938–3942.
   PubMed Web of Science ®Google Scholar
• Kim, T. K., and T. Maniatis 1996. Regulation of interferon-g-activated STAT1 by the ubiquitin-proteasome pathway. Science 273: 1717–1719.
   PubMed Web of Science ®Google Scholar
• Kinoshita, T., T. Yokota, K. Arai, and A. Miyajima 1995. Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors. EMBO J. 14: 266–275.
   PubMed Web of Science ®Google Scholar
• Kitamura, T., M. Onishi, S. Kinoshita, A. Shibuya, A. Miyajima, and G. P. Nolan 1995. Efficient screening of retroviral cDNA expression libraries. Proc. Natl. Acad. Sci. USA 92: 9146–9150.
   PubMedGoogle Scholar
• Kitamura, T., T. Tange, T. Terasawa, S. Chiba, T. Kuwaki, K. Miyagawa, Y.-F. Piao, K. Miyazono, A. Urabe, and F. Takaku 1989. Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin. J. Cell. Physiol. 140: 323–334.
   PubMed Web of Science ®Google Scholar
• Lacronique, V., A. Boureux, V. Della Valle, H. Poirel, C. Tran Quang, M. Mauchauffe, C. Berthou, M. Lessard, R. Berger, J. Ghysdael, and O. A. Bernard 1997. A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. Science 278: 1309–1312.
   PubMed Web of Science ®Google Scholar
• Lin, J. X., J. Mietz, W. S. Modi, S. John, and W. J. Leonard 1996. Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells. J. Biol. Chem. 271: 10738–10744.
   PubMedGoogle Scholar
• Liu, X., G. W. Robinson, F. Gouilleux, B. Groner, and L. Hennighausen 1995. Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue. Proc. Natl. Acad. Sci. USA 92: 8831–8835.
   PubMedGoogle Scholar
• Liu, X., G. W. Robinson, K.-U. Wagner, L. Garrett, A. Wynshaw-Boris, and L. Hennighausen 1997. Stat5a is mandatory for adult mammary gland and lactogenesis. Genes Dev. 11: 179–186.
   PubMed Web of Science ®Google Scholar
• Migone, T.-S., J.-X. Lin, A. Cereseto, J. C. Mulloy, J. J. O’Shea, G. Franchini, and W. J. Leonard 1995. Constitutive activated Jak-STAT pathway in T cells transformed with HTLV-I. Science 269: 79–83.
   PubMed Web of Science ®Google Scholar
• Miyajima, A., J. Schreurs, K. Otsu, A. Kondo, K. Arai, and S. Maeda 1987. Use of the silkworm, Bombyx mori, and an insect baculovirus vector for high-level expression and secretion of biologically active mouse interleukin-3. Gene 58: 273–281.
   PubMed Web of Science ®Google Scholar
• Moriggl, R., V. Gouilleux-Gruart, R. Jähne, S. Berchtold, C. Gartmann, X. Liu, L. Hennighausen, A. Sotiropoulos, B. Groner, and F. Gouilleux 1996. Deletion of the carboxyl-terminal transactivation domain of MGF-Stat5 results in sustained DNA binding and a dominant negative phenotype. Mol. Cell. Biol. 16: 5691–5700.
   PubMed Web of Science ®Google Scholar
• Mui, A. L.-F., H. Wakao, A. O’Farrell, N. Harada, and A. Miyajima 1995. Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs. EMBO J. 14: 1166–1175.
   PubMed Web of Science ®Google Scholar
• Mui, A. L. F., H. Wakao, T. Kinoshita, T. Kitamura, and A. Miyajima 1996. Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation. EMBO J. 15: 2425–2433.
   PubMed Web of Science ®Google Scholar
• Nosaka, T., K. Ikuta, and T. Kitamura. Unpublished data.
   Google Scholar
• Onishi, M., S. Kinoshita, Y. Morikawa, A. Shibuya, J. Phillips, L. L. Lanier, D. M. Gorman, G. P. Nolan, A. Miyajima, and T. Kitamura 1996. Applications of retrovirus-mediated expression cloning. Exp. Hematol. 24: 324–329.
   PubMed Web of Science ®Google Scholar
• Onishi, M., A. L. F. Mui, Y. Morikawa, L. Cho, S. Kinoshita, G. P. Nolan, D. M. Gorman, A. Miyajima, and T. Kitamura 1996. Identification of an oncogenic form of the thrombopoietin receptor MPL using retrovirus-mediated gene transfer. Blood 88: 1399–1406.
   PubMed Web of Science ®Google Scholar
• Osborne, C. K., E. B. Coronado-Heinsohn, S. G. Hilsenbeck, B. L. McCue, A. E. Wakeling, R. A. McClelland, D. L. Manning, and R. I. Nicholson 1995. Comparison of the effects of a pure steroidal anti-estrogen with those of tamoxifen in a model of human breast cancer. J. Natl. Cancer Inst. 87: 746–750.
   PubMed Web of Science ®Google Scholar
• O’Shea, J. J. 1997. Jaks, STATs, cytokine signal transduction, and immunoregulation: are we there yet? Immunity 7: 1–11.
   PubMedGoogle Scholar
• Pear, W. S., G. P. Nolan, M. L. Scott, and D. Baltimore 1993. Production of high-titer helper-free retroviruses by transient transfection. Proc. Natl. Acad. Sci. USA 90: 8392–8396.
   PubMed Web of Science ®Google Scholar
• Peeters, P., S. D. Raynaud, J. Cools, I. Wlodarska, J. Grosgeorge, P. Philip, F. Monpoux, L. Van Rompaey, M. Baens, H. Van den Berghe, and P. Marynen 1997. Fusion of TEL, the ets-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia. Blood 90: 2535–2540.
   PubMed Web of Science ®Google Scholar
• Quelle, F. W., D. Wang, T. Nosaka, W. E. Thierfelder, D. Stravopodis, Y. Weinstein, and J. N. Ihle 1996. Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response. Mol. Cell. Biol. 16: 1622–1631.
   PubMed Web of Science ®Google Scholar
• Raitano, A. B., Y. E. Whang, and C. L. Sawyers 1997. Signal transduction by wild-type and leukemogenic Abl proteins. Biochim. Biophys. Acta 1333: 201–216.
   PubMed Web of Science ®Google Scholar
• Rayanade, R. J., K. Patel, M. Ndubuisi, S. Shama, S. Omura, J. D. Etlinger, R. Pine, and P. B. Sehgal 1997. Proteasome- and p53-dependent masking of signal transducer and activator of transcription (STAT) factors. J. Biol. Chem. 272: 4659–4662.
   PubMedGoogle Scholar
• Samuels, M. L., M. J. Weber, J. M. Bishop, and M. McMahon 1993. Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human Raf-1 protein kinase. Mol. Cell. Biol. 13: 6241–6252.
   PubMedGoogle Scholar
• Sato, N., K. Sakamaki, N. Terada, K. Arai, and A. Miyajima 1993. Signal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common beta subunit responsible for different signaling. EMBO J. 12: 4181–4189.
   PubMed Web of Science ®Google Scholar
• Schindler, C., Darnell, J.Jr. 1995. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu. Rev. Biochem. 64: 621–651.
   PubMed Web of Science ®Google Scholar
• Shuai, K., J. Liao, and M. M. Song 1996. Enhancement of antiproliferative activity of gamma interferon by the specific inhibition of tyrosine dephosphorylation of Stat1. Mol. Cell. Biol. 16: 4932–4941.
   PubMed Web of Science ®Google Scholar
• Taniguchi, T. 1995. Cytokine signaling through nonreceptor protein tyrosine kinases. Science 268: 251–255.
   PubMed Web of Science ®Google Scholar
• Udy, G. B., R. P. Towers, R. G. Snell, R. J. Wilkins, S.-H. Park, P. Ram, D. J. Waxman, and H. W. Davey 1997. Requirement of Stat5b for sexual dimorphism of body growth rates and liver gene expression. Proc. Natl. Acad. Sci. USA 94: 7239–7244.
   PubMed Web of Science ®Google Scholar
• Wakao, H., F. Gouilleux, and B. Groner 1994. Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response. EMBO J. 13: 2182–2191.
   PubMed Web of Science ®Google Scholar
• Wang, D., D. Stravopodis, S. Teglund, J. Kitazawa, and J. N. Ihle 1996. Naturally occurring dominant negative variants of Stat5. Mol. Cell. Biol. 16: 6141–6148.
   PubMedGoogle Scholar
• Weber-Nordt, R. M., C. Egen, J. Wehinger, W. Ludwig, V. Gouilleux-Gruart, R. Mertelsmann, and J. Finke 1996. Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines. Blood 88: 809–816.
   PubMed Web of Science ®Google Scholar