zfh-1, the Drosophila Homologue of ZEB, Is a Transcriptional Repressor That Regulates Somatic Myogenesis

REFERENCES

• Bate, M. 1993. The mesoderm and its derivatives, p. 1013–1090. In M. Bate, A. Martinez-Arias (ed.), The development of Drosophila melanoganster. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
   Google Scholar
• Baylies, M. K., and J. Bate 1996. Twist: a myogenic switch in Drosophila. Science 272:1481–1484.
   PubMedGoogle Scholar
• Baylies, M. K., M. Bate, and J. Gomez 1998. Myogenesis: a view from Drosophila. Cell 93:921–927.
   PubMed Web of Science ®Google Scholar
• Benezra, R., R. L. Davis, D. Lockshon, D. L. Turner, and J. Weintraub 1990. The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell 61:49–59.
   PubMed Web of Science ®Google Scholar
• Bour, B. A., M. A. O’Brien, W. L. Lockwood, E. S. Goldstein, R. Bodmer, P. H. Taghert, S. M. Abmayr, and J. Nguyen 1995. Drosophila Mef2, a transcription factor that is essential for myogenesis. Genes Dev. 15:730–741.
   Google Scholar
• Broihier, H., L. Moore, M. Doren, S. Newman, and J. Lehmann 1998. zfh-1 is required for germ cell migration and gonadal mesoderm development in Drosophila. Development 125:655–666.
   PubMedGoogle Scholar
• Cabanillas, A. M., and J. Darling 1996. Alternative splicing gives rise to two isoforms of Zfhep, a zinc finger/homeodomain protein that binds T3-response elements. DNA Cell Biol. 15:643–651.
   PubMedGoogle Scholar
• Casal, J., and J. Leptin 1996. Identification of novel genes in Drosophila reveals the complex regulation of early genes activity in the mesoderm. Proc. Natl. Acad. Sci. USA 93:10327–10332.
   PubMedGoogle Scholar
• Chen, C. M. A., N. Kraut, M. Groudine, and J. Weintraub 1996. I-mf, a novel myogenic repressor that interacts with members of the MyoD family. Cell 86:731–741.
   PubMed Web of Science ®Google Scholar
• Chow, K. N., and J. Dean 1996. Domains A and B in the Rb pocket interact to form a transcriptional repressor motif. Mol. Cell. Biol. 16:4862–4868.
   PubMedGoogle Scholar
• Cripps, R. M., B. L. Black, B. Zhao, C. L. Lien, R. A. Schulz, and J. Olson 1998. The myogenic regulatory gene Mef2 is a direct target for transcriptional activation by Twist during Drosophila myogenesis. Genes Dev. 12:422–434.
   PubMedGoogle Scholar
• DiNardo, S., J. M. Kuner, J. Theis, and J. O’Farrell 1985. Development of embryonic pattern in D. melanogaster as revealed by accumulation of the nuclear engrailed protein. Cell 43:59–69.
   PubMedGoogle Scholar
• Fortini, M. E., Z. C. Lai, and J. Rubin 1991. The Drosophila zfh-1 and zfh-2 genes encode novel proteins containing both zinc-finger and homeodomain motifs. Mech. Dev. 34:113–122.
   PubMed Web of Science ®Google Scholar
• Franklin, A. J., T. L. Jetton, K. D. Shelton, and J. Magnuson 1994. BZP, a novel serum-responsive zinc finger protein that inhibits gene transcription. Mol. Cell. Biol. 14:6773–6788.
   PubMed Web of Science ®Google Scholar
• Funahashi, J., R. Seikido, K. Murai, Y. Kamachi, and J. Kondoh 1993. Delta-crystallin enhancer binding protein delta EF1 is a zinc finger-homeodomain protein implicated in postgastrulation embryogenesis. Development 119:433–446.
   PubMed Web of Science ®Google Scholar
• Fuse, N., S. Hirose, and J. Hayashi 1994. Diploidy of Drosophila imaginal cells is maintained by a transcriptional repressor encoded by escargot. Genes Dev. 8:2270–2281.
   PubMedGoogle Scholar
• Fuse, N., S. Hirose, and J. Hayashi 1996. Determination of wing cell fate by the escargot and snail genes in Drosophila. Development 122:1059–1067.
   PubMed Web of Science ®Google Scholar
• Genetta, T., D. Ruezinsky, and J. Kadesch 1994. Displacement of an E box-binding repressor by basic helix-loop-helix proteins: implications for B-cell specificity of the immunoglobulin heavy-chain enhancer. Mol. Cell. Biol. 14:6153–6163.
   PubMed Web of Science ®Google Scholar
• Genetta, T., and J. Kadesch 1996. Cloning of a cDNA encoding a mouse transcriptional repressor displaying striking sequence conservation across vertebrates. Gene 169:289–290.
   PubMedGoogle Scholar
• Gray, S., and J. Levine 1996. Short-range transcriptional repressors mediate both quenching and direct repression within complex loci in Drosophila. Genes Dev. 10:700–710.
   PubMedGoogle Scholar
• Hemavathy, K., X. Meng, and J. Ip 1997. Differential regulation of gastrulation and neuroectodermal gene expression by snail in the Drosophila embryo. Development 124:3683–3691.
   PubMedGoogle Scholar
• Ip, Y. T., R. E. Park, D. Kosman, E. Bier, and J. Levine 1992. The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo. Genes Dev. 6:1728–1739.
   PubMed Web of Science ®Google Scholar
• Kasai, Y., J. R. Nambu, P. M. Lieberman, and J. Crews 1992. Dorsal-ventral patterning in Drosophila: DNA binding of snail protein to the single-minded gene. Proc. Natl. Acad. Sci. USA 89:3414–3418.
   PubMedGoogle Scholar
• Kosman, D., Y. T. Ip, M. Levine, and J. Arora 1991. Establishment of the mesoderm-neuroectoderm boundary in the Drosophila embryo. Science 254:118–122.
   PubMedGoogle Scholar
• Kostich, W. A., and J. Sanes 1995. Expression of zfh-4, a new member of the zinc finger-homeodomain family, in developing brain and muscle. Dev. Dyn. 202:145–152.
   PubMedGoogle Scholar
• Lai, Z., M. E. Fortini, and J. Rubin 1991. The embryonic expression patterns of zfh-1 and zfh-2, two Drosophila genes encoding novel zinc-finger homeodomain proteins. Mech. Dev. 34:123–134.
   PubMed Web of Science ®Google Scholar
• Lai, Z., E. Rushton, M. Bate, and J. Rubin 1993. Loss of function of the Drosophila zfh-1 gene results in abnormal development of mesodermally derived tissues. Proc. Natl. Acad. Sci. USA 90:4122–4126.
   PubMed Web of Science ®Google Scholar
• Lemmon, M. A., K. M. Ferguson, and J. Schlessinger 1996. PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface. Cell 85:621–624.
   PubMed Web of Science ®Google Scholar
• Leptin, M. 1991. twist and snail as positive and negative regulators during Drosophila mesoderm development. Genes Dev. 5:1568–1576.
   PubMedGoogle Scholar
• Lilly, B., B. Zhao, G. Ranganayakulu, B. M. Paterson, R. A. Schulz, and J. Olson 1995. Requirement of MADS domain transcription factor D-MEF2 for muscle formation in Drosophila. Science 267:688–693.
   PubMed Web of Science ®Google Scholar
• Mauhin, V., Y. Lutz, C. Dennefeld, and J. Alberga 1993. Definition of the DNA-binding site repertoire for the Drosophila transcription factor SNAIL. Nucleic Acids Res. 21:3951–3957.
   PubMedGoogle Scholar
• Molkentin, J. D., B. L. Black, J. F. Martin, and J. Olson 1995. Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins. Cell 83:1125–1136.
   PubMedGoogle Scholar
• Moore, L., H. Broihier, M. Doren, and J. Lehmann 1998. Gonadal mesoderm and fat body initially follow a common developmental path in Drosophila. Development 125:837–844.
   PubMedGoogle Scholar
• Nambu, J. R., J. O. Lewis, K. A. Wharton, and J. Crews 1991. The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development. Cell 67:1157–1167.
   PubMed Web of Science ®Google Scholar
• Nguyen, H. T., R. Bodmer, S. M. Abmayr, J. C. McDermott, and J. Spoerel 1994. D-Mef2: a Drosophila mesoderm-specific MADS box-containing gene with a biphasic expression profile during embryogenesis. Proc. Natl. Acad. Sci. USA 91:7520–7524.
   PubMedGoogle Scholar
• Olson, E., and R. Cripps. Personal communication.
   Google Scholar
• Postigo, A. A., and J. Dean 1997. ZEB, a vertebrate homologue of Drosophila zfh-1, is a negative regulator of muscle differentiation. EMBO J. 16:3935–3943.
   PubMedGoogle Scholar
• Postigo, A. A., A. M. Sheppard, M. L. Mucenski, and J. Dean 1997. c-myb and ets factors synergize to overcome transcriptional repression by ZEB. EMBO J. 16:3924–3934.
   PubMedGoogle Scholar
• Postigo, A. A., and J. Dean 1999. ZEB represses transcription through interaction with the corepressor CtBP. Proc. Natl. Acad. Sci. USA 96:6683–6688.
   PubMedGoogle Scholar
• Rosen, G. D., J. L. Barks, M. F. Iademarco, R. J. Fisher, and J. Dean 1994. An intricate arrangement of binding sites for the Ets family of transcription factors regulates activity of the alpha 4 integrin gene promoter. J. Biol. Chem. 269:15652–15660.
   PubMed Web of Science ®Google Scholar
• Schaeper, U., J. M. Boyd, S. Verma, E. Uhlmann, T. Subramanian, and J. Chinnadurai 1995. Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation. Proc. Natl. Acad. Sci. USA 92:10467–10471.
   PubMed Web of Science ®Google Scholar
• Sekido, R., K. Murai, J. Funahashi, Y. Kamachi, A. Fujisawa-Sehara, K. Nabeshima, and J. Kondoh 1994. The delta-crystallin enhancer-binding protein delta EF1 is a repressor of E2-box-mediated gene activation. Mol. Cell. Biol. 14:5692–5700.
   PubMedGoogle Scholar
• Sekido, R., T. Takagi, M. Okanami, H. Moribe, M. Yamamura, Y. Higashi, and J. Kondoh 1996. Organization of the gene encoding transcriptional repressor delta EF1 and cross-species conservation of its domains. Gene 173:227–232.
   PubMedGoogle Scholar
• Spicer, D. B., J. Rhee, W. L. Cheung, and J. Lassar 1996. Inhibition of myogenic bHLH and MEF2 transcription factors by the bHLH twist. Science 254:1385–1387.
   Google Scholar
• Sundqvist, A., K. Sollerbrant, and J. Svensson 1998. The carboxy-terminal region of adenovirus E1A activates transcription through targeting of a C-terminal binding protein-histone deacetylase complex. FEBS Lett. 429:183–188.
   PubMed Web of Science ®Google Scholar
• Thayer, M. J., and J. Weintraub 1990. Activation and repression of myogenesis in somatic cell hybrids: evidence for trans-negative regulation of myoD in primary fibroblasts. Cell 63:23–32.
   PubMedGoogle Scholar
• Weintraub, H., R. Davis, S. Tapscott, M. Thayer, M. Krause, R. Benezra, T. K. Blackwell, D. Turner, R. Rupp, S. Hollenberg, Y. Zhuang, and J. Lassar 1991. The myoD gene family: nodal point during specification of the muscle cell lineage. Science 251:761–766.
   PubMed Web of Science ®Google Scholar
• Weintraub, S. J., K. N. Chow, R. X. Luo, S. H. Zhang, S. He, and J. Dean 1995. Mechanism of active transcriptional repression by the retinoblastoma protein. Nature 375:812–815.
   PubMed Web of Science ®Google Scholar
• Whiteley, M., P. D. Noguchi, S. M. Sensabaugh, W. F. Odenwald, and J. Kassis 1992. The Drosophila gene escargot encodes a zinc finger motif found in snail-related genes. Mech. Dev. 36:117–127.
   PubMedGoogle Scholar
• Yasuda, H., A. Mizuno, T. Tamaoki, and J. Morinaga 1994. ATBF1, a multiple-homeodomain zinc finger protein, selectively down-regulates AT-rich elements of the human alpha-fetoprotein gene. Mol. Cell. Biol. 14:1395–1401.
   PubMedGoogle Scholar