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Nucleocytoplasmic Communication

Evidence for Distinct Substrate Specificities of Importin α Family Members in Nuclear Protein Import

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Pages 7782-7791 | Received 03 Mar 1999, Accepted 03 Aug 1999, Published online: 28 Mar 2023

REFERENCES

  • Adam, E. J., and J. Adam 1994. Identification of cytosolic factors required for nuclear location sequence-mediated binding to the nuclear envelope. J. Cell Biol. 125:547–555.
  • Adam, S. A., R. Sterne-Marr, and J. Gerace 1990. Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors. J. Cell Biol. 111:807–816.
  • Bischoff, F. R., and J. Postingl 1991. Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1. Nature 354:80–82.
  • Chi, N. C., E. J. H. Adam, and J. Adam 1995. Sequence and characterization of cytoplasmic nuclear import factor p97. J. Cell Biol. 130:265–274.
  • Conti, E., M. Uy, L. Leighton, G. Blobel, and J. Kuriyan 1998. Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin α. Cell 94:193–204.
  • Cortes, P., Y. Zheng-Sheng, and J. Baltimore 1994. RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1. Proc. Natl. Acad. Sci. USA 91:7633–7637.
  • Cuomo, C. A., S. A. Kirch, J. Gyuris, R. Brent, and J. Oettinger 1994. Rch1, a protein that specifically interacts with the RAG-1 recombination-activating protein. Proc. Natl. Acad. Sci. USA 91:6156–6160.
  • Dingwall, C., and J. Laskey 1991. Nuclear targeting sequences—a consensus? Trends Biochem. Sci. 16:478–481.
  • Dingwall, C., A. V. Sharnick, and J. Laskey 1982. A polypeptide domain that specifies migration of nucleoplasmin into the nucleus. Cell 30:449–458.
  • Edelhoch, H. 1967. Spectroscopic determination of tryptophan and tyrosine in proteins. Biochemistry 6:1948–1954.
  • Fischer, N., E. Kremmer, G. Lautscham, N. Mueller-Lantzsch, and J. Grässer 1997. Epstein-Barr virus nuclear antigen 1 forms a complex with the nuclear transporter karyopherin α2. J. Biol. Chem. 272:3999–4005.
  • Görlich, D. 1998. Transport into and out of the cell nucleus. EMBO J. 17:2721–2727.
  • Görlich, D., P. Henklein, R. A. Laskey, and J. Hartmann 1996. A 41 amino acid motif in importin alpha confers binding to importin beta and hence transit into the nucleus. EMBO J. 15:1810–1817.
  • Görlich, D., S. Kostka, R. Kraft, C. Dingwall, R. A. Laskey, E. Hartmann, and J. Prehn 1995. Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope. Curr. Biol. 5:383–392.
  • Görlich, D., N. Panté, U. Kutay, U. Aebi, and J. Bischoff 1996. Identification of different roles for RanGDP and RanGTP in nuclear protein import. EMBO J. 15:5584–5594.
  • Görlich, D., S. Prehn, R. A. Laskey, and J. Hartmann 1994. Isolation of a protein that is essential for the first step of nuclear protein import. Cell 79:767–778.
  • Görlich, D., F. Vogel, A. D. Mills, E. Hartmann, and J. Laskey 1995. Distinct functions for the two importin subunits in nuclear protein import. Nature 377:246–248.
  • Herold, A., R. Truant, H. Wiegand, and J. Cullen 1998. Determination of the functional domain organization of the importin α nuclear import factor. J. Cell Biol. 143:309–318.
  • Imamoto, N., T. Shimamoto, S. Kose, T. Takao, T. Tachibana, M. Matsubae, T. Sekimoto, Y. Shimonishi, and J. Yoneda 1995. The nuclear pore targeting complex binds to nuclear pores after association with a karyophile. FEBS Lett. 368:415–419.
  • Imamoto, N., T. Shimamoto, T. Takao, T. Tachibana, S. Kose, M. Matsubae, T. Sekimoto, Y. Shimonishi, and J. Yoneda 1995. In vivo evidence for involvement of a 58 kDa component of nuclear pore targeting complex in nuclear protein import. EMBO J. 14:3617–3626.
  • Jäkel, S., and J. Görlich 1998. Importin β, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells. EMBO J. 17:4491–4502.
  • Johnson, B., S. Lofas, and J. Lindquist 1991. Immobilization of proteins to a carboxymethyldextran-modified gold surface for biospecific interaction analysis in surface plasmon resonance sensors. Anal. Biochem. 198:268–277.
  • Köhler, M., S. Ansieau, S. Prehn, A. Leutz, H. Haller, and J. Hartmann 1997. Cloning of two novel importin-α subunits and analysis of the expression pattern of the importin-α protein family. FEBS Lett. 417:104–108.
  • Kutay, U., F. R. Bischoff, S. Kostka, R. Kraft, and J. Görlich 1997. Export of importin α from the nucleus is mediated by a specific nuclear transport factor. Cell 90:1061–1071.
  • Kutay, U., E. Izaurralde, F. R. Bischoff, I. W. Mattaj, and J. Görlich 1997. Dominant-negative mutants of importin-β block multiple pathways of import and export through the nuclear pore complex. EMBO J. 16:1153–1163.
  • Melchior, F., B. Paschal, E. Evans, and J. Gerace 1993. Inhibition of nuclear protein import by nonhydrolyzable analogs of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor. J. Cell Biol. 123:1649–1659.
  • Michael, W. M., P. S. Eder, and J. Dreyfuss 1997. The K nuclear shuttling domain: a novel signal for nuclear import and nuclear export in the hnRNP K protein. EMBO J. 16:3587–3598.
  • Miyamoto, Y., N. Imamoto, T. Sekimoto, T. Tachibana, T. Seki, S. Tada, T. Enomoto, and J. Yoneda 1997. Differential modes of nuclear localization signal (NLS) recognition by three distinct classes of NLS receptors. J. Biol. Chem. 272:26375–26381.
  • Moore, M. S. 1998. Ran and nuclear transport. J. Biol. Chem. 273:22857–22860.
  • Moore, M. S., and J. Blobel 1993. The GTP-binding protein Ran/TC4 is required for protein import into the nucleus. Nature 365:661–663.
  • Moore, M. S., and J. Blobel 1994. Purification of a Ran-interacting protein that is required for protein import into the nucleus. Proc. Natl. Acad. Sci. USA 91:10212–10216.
  • Nachury, M. V., U. W. Ryder, A. I. Lamond, and J. Weis 1998. Cloning and characterization of hSRP1γ, a tissue-specific nuclear transport factor. Proc. Natl. Acad. Sci. USA 95:582–587.
  • Nadler, S. G., D. Tritschler, O. K. Haffar, J. Blake, A. G. Bruce, and J. Cleaveland 1997. Differential expression and sequence-specific interaction of karyopherin α with nuclear localization sequences. J. Biol. Chem. 272:4310–4315.
  • Ohno, M., M. Fornerod, and J. Mattaj 1998. Nucleocytoplasmic transport: the last 200 nanometers. Cell 92:327–336.
  • Ohtsubo, M., H. Okazaki, and J. Nishimoto 1989. The RCC1 protein, a regulator for the onset of chromosome condensation, locates in the nucleus and binds to DNA. J. Cell Biol. 109:1389–1397.
  • Paschal, B. M., and J. Gerace 1995. Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore protein p62. J. Cell Biol. 129:925–937.
  • Prieve, M. G., K. L. Guttridge, J. Munguia, and J. Waterman 1998. Differential importin-α recognition and nuclear transport by nuclear localization signals within the high-mobility-group DNA binding domains of lymphoid enhancer factor 1 and T-cell factor 1. Mol. Cell. Biol. 18:4819–4832.
  • Prieve, M. G., K. L. Guttridge, J. Munguia, and J. Waterman 1996. The nuclear localization signal of lymphoid enhancer factor-1 is recognized by two differentially expressed Srp1-nuclear localization sequence receptor proteins. J. Biol. Chem. 271:7654–7658.
  • Radu, A., G. Blobel, and J. Moore 1995. Identification of a protein complex that is required for nuclear protein import and mediates docking of the import substrate to distinct nucleoporins. Proc. Natl. Acad. Sci. USA 92:1769–1773.
  • Reid, J. L., J. A. Bannister, P. Zegerman, M. A. Martinez-Balbás, and J. Kouzarides 1998. E1A directly binds and regulates the P/CAF acetyltransferase. EMBO J. 17:4469–4477.
  • Ribbeck, K., G. Lipowsky, H. M. Kent, M. Stewart, and J. Görlich 1998. NTF2 mediates nuclear import of Ran. EMBO J. 17:6587–6598.
  • Seki, T., S. Tada, T. Katada, and J. Enomoto 1997. Cloning of a cDNA encoding novel importin-α homologue, Qip1: discrimination of Qip1 and Rch1 from hSrp1 by their ability to interact with DNA helicase Q1/RecQL. Biochem. Biophys. Res. Commun. 234:7633–7637.
  • Sekimoto, T., N. Imamoto, K. Nakajima, T. Hirano, and J. Yoneda 1997. Extracellular signal-dependent nuclear import of Stat1 is mediated by nuclear pore-targeting complex formation with NPI-1, but not Rch1. EMBO J. 16:7067–7077.
  • Tsuji, L., T. Takumi, N. Imamoto, and J. Yoneda 1997. Identification of novel homologues of mouse importin α, the α subunit of the nuclear pore-targeting complex, and their tissue-specific expression. FEBS Lett. 416:30–34.
  • Weis, K., I. W. Mattaj, and J. Lamond 1995. Identification of hSRP1α as a functional receptor for nuclear localization sequences. Science 268:1049–1053.
  • Weis, K., U. Ryder, and J. Lamond 1996. The conserved amino terminal domain of hSRP1α is essential for nuclear protein import. EMBO J. 15:1818–1825.

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