Biological and Regulatory Properties of Vav-3, a New Member of the Vav Family of Oncoproteins

REFERENCES

• Boguski, M. S., and J. McCormick 1993. Proteins regulating Ras and its relatives. Nature 366:643–654.
   PubMed Web of Science ®Google Scholar
• Bustelo, X. R. 1996. The VAV family of signal transduction molecules. Crit. Rev. Oncog. 7:65–88.
   PubMed Web of Science ®Google Scholar
• Bustelo, X. R., K. L. Suen, W. M. Michael, G. Dreyfuss, and J. Barbacid 1995. Association of the vav proto-oncogene product with poly(rC)-specific RNA-binding proteins. Mol. Cell. Biol. 15:1324–1332.
   PubMed Web of Science ®Google Scholar
• Cerione, R. A., and J. Zheng 1996. The Dbl family of oncogenes. Curr. Opin. Cell. Biol. 8:216–222.
   PubMed Web of Science ®Google Scholar
• Coppola, J., S. Bryant, T. Koda, D. Conway, and J. Barbacid 1991. Mechanism of activation of the vav protooncogene. Cell Growth Differ. 2:95–105.
   PubMedGoogle Scholar
• Crespo, P., X. R. Bustelo, D. S. Aaronson, O. A. Coso, M. Lopez-Barahona, M. Barbacid, and J. Gutkind 1996. Rac-1-dependent stimulation of the JNK/SAPK signaling pathway by Vav. Oncogene 13:455–460.
   PubMed Web of Science ®Google Scholar
• Crespo, P., K. E. Schuebel, A. A. Ostrom, J. S. Gutkind, and J. Bustelo 1997. Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product. Nature 385:169–172.
   PubMed Web of Science ®Google Scholar
• D’Adamo, D. R., S. Novick, J. M. Kahn, P. Leonardi, and J. Pellicer 1997. rsc: a novel oncogene with structural and functional homology with the gene family of exchange factors for Ral. Oncogene 14:1295–1305.
   PubMed Web of Science ®Google Scholar
• Ferguson, K. M., M. A. Lemmon, J. Schlessinger, and J. Sigler 1994. Crystal structure at 2.2 Å resolution of the pleckstrin homology domain from human dynamin. Cell 79:199–209.
   PubMed Web of Science ®Google Scholar
• Fischer, K. D., Y. Y. Kong, H. Nishina, K. Tedford, L. E. Marengere, I. Kozieradzki, T. Sasaki, M. Starr, G. Chan, S. Gardener, M. P. Nghiem, D. Bouchard, M. Barbacid, A. Bernstein, and J. Penninger 1998. Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor. Curr Biol 8:554–562.
   PubMed Web of Science ®Google Scholar
• Hall, A. 1998. Rho GTPases and the actin cytoskeleton. Science 279:509–514.
   PubMed Web of Science ®Google Scholar
• Hart, M., and J. Powers 1995. Ras-Cdc25 and Rho-Dbl binding assays: complex formation in vitro. Methods Enzymol. 255:129–135.
   PubMedGoogle Scholar
• Henske, E. P., M. P. Short, S. Jozwiak, C. M. Bovey, S. Ramlakhan, J. L. Haines, and J. Kwiatkowski 1995. Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1. Ann. Hum. Genet. 59:25–37.
   PubMedGoogle Scholar
• Holsinger, L. J., I. A. Graef, W. Swat, T. Chi, D. M. Bautista, L. Davidson, R. S. Lewis, F. W. Alt, and J. Crabtree 1998. Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction. Curr. Biol. 8:563–572.
   PubMed Web of Science ®Google Scholar
• Kong, Y. Y., K. D. Fischer, M. F. Bachmann, S. Mariathasan, I. Kozieradzki, M. P. Nghiem, D. Bouchard, A. Bernstein, P. S. Ohashi, and J. Penninger 1998. Vav regulates peptide-specific apoptosis in thymocytes. J. Exp. Med. 188:2099–2111.
   PubMedGoogle Scholar
• Lemmon, M. A., K. M. Ferguson, and J. Schlessinger 1996. PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface. Cell 85:621–624.
   PubMed Web of Science ®Google Scholar
• Liu, X., H. Wang, M. Eberstadt, A. Schnuchel, E. T. Olejniczak, R. P. Meadows, J. M. Schkeryantz, D. A. Janowick, J. E. Harlan, E. A. Harris, D. E. Staunton, and J. Fesik 1998. NMR structure and mutagenesis of the N-terminal Dbl homology domain of the nucleotide exchange factor Trio. Cell 95:269–277.
   PubMedGoogle Scholar
• Madaule, P., M. Eda, N. Watanabe, K. Fujisawa, T. Matsuoka, H. Bito, T. Ishizaki, and J. Narumiya 1998. Role of citron kinase as a target of the small GTPase Rho in cytokinesis. Nature 394:491–494.
   PubMed Web of Science ®Google Scholar
• Movilla, M., and X. R. Bustelo. Unpublished results.
   Google Scholar
• Nimnual, A. S., B. A. Yatsula, and J. Bar-Sagi 1998. Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos. Science 279:560–563.
   PubMed Web of Science ®Google Scholar
• Olson, M. F., P. Sterpetti, K. Nagata, D. Toksoz, and J. Hall 1997. Distinct roles for DH and PH domains in the Lbc oncogene. Oncogene 15:2827–2831.
   PubMed Web of Science ®Google Scholar
• Schuebel, K. E., X. R. Bustelo, D. A. Nielsen, B. J. Song, M. Barbacid, D. Goldman, and J. Lee 1996. Isolation and characterization of murine vav2, a member of the vav family of proto-oncogenes. Oncogene 13:363–371.
   PubMedGoogle Scholar
• Schuebel, K. E., N. Movilla, J. L. Rosa, and J. Bustelo 1998. Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2. EMBO J. 17:6608–6621.
   PubMedGoogle Scholar
• Soisson, S. M., A. S. Nimnual, M. Uy, D. Bar-Sagi, and J. Kuriyan 1998. Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein. Cell 95:259–268.
   PubMed Web of Science ®Google Scholar
• Tarakhovsky, A., M. Turner, S. Schaal, P. J. Mee, L. P. Duddy, K. Rajewsky, and J. Tybulewicz 1995. Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav. Nature 374:467–470.
   PubMed Web of Science ®Google Scholar
• Teramoto, H., P. Salem, K. C. Robbins, X. R. Bustelo, and J. Gutkind 1997. Tyrosine phosphorylation of the vav proto-oncogene product links FcɛRI to the Rac1-JNK pathway. J. Biol. Chem. 272:10751–10755.
   PubMed Web of Science ®Google Scholar
• Turner, M., P. J. Mee, A. E. Walters, M. E. Quinn, A. L. Mellor, R. Zamoyska, and J. Tybulewicz 1997. A requirement for the Rho-family GTP exchange factor Vav in positive and negative selection of thymocytes. Immunity 7:451–460.
   PubMed Web of Science ®Google Scholar
• Van Aelst, L., and J. D’Souza-Schorey 1997. Rho GTPases and signaling networks. Genes Dev. 11:2295–2322.
   PubMed Web of Science ®Google Scholar
• Whitehead, I., H. Kirk, C. Tognon, G. Trigo-Gonzalez, and J. Kay 1995. Expression cloning of lfc, a novel oncogene with structural similarities to guanine nucleotide exchange factors and to the regulatory region of protein kinase C. J. Biol. Chem. 270:18388–18395.
   PubMed Web of Science ®Google Scholar
• Wilson, R., R. Ainscough, K. Anderson, C. Baynes, M. Berks, J. Bonfield, J. Burton, M. Connell, T. Copsey, J. Cooper et al.. 1994. 2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans. Nature 368:32–38.
   PubMed Web of Science ®Google Scholar
• Zhang, R., F. W. Alt, L. Davidson, S. H. Orkin, and J. Swat 1995. Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene. Nature 374:470–473.
   PubMed Web of Science ®Google Scholar
• Zheng, J., R. H. Chen, S. Corblan-Garcia, S. M. Cahill, D. Bar-Sagi, and J. Cowburn 1997. The solution structure of the pleckstrin homology domain of human SOS1. A possible structural role for the sequential association of diffuse B cell lymphoma and pleckstrin homology domains. J. Biol. Chem. 272:30340–30344.
   PubMedGoogle Scholar
• Zheng, Y., M. J. Hart, and J. Cerione 1995. Guanine nucleotide exchange catalyzed by dbl oncogene product. Methods Enzymol. 256:77–84.
   PubMedGoogle Scholar
• Zheng, Y., M. F. Olson, A. Hall, R. A. Cerione, and J. Toksoz 1995. Direct involvement of the small GTP-binding protein Rho in lbc oncogene function. J. Biol. Chem. 270:9031–9034.
   PubMed Web of Science ®Google Scholar
• Zheng, Y., D. Zangrilli, R. A. Cerione, and J. Eva 1996. The pleckstrin homology domain mediates transformation by oncogenic dbl through specific intracellular targeting. J. Biol. Chem. 271:19017–19020.
   PubMed Web of Science ®Google Scholar