12
Views
22
CrossRef citations to date
0
Altmetric
Cell Growth and Development

A Low-Affinity Serum Response Element Allows Other Transcription Factors To Activate Inducible Gene Expression in Cardiac Myocytes

, &
Pages 1841-1852 | Received 03 Sep 1998, Accepted 10 Dec 1998, Published online: 27 Mar 2023

REFERENCES

  • Akhter, S. A., L. M. Luttrell, H. A. Rockman, G. Iaccarino, R. J. Lefkowitz, and J. Koch 1998. Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy. Science 280:574–577.
  • Alberts, A. S., O. Geneste, and J. Treisman 1998. Activation of SRF-regulated chromosomal templates by Rho-family GTPases requires a signal that also induces H4 hyperacetylation. Cell 92:475–487.
  • Allo, S. N., P. J. McDermott, L. L. Carl, and J. Morgan 1991. Phorbol ester stimulation of protein kinase C activity and ribosomal DNA transcription: role in hypertrophic growth of cultured cardiomyocytes. J. Biol. Chem. 266:22003–22009.
  • Ardati, A., and J. Nemer 1993. A nuclear pathway for α1-adrenergic receptor signaling in cardiac cells. EMBO J. 12:5131–5139.
  • Bogoyevitch, M. A., J. Gillespie-Brown, A. J. Ketterman, S. J. Fuller, R. Ben-Levy, A. Ashworth, C. J. Marshall, and J. Sugden 1996. Stimulation of the stress-activated mitogen-activated protein kinase subfamilies in perfused heart. Circ. Res. 79:162–173.
  • Bogoyevitch, M. A., P. E. Glennon, M. B. Andersson, A. Clerk, A. Lazou, C. J. Marshall, P. J. Parker, and J. Sugden 1994. Endothelin-1 and fibroblast growth factors stimulate the mitogen-activated protein kinase signaling cascade in cardiac myocytes. J. Biol. Chem. 269:1110–1119.
  • Bogoyevitch, M. A., P. E. Glennon, and J. Sugden 1993. Endothelin-1, phorbol esters and phenylephrine stimulate MAP kinase activities in ventricular cardiomyocytes. FEBS Lett. 317:271–275.
  • Bogoyevitch, M. A., C. Marshall, and J. Sugden 1995. Hypertrophic agonists stimulate the activities of the protein kinases c-Raf and A-Raf in cultured ventricular myocytes. J. Biol. Chem. 270:26303–26310.
  • Carey, M. 1998. The enhanceosome and transcriptional synergy. Cell 92:5–8.
  • Chen, C. Y., and J. Schwartz 1996. Recruitment of the tinman homolog Nkx-2.5 by serum response factor activates cardiac α-actin gene transcription. Mol. Cell. Biol. 16:6372–6384.
  • Chien, K. R., K. U. Knowlton, H. Zhu, and J. Chien 1991. Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive response. FASEB J. 5:3037–3046.
  • Clerk, A., A. Michael, and J. Sugden 1998. Stimulation of the p38 mitogen-activated protein kinase pathway in neonatal rat ventricular myocytes by the G protein-coupled receptor agonists, endothelin-1 and phenylephrine: a role in cardiac myocyte hypertrophy? J. Cell Biol. 142:523–535.
  • Dunnmon, P., K. Iwaki, S. Henderson, A. Sen, and J. Chien 1990. Phorbol esters induce immediate-early genes and stimulate cardiac gene transcription in neonatal rat myocardial cells. J. Mol. Cell. Cardiol. 22:901–910.
  • Durocher, D., F. Charron, R. Warren, R. J. Schwartz, and J. Nemer 1997. The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors. EMBO J. 16:5687–5696.
  • Durocher, D., C. Y. Chen, A. Ardati, R. J. Schwartz, and J. Nemer 1996. The atrial natriuretic factor promoter is a downstream target for Nkx-2.5 in the myocardium. Mol. Cell. Biol. 16:4648–4655.
  • Durocher, D., and J. Nemer 1998. Combinatorial interactions regulating cardiac transcription. Dev. Genet. 22:250–262.
  • Gillespie-Brown, J., S. J. Fuller, M. A. Bogoyevitch, S. Cowley, and J. Sugden 1995. The mitogen-activated protein kinase kinase MEK1 stimulates a pattern of gene expression typical of the hypertrophic phenotype in rat ventricular cardiomyocytes. J. Biol. Chem. 270:28092–28096.
  • Glennon, P. E., S. Kaddoura, E. M. Sale, G. J. Sale, S. J. Fuller, and J. Sugden 1996. Depletion of mitogen-activated protein kinase using an antisense oligodeoxynucleotide approach downregulates the phenylephrine-induced hypertrophic response in cardiac myocytes. Circ. Res. 78:954–961.
  • Gupta, S., D. Campbell, B. Derijard, and J. Davis 1995. Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science 267:389–393.
  • Han, J., Y. Jiang, Z. Li, V. V. Kravchenko, and J. Ulevitch 1997. Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation. Nature 386:296–299.
  • Hill, C. S., and J. Treisman 1995. Differential activation of c-fos promoter elements by serum, lysophosphatidic acid, G proteins and polypeptide growth factors. EMBO J. 14:5037–5047.
  • Hill, C. S., J. Wynne, and J. Treisman 1995. The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF. Cell 81:1159–1170.
  • Hill, C. S., J. Wynne, and J. Treisman 1994. Serum-regulated transcription by serum response factor (SRF): a novel role for the DNA binding domain. EMBO J. 13:5421–5432.
  • Hines, W. A., and J. Thorburn 1998. Ras and rho are required for Gαq-induced hypertrophic gene expression in neonatal rat cardiac myocytes. J. Mol. Cell. Cardiol. 30:485–494.
  • Hines, W. A., J. Thorburn, and A. Thorburn. Submitted for publication.
  • Hipskind, R. A., M. Baccarini, and J. Nordheim 1994. Transient activation of Raf-1, MEK, and ERK2 coincides kinetically with ternary complex factor phosphorylation and immediate-early gene promoter activity in vivo. Mol. Cell. Biol. 14:6219–6231.
  • Hipskind, R. A., D. Buscher, A. Nordheim, and J. Baccarini 1994. Ras/MAP kinase-dependent and -independent signaling pathways target distinct ternary complex factors. Genes Dev. 8:1803–1816.
  • Knowlton, K. U., E. Barrachini, R. S. Ross, A. N. Harris, S. A. Henderson, S. M. Evans, C. C. Glembotski, and J. Chien 1991. Co-regulation of the atrial natriuretic factor and cardiac myosin light chain-2 genes during α-adrenergic stimulation of neonatal rat ventricular cells. J. Biol. Chem. 266:7759–7768.
  • Lee, Y., T. Shioi, H. Kasahara, S. M. Jobe, R. J. Wiese, B. E. Markham, and J. Izumo 1998. The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression. Mol. Cell. Biol. 18:3120–3129.
  • MacLellan, W. R., T.-C. Lee, R. J. Schwartz, and J. Schneider 1994. Transforming growth factor-β response elements of the skeletal a actin gene. J. Biol. Chem. 269:16754–16760.
  • Marais, R., J. Wynne, and J. Treisman 1993. The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell 73:381–393.
  • Marais, R. M., J. J. Hsuan, C. McGuigan, J. Wynne, and J. Treisman 1992. Casein kinase II phosphorylation increases the rate of serum response factor-binding site exchange. EMBO J. 11:97–105.
  • McDonough, P. M., and J. Glembotski 1992. Induction of atrial natriuretic factor and myosin light chain-2 gene expression in cultured ventricular myocytes by electrical stimulation of contraction. J. Biol. Chem. 267:11665–11668.
  • Nemoto, S., Z. Sheng, and J. Lin 1998. Opposing effects of Jun kinase and p38 mitogen-activated protein kinases on cardiomyocyte hypertrophy. Mol. Cell. Biol. 18:3518–3526.
  • Parker, T. G., S. E. Packer, and J. Schneider 1990. Peptide growth factors can provoke “fetal” contractile protein gene expression in rat cardiac myocytes. J. Clin. Invest. 85:507–514.
  • Pennica, D., K. L. Ling, K. J. Shaw, E. Luis, J. Rullamas, S.-H. Luoh, W. C. Darbonne, D. S. Knutzon, R. Yen, K. R. Chien, J. B. Baker, and J. Wood 1995. Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy. Proc. Natl. Acad. Sci. USA 92:1142–1146.
  • Pollock, R., and J. Treisman 1991. Human SRF-related proteins: DNA-binding properties and potential regulatory targets. Genes Dev. 5:2327–2341.
  • Post, G. R., D. Goldstein, D. J. Thuerauf, C. C. Glembotski, and J. Brown 1996. Dissociation of p44 and p42 mitogen-activated protein kinase activation from receptor-induced hypertrophy in neonatal rat ventricular myocytes. J. Biol. Chem. 271:8452–8457.
  • Ramirez, M. T., V. P. Sah, X.-L. Zhao, J. J. Hunter, K. R. Chien, and J. Brown 1997. The MEKK-JNK pathway is stimulated by α-adrenergic receptor and Ras activation and is associated with in vitro and in vivo cardiac hypertrophy. J. Biol. Chem. 272:14057–14061.
  • Rivera, V. M., C. K. Miranti, R. P. Misra, D. D. Ginty, R. H. Chen, J. Blenis, and J. Greenberg 1993. A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity. Mol. Cell. Biol. 13:6260–6273.
  • Sadoshima, J., and J. Izumo 1996. The heterotrimeric Gq protein-coupled angiotensin II receptor activates p21ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes. EMBO J. 15:775–787.
  • Sadoshima, J., and J. Izumo 1993. Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism. EMBO J. 12:1681–1692.
  • Sadoshima, J., and J. Izumo 1993. Molecular characterization of angiotensin II-induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Circ. Res. 73:413–423.
  • Sadoshima, J., L. Jahn, T. Takahashi, T. J. Kulik, and J. Izumo 1992. Molecular characterization of the stretch-induced adaptation of cultured cardiac cells. J. Biol. Chem. 267:10551–10560.
  • Sahai, E., A. S. Alberts, and J. Treisman 1998. RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation. EMBO J. 17:1350–1361.
  • Samuels, M. L., M. J. Weber, J. M. Bishop, and J. McMahon 1993. Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human Raf-1 protein kinase. Mol. Cell. Biol. 13:6241–6252.
  • Sei, C. A., C. E. Irons, A. B. Sprenkle, P. M. McDonough, J. H. Brown, and J. Glembotski 1991. The α-adrenergic stimulation of atrial natriuretic factor expression in cardiac myocytes requires calcium influx, protein kinase C, and calmodulin-regulated pathways. J. Biol. Chem. 266:15910–15916.
  • Sheng, Z., K. Knowlton, J. Chen, M. Hoshijima, J. H. Brown, and J. Chien 1997. Cardiotrophin 1 (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway. J. Biol. Chem. 272:5783–5791.
  • Sprenkle, A., S. F. Murray, and J. Glembotski 1995. Involvement of multiple cis elements in basal- and α-adrenergic agonist-inducible atrial natriuretic factor transcription. Circ. Res. 77:1060–1069.
  • Thorburn, J., M. Carlson, S. J. Mansour, K. R. Chien, N. G. Ahn, and J. Thorburn 1995. Inhibition of a signaling pathway in cardiac muscle cells by active mitogen-activated protein kinase kinase. Mol. Biol. Cell 6:1479–1490.
  • Thorburn, J., M. McMahon, and J. Thorburn 1994. Raf-1 kinase activity is necessary and sufficient for gene expression changes but not sufficient for cellular morphology changes associated with cardiac myocyte hypertrophy. J. Biol. Chem. 269:30580–30586.
  • Thorburn, J., S. Xu, and J. Thorburn 1997. MAP kinase- and Rho-dependent signals interact to regulate gene expression but not actin morphology in cardiac muscle cells. EMBO J. 16:1888–1900.
  • Thorburn, J. S., J. A. Frost, and J. Thorburn 1994. Mitogen-activated protein kinases mediate changes in gene expression, but not cytoskeletal organization associated with cardiac muscle cell hypertrophy. J Cell Biol. 126:1565–1572.
  • van Dam, H., D. Wilhelm, I. Herr, A. Steffen, P. Herrlich, and J. Angel 1995. ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents. EMBO J. 14:1798–1811.
  • von Harsdorf, R., J. G. Edwards, Y.-T. Shen, R. K. Kudej, R. Dietz, L. A. Leinwand, B. Nadal-Ginard, and J. Vatner 1997. Identification of a cis-acting regulatory element conferring inducibility of the atrial natriuretic factor gene in acute pressure overload. J. Clin. Invest. 100:1294–1304.
  • Wang, Y., S. Huang, V. P. Sah, J. Ross, J. H. Brown, J. Han, and J. Chien 1998. Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family. J. Biol. Chem. 273:2161–2168.
  • Wang, Y., B. Su, V. P. Sah, J. H. Brown, J. Han, and J. Chien 1998. Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells. J. Biol. Chem. 273:5423–5426.
  • Whitmarsh, A. J., P. Shore, A. D. Sharrocks, and J. Davis 1995. Integration of MAP kinase signal transduction pathways at the serum response element. Science 269:403–407.
  • Yamazaki, T., K. Tobe, E. Hoh, K. Meamura, T. Kaida, I. Komuro, H. Tamemoto, T. Kadowski, R. Nagai, and J. Yazaki 1993. Mechanical loading activates mitogen-activated protein kinase and S6 peptide kinase in cultured rat cardiac myocytes. J. Biol. Chem. 268:12069–12076.
  • Zechner, D., D. J. Thuerauf, D. S. Hanford, P. M. McDonough, and J. Glembotski 1997. A role for the p38 mitogen-activated protein kinase pathway in myocardial cell growth, sarcomeric organization and cardiac-specific gene expression. J. Cell Biol. 139:115–127.
  • Zhu, H., V. Joliot, and J. Prywes 1994. Role of transcription factor TFIIF in serum response factor-activated transcription. J. Biol. Chem. 269:3489–3497.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.