NF-κB Function in Growth Control: Regulation of Cyclin D1 Expression and G₀/G₁-to-S-Phase Transition

REFERENCES

• Aktas, H., H. Cai, and J. Cooper 1997. Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1. Mol. Cell. Biol. 17:3850–3857.
   PubMed Web of Science ®Google Scholar
• Albanese, C., J. Johnson, G. Watanabe, N. Eklund, D. Vu, A. Arnold, and J. Pestell 1995. Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions. J. Biol. Chem. 270:23589–23597.
   PubMed Web of Science ®Google Scholar
• Baeuerle, P. A., and J. Baltimore 1996. NF-κB: ten years after. Cell 87:13–20.
   PubMed Web of Science ®Google Scholar
• Baichwal, V. R., and J. Baeuerle 1997. Activate NF-κB or die? Curr. Biol. 7:R94–R96.
   PubMed Web of Science ®Google Scholar
• Baldwin, A. S. Jr.. 1996. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649–683.
   PubMed Web of Science ®Google Scholar
• Baldwin, A. S. Jr., J. C. Azizkhan, D. E. Jensen, A. A. Beg, and J. Coodly 1991. Induction of NF-κB DNA-binding activity during the G0-to-G1 transition in mouse fibroblasts. Mol. Cell. Biol. 11:4943–4951.
   PubMed Web of Science ®Google Scholar
• Bargou, R. C., F. Emmerich, D. Krappmann, K. Bommert, M. Y. Mapara, W. Arnold, H. D. Royer, E. Grienstein, A. Greiner, C. Scheidereit, and J. Dörken 1997. Constitutive nuclear factor-κB-RelA activation is required for proliferation and survival of Hodgkin’s disease tumor cells. J. Clin. Invest. 100:2961–2969.
   PubMed Web of Science ®Google Scholar
• Bartek, J., J. Bartkova, and J. Lukas 1996. The retinoblastoma protein pathway and the restriction point. Curr. Opin. Cell Biol. 8:805–814.
   PubMed Web of Science ®Google Scholar
• Bash, J., W. X. Zong, and J. Gelinas 1997. c-Rel arrests the proliferation of HeLa cells and affects critical regulators of the G1/S-phase transition. Mol. Cell Biol. 17:6526–6536.
   PubMed Web of Science ®Google Scholar
• Beg, A. A., W. C. Sha, R. T. Bronson, S. Ghosh, and J. Baltimore 1995. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB. Nature 376:167–170.
   PubMed Web of Science ®Google Scholar
• Beijersbergen, R. L., and J. Bernards 1996. Cell cycle regulation by the retinoblastoma family of growth inhibitory proteins. Biochim. Biophys. Acta 1287:103–120.
   PubMed Web of Science ®Google Scholar
• Chen, Z. J., L. Parent, and J. Maniatis 1996. Site-specific phosphorylation of IκBα by a novel ubiquitination-dependent protein kinase activity. Cell 84:853–862.
   PubMed Web of Science ®Google Scholar
• Cressman, D. E., L. E. Greenbaum, B. A. Haber, and J. Taub 1994. Rapid activation of post-hepatectomy factor/nuclear factor κB in hepatocytes, a primary response in the regenerating liver. J. Biol. Chem. 269:30429–30435.
   PubMed Web of Science ®Google Scholar
• Cressman, D. E., and J. Taub 1994. Physiologic turnover of nuclear factor κB by nuclear proteolysis. J. Biol. Chem. 269:26594–26597.
   PubMedGoogle Scholar
• Duckett, C. S., N. D. Perkins, K. Leung, A. B. Agranoff, and J. Nabel 1995. Cytokine induction of nuclear factor κB in cycling and growth-arrested cells. Evidence for cell cycle-independent activation. J. Biol. Chem. 270:18836–18840.
   PubMed Web of Science ®Google Scholar
• Finco, T. S., A. S. Baldwin Jr.. 1993. κB site-dependent induction of gene expression by diverse inducers of nuclear factor κB requires Raf-1. J. Biol. Chem. 268:17676–17679.
   PubMed Web of Science ®Google Scholar
• Finco, T. S., J. K. Westwick, J. L. Norris, A. A. Beg, C. J. Der, A. S. Baldwin Jr.. 1997. Oncogenic Ha-Ras-induced signaling activates NF-κB transcriptional activity, which is required for cellular transformation. J. Biol. Chem. 272:24113–24116.
   PubMed Web of Science ®Google Scholar
• FitzGerald, M. J., E. M. Webber, J. R. Donovan, and J. Fausto 1995. Rapid DNA binding by nuclear factor κB in hepatocytes at the start of liver regeneration. Cell Growth Differ. 6:417–427.
   PubMedGoogle Scholar
• Ghoda, L., X. Lin, and J. Greene 1997. The 90-kDa ribosomal S6 kinase (pp90rsk) phosphorylates the N-terminal regulatory domain of IκBα and stimulates its degradation in vitro. J. Biol. Chem. 272:21281–21288.
   PubMed Web of Science ®Google Scholar
• Heldin, C. H. 1995. Dimerization of cell surface receptors in signal transduction. Cell 80:213–223.
   PubMed Web of Science ®Google Scholar
• Helin, K., and J. Harlow 1993. The retinoblastoma protein as a transcriptional repressor. Trends Cell Biol. 3:43–46.
   PubMedGoogle Scholar
• Herber, B., M. Truss, M. Beato, and J. Muller 1994. Inducible regulatory elements in the human cyclin D1 promoter. Oncogene 9:2105–2107.
   PubMedGoogle Scholar
• Hill, C. S., and J. Treisman 1995. Transcriptional regulation by extracellular signals: mechanisms and specificity. Cell 80:199–211.
   PubMed Web of Science ®Google Scholar
• Kanno, T., and J. Siebenlist 1996. Activation of nuclear factor-κB via T cell receptor requires a Raf kinase and Ca2+ influx. Functional synergy between Raf and calcineurin. J. Immunol. 157:5277–5283.
   PubMedGoogle Scholar
• Krappmann, D., F. G. Wulczyn, and J. Scheidereit 1996. Different mechanisms control signal-induced degradation and basal turnover of the NF-κB inhibitor IκB alpha in vivo. EMBO J. 15:6716–6726.
   PubMed Web of Science ®Google Scholar
• Kundu, M., M. Guermah, R. G. Roeder, S. Amini, and J. Khalili 1997. Interaction between cell cycle regulator, E2F-1, and NF-κB mediates repression of HIV-1 gene transcription. J. Biol. Chem. 272:29468–29474.
   PubMed Web of Science ®Google Scholar
• LaThangue, N. B. 1994. DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control. Trends Biochem. Sci. 19:108–114.
   PubMed Web of Science ®Google Scholar
• Lavoie, J. N., G. L’Allemain, A. Brunet, R. Muller, and J. Pouyssegur 1996. Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway. J. Biol. Chem. 271:20608–20616.
   PubMed Web of Science ®Google Scholar
• Lee, F. S., J. Hagler, Z. J. Chen, and J. Maniatis 1997. Activation of the IκBα kinase complex by MEKK1, a kinase of the JNK pathway. Cell 88:213–222.
   PubMed Web of Science ®Google Scholar
• Li, S., and J. Sedivy 1993. Raf-1 protein kinase activates the NF-κB transcription factor by dissociating the cytoplasmic NF-κB-IκB complex. Proc. Natl. Acad. Sci. USA 90:9247–9251.
   PubMed Web of Science ®Google Scholar
• Lukas, J., J. Bartkova, and J. Bartek 1996. Convergence of mitogenic signalling cascades from diverse classes of receptors at the cyclin D–cyclin-dependent kinase–pRb-controlled G1 checkpoint. Mol. Cell. Biol. 16:6917–6925.
   PubMed Web of Science ®Google Scholar
• Lukas, J., J. Bartkova, M. Rohde, M. Strauss, and J. Bartek 1995. Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity. Mol. Cell. Biol. 15:2600–2611.
   PubMed Web of Science ®Google Scholar
• Marshall, C. J. 1996. Ras effectors. Curr. Opin. Cell Biol. 8:197–204.
   PubMed Web of Science ®Google Scholar
• May, M. J., and J. Ghosh 1997. Rel/NF-κB and IκB proteins: an overview. Semin. Cancer Biol. 8:63–73.
   PubMed Web of Science ®Google Scholar
• Mayo, M. W., C. Y. Wang, P. C. Cogswell, K. S. Rogers Graham, S. W. Lowe, C. J. Der, A. S. Baldwin Jr.. 1997. Requirement of NF-κB activation to suppress p53-independent apoptosis induced by oncogenic Ras. Science 278:1812–1815.
   PubMed Web of Science ®Google Scholar
• Muller, H., J. Lukas, A. Schneider, P. Warthoe, J. Bartek, M. Eilers, and J. Strauss 1994. Cyclin D1 expression is regulated by the retinoblastoma protein. Proc. Natl. Acad. Sci. USA 91:2945–2949.
   PubMed Web of Science ®Google Scholar
• Musgrove, E. A., C. S. L. Lee, M. F. Buckley, and J. Sutherland 1994. Cyclin D1 induction in breast cancer cells shortens G1 and is sufficient for cells arrested in G1 to complete the cell cycle. Proc. Natl. Acad. Sci. USA 91:8022–8026.
   PubMed Web of Science ®Google Scholar
• Naumann, M., F. G. Wulczyn, and J. Scheidereit 1993. The NF-κB precursor p105 and the proto-oncogene product Bcl-3 are IκB molecules and control nuclear translocation of NF-κB. EMBO J. 12:213–222.
   PubMedGoogle Scholar
• Nevins, J. R. 1992. E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science 258:424–429.
   PubMed Web of Science ®Google Scholar
• Peeper, D. S., T. M. Upton, M. H. Ladha, E. Neuman, J. Zalvide, R. Bernards, J. A. DeCaprio, and J. Ewen 1997. Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein. Nature 386:177–181.
   PubMed Web of Science ®Google Scholar
• Perkins, N. D., L. K. Felzien, J. C. Betts, K. Leung, D. H. Beach, and J. Nabel 1997. Regulation of NF-κB by cyclin-dependent kinases associated with the p300 coactivator. Science 275:523–527.
   PubMed Web of Science ®Google Scholar
• Russell, M., C. A. Lange Carter, and J. Johnson 1995. Direct interaction between Ras and the kinase domain of mitogen-activated protein kinase kinase kinase (MEKK1). J. Biol. Chem. 270:11757–11760.
   PubMed Web of Science ®Google Scholar
• Schouten, G. J., A. C. Vertegaal, S. T. Whiteside, A. Israel, M. Toebes, J. C. Dorsman, A. J. van der Eb, and J. Zantema 1997. IκBα is a target for the mitogen-activated 90 kDa ribosomal S6 kinase. EMBO J. 16:3133–3144.
   PubMedGoogle Scholar
• Sherr, C. J. 1993. Mammalian G1 cyclins. Cell 73:1059–1065.
   PubMed Web of Science ®Google Scholar
• Sherr, C. J. 1996. Cancer cell cycles. Science 274:1672–1677.
   PubMed Web of Science ®Google Scholar
• Sherr, C. J., and J. Roberts 1995. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 9:1149–1163.
   PubMed Web of Science ®Google Scholar
• Siebenlist, U., G. Franzoso, and J. Brown 1994. Structure, regulation and function of NF-κB. Annu. Rev. Cell Biol. 10:405–455.
   PubMedGoogle Scholar
• Sovak, M. A., R. E. Bellas, D. W. Kim, G. J. Zanieski, A. E. Rogers, A. M. Traish, and J. Sonenshein 1997. Aberrant nuclear factor-κB/Rel expression and the pathogenesis of breast cancer. J. Clin. Invest. 100:2952–2960.
   PubMed Web of Science ®Google Scholar
• Verma, I. M., J. K. Stevenson, E. M. Schwarz, D. Van Antwerp, and J. Miyamoto 1995. Rel/NF-κB/IκB family: intimate tales of association and dissociation. Genes Dev. 9:2723–2735.
   PubMed Web of Science ®Google Scholar
• Watanabe, G., C. Albanese, J. Lee, A. Reutens, G. Vario, B. Henglein, and J. Pestell 1998. Inhibition of cyclin D1 kinase activity is associated with E2F-mediated inhibition of cyclin D1 promoter activity through E2F and Sp1. Mol. Cell. Biol. 18:3212–3222.
   PubMed Web of Science ®Google Scholar
• Weinberg, R. A. 1995. The retinoblastoma protein and cell cycle control. Cell 81:323–330.
   PubMed Web of Science ®Google Scholar
• Wu, M., H. Lee, R. E. Bellas, S. L. Schauer, M. Arsura, D. Katz, M. J. FitzGerald, T. L. Rothstein, D. H. Sherr, and J. Sonenshein 1996. Inhibition of NF-κB/Rel induces apoptosis of murine B cells. EMBO J. 15:4682–4690.
   PubMed Web of Science ®Google Scholar
• Wulczyn, F. G., D. Krappmann, and J. Scheidereit 1996. The NF-κB/Rel and IκB gene families: mediators of immune response and inflammation. J. Mol. Med. 74:749–769.
   PubMed Web of Science ®Google Scholar
• Yamada, Y., I. Kirillova, J. J. Peschon, and J. Fausto 1997. Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor. Proc. Natl. Acad. Sci. USA 94:1441–1446.
   PubMed Web of Science ®Google Scholar
• Zhong, H., H. SuYang, H. Erdjument Bromage, P. Tempst, and J. Ghosh 1997. The transcriptional activity of NF-κB is regulated by the IκB-associated PKAc subunit through a cyclic AMP-independent mechanism. Cell 89:413–424.
   PubMed Web of Science ®Google Scholar
• Zhong, H., R. E. Voll, and J. Ghosh 1998. Phosphorylation of NF-κB p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. Mol. Cell 1:661–672.
   PubMed Web of Science ®Google Scholar