FKLF, a Novel Krüppel-Like Factor That Activates Human Embryonic and Fetal β-Like Globin Genes

REFERENCES

• Anderson, K. P., C. B. Kern, S. C. Crable, and J. Lingrel 1995. Isolation of a gene encoding a functional zinc finger protein homologous to erythroid Krüppel-like factor: identification of a new multigene family. Mol. Cell. Biol. 15:5957–5965.
   PubMed Web of Science ®Google Scholar
• Asano, H., and J. Stamatoyannopoulos 1998. Activation of β-globin promoter by erythroid Krüppel-like factor. Mol. Cell. Biol. 18:102–109.
   PubMed Web of Science ®Google Scholar
• Ausubel F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, K. Struhl 1994. Current protocols in molecular biology. John Wiley & Sons, Inc., New York, N.Y.
   Google Scholar
• Berg, J. M. 1992. Sp1 and the subfamily of zinc finger proteins with guanine-rich binding sites. Proc. Natl. Acad. Sci. USA 89:11109–11110.
   PubMedGoogle Scholar
• Bieker, J. J. 1995. Role of erythroid Krüppel-like factor (EKLF) in erythroid-specific transcription, p. 231–241. In G. Stamatoyannopoulos (ed.), Molecular biology of hemoglobin switching. Intercept, Andover, United Kingdom.
   Google Scholar
• Catala, F., E. deBoer, G. Habets, and J. Grosveld 1989. Nuclear protein factors and erythroid transcription of the human Aγ-globin gene. Nucleic Acids Res. 17:3811–3827.
   PubMedGoogle Scholar
• Crossley, M., E. Whitelaw, A. Perkins, G. Williams, Y. Fujiwara, and J. Orkin 1996. Isolation and characterization of the cDNA encoding BKLF/TEF-2, a major CACCC-box-binding protein in erythroid cells and selected other cells. Mol. Cell. Biol. 16:1695–1705.
   PubMed Web of Science ®Google Scholar
• Donze, D., T. M. Townes, and J. Bieker 1995. Role of erythroid Kruppel-like factor in human γ- to β-globin gene switching. J. Biol. Chem. 270:1955–1959.
   PubMed Web of Science ®Google Scholar
• Evans, T., G. Felsenfeld, and J. Reitman 1990. Control of globin gene transcription. Annu. Rev. Cell Biol. 6:95–124.
   PubMedGoogle Scholar
• Frohman, M. A., M. K. Dush, and J. Martin 1988. Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. Proc. Natl. Acad. Sci. USA 85:8998–9002.
   PubMed Web of Science ®Google Scholar
• Garrett-Sinha, L. A., H. Eberspaecher, M. F. Seldin, and J. de Crombrugghe 1996. A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells. J. Biol. Chem. 271:31384–31390.
   PubMed Web of Science ®Google Scholar
• Giniger, E., and J. Ptashne 1987. Transcription in yeast activated by a putative amphipathic α helix linked to a DNA binding unit. Nature (London) 330:670–672.
   PubMedGoogle Scholar
• Gumucio, D. L., K. L. Rood, K. L. Blanchard-McQuate, T. A. Gray, A. Saulino, and J. Collins 1991. Interaction of Sp1 with the human γ globin promoter: binding and transactivation of normal and mutant promoters. Blood 78:1853–1863.
   PubMed Web of Science ®Google Scholar
• Hagen, G., S. Müller, M. Beato, and J. Suske 1992. Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes. Nucleic Acids Res. 21:5519–5525.
   Google Scholar
• Hartzog, G. A., and J. Myers 1993. Discrimination among potential activators of the β-globin CACCC element by correlation of binding and transcriptional properties. Mol. Cell. Biol. 13:44–56.
   PubMedGoogle Scholar
• Ikuta, T., T. Papayannopoulou, G. Stamatoyannopoulos, and J. Kan 1996. Globin gene switching. In vivo protein-DNA interactions of the human β-globin locus in erythroid cells expressing the fetal or the adult globin gene program. J. Biol. Chem. 271:14082–14091.
   PubMedGoogle Scholar
• Imataka, H., K. Sogawa, K. Yasumoto, Y. Kikuchi, K. Sasano, A. Kobayashi, M. Hayami, and J. Fujii-Kuriyama 1992. Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P-4501A1 gene. EMBO J. 11:3663–3671.
   PubMed Web of Science ®Google Scholar
• Kadonaga, J. T., K. R. Carner, F. Masiarz, and J. Tjian 1987. Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain. Cell 51:1079–1090.
   PubMed Web of Science ®Google Scholar
• Kingsley, C., and J. Winoto 1992. Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression. Mol. Cell. Biol. 12:4251–4261.
   PubMedGoogle Scholar
• Kulozik, A. E., A. Bellan-Koch, S. Bail, E. Kohne, and J. Kleihauer 1991. Thalassemia intermedia: moderate reduction of β globin gene transcriptional activity by a novel mutation of the proximal CACCC promoter element. Blood 77:2054–2058.
   PubMed Web of Science ®Google Scholar
• Lin, H. J., C. Y. Han, and J. Nienhuis 1992. Functional profile of the human fetal γ-globin gene upstream promoter region. Am. J. Hum. Genet. 51:363–370.
   PubMedGoogle Scholar
• Marin, M., A. Karis, P. Visser, F. Grosveld, and J. Philipsen 1997. Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation. Cell 89:619–628.
   PubMed Web of Science ®Google Scholar
• Mignotte, V., J. F. Eleouet, N. Raich, and J. Romeo 1989. Cis- and trans-acting elements involved in the regulation of the erythroid promoter of the human porphobilinogen deaminase gene. Proc. Natl. Acad. Sci. USA 86:6548–6552.
   PubMed Web of Science ®Google Scholar
• Miller, I. J., and J. Bieker 1993. A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krüppel family of nuclear proteins. Mol. Cell. Biol. 13:2776–2786.
   PubMed Web of Science ®Google Scholar
• Mitchell, P. J., and J. Tjian 1989. Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. Science 245:371–378.
   PubMed Web of Science ®Google Scholar
• Nuez, B., D. Michalovich, A. Bygrave, R. Ploemacher, and J. Grosveld 1995. Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene. Nature (London) 375:316–318.
   PubMed Web of Science ®Google Scholar
• Orkin, S. H. 1995. Transcriptional factors and hematopoietic development. J. Biol. Chem. 270:4955–4958.
   PubMed Web of Science ®Google Scholar
• Orkin, S. H., S. E. Antonarakis, H. H. Kazazian Jr.. 1984. Base substitution at position −88 in a β-thalassemic globin gene. Further evidence for the role of distal promoter element ACACCC. J. Biol. Chem. 259:8679–8681.
   PubMed Web of Science ®Google Scholar
• Orkin, S. H., H. H. Kazazian Jr., S. E. Antonarakis, S. C. Goff, C. D. Boehm, J. P. Sexton, P. G. Waber, and J. Giardina 1982. Linkage of β-thalassemia mutations and β-globin gene polymorphisms with DNA polymorphisms in human β-globin gene cluster. Nature (London) 296:627–631.
   PubMed Web of Science ®Google Scholar
• Pellegrino, G. R., and J. Berg 1991. Identification and characterization of “zinc-finger” domains by the polymerase chain reaction. Proc. Natl. Acad. Sci. USA 88:671–675.
   PubMedGoogle Scholar
• Perkins, A. C., K. M. L. Gaensler, and J. Orkin 1996. Silencing of human fetal globin expression is impaired in the absence of the adult β-globin gene activator protein EKLF. Proc. Natl. Acad. Sci. USA 93:12267–12271.
   PubMedGoogle Scholar
• Perkins, A. C., A. H. Sharpe, and J. Orkin 1995. Lethal β-thalassemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature (London) 375:318–322.
   PubMed Web of Science ®Google Scholar
• Ptashne, M., and J. Gann 1997. Transcriptional activation by recruitment. Nature (London) 386:569–577.
   PubMed Web of Science ®Google Scholar
• Rahuel, C., M.-A. Vinit, V. Lemarchandel, J.-P. Cartron, and J. Roméo 1992. Erythroid-specific activity of the glycophorin B promoter requires GATA-1 mediated displacement of a repressor. EMBO J. 11:4095–4102.
   PubMedGoogle Scholar
• Sambrook, J., E. F. Fritsch, T. Maniatis 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
   Google Scholar
• Shields, J. M., R. J. Christy, and J. Yang 1996. Identification and characterization of a gene encoding a gut-enriched Krüppel-like factor expressed during growth arrest. J. Biol. Chem. 271:20009–20017.
   PubMed Web of Science ®Google Scholar
• Sogawa, K., H. Imataka, Y. Yamasaki, H. Kusume, H. Abe, and J. Fujii-Kuriyama 1993. cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2. Nucleic Acids Res. 7:1527–1532.
   Google Scholar
• Stamatoyannopoulos, G., B. Josephson, J.-W. Zhang, and J. Li 1993. Developmental regulation of human γ-globin genes in transgenic mice. Mol. Cell. Biol. 13:7636–7644.
   PubMed Web of Science ®Google Scholar
• Stamatoyannopoulos, G., A. W. Nienhuis 1993. Hemoglobin switching, p. 107–154. In G. Stamatoyannopoulos, A. W. Nienhuis, P. Majerus, H. Varmus (ed.), The molecular basis of blood diseases. W. B. Saunders, Philadelphia, Pa.
   Google Scholar
• Stargell, L. A., and J. Struhl 1996. Mechanisms of transcriptional activation in vivo: two steps forward. Trends Genet. 12:311–315.
   PubMedGoogle Scholar
• Subramaniam, M., S. A. Harris, M. J. Oursler, K. Rasmussen, B. L. Riggs, and J. Spelsberg 1995. Identification of a novel TGF-β-regulated gene encoding a putative zinc finger protein in human osteoblasts. Nucleic Acids Res. 23:4907–4912.
   PubMed Web of Science ®Google Scholar
• Surinya, K. H., T. C. Cox, and J. May 1997. Transcriptional regulation of the human erythroid 5-aminolevulinate synthase gene. J. Biol. Chem. 272:26585–26594.
   PubMed Web of Science ®Google Scholar
• Troutt, A. B., M. G. McHeyzer-Williams, B. Pulendran, and J. Nossal 1992. Ligation-anchored PCR: a simple amplification technique with single-sided specificity. Proc. Natl. Acad. Sci. USA 89:9823–9825.
   PubMed Web of Science ®Google Scholar
• Tugores, A., S. T. Magness, and J. Brenner 1994. A single promoter directs both housekeeping and erythroid preferential expression of the human ferrochelatase gene. J. Biol. Chem. 269:30789–30797.
   PubMedGoogle Scholar
• Ulrich, M. J., and J. Ley 1990. Function of normal and mutated γ-globin gene promoters in electroporated K562 erythroleukemia cells. Blood 75:990–999.
   PubMedGoogle Scholar
• Wijgerde, M., J. Gribnau, T. Trimborn, B. Nuez, S. Philipsen, F. Grosveld, and J. Fraser 1996. The role of EKLF in human β-globin gene competition. Genes Dev. 10:2894–2902.
   PubMed Web of Science ®Google Scholar
• Yu, C.-Y., K. Motamed, J. Chen, A. D. Bailey, and J. Shen 1991. The CACC box upstream of human embryonic ɛ globin gene binds Sp1 and is a functional promoter element in vitro and in vivo. J. Biol. Chem. 266:8907–8915.
   PubMedGoogle Scholar
• Zon, L. I., and J. Orkin 1992. Sequence of the human GATA-1 promoter. Nucleic Acids Res. 20:1812.
   PubMedGoogle Scholar