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Cell Growth and Development

Expression of the p56lck Y505F Mutation in CD45-Deficient Mice Rescues Thymocyte Development

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Pages 4200-4208 | Received 19 Jan 1999, Accepted 23 Mar 1999, Published online: 27 Mar 2023

REFERENCES

  • Abraham, K. M., S. D. Levin, J. D. Marth, K. A. Forbush, and J. Perlmutter 1991. Delayed thymocyte development induced by augmented expression of p56lck. J. Exp. Med. 173:1421–1432.
  • Abraham, K. M., S. D. Levin, J. D. Marth, K. A. Forbush, and J. Perlmutter 1991. Thymic tumorigenesis induced by overexpression of p56lck. Proc. Natl. Acad. Sci. USA 88:3977–3981.
  • Abraham, N., M. C. Miceli, J. R. Parnes, and J. Veillette 1991. Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine kinase p56lck. Nature 350:62–66.
  • Abraham, N., and J. Veillette 1990. Activation of p56lck through mutation of a regulatory carboxy-terminal tyrosine residue requires intact sites of autophosphorylation and myristylation. Mol. Cell. Biol. 10:5197–5206.
  • Amrein, K. E., and J. Sefton 1988. Mutation of a site of tyrosine phosphorylation in the lymphocyte-specific tyrosine protein kinase, p56lck, reveals its oncogenic potential in fibroblasts. Proc. Natl. Acad. Sci. USA 85:4247–4251.
  • Anderson, S. J., K. M. Abraham, T. Nakayama, A. Singer, and J. Perlmutter 1992. Inhibition of T-cell receptor β-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck. EMBO J. 11:4877–4886.
  • Anderson, S. J., S. D. Levin, and J. Perlmutter 1993. Protein tyrosine kinase p56lck controls allelic exclusion of T-cell receptor β-chain genes. Nature 365:552–554.
  • Burns, C. M., K. Sakaguchi, E. Appella, and J. Ashwell 1994. CD45 regulation of tyrosine phosphorylation and enzyme activity of src-family kinases. J. Biol. Chem. 269:13594–13600.
  • Byth, K. F., L. A. Conroy, S. Howlett, A. J. H. Smith, J. May, D. R. Alexander, and J. Holmes 1996. CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+ CD8+ thymocytes, and in B cell maturation. J. Exp. Med. 183:1707–1718.
  • Cahir McFarland, E. D., T. R. Hurley, J. T. Pingel, B. M. Sefton, A. Shaw, and J. Thomas 1993. Correlation between Src-family member regulation by the protein tyrosine phosphatase, CD45, and transmembrane signaling through the T-cell receptor. Proc. Natl. Acad. Sci. USA 90:1402–1406.
  • D’Oro, U., and J. Ashwell 1999. The CD45 tyrosine phosphatase is an inhibitor of Lck activity in thymocytes. J. Immunol. 162:1879–1883.
  • D’Oro, U., K. Sakaguchi, E. Appella, and J. Ashwell 1996. Mutational analysis of Lck in CD45-negative T cells: dominant role of tyrosine 394 phosphorylation in kinase activity. Mol. Cell. Biol. 16:4996–5003.
  • D’Oro, U., M. S. Vacchio, A. M. Weissman, and J. Ashwell 1997. Activation of the Lck tyrosine kinase targets cell surface T cell antigen receptors for lysosomal degradation. Immunity 7:619–628.
  • Hurley, T. R., R. Hyman, and J. Sefton 1993. Differential effects of expression of the CD45 tyrosine protein phosphatase on the tyrosine phosphorylation of the lck, fyn, and c-src tyrosine protein kinases. Mol. Cell. Biol. 13:1651–1656.
  • Kishihara, K., J. Penninger, V. A. Wallace, T. M. Kundig, K. Kawai, A. Wakeham, E. Timms, K. Pfeffer, P. S. Ohashi, M. L. Thomas, C. Furlonger, C. J. Paige, and J. Mak 1993. Normal B lymphocyte development but impaired T cell maturation in CD45-exon 6 protein tyrosine phosphatase-deficient mice. Cell 74:143–156.
  • Koretzky, G. A., J. Picus, T. Schultz, and J. Weiss 1991. Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production. Proc. Natl. Acad. Sci. USA 88:2037–2041.
  • Koretzky, G. A., J. Picus, M. L. Thomas, and J. Weiss 1990. Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway. Nature 346:66–68.
  • Levin, S. D., K. M. Abraham, S. J. Anderson, K. A. Forbush, and J. Perlmutter 1993. The protein tyrosine p56lck regulates thymocyte development independently of its interaction with CD4 and CD8 coreceptors. J. Exp. Med. 178:245–255.
  • Levin, S. D., S. J. Anderson, K. A. Forbush, and J. Perlmutter 1993. A dominant-negative transgene defines a role for p56lck in thymopoiesis. EMBO J. 12:1671–1680.
  • Liu, X., S. R. Brodeur, G. Gish, Z. Songyang, L. C. Cantley, A. P. Laudano, and J. Pawson 1993. Regulation of c-Src tyrosine kinase activity by the Src SH2 domain. Oncogene 8:1119–1126.
  • Loh, D. Y., W. C. Sha, C. A. Nelson, R. D. Newberry, D. M. Kranz, and J. Russell 1989. Positive and negative selection of T lymphocytes. Cold Spring Harbor Symp. Quant. Biol. 54:147–151.
  • Marth, J. D., D. B. Lewis, C. B. Wilson, M. E. Gearn, E. G. Krebs, and J. Perlmutter 1987. Regulation of pp56lck during T cell activation: functional implications for the src-like protein tyrosine kinases. EMBO J. 6:2727–2734.
  • Moarefi, I., M. LaFevre-Bernt, F. Sicheri, M. Huse, C. H. Lee, J. Kuriyan, and J. Miller 1997. Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement. Nature 385:650–653.
  • Molina, T. J., K. Kishihara, D. P. Siderorski, W. van Ewijk, A. Narendran, E. Timms, A. Wakeham, C. J. Paige, K.-U. Hartmann, A. Veillette, D. Davidson, and J. Mak 1992. Profound block in thymocyte development in mice lacking p56lck. Nature 357:161–164.
  • Murphy, K. M., A. B. Heimberger, and J. Loh 1990. Induction by antigen of intrathymic apoptosis of CD4+ CD8+ TCRlo thymocytes in vivo. Science 250:1720–1723.
  • Mustelin, T., K. M. Coggeshall, and J. Altman 1989. Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase. Proc. Natl. Acad. Sci. USA 86:6302–6306.
  • Ostergaard, H. L., D. A. Schackelford, T. R. Hurley, P. Johnson, R. Hyman, B. M. Sefton, and J. Trowbridge 1989. Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines. Proc. Natl. Acad. Sci. USA 86:8959–8963.
  • Ostergaard, H. L., and J. Trowbridge 1990. Coclustering CD45 with CD4 or CD8 alters the phosphorylation and kinase activity of p56lck. J. Exp. Med. 172:347–350.
  • Penninger, J., V. Wallace, K. Kishihara, and J. Mak 1993. The role of p56lck and p59fyn tyrosine kinases and CD45 protein tyrosine phosphatase in T-cell development and clonal selection. Immunol. Rev. 135:183–214.
  • Perlmutter, R. M., S. D. Levin, M. W. Appleby, S. J. Anderson, and J. Alberola-Ila 1993. Regulation of lymphocyte function by protein phosphorylation. Annu. Rev. Immunol. 11:451–499.
  • Pingel, J. T., and J. Thomas 1989. Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation. Cell 58:1055–1065.
  • Roach, T. I. A., S. E. Slater, M. Koval, L. White, E. D. Cahir McFarland, M. Okumura, M. L. Thomas, and J. Brown 1997. CD45 regulates Src-family member kinase activity associated with macrophage integrin-mediated adhesion. Curr. Biol. 7:408–417.
  • Shiroo, M., L. Goff, M. Biffen, E. Shivnan, and J. Alexander 1992. CD45 tyrosine phosphatase-activated p59fyn couples the T cell antigen receptor to pathways of diacylglycerol production, protein kinase C activation and calcium influx. EMBO J. 11:4887–4897.
  • Sieh, M., J. B. Bolen, and J. Weiss 1993. CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck. EMBO J. 12:315–321.
  • Stone, J. D., L. A. Conroy, K. F. Byth, R. A. Hederer, S. Howlett, Y. Takemoto, N. Holmes, and J. Alexander 1997. Aberrant TCR-mediated signaling in CD45-null thymocytes involves dysfunctional regulation of Lck, Fyn, TCR-ζ, and ZAP-70. J. Immunol. 158:5773–5782.
  • Straus, D. B., and J. Weiss 1992. Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor. Cell 70:585–593.
  • Thomas, M. L., and E. J. Brown. Positive and negative regulation of Src-family kinases by the protein tyrosine phosphatase CD45. Immunol. Today, in press.
  • Trowbridge, I. S., and J. Thomas 1994. CD45: an emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development. Annu. Rev. Immunol. 12:85–116.
  • Weiss, A., and J. Littman 1994. Signal transduction by lymphocyte antigen receptors. Cell 76:263–274.
  • Yanagi, S., H. Sugawara, M. Kurosaki, H. Sabe, H. Yamamura, and J. Kurosaki 1996. CD45 modulates phosphorylation of both autophosphorylation and negative regulatory tyrosines of Lyn in B cells. J. Biol. Chem. 271:30487–30492.

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