Evidence that Tristetraprolin Binds to AU-Rich Elements and Promotes the Deadenylation and Destabilization of Tumor Necrosis Factor Alpha mRNA

REFERENCES

• Akashi, M., G. Shaw, M. Gross, M. Saito, and J. Koeffler 1991. Role of AUUUA sequences in stabilization of granulocyte-macrophage colony-stimulating factor RNA in stimulated cells. Blood 78:2005–2012.
   PubMed Web of Science ®Google Scholar
• Blackshear, P. J. 1984. Systems for polyacrylamide gel electrophoresis. Methods Enzymol. 104:237–255.
   PubMed Web of Science ®Google Scholar
• Bohjanen, P. R., B. Petryniak, C. H. June, C. B. Thompson, and J. Lindsten 1991. An inducible cytoplasmic factor (AU-B) binds selectively to AUUUA multimers in the 3′ untranslated region of lymphokine mRNA. Mol. Cell. Biol. 11:3288–3295.
   PubMed Web of Science ®Google Scholar
• Bohjanen, P. R., B. Petryniak, C. H. June, C. B. Thompson, and J. Lindsten 1992. AU RNA-binding factors differ in their binding specificities and affinities. J. Biol. Chem. 267:6302–6309.
   PubMed Web of Science ®Google Scholar
• Caput, D., B. Beutler, K. Hartog, R. Thayer, S. Brown-Shimer, and J. Cerami 1986. Identification of a common nucleotide sequence in the 3′-untranslated region of mRNA molecules specifying inflammatory mediators. Proc. Natl. Acad. Sci. USA 83:1670–1674.
   PubMed Web of Science ®Google Scholar
• Carballo, E., G. S. Gilkeson, and J. Blackshear 1997. Bone marrow transplantation reproduces the tristetraprolin-deficiency syndrome in recombination activating gene-2 (−/−) mice. J. Clin. Investig. 100:986–995.
   PubMed Web of Science ®Google Scholar
• Carballo, E., W. S. Lai, and J. Blackshear 1998. Feedback inhibition of macrophage tumor necrosis factor α (TNFα) production by tristetraprolin (TTP). Science 281:1001–1005.
   PubMed Web of Science ®Google Scholar
• Chen, C.-Y. A., and J. Shyu 1995. AU-rich elements: characterization and importance in mRNA degradation. Trends Biochem. Sci. 20:465–470.
   PubMed Web of Science ®Google Scholar
• Cheng, J., K. Tursken, Q.-C. Yu, H. Schreiber, and J. Teng 1992. Cachexia and graft-vs.-host-disease-type skin changes in keratin promoter-driven TNFα transgenic mice. Genes Dev. 6:1444–1456.
   PubMed Web of Science ®Google Scholar
• De, J., W. S. Lai, J. Thorn, X. Liu, T. K. Blackwell, and J. Blackshear 1999. Identification of four CCCH zinc finger proteins in Xenopus, including a novel vertebrate protein with four zinc fingers and severely restricted expression. Gene 228:133–145.
   PubMedGoogle Scholar
• DuBois, R. N., N. W. McLane, K. Ryder, L. F. Lau, and J. Nathans 1990. Growth factor-inducible nuclear protein with a novel cysteine/histidine repetitive sequence. J. Biol. Chem. 265:19185–19191.
   PubMedGoogle Scholar
• Flach, J., M. Bossie, J. Vogel, A. Corbett, T. Jinks, D. A. Willins, and J. Silver 1994. A yeast RNA-binding protein shuttles between the nucleus and the cytoplasm. Mol. Cell. Biol. 50:1–12.
   Google Scholar
• Gomperts, M., J. C. Pascall, and J. Brown 1990. The nucleotide sequence of an EGF-inducible gene indicates the existence of a new family of mitogen-inducible genes. Oncogene 5:1081–1083.
   PubMed Web of Science ®Google Scholar
• Gueydan, C., L. Houetz, A. Marchant, A. Sels, G. Huez, and J. Kruys 1996. Engagement of tumor necrosis factor mRNA by an endotoxin-inducible cytoplasmic protein. Mol. Med. 2:479–488.
   PubMed Web of Science ®Google Scholar
• Hel, Z., E. Skamene, and J. Radzioch 1996. Two distinct regions in the 3′ untranslated region of tumor necrosis factor alpha mRNA form complexes with macrophage proteins. Mol. Cell. Biol. 16:5579–5590.
   PubMed Web of Science ®Google Scholar
• Hel, Z., S. Di Marco, and J. Radzioch 1998. Characterization of the RNA binding proteins forming complexes with a novel putative regulatory region in the 3′-UTR of TNF-α mRNA. Nucleic Acids Res. 26:2803–2812.
   PubMedGoogle Scholar
• Heximer, S. P., and J. Forsdyke 1993. A human putative lymphocyte G0/G1 switch gene homologous to a rodent gene encoding a zinc-binding potential transcription factor. DNA Cell Biol. 12:73–88.
   PubMed Web of Science ®Google Scholar
• Katz, D. A., N. G. Theodorakis, D. W. Cleveland, T. Lindsten, and J. Thompson 1994. AU-A, an RNA-binding activity distinct from hnRNP A1, is selective for AUUUA repeats and shuttles between the nucleus and the cytoplasm. Nucleic Acids Res. 22:238–246.
   PubMedGoogle Scholar
• Keffer, J., L. Probert, H. Cazlaris, S. Georgopoulos, E. Kaslaris, D. Kioussis, and J. Kollias 1991. Transgenic mice expressing tumor necrosis factor: a predictive genetic model of arthritis. EMBO J. 10:4025–4031.
   PubMed Web of Science ®Google Scholar
• Kim, Y.-U., H. G. Rus, S. N. Fisher, P. M. Pitha, and J. Shin 1996. Binding of a protein to an AU-rich domain of tumor necrosis factor α mRNA as a 35 kDa complex and its regulation in primary rat astrocytes. Biochem. J. 316:455–460.
   PubMedGoogle Scholar
• Kolodziej, P. A., and J. Young 1991. Epitope tagging and protein surveillance. Methods Enzymol. 194:508–519.
   PubMed Web of Science ®Google Scholar
• Lai, W. S., D. J. Stumpo, and J. Blackshear 1990. Rapid insulin-stimulated accumulation of an mRNA encoding a proline-rich protein. J. Biol. Chem. 265:16556–16563.
   PubMed Web of Science ®Google Scholar
• Lai, W. S., M. J. Thompson, G. A. Taylor, Y. Liu, and J. Blackshear 1995. Promoter analysis of Zfp-36, the mitogen-inducible gene encoding the zinc finger protein tristetraprolin. J. Biol. Chem. 270:25266–25272.
   PubMedGoogle Scholar
• Lai, W. S., M. J. Thompson, and J. Blackshear 1998. Characteristics of the intron involvement in the mitogen-induced expression of Zfp-36. J. Biol. Chem. 273:506–517.
   PubMedGoogle Scholar
• Lai, W. S., and P. J. Blackshear. Unpublished data.
   Google Scholar
• Lewis, T., C. Gueydan, G. Huez, J.-J. Toulme, and J. Kruys 1998. Mapping of a minimal AU-rich sequence required for lipopolysaccharide-induced binding of a 55-kDa protein on tumor necrosis factor-α mRNA. J. Biol. Chem. 273:13781–13786.
   PubMedGoogle Scholar
• Ma, Q., and J. Herschman 1991. A corrected sequence for the predicted protein from the mitogen-inducible TIS11 primary response gene. Oncogene 6:1277–1278.
   PubMedGoogle Scholar
• Ma, Q., D. Wadleigh, T. Chi, and J. Herschman 1994. The Drosophila TIS11 homologue encodes a developmentally regulated gene. Oncogene 9:3329–3334.
   PubMedGoogle Scholar
• Ma, Q., and J. Herschman 1995. The yeast homologue YTIS11, of the mammalian TIS11 gene family is a non-essential, glucose repressible gene. Oncogene 10:487–494.
   PubMedGoogle Scholar
• Mello, C. C., C. Schubert, B. Draper, W. Zhang, R. Lobel, and J. Priess 1996. The PIE-1 protein and germline specification in C. elegans embryos. Nature 382:710–712.
   PubMed Web of Science ®Google Scholar
• Mercer, J. F. B., and J. Wake 1985. An analysis of the rate of metallothionein mRNA poly(A)-shortening using RNA blot hybridization. Nucleic Acids Res. 13:7929–7943.
   PubMed Web of Science ®Google Scholar
• Montague, J., and P. J. Blackshear. Unpublished data.
   Google Scholar
• Muller, W. E., H. Slor, K. Pfeifer, P. Huhn, A. Bek, S. Orsulic, H. Ushijima, and J. Schroder 1992. Association of AUUUA-binding protein with A+U-rich mRNA during nucleo-cytoplasmic transport. J. Mol. Biol. 226:721–733.
   PubMedGoogle Scholar
• Natesan, S., V. M. Rivera, E. Molinari, and J. Gilman 1997. Transcriptional squelching re-examined. Nature 390:349–350.
   PubMedGoogle Scholar
• Nie, X. F., K. N. Maclean, V. Kumar, I. A. McKay, and J. Bustin 1995. ERF-2, the human homologue of the murine Tis11d early response gene. Gene 152:285–286.
   PubMedGoogle Scholar
• Otsuka, T., A. Miyajima, N. Brown, K. Otsu, J. S. Abrams, S. Saeland, C. Caux, R. D. W. Malefijt, J. DeVries, P. Meyerson, T. Yokota, L. Gemmel, D. Rennick, F. Lee, K.-I. Arai, and J. Yokota 1988. Isolation and characterization of an expressible cDNA encoding human IL-3. Induction of IL-3 mRNA in human T cell clones. J. Immunol. 140:2288–2295.
   PubMed Web of Science ®Google Scholar
• Peng, S. S.-Y., C.-Y. A. Chen, and J. Shyu 1996. Functional characterization of a non-AUUUA AU-rich element from the c-jun proto-oncogene mRNA: evidence for a novel class of AU-rich elements. Mol. Cell. Biol. 16:1490–1499.
   PubMed Web of Science ®Google Scholar
• Phillips, R. S., and P. J. Blackshear. Unpublished data.
   Google Scholar
• Rizzuto, R., M. Brini, P. Pizzo, M. Murgia, and J. Pozzan 1995. Chimeric green fluorescent protein as a tool for visualizing subcellular organelles in living cells. Curr. Biol. 5:635–642.
   PubMed Web of Science ®Google Scholar
• Seydoux, G., C. C. Mello, J. Pettitt, W. B. Wood, J. R. Priess, and J. Fire 1996. Repression of gene expression in the embryonic germ lineage of C. elegans. Nature 382:713–716.
   PubMed Web of Science ®Google Scholar
• Shaw, G., and J. Kamen 1986. A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 46:659–667.
   PubMed Web of Science ®Google Scholar
• Stoecklin, G., S. Hahn, and J. Moroni 1994. Functional hierarchy of AUUUA motifs in mediating rapid interleukin-3 mRNA decay. J. Biol. Chem. 269:28591–28597.
   PubMed Web of Science ®Google Scholar
• Taylor, G. A., W. S. Lai, R. J. Oakey, M. F. Seldin, T. B. Shows, R. L. Eddy Jr., and J. Blackshear 1991. The human TTP protein: sequence, alignment with related proteins, and chromosomal localization of the mouse and human genes. Nucleic Acids Res. 19:3454.
   PubMed Web of Science ®Google Scholar
• Taylor, G. A., M. J. Thompson, W. S. Lai, and J. Blackshear 1995. Phosphorylation of tristetraprolin, a potential zinc finger transcription factor, by mitogen stimulation in intact cells and by mitogen activated protein kinase in vitro. J. Biol. Chem. 270:13341–13347.
   PubMed Web of Science ®Google Scholar
• Taylor, G. A., M. J. Thompson, W. S. Lai, and J. Blackshear 1996. Mitogens stimulate the rapid nuclear to cytosolic translocation of tristetraprolin, a potential zinc-finger transcription factor. Mol. Endocrinol. 10:140–146.
   PubMed Web of Science ®Google Scholar
• Taylor, G. A., E. Carballo, D. M. Lee, W. S. Lai, M. J. Thompson, D. D. Patel, D. I. Schenkman, G. S. Gilkeson, H. E. Broxmeyer, B. F. Haynes, and J. Blackshear 1996. A pathogenetic role for TNFα in the syndrome of cachexia, arthritis and autoimmunity resulting from tristetraprolin (TTP) deficiency. Immunity 4:445–454.
   PubMed Web of Science ®Google Scholar
• Thompson, M. J., W. S. Lai, G. A. Taylor, and J. Blackshear 1996. Cloning and characterization of two yeast genes encoding members of the CCCH class of zinc finger proteins: zinc finger-mediated impairment of cell growth. Gene 174:225–233.
   PubMedGoogle Scholar
• Ulich, T. R., S. S. Shin, and J. del Castillo 1993. Haematologic effects of TNF. Res. Immunol. 144:347–354.
   PubMedGoogle Scholar
• Varnum, B. C., R. W. Lim, V. P. Sukhatme, and J. Herschman 1989. Nucleotide sequence of a cDNA encoding TIS11, a message induced in Swiss 3T3 cells by the tumor promoter tetradecanoyl phorbol acetate. Oncogene 4:119–120.
   PubMed Web of Science ®Google Scholar
• Varnum, B. C., Q. Ma, T. Chi, B. Fletcher, and J. Herschman 1991. The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeat. Mol. Cell. Biol. 11:1754–1758.
   PubMed Web of Science ®Google Scholar
• Wang, E., W. J. Ma, C. Aghajanian, and J. Spriggs 1997. Posttranscriptional regulation of protein expression in human epithelial carcinoma cells by adenine-uridine-rich elements in the 3′-untranslated region of tumor necrosis factor-alpha messenger RNA. Cancer Res. 57:5426–5433.
   PubMedGoogle Scholar
• Worthington, M. T., B. T. Amann, D. Nathans, and J. Berg 1996. Metal binding properties and secondary structure of the zinc-binding domain of Nup475. Proc. Natl. Acad. Sci. USA 93:13754–13759.
   PubMedGoogle Scholar
• Xu, N., C.-Y. Chen, and J. Shyu 1997. Modulation of the fate of cytoplasmic mRNA by AU-rich elements: key sequence features controlling mRNA deadenylation and decay. Mol. Cell. Biol. 17:4611–4621.
   PubMed Web of Science ®Google Scholar