Assembly of the α-Globin mRNA Stability Complex Reflects Binary Interaction between the Pyrimidine-Rich 3′ Untranslated Region Determinant and Poly(C) Binding Protein αCP

REFERENCES

• Aasheim, H. C., T. Loukianova, A. Deggerdal, and J. Smeland 1994. Tissue specific expression and cDNA structure of a human transcript encoding a nucleic acid binding [oligo(dC)] protein related to the pre-mRNA binding protein K. Nucleic Acids Res. 22:959–964.
   PubMedGoogle Scholar
• Atwater, J. A., R. Wisdom, and J. Verma 1990. Regulated mRNA stability. Annu. Rev. Genet. 24:519–641.
   PubMed Web of Science ®Google Scholar
• Aviv, H., Z. Voloch, R. N. Bastos, and J. Levy 1976. Biosynthesis and stability of globin mRNA in cultured erythroleukemic Friend cells. Cell 8:495–503.
   PubMed Web of Science ®Google Scholar
• Bastos, R. N., and J. Aviv 1977. Theoretical analysis of a model for globin messenger RNA accumulation during erythropoiesis. J. Mol. Biol. 110:205–218.
   PubMedGoogle Scholar
• Bastos, R. N., Z. Volloch, and J. Aviv 1977. Messenger RNA population analysis during erythroid differentiation: a kinetical approach. J. Mol. Biol. 110:191–203.
   PubMed Web of Science ®Google Scholar
• Beelman, C. A., and J. Parker 1995. Degradation of mRNA in eukaryotes. Cell 81:179–183.
   PubMed Web of Science ®Google Scholar
• Belasco, J., G. Brawerman 1993. Control of mRNA stability. Academic Press, San Diego, Calif.
   Google Scholar
• Binder, R., J. A. Horowitz, J. P. Basilion, D. M. Koeller, R. D. Klausner, and J. Harford 1994. Evidence that the pathway of transferrin receptor mRNA degradation involves an endonucleolytic cleavage within the 3′ UTR and does not involve poly(A) tail shortening. EMBO J. 13:1969–1980.
   PubMed Web of Science ®Google Scholar
• Brown, B. D., I. D. Zipkin, and J. Harland 1993. Sequence-specific endonucleolytic cleavage and protection of mRNA in Xenopus and Drosophila. Genes Dev. 7:1620–1631.
   PubMedGoogle Scholar
• Carey, J. 1991. Gel retardation. Methods Enzymol. 208:103–117.
   PubMedGoogle Scholar
• Clegg, J. B., D. J. Weatherall, and J. Milner 1971. Haemoglobin Constant Spring—a chain termination mutant? Nature (London) 234:337–340.
   PubMed Web of Science ®Google Scholar
• Craig, A. W. B., A. Haghighat, A. T. K. Yu, and J. Sonenberg 1998. Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation. Nature (London) 392:520–523.
   PubMed Web of Science ®Google Scholar
• Czyzyk-Krzeska, M. F., and J. Beresh 1996. Characterization of the hypoxia-inducible protein binding site within the pyrimidine-rich tract in the 3′-untranslated region of the tyrosine hydroxylase mRNA. J. Biol. Chem. 271:3293–3299.
   PubMedGoogle Scholar
• Decker, C. J., and J. Parker 1993. A turnover pathway for both stable and unstable mRNAs in yeast: evidence for a requirement for deadenylation. Genes Dev. 7:1632–1643.
   PubMed Web of Science ®Google Scholar
• Decker, C. J., and J. Parker 1994. Mechanisms of mRNA degradation in eukaryotes. Trends Biochem. Sci. 19:336–340.
   PubMed Web of Science ®Google Scholar
• Ebersole, T. A., Q. Chen, M. J. Justice, and J. Artzt 1996. The quaking gene product necessary in embryogenesis and myelination combines features of RNA binding and signal transduction proteins. Nat. Genet. 12:260–265.
   PubMed Web of Science ®Google Scholar
• Ehrenman, K., L. Long, B. J. Wagner, and J. Brewer 1994. Characterization of cDNAs encoding the murine A+U-rich RNA-binding protein AUF1. Gene 149:315–319.
   PubMedGoogle Scholar
• Fumagalli, S., N. F. Totty, J. J. Hsuan, and J. Courtneidge 1994. A target for Src in mitosis. Nature (London) 368:871–874.
   PubMedGoogle Scholar
• Funke, B., B. Zuleger, R. Benavente, T. Schuster, M. Goller, J. Stevenin, and J. Horak 1996. The mouse poly(C)-binding protein exists in multiple isoforms and interacts with several RNA-binding proteins. Nucleic Acids Res. 24:3821–3828.
   PubMedGoogle Scholar
• Gamarnik, A., and J. Andino 1997. Two functional complexes formed by KH domain containing proteins with the 5′ noncoding region of poliovirus RNA. RNA 3:882–892.
   PubMed Web of Science ®Google Scholar
• Hahm, K., G. Kim, C. W. Turck, and J. Smale 1993. Isolation of a murine gene encoding a nucleic acid-binding protein with homology to hnRNP K. Nucleic Acids Res. 21:3894.
   PubMedGoogle Scholar
• Holcik, M., and J. Liebhaber 1997. Four highly stable eukaryotic mRNAs assemble 3′ untranslated region RNA-protein complexes sharing cis and trans components. Proc. Natl. Acad. Sci. USA 94:2410–2414.
   PubMed Web of Science ®Google Scholar
• Holcik, M., S. A. Liebhaber 1997. Analysis of mRNP complexes assembled in vitro, p. 196–208. In J. Richter (ed.), mRNA formation and function. Academic Press, San Diego, Calif.
   Google Scholar
• Hunt, D. M., D. R. Higgs, P. Winichagoon, J. B. Clegg, and J. Weatherall 1982. Haemoglobin Constant Spring has an unstable alpha chain messenger RNA. Br. J. Haematol. 51:405–413.
   PubMed Web of Science ®Google Scholar
• Jackson, R. J. 1993. Cytoplasmic regulation of mRNA function: the importance of the 3′ untranslated region. Cell 74:9–14.
   PubMed Web of Science ®Google Scholar
• Jacobson, A., and J. Peltz 1996. Interrelationships of the pathways of mRNA decay and translation in eukaryotic cells. Annu. Rev. Biochem. 65:693–739.
   PubMed Web of Science ®Google Scholar
• Jones, A. R., and J. Schedl 1995. Mutations in gld-1, a female germ cell-specific tumor suppressor gene in Caenorhabditis elegans, affect a conserved domain also found in Src-associated protein Sam68. Genes Dev. 9:1491–1504.
   PubMedGoogle Scholar
• Kajita, Y., J. Nakayama, M. Aizawa, and J. Ishikawa 1995. The UUAG-specific RNA binding protein, heterogeneous nuclear ribonucleoprotein D0. Common modular structure and binding properties of the 2×RBD-Gly family. J. Biol. Chem. 270:22167–22175.
   PubMed Web of Science ®Google Scholar
• Kiledjian, M., C. T. DeMaria, G. Brewer, and J. Novick 1997. Identification of AUF1 (heterogeneous nuclear ribonucleoprotein D) as a component of the alpha-globin mRNA stability complex. Mol. Cell. Biol. 17:4870–4876.
   PubMedGoogle Scholar
• Kiledjian, M., X. Wang, and J. Liebhaber 1995. Identification of two KH domain proteins in the α-globin mRNA stability complex. EMBO J. 14:4357–4364.
   PubMed Web of Science ®Google Scholar
• Klausner, R. D., T. A. Rouault, and J. Harford 1993. Regulating the fate of mRNA: the control of cellular iron metabolism. Cell 72:19–28.
   PubMed Web of Science ®Google Scholar
• Krowczynska, A., R. Yenofsky, and J. Brawerman 1985. Regulation of messenger RNA stability in mouse erythroleukemia cells. J. Mol. Biol. 181:231–239.
   PubMedGoogle Scholar
• Kuhn, L. C. 1991. mRNA-protein interactions regulate critical pathways in cellular iron metabolism. Br. J. Haematol. 79:1–5.
   PubMed Web of Science ®Google Scholar
• Leffers, H., K. Dejgaard, and J. Celis 1995. Characterization of two major cellular poly(rC)-binding human proteins, each containing three K-homologous (KH) domains. Eur. J. Biochem. 230:447–453.
   PubMedGoogle Scholar
• Liebhaber, S. A., and J. Kan 1981. Differentiation of the mRNA transcripts originating from the alpha 1- and alpha 2-globin loci in normals and alpha-thalassemics. J. Clin. Investig. 68:439–446.
   PubMed Web of Science ®Google Scholar
• Liu, K., and J. Hanna 1995. NusA contacts nascent RNA in Escherichia coli transcription complexes. J. Mol. Biol. 247:547–558.
   PubMedGoogle Scholar
• Mahone, M., E. E. Saffman, and J. Lasko 1995. Localized Bicaudal-C RNA encodes a protein containing a KH domain, the RNA binding motif of FMR1. EMBO J. 14:2043–2055.
   PubMedGoogle Scholar
• Matunis, M. J., W. M. Michael, and J. Dreyfuss 1992. Characterization and primary structure of the poly(C)-binding heterogeneous nuclear ribonucleoprotein complex K protein. Mol. Cell. Biol. 12:164–171.
   PubMed Web of Science ®Google Scholar
• Menhra, M. 1996. RNA isolation from cell and tissues, p. 1–20. In P. A. Krieg (ed.), A laboratory guide to RNA: isolation, analysis, and synthesis. Wiley-Liss, Inc., New York, N.Y.
   Google Scholar
• Milligan, J. F., and J. Uhlenbeck 1989. Synthesis of small RNAs using T7 RNA polymerase. Methods Enzymol. 180:51–62.
   PubMed Web of Science ®Google Scholar
• Morales, J., J. E. Russell, and J. Liebhaber 1997. Destabilization of human α-globin mRNA by translation anti-termination is controlled during erythroid differentiation and is paralleled by phased shortening of the poly(A) tail. J. Biol. Chem. 272:6607–6613.
   PubMed Web of Science ®Google Scholar
• Muhlrad, D., C. J. Decker, and J. Parker 1994. Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5′→3′ digestion of the transcript. Genes Dev. 8:855–866.
   PubMed Web of Science ®Google Scholar
• Muhlrad, D., and J. Parker 1994. Premature translational termination triggers mRNA decapping. Nature (London) 370:578–581.
   PubMed Web of Science ®Google Scholar
• Nandabalan, K., L. Price, and J. Roeder 1993. Mutations in U1 snRNA bypass the requirement for a cell type-specific RNA splicing factor. Cell 73:407–415.
   PubMed Web of Science ®Google Scholar
• Nielson, D. A., and J. Shapiro 1990. Insights into hormonal control of messenger RNA stability. Mol. Endocrinol. 4:953–957.
   PubMedGoogle Scholar
• Osley, M. A. 1991. The regulation of histone synthesis in the cell cycle. Annu. Rev. Biochem. 60:827–861.
   PubMed Web of Science ®Google Scholar
• Ostareck-Lederer, A., D. H. Ostareck, N. Standart, and J. Thiele 1994. Translation of 15-lipoxygenase mRNA is inhibited by a protein that binds to a repeated sequence in the 3′ untranslated region. EMBO J. 13:1476–1481.
   PubMed Web of Science ®Google Scholar
• Ostareck, D. H., A. Ostareck-Lederer, M. Wilm, B. J. Thiele, M. Mann, and J. Hentze 1997. mRNA silencing in erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3′ end. Cell 89:597–606.
   PubMed Web of Science ®Google Scholar
• Peltz, S. W., G. Brewer, P. Bernstein, P. A. Hart, and J. Ross 1991. Regulation of mRNA turnover in eukaryotic cells. Crit. Rev. Eukaryotic Gene Expr. 1:99–126.
   PubMedGoogle Scholar
• Peltz, S. W., and J. Jacobson 1992. mRNA stability: in trans-it. Curr. Opin. Cell Biol. 4:979–983.
   PubMedGoogle Scholar
• Regnier, P., M. Grunberg-Manago, and J. Portier 1987. Nucleotide sequence of the pnp gene of Escherichia coli encoding polynucleotide phosphorylase. Homology of the primary structure of the protein with the RNA-binding domain of ribosomal protein S1. J. Biol. Chem. 262:63–68.
   PubMed Web of Science ®Google Scholar
• Ross, J. 1988. Messenger RNA turnover in eukaryotic cells. J. Mol. Biol. Med. 5:1–14.
   PubMedGoogle Scholar
• Ross, J. 1995. mRNA stability in mammalian cells. Microbiol. Rev. 59:423–450.
   PubMedGoogle Scholar
• Ross, J., and J. Sullivan 1985. Half-lives of beta and gamma globin messenger RNAs and of protein synthetic capacity in cultured human reticulocytes. Blood 66:1149–1154.
   PubMed Web of Science ®Google Scholar
• Russell, J. E., J. Morales, A. Makeyev, and J. Liebhaber 1998. Sequence divergence in the 3′ untranslated regions of human ζ- and α-globin mRNAs mediates a difference in their stabilities and contributes to efficient α-to-ζ gene developmental switching. Mol. Cell. Biol. 18:2173–2183.
   PubMedGoogle Scholar
• Sachs, A. B. 1993. Messenger RNA degradation in eukaryotes. Cell 74:413–421.
   PubMed Web of Science ®Google Scholar
• Schmidt, C., B. Henkel, E. Poschl, H. Zorbas, W. G. Purschke, T. R. Gloe, and J. Muller 1992. Complete cDNA sequence of chicken vigilin, a novel protein with amplified and evolutionary conserved domains. Eur. J. Biochem. 206:625–634.
   PubMedGoogle Scholar
• Shyu, A. B., J. G. Belasco, and J. Greenberg 1991. Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay. Genes Dev. 5:221–231.
   PubMed Web of Science ®Google Scholar
• Siebel, C. W., A. Admon, and J. Rio 1995. Soma-specific expression and cloning of PSI, a negative regulator of P element pre-mRNA splicing. Genes Dev. 9:269–283.
   PubMedGoogle Scholar
• Siomi, H., M. J. Matunis, W. M. Michael, and J. Dreyfuss 1993. The pre-mRNA binding K protein contains a novel evolutionarily conserved motif. Nucleic Acids Res. 21:1193–1198.
   PubMed Web of Science ®Google Scholar
• Siomi, H., M. C. Siomi, R. L. Nussbaum, and J. Dreyfuss 1993. The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein. Cell 74:291–298.
   PubMed Web of Science ®Google Scholar
• Smith, C. W. J., C. Gooding, G. C. Roberts, A. D. J. Scadden 1996. Analyzing patterns of alternative splicing, p. 411–440. In P. A. Krieg (ed.), A laboratory guide to RNA: isolation, analysis, and synthesis. Wiley-Liss, Inc., New York, N.Y.
   Google Scholar
• Stefanovic, B., C. Hellerbrand, M. Holcik, M. A. Briendl, S. Liebhaber, and J. Brenner 1997. Posttranscriptional regulation of collagen alpha1(I) mRNA in hepatic stellate cells. Mol. Cell. Biol. 17:5201–5209.
   PubMed Web of Science ®Google Scholar
• Surdej, P., A. Riedl, and J. Jacobs-Lorena 1994. Regulation of mRNA stability in development. Annu. Rev. Genet. 28:263–282.
   PubMedGoogle Scholar
• Urlaub, H., V. Kruft, O. Bischof, E. C. Muller, and J. Wittmann-Liebold 1995. Protein-rRNA binding features and their structural and functional implications in ribosomes as determined by cross-linking studies. EMBO J. 14:4578–4588.
   PubMedGoogle Scholar
• Wagner, B. J., L. Long, P. N. Rao, M. J. Pettenati, and J. Brewer 1996. Localization and physical mapping of genes encoding the A+U-rich element RNA-binding protein AUF1 to human chromosomes 4 and X. Genomics 34:219–222.
   PubMedGoogle Scholar
• Wang, A. M., M. V. Doyle, and J. Mark 1989. Quantitation of mRNA by the polymerase chain reaction. Proc. Natl. Acad. Sci. USA 86:9717–9721.
   PubMed Web of Science ®Google Scholar
• Wang, X., M. Kiledjian, I. M. Weiss, and J. Liebhaber 1995. Detection and characterization of a 3′ untranslated region ribonucleoprotein complex associated with human α-globin mRNA stability. Mol. Cell. Biol. 15:1769–1777.
   PubMedGoogle Scholar
• Wang, Z., N. Day, P. Trifillis, and J. Kiledjian 1999. An mRNA stability complex functions with the poly(A)–binding protein to stabilize mRNA in vitro. Mol. Cell. Biol. 19:4552–4560.
   PubMed Web of Science ®Google Scholar
• Weiss, I. M., and J. Liebhaber 1994. Erythroid cell-specific determinants of α-globin mRNA stability. Mol. Cell. Biol. 14:8123–8132.
   PubMed Web of Science ®Google Scholar
• Weiss, I. M., and J. Liebhaber 1995. Erythroid cell-specific mRNA stability elements in the α2-globin 3′ nontranslated region. Mol. Cell. Biol. 15:2457–2465.
   PubMed Web of Science ®Google Scholar
• Wells, S. E., P. E. Hillner, R. D. Vale, and J. Sachs 1998. Circularization of mRNA by eukaryotic translation initiation factors. Mol. Cell 2:135–140.
   PubMed Web of Science ®Google Scholar
• Zhang, W., B. J. Wagner, K. Ehrenman, A. W. Schaefer, C. T. DeMaria, D. Crater, K. DeHaven, L. Long, and J. Brewer 1993. Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1. Mol. Cell. Biol. 13:7652–7665.
   PubMed Web of Science ®Google Scholar