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Cell Growth and Development

Induction of Apoptosis by Double-Stranded-RNA-Dependent Protein Kinase (PKR) Involves the α Subunit of Eukaryotic Translation Initiation Factor 2 and NF-κB

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Pages 4653-4663 | Received 28 Dec 1998, Accepted 25 Mar 1999, Published online: 28 Mar 2023

REFERENCES

  • Abbaddie, C. N., F. Kabrun, F. Bouali, B. Vandenbunder, and J. Enrietto 1993. High levels of c-rel expression are associated with programmed cell death in the developing avian embryo and in bone marrow cells in vitro. Cell 75:899–912.
  • Alcamí, J., T. Lain de Lera, L. Folgueira, M. A. Pedraza, J. M. Jacqué, F. Bachelerie, A. R. Noriega, R. T. Hay, D. Harrich, R. B. Gaynor, J. L. Virelizier, and J. Arenzana-Seisdedos 1995. Absolute dependence on κB responsive elements for initiation and Tat-mediated amplification of HIV transcription in blood CD4 T lymphocytes. EMBO J. 14:1552–1560.
  • Arenzana-Seisdedos, F., B. Fernandez, J. Dominguez, M. Jaqué, D. Thompson, M. T. Díaz-Meco, J. Moscat, and J. Virelizier 1993. Phosphatidylcholine hydrolysis activates NF-κB and increases human immunodeficiency virus replication in human monocytes and T lymphocytes. J. Virol. 67:6596–6604.
  • Arenzana-Seisdedos, F., J. Thompson, M. S. Rodriguez, F. Bachelerie, D. Thomas, and J. Hay 1995. Inducible nuclear expression of newly synthesized IκBα negatively regulates DNA-binding and transcriptional activities of NF-κB. Mol. Cell. Biol. 15:2689–2696.
  • Baeuerle, P. A., and J. Henkel 1994. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12:141–179.
  • Baldwin, A. S. Jr.. 1996. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649–681.
  • Beg, A., and J. Baltimore 1996. An essential role for NF-κB in preventing TNF-α-induced cell death. Science 274:782–784.
  • Behrmann, I., H. Walczac, and J. Krammer 1994. Structure of the human APO-1 gene. Eur. J. Immunol. 24:3057–3062.
  • Belich, M. P., A. Salmeron, L. H. Johnston, and J. Ley 1999. TPL-2 kinase regulates the proteolysis of the NF-κB-inhibitory protein NF-κB1 p105. Nature 397:363–368.
  • Braiser, A. R., J. E. Tate, and J. Habener 1989. Optimized use of the firefly luciferase assay as a reporter gene in mammalian cell lines. BioTechniques 7:1116–1122.
  • Brun, A., C. Rivas, M. Esteban, J. M. Escribano, and J. Alonso 1996. African swine fever virus gene A179L, a viral homologue of bcl-2 protects cells from programmed cell death. Virology 225:227–230.
  • Casano, F. J., A. M. Rolando, U. S. Mudgett, and J. Molineaux 1994. The structure and complete nucleotide sequence of the murine gene encoding interleukin-1 beta converting enzyme (ICE). Genomics 20:474–481.
  • Castelli, J. A., B. A. Hassel, K. A. Wood, X.-L. Li, K. Amemiya, M. C. Dalakas, P. Torrence, and J. Youle 1997. A study of the interferon antiviral mechanism: apoptosis activation of the 2-5A system. J. Exp. Med. 186:967–972.
  • Craiu, A., M. Gaczynska, T. Akopian, C. F. Gramm, G. Fenteany, A. L. Goldberg, and J. Rock 1997. Lactacystin and clasto-lactacystin beta-lactone modify multiple proteasome beta-subunits and inhibit intracellular protein degradation and major histocompatibility complex class I antigen presentation. J. Biol. Chem. 272:13437–13445.
  • Der, S. D., Y. Yang, C. Weissmann, and J. Williams 1997. A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis. Proc. Natl. Acad. Sci. USA 94:3279–3283.
  • Díaz-Guerra, M., C. Rivas, and J. Esteban 1997. Inducible expression of the 2-5A-synthetase/RNase L system results in inhibition of vaccinia virus replication. Virology 227:220–228.
  • Díaz-Guerra, M., C. Rivas, and J. Esteban 1997. Activation of the IFN-inducible enzyme RNase L causes apoptosis of animal cells. Virology 236:354–363.
  • Donzé, O., R. Jagus, A. E. Koromilas, J. W. B. Hershey, and J. Sonenberg 1995. Abrogation of translation initiation factor eIF2 phosphorylation causes malignant transformation of NIH 3T3 cells. EMBO J. 14:3828–3834.
  • Figueiredo-Pereira, M. E., K. A. Berg, and J. Wilk 1994. A new inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (20S proteasome) induces accumulation of ubiquitin-protein conjugates in a neuronal cell. J. Neurochem. 63:1578–1581.
  • Fuerst, T. R., E. G. Niles, F. W. Studier, and J. Moss 1986. Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes T7 RNA polymerase. Proc. Natl. Acad. Sci. USA 83:8122–8126.
  • Grimm, S., M. K. A. Bauer, P. A. Bauerle, and J. Schulze-Osthoff 1996. Bcl-2 down-regulates the activity of transcription factor NF-κB induced upon apoptosis. J. Cell Biol. 134:13–23.
  • Hershey, J. W. B. 1991. Translational control in mammalian cells. Annu. Rev. Biochem. 60:715–754.
  • Hinnebusch, A. G. 1993. Gene-specific translational control of the yeast GCN4 gene by phosphorylation of eukaryotic initiation factor 2. Mol. Microbiol. 10:215–223.
  • Imbert, V., R. A. Rupec, A. Livolsi, H. L. Pahl, E. B. M. Traenckner, C. Mueller-Dieckmann, D. Farahifar, B. Rossi, P. Auberger, P. A. Bauerle, and J. Peyron 1996. Tyrosine phosphorylation of I-κBα activates NF-κB without proteolytic degradation of I-κBα. Cell 86:787–798.
  • Jacobs, B. L., and J. Langland 1996. When two strands are better than one: the mediators and modulators of the cellular responses to double-stranded RNA. Virology 219:339–349.
  • Kasibhatla, S., T. Brunner, L. Genestier, F. Echeverri, A. Mahboubi, and J. Green 1998. DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-κB and AP-1. Mol. Cell 1:543–551.
  • Katze, M. G. 1993. Games viruses play: a strategic initiative against the IFN-induced, ds-RNA activated protein kinase. Semin. Virol. 4:259–268.
  • Kibler, K. V., T. Shors, K. B. Perkins, C. C. Zeman, M. P. Banaszak, J. Biesterfeldt, J. O. Langland, and J. Jacobs 1997. Double-stranded RNA is a trigger for apoptosis in vaccinia virus-infected cells. J. Virol. 71:1992–2003.
  • Kumar, A., J. Haque, J. Lacoste, J. Hiscott, and J. Williams 1994. Double-stranded RNA-dependent protein kinase activates transcription factor NF-κB by phosphorylating IκB. Proc. Natl. Acad. Sci. USA 91:6288–6292.
  • Kumar, A., Y. Yang, V. Flati, S. Der, S. Kadereit, A. Deb, J. Haque, L. Reis, C. Weissmann, and J. Williams 1997. Deficient cytokine signalling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-κB. EMBO J. 16:406–416.
  • La Rosa, F. A., J. W. Pierce, and J. Sorenshein 1994. Differential regulation of the c-myc oncogene promoter by the NF-κB Rel family of transcription factors. Mol. Cell. Biol. 14:1039–1044.
  • Leaman, D. W., A. Salvekar, R. Patel, C. S. Sen, and J. Stark 1998. A mutant cell line defective in response to double-stranded RNA and in regulating basal expression of interferon-stimulated genes. Proc. Natl. Acad. Sci. USA 95:9442–9447.
  • Lee, S. B., and J. Esteban 1994. The interferon-induced double-stranded RNA-activated protein kinase induces apoptosis. Virology 199:491–496.
  • Lee, S. B., Z. Melkova, W. Yan, B. R. G. Williams, A. G. Hovanessian, and J. Esteban 1993. The interferon-induced double-stranded RNA-activated human p68 protein kinase potently inhibits protein synthesis in cultured cells. Virology 192:380–385.
  • Lee, S. B., D. Rodriguez, J. R. Rodriguez, and J. Esteban 1997. The apoptosis pathway triggered by the IFN-induced dsRNA activated protein kinase PKR requires the third basic domain, initiates upstream of Bcl-2 and involves ICE-like proteases. Virology 231:81–88.
  • Lin, K., J. A. DiDonato, A. Hoffmann, J. M. Hardwick, and J. Ratan 1998. Suppression of steady-state, but not stimulus-induced NF-κB activity inhibits alphavirus-induced apoptosis. J. Cell Biol. 141:1479–1487.
  • Lin, K., S. Lee, R. Narayanan, J. M. Barbarian, J. M. Hardwick, and J. Ratan 1995. Thiol agents and Bcl-2 identify an alphavirus-induced apoptotic pathway that requires activation of the transcription factor NF-kappa B. J. Cell Biol. 131:1149–1161.
  • Marianneau, P., A. Cardona, L. Edelman, V. Deubel, and J. Després 1997. Dengue virus replication in human hepatoma cells activates NF-κB which in turn induces apoptotic cell death. J. Virol. 71:3244–3249.
  • Mayo, M. W., C. Wang, P. C. Cogswell, K. S. Rogers-Graham, S. L. Lowe, C. J. Der, A. S. Baldwin Jr.. 1997. Requirement of NF-κB activation to suppress p53-independent apoptosis induced by oncogenic ras. Science 278:1812–1815.
  • McFadden, G. 1998. Even viruses can learn to cope with stress. Science 279:40–41.
  • Meurs, E. F., K. Chong, J. Galabru, N. S. Thomas, I. M. Kerr, B. R. Williams, and J. Hovanessian 1990. Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon. Cell 62:379–390.
  • Pathak, V. K., D. Schindler, and J. Hershey 1988. Generation of a mutant form of protein synthesis initiation factor eIF-2 lacking the site of phosphorylation by eIF-2 kinases. Mol. Cell. Biol. 8:993–995.
  • Powel, P. P., L. K. Dixon, and J. Parkhouse 1996. An I-κB homolog encoded by african swine fever virus provides a novel mechanism for downregulation of proinflammatory cytokine responses in host macrophages. J. Virol. 70:8527–8533.
  • Proud, C. G. 1995. PKR: a new name and new roles. Trends Biochem. Sci. 20:241–246.
  • Randall, R. E., D. F. Young, K. K. A. Goswami, and J. Russell 1987. Isolation and characterization of monoclonal antibodies to simian virus 5 and their use in revealing antigenic differences between human, canine and simian isolates. J. Gen. Virol. 68:2769–2780.
  • Rodriguez, J. F., and J. Smith 1990. Inducible gene expression from vaccinia virus vectors. Virology 177:239–250.
  • Roff, M., J. Thompson, M. S. Rodriguez, J. M. Jaque, F. Baleux, F. Arenzana-Seisdedos, and J. Hay 1996. Role of I-κBα ubiquitination in signal-induced activation of NF-κB in vivo. J. Biol. Chem. 271:7844–7850.
  • Rowlands, A. G., R. Panniers, and J. Henshaw 1988. The catalytic mechanism of guanine nucleotide exchange factor action and competitive inhibition by phosphorylated eukaryotic initiation factor 2. J. Biol. Chem. 263:5526–5533.
  • Samuel, C. E. 1991. Antiviral actions of interferon. Interferon-regulated cellular proteins and their surprisingly selective antiviral activities. Virology 183:1–11.
  • Schouten, G. J., A. C. O. Vertegaal, S. T. Whiteside, A. Israel, M. Toebes, J. C. Dorsman, A. J. van der Eb, and J. Zantema 1997. I-κBα is a target for the mitogen-activated 90 kDa ribosomal S6 kinase. EMBO J. 16:3133–3144.
  • Srivastava, S. P., K. U. Kumar, and J. Kaufman 1998. Phosphorylation of eukaryotic translation initiation factor 2 mediates apoptosis in response to activation of the double-stranded RNA-dependent protein kinase. J. Biol. Chem. 273:2416–2423.
  • Stancovski, I., and J. Baltimore 1997. NF-κB activation: the I-κBα kinase revealed? Cell 91:299–302.
  • Stark, G. R., I. M. Kerr, B. R. G. Williams, R. H. Silverman, and J. Schreiber 1998. How cells respond to interferons. Annu. Rev. Biochem. 67:227–264.
  • Suarez, P., M. Díaz-Guerra, C. Prieto, M. Esteban, J. M. Castro, A. Nieto, and J. Ortín 1996. Open reading frame 5 of porcine reproductive and respiratory syndrome virus as a cause of virus-induced apoptosis. J. Virol. 70:2876–2882.
  • Takahashi, T., M. Tanaka, J. Inazawa, T. Abe, T. Suda, and J. Nagata 1994. Human Fas ligand: gene structure, chromosomal localization and species specificity. Int. Immunol. 6:1567–1574.
  • Takizawa, T., K. Ohashi, and J. Nakanishi 1996. Possible involvement of double-stranded RNA-activated protein kinase in cell death by influenza virus infection. J. Virol. 70:8128–8132.
  • Tanaka, N., M. Ishihara, M. Kitagawa, H. Harada, T. Kimura, T. Matsuyama, M. S. Lamphier, S. Aizawa, T. W. Mak, and J. Taniguchi 1994. Cellular commitment to oncogene-induced transformation or apoptosis is dependent of the transcription factor IRF-1. Cell 77:829–839.
  • Traenckner, E. B. M., S. Wilk, and J. Baeuerle 1994. A proteasome inhibitor prevents activation of NF-κB and stabilizes a newly phosphorylated form of I-κBα that is still bound to NF-κB. EMBO J. 13:5433–5441.
  • Tschopp, J., M. Thome, K. Hofmann, and J. Mein 1998. The fight of viruses against apoptosis. Curr. Opin. Genet. Dev. 8:82–87.
  • Van Antwerp, D. J., S. J. Martin, T. Kafri, D. R. Green, and J. Verma 1996. Suppression of TNF-α-induced apoptosis by NF-κB. Science 274:787–789.
  • Wada, N., M. Matsumura, Y. Ohba, N. Kobayashi, T. Takizawa, and J. Nakanishi 1995. Transcription stimulation of the Fas-encoding gene by nuclear factor for interleukin-6 expression upon influenza virus infection. J. Biol. Chem. 270:18007–18012.
  • Wang, C., M. W. Mayo, A. S. Baldwin Jr.. 1996. TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB. Science 274:784–787.
  • Wang, C., M. W. Mayo, R. G. Korneluk, D. V. Goeddel, A. S. Baldwin Jr.. 1998. NF-κB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 281:1680–1683.
  • White, E. 1996. Life, death, and the pursuit of apoptosis. Genes Dev. 10:1–15.
  • Wu, H., and J. Lozano 1994. NF-κB activation of p53. A potential mechanism for suppressing cell growth in response to stress. J. Biol. Chem. 269:20067–20074.
  • Yeung, M. C., and J. Lau 1998. Tumor suppressor p53 as a component of the tumor necrosis factor-induced, protein kinase PKR-mediated apoptotic pathway in human promonocytic U937 cells. J. Biol. Chem. 273:25198–25202.
  • Zhou, A., J. Paranjape, T. L. Brown, H. Nie, S. Naik, B. Dong, A. Chang, B. Trapp, R. Fairchild, C. Colmenares, and J. Silverman 1997. Interferon action and apoptosis are defective in mice devoid of 2′,5′-oligoadenylate-dependent RNase L. EMBO J. 16:6355–6363.

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