Major Egr3 Isoforms Are Generated via Alternate Translation Start Sites and Differ in Their Abilities To Activate Transcription

REFERENCES

• Bhat, R. V., A. J. Cole, and J. Baraban 1992. Chronic cocaine treatment suppresses basal expression of zif268 in rat forebrain: in situ hybridization studies. J. Pharmacol. Exp. Ther. 263:343–349.
   PubMedGoogle Scholar
• Bhat, R. V., P. F. Worley, A. J. Cole, and J. Baraban 1992. Activation of the zinc finger encoding gene krox-20 in adult rat brain: comparison with zif268. Brain Res. Mol. Brain Res. 13:263–266.
   PubMedGoogle Scholar
• Chen, C., and J. Okayama 1987. High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol. 7:2745–2752.
   PubMed Web of Science ®Google Scholar
• Christy, B., and J. Nathans 1989. DNA binding site of the growth factor-inducible protein Zif268. Proc. Natl. Acad. Sci. USA 86:8737–8741.
   PubMed Web of Science ®Google Scholar
• Cole, A. J., S. Abu-Shakra, D. W. Saffen, J. M. Baraban, and J. Worley 1990. Rapid rise in transcription factor mRNAs in rat brain after electroshock-induced seizures. J. Neurochem. 55:1920–1927.
   PubMedGoogle Scholar
• Cole, A. J., D. W. Saffen, J. M. Baraban, and J. Worley 1989. Rapid increase of an immediate early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation. Nature 340:474–476.
   PubMed Web of Science ®Google Scholar
• Crosby, S. D., J. J. Puetz, K. S. Simburger, T. J. Fahrner, and J. Milbrandt 1991. The early response gene NGFI-C encodes a zinc finger transcriptional activator and is a member of the GCGGGGGCG (GSG) element-binding protein family. Mol. Cell. Biol. 11:3835–3841.
   PubMed Web of Science ®Google Scholar
• Crosby, S. D., R. A. Veile, H. Donis-Keller, J. M. Baraban, R. V. Bhat, K. S. Simburger, and J. Milbrandt 1992. Neural-specific expression, genomic structure, and chromosomal localization of the gene encoding the zinc-finger transcription factor NGFI-C. Proc. Natl. Acad. Sci. USA 89:4739–4743 (Erratum, 89:6663.)
   PubMedGoogle Scholar
• Descombes, P., and J. Schibler 1991. A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA. Cell 67:569–579.
   PubMed Web of Science ®Google Scholar
• Dey, B. R., V. P. Sukhatme, A. B. Roberts, M. B. Sporn, F. J. Rauscher III, and J. Kim 1994. Repression of the transforming growth factor-beta 1 gene by the Wilms’ tumor suppressor WT1 gene product. Mol. Endocrinol. 8:595–602.
   PubMed Web of Science ®Google Scholar
• Gashler, A., and J. Sukhatme 1995. Early growth response protein 1 (Egr-1): prototype of a zinc-finger family of transcription factors. Prog. Nucleic Acid Res. Mol. Biol. 50:191–224.
   PubMed Web of Science ®Google Scholar
• Horton, R. M., H. D. Hunt, S. N. Ho, J. K. Pullen, and J. Pease 1989. Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension. Gene 77:61–68.
   PubMed Web of Science ®Google Scholar
• Jansen, E., T. A. Ayoubi, S. M. Meulemans, and J. Van De Ven 1997. Regulation of human prohormone convertase 2 promoter activity by the transcription factor EGR-1. Biochem. J. 328:69–74.
   PubMedGoogle Scholar
• Khachigian, L. M., V. Lindner, A. J. Williams, and J. Collins 1996. Egr-1-induced endothelial gene expression: a common theme in vascular injury. Science 271:1427–1431.
   PubMedGoogle Scholar
• Khachigian, L. M., A. J. Williams, and J. Collins 1995. Interplay of Sp1 and Egr-1 in the proximal platelet-derived growth factor A-chain promoter in cultured vascular endothelial cells. J. Biol. Chem. 270:27679–27686.
   PubMed Web of Science ®Google Scholar
• Kim, S. J., K. Park, B. B. Rudkin, B. R. Dey, M. B. Sporn, and J. Roberts 1994. Nerve growth factor induces transcription of transforming growth factor-beta 1 through a specific promoter element in PC12 cells. J. Biol. Chem. 269:3739–3744.
   PubMed Web of Science ®Google Scholar
• Kozak, M. 1989. The scanning model for translation: an update. J. Cell Biol. 108:229–241.
   PubMed Web of Science ®Google Scholar
• Lee, S. L., Y. Sadovsky, A. H. Swirnoff, J. A. Polish, P. Goda, G. Gavrilina, and J. Milbrandt 1996. Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1). Science 273:1219–1221.
   PubMedGoogle Scholar
• Lin, K. I., S. H. Lee, R. Narayanan, J. M. Baraban, J. M. Hardwick, and J. Ratan 1995. Thiol agents and Bcl-2 identify an alphavirus-induced apoptotic pathway that requires activation of the transcription factor NF-kappa B. J. Cell Biol. 131:1149–1161.
   PubMed Web of Science ®Google Scholar
• Linden, D. J. 1996. A protein synthesis-dependent late phase of cerebellar long-term depression. Neuron 17:483–490.
   PubMedGoogle Scholar
• Mack, K. J., and J. Mack 1992. Induction of transcription factors in somatosensory cortex after tactile stimulation. Brain Res. Mol. Brain Res. 12:141–147.
   PubMedGoogle Scholar
• Mello, C. V., and J. Clayton 1994. Song-induced ZENK gene expression in auditory pathways of songbird brain and its relation to the song control system. J. Neurosci. 14:6652–6666.
   PubMed Web of Science ®Google Scholar
• Mittelstadt, P. R., and J. Ashwell 1998. Cyclosporin A-sensitive transcription factor Egr-3 regulates Fas ligand expression. Mol. Cell. Biol. 18:3744–3751.
   PubMedGoogle Scholar
• Montarolo, P. G., P. Goelet, V. F. Castellucci, J. Morgan, E. R. Kandel, and J. Schacher 1986. A critical period for macromolecular synthesis in long-term heterosynaptic facilitation in Aplysia. Science 234:1249–1254.
   PubMed Web of Science ®Google Scholar
• Moratalla, R., H. A. Robertson, and J. Graybiel 1992. Dynamic regulation of NGFI-A (zif268, egr1) gene expression in the striatum. J. Neurosci. 12:2609–2622.
   PubMedGoogle Scholar
• Morris, M. E., N. Viswanathan, S. Kuhlman, F. C. Davis, and J. Weitz 1998. A screen for genes induced in the suprachiasmatic nucleus by light. Science 279:1544–1547.
   PubMedGoogle Scholar
• O’Donovan, K. J. Unpublished data.
   Google Scholar
• O’Donovan, K. J., W. G. Tourtellotte, J. Milbrandt, and J. Baraban 1999. The Egr family of transcription regulatory factors: progress at the interface of molecular and systems neuroscience. Trends Neurosci. 22:167–173.
   PubMed Web of Science ®Google Scholar
• O’Donovan, K. J., E. P. Wilkens, and J. Baraban 1998. Sequential expression of Egr-1 and Egr-3 in hippocampal granule cells following electroconvulsive stimulation. J. Neurochem. 70:1241–1248.
   PubMedGoogle Scholar
• Okuno, H., and J. Miyashita 1996. Expression of the transcription factor Zif268 in the temporal cortex of monkeys during visual paired associate learning. Eur. J. Neurosci. 8:2118–2128.
   PubMedGoogle Scholar
• Ossipow, V., P. Descombes, and J. Schibler 1993. CCAAT/enhancer-binding protein mRNA is translated into multiple proteins with different transcription activation potentials. Proc. Natl. Acad. Sci. USA 90:8219–8223.
   PubMed Web of Science ®Google Scholar
• Russo, M. W., B. R. Sevetson, and J. Milbrandt 1995. Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription. Proc. Natl. Acad. Sci. USA 92:6873–6877.
   PubMed Web of Science ®Google Scholar
• Sachs, A. B., P. Sarnow, and J. Hentze 1997. Starting at the beginning, middle, and end: translation initiation in eukaryotes. Cell 89:831–838.
   PubMed Web of Science ®Google Scholar
• Silverman, E. S., L. M. Khachigian, V. Lindner, A. J. Williams, and J. Collins 1997. Inducible PDGF A-chain transcription in smooth muscle cells is mediated by Egr-1 displacement of Sp1 and Sp3. Am. J. Physiol. 273:H1415–H1426.
   PubMedGoogle Scholar
• Svaren, J., B. R. Sevetson, E. D. Apel, D. B. Zimonjic, N. C. Popescu, and J. Milbrandt 1996. NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli. Mol. Cell. Biol. 16:3545–3553.
   PubMed Web of Science ®Google Scholar
• Swirnoff, A. H., and J. Milbrandt 1995. DNA-binding specificity of NGFI-A and related zinc finger transcription factors. Mol. Cell. Biol. 15:2275–2287.
   PubMed Web of Science ®Google Scholar
• Thiel, G., S. Schoch, and J. Petersohn 1994. Regulation of synapsin I gene expression by the zinc finger transcription factor zif268/egr-1. J. Biol. Chem. 269:15294–15301.
   PubMedGoogle Scholar
• Tourtellotte, W. G., and J. Milbrandt 1998. Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3. Nat. Genet. 20:87–91.
   PubMedGoogle Scholar
• Wallace, C. S., G. S. Withers, I. J. Weiler, J. M. George, D. F. Clayton, and J. Greenough 1995. Correspondence between sites of NGFI-A induction and sites of morphological plasticity following exposure to environmental complexity. Brain Res. Mol. Brain Res. 32:211–220.
   PubMedGoogle Scholar
• Wisden, W., M. L. Errington, S. Williams, S. B. Dunnett, C. Waters, D. Hitchcock, G. Evan, T. V. Bliss, and J. Hunt 1990. Differential expression of immediate early genes in the hippocampus and spinal cord. Neuron 4:603–614.
   PubMedGoogle Scholar
• Worley, P. F., B. A. Christy, Y. Nakabeppu, R. V. Bhat, A. J. Cole, and J. Baraban 1991. Constitutive expression of zif268 in neocortex is regulated by synaptic activity. Proc. Natl. Acad. Sci. USA 88:5106–5110.
   PubMed Web of Science ®Google Scholar
• Yamagata, K., W. E. Kaufmann, A. Lanahan, M. Papapavlou, C. A. Barnes, K. I. Andreasson, and J. Worley 1994. Egr3/Pilot, a zinc finger transcription factor, is rapidly regulated by activity in brain neurons and colocalizes with Egr1/zif268. Learn. Mem. 1:140–152.
   PubMedGoogle Scholar