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Transcriptional Regulation

p70s6k Integrates Phosphatidylinositol 3-Kinase and Rapamycin-Regulated Signals for E2F Regulation in T Lymphocytes

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Pages 4729-4738 | Received 14 Sep 1998, Accepted 22 Apr 1999, Published online: 28 Mar 2023

REFERENCES

  • Beadling, C., D. Guschin, B. A. Witthuhn, A. Ziemiecki, J. N. Ihle, I. M. Kerr, and J. Cantrell 1994. Activation of JAK kinases and STAT proteins by interleukin-2 and interferon-α, but not the T cell antigen receptor, in human T lymphocytes. EMBO J. 13:5605–5615.
  • Beadling, C., J. Ng, J. W. Babbage, and J. Cantrell 1996. Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase distinct from the Raf-1/Erk2 MAP kinase pathway. EMBO J. 15:1902–1913.
  • Beretta, L., A. C. Gingras, Y. V. Svitkin, M. N. Hall, and J. Sonenberg 1996. Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation. EMBO J. 15:658–664.
  • Botz, J., K. Zerfass-Thome, D. Spitzovsky, H. Delius, B. Vogt, M. Eilers, A. Hatzigeorgiou, and J. Jansen-Durr 1996. Cell cycle regulation of the murine cyclin E gene depends on an E2F binding site in the promoter. Mol. Cell. Biol. 16:3401–3409.
  • Brennan, P., J. W. Babbage, B. M. T. Burgering, B. Groner, K. Reif, and J. Cantrell 1997. Phosphatidylinositol 3-kinase controls E2F transcriptional activity in response to interleukin-2. Immunity 7:679–689.
  • Brown, E. J., M. W. Albers, T. B. Shin, K. Ichikawa, C. T. Keith, W. S. Lane, and J. Schreiber 1994. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature 369:756–758.
  • Brunn, G. J., C. C. Hudson, A. Sekulic, J. M. Williams, H. Hosoi, P. J. Houghton, J. C. J. Lawrence, and J. Abraham 1997. Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. Science 277:99–101.
  • Cantrell, D. A., and J. Smith 1984. The interleukin-2 T-cell system: a new cell growth model. Science 224:1312–1316.
  • Chen, Y., E. S. Knudsen, and J. Wang 1996. The RB/p107/p130 phosphorylation pathway is not inhibited in rapamycin-induced G1-prolongation of NIH3T3 cells. Oncogene 13:1765–1771.
  • Dennis, P. B., S. Fumagalli, and J. Thomas 1999. Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation. Curr. Opin. Genet. Dev. 9:49–54.
  • Fairhurst, R. M., M. Daeipour, M. C. Amaral, and J. Nel 1993. Activation of mitogen-activated protein kinase/ERK-2 in phytohaemagglutinin in blasts by recombinant interleukin-2: contrasting features with CD3 activation. Immunology 79:112–118.
  • Genot, E. M., P. J. Parker, and J. Cantrell 1995. Analysis of the role of the protein kinase Cα, ε, and ζ in T cell activation. J. Biol. Chem. 270:9833–9839.
  • Hamel, P. A., R. M. Gill, R. A. Phillips, and J. Gallie 1992. Regions controlling hyperphosphorylation and conformation of the retinoblastoma gene product are independent of domains required for transcriptional repression. Oncogene 7:693–701.
  • Hashemolhosseini, S., Y. Nagamine, S. J. Morley, S. Desrivières, L. Mercep, and J. Ferrari 1998. Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability. J. Biol. Chem. 273:14424–14429.
  • Helin, K. 1998. Regulation of cell proliferation by the E2F transcription factors. Curr. Opin. Genet. Dev. 8:28–35.
  • Hori, T., T. Uchiyama, M. Tsudo, H. Umadome, H. Ohno, S. Fukuhara, K. Kita, and J. Uchino 1987. Establishment of an interleukin-2-dependent human T cell line from a patient with T cell chronic lymphocytic leukemia who is not infected with human T cell leukemia/lymphoma virus. Blood 70:1069–1072.
  • Hou, J., U. Schindler, W. J. Henzel, S. C. Wong, and J. McKnight 1995. Identification and purification of human Stat proteins activated in response to interleukin-2. Immunity 2:321–329.
  • Izquierdo Pastor, M., K. Reif, and J. Cantrell 1995. The regulation and function of p21ras during T-cell activation and growth. Immunol. Today 16:159–164.
  • Jefferies, H. B., S. Fumagalli, P. B. Dennis, C. Reinhard, R. B. Pearson, and J. Thomas 1997. Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6k. EMBO J. 16:3693–3704.
  • Johnston, J., M. Kawamura, R. Kirken, Y. Chen, T. Blake, K. Shibuya, J. Ortaldo, D. McVicar, and J. O’Shea 1994. Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2. Nature 370:151–153.
  • Johnston, J. A., C. M. Bacon, D. S. Finbloom, R. C. Rees, D. Kaplan, K. Shibuya, J. R. Ortaldo, S. Gupta, Y. Q. Chen, J. D. Giri, and J. O’Shea 1995. Tyrosine phosphorylation and activation of Stat5, Stat3, and Janus kinases by interleukin-2 and interleukin-15. Proc. Natl. Acad. Sci. USA 92:8705–8709.
  • Karnitz, L. M., L. A. Burns, S. L. Sutor, J. Blenis, and J. Abraham 1995. Interleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathway. Mol. Cell. Biol. 15:3049–3057.
  • Kawasame, H., P. Papst, S. Webb, G. M. Keller, G. L. Johnson, E. W. Gelfand, and J. Terada 1998. Targeted disruption of p70S6k defines its role in protein synthesis and rapamycin sensitivity. Proc. Natl. Acad. Sci. USA 95:5033–5038.
  • Lin, J.-X., T.-S. Migone, M. Tsang, M. Friedmann, J. A. Weatherbee, L. Zhou, A. Yamauchi, E. T. Bloom, J. Mietz, S. John, and J. Leonard 1995. The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. Immunity 2:331–339.
  • Loeken, M. R., and J. Brady 1989. The adenovirus EIIA enhancer. Analysis of regulatory sequences and changes in binding activity of ATF and EIIF following adenovirus infection. J. Biol. Chem. 264:6572–6579.
  • Mann, D. J., and J. Jones 1996. E2F-1 but not E2F-4 can overcome p16-induced G1 cell-cycle arrest. Curr. Biol. 6:474–483.
  • Meyuhas, O., D. Avni, S. Shama 1996. Translational control of ribosomal protein mRNAs in eukaryotes, p. 363–388. In J. W. B. Hershey, M. B. Matthews, N. Sonenberg (ed.), Translational control. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
  • Ming, X.-F., B. M. T. Burgering, S. Wennström, L. Claesson-Welsh, C.-H. Heldin, J. L. Bos, S. C. Kozma, and J. Thomas 1994. Activation of p70/p85 S6 kinase by a pathway independent of p21ras. Nature 371:426–429.
  • Miyazaki, T., A. Kawahara, H. Fujii, Y. Nakagawa, Y. Minami, Z.-J. Liu, I. Oishi, O. Silvennoinen, B. Witthuhn, J. Ihle, and J. Taniguchi 1994. Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. Science 266:1045–1047.
  • Moberg, K., M. A. Starz, and J. Lees 1996. E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry. Mol. Cell. Biol. 16:1436–1449.
  • Murthy, S. C., G. P. Bhat, and J. Thimmappaya 1985. Adenovirus EIIA early promoter: transcriptional control elements and induction by the viral pre-early EIA gene, which appears to be sequence independent. Proc. Natl. Acad. Sci. USA 82:2230–2234.
  • Nourse, J., E. Firpo, W. M. Flanagan, S. Coats, K. Polyak, M. H. Lee, J. Massague, G. R. Crabtree, and J. Roberts 1994. Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature 372:570–573.
  • Ohtani, K., and J. Nevins 1994. Functional properties of a Drosophila homolog of the E2F1 gene. Mol. Cell. Biol. 14:1603–1612.
  • Reif, K., B. M. T. Burgering, and J. Cantrell 1997. Phosphatidylinositol 3-kinase links the interleukin-2 receptor to protein kinase B and p70 S6 kinase. J. Biol. Chem. 272:14426–14438.
  • Reif, K., C. D. Nobes, G. Thomas, A. Hall, and J. Cantrell 1996. Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways. Curr. Biol. 6:1445–1455.
  • Remillard, B., R. Petrillo, W. Maslinski, M. Tsudo, T. B. Strom, L. Cantley, and J. Varticovski 1991. Interleukin-2 receptor regulates activation of phosphatidylinositol 3-kinase. J. Biol. Chem. 266:14167–14170.
  • Russell, S., J. Johnston, M. Noguchi, M. Kawamura, C. Bacon, M. Friedman, M. Berg, D. McVicar, B. Witthuhn, O. Silvennoinen, A. Goldman, F. Schmalstieg, J. Ihle, J. O’Shea, and J. Leonard 1994. Interaction of IL-2R β and γ chains with Jak1 and Jak3: implications for XSCID and XCID. Science 266:1042–1045.
  • Sabatini, D. M., H. Erdjumentbromage, M. Lui, P. Tempst, and J. Snyder 1994. Raft1—a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast Tors. Cell 78:35–43.
  • Sheaff, R. J., M. Groudine, M. Gordon, J. M. Roberts, and J. Clurman 1997. Cyclin E-CDK2 is a regulator of p27Kip1. Genes Dev. 11:1464–1478.
  • Shi, Y., R. Wang, A. Sharma, C. Gao, M. Collins, L. Penn, and J. Mills 1997. Dissociation of cytokine signals for proliferation and apoptosis. J. Immunol. 159:5318–5328.
  • Shima, H., M. Pende, Y. Chem, S. Fumagalli, G. Thomas, and J. Kozma 1998. Disruption of the p70S6k/p85S6k gene reveals a small mouse phenotype and a new functional S6 kinase. EMBO J. 17:6649–6659.
  • Smith, K. A., and J. Cantrell 1985. Interleukin 2 regulates its own receptors. Proc. Natl. Acad. Sci. USA 82:864–868.
  • Terada, N., K. Takase, P. Papst, A. Nairn, and J. Gelfand 1995. Rapamycin inhibits ribosomal protein synthesis and induces G1 prolongation in mitogen activated T lymphocytes. J. Immunol. 155:3418–3426.
  • Thomas, G., and J. Hall 1997. TOR signalling and control of cell growth. Curr. Opin. Cell Biol. 9:782–787.
  • Turner, B., U. Rapp, H. App, M. Greene, K. Dobashi, and J. Reid 1991. Interleukin-2 induces tyrosine phosphorylation and activation of p72-74 Raf-1 kinase in a T cell line. Proc. Natl. Acad. Sci. USA 88:1227–1232.
  • Von Manteuffel, S. R., A. C. Gingras, X. F. Ming, N. Sonenberg, and J. Thomas 1996. 4E-BP1 phosphorylation is mediated by the Frap-p70 S6 kinase pathway and is independent of mitogen-activated protein-kinase. Proc. Natl. Acad. Sci. USA 93:4076–4080.
  • Witthuhn, B., O. Silvennoinen, O. Miura, K. Lai, C. Cwik, E. Liu, and J. Ihle 1994. Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature 370:153–157.

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