Upstream Stimulatory Factor Regulates Major Histocompatibility Complex Class I Gene Expression: the U2ΔE4 Splice Variant Abrogates E-Box Activity

REFERENCES

• Aperlo, C., K. E. Boulukos, and J. Pognonec 1996. The basic region/helix-loop-helix/leucine repeat transcription factor USF interferes with Ras transformation. Eur. J. Biochem. 241:249–253.
   PubMedGoogle Scholar
• Beckman, H., L.-K. Su, and J. Kadesch 1989. TFE3: a helix-loop-helix protein that activates transcription through the immunoglobulin enhancer uE3 motif. Genes Dev. 4:1730–1740.
   Google Scholar
• Bendall, A. J., and J. Molloy 1994. Base preferences for DNA binding by the bHLH-Zip protein USF: effects of MgCl2 on specificity and comparison with binding of Myc family members. Nucleic Acids Res. 22:2801–2810.
   PubMed Web of Science ®Google Scholar
• Bodor, J., and J. Habener 1998. Role of transcriptional repressor ICER in cyclic AMP-mediated attenuation of cytokine gene expression in human thymocytes. J. Biol. Chem. 273:9544–9551.
   PubMedGoogle Scholar
• Bresnick, E. H., and J. Felsenfeld 1994. The leucine zipper is necessary for stabilizing a dimer of the helix-loop-helix transcription factor USF but not for maintenance of an elongated conformation. J. Biol. Chem. 269:21110–21116.
   PubMedGoogle Scholar
• Cai, M., and J. Davis 1990. Yeast centromere binding protein CBF1, of the helix-loop-helix protein family, is required for chromosome stability and methionine prototrophy. Cell 61:437–446.
   PubMed Web of Science ®Google Scholar
• Carr, C. S., and J. Sharp 1990. A helix-loop-helix protein related to immunoglobulin E box-binding proteins. Mol. Cell. Biol. 10:4384–4388.
   PubMed Web of Science ®Google Scholar
• Carthew, R. W., L. A. Chodosh, and J. Sharp 1985. An RNA polymerase II transcription factor binds to an upstream element in the adenovirus major late promoter. Cell 43:439–448.
   PubMed Web of Science ®Google Scholar
• Chamberlain, J. W., H. A. Vasavada, S. Ganguly, and J. Weissman 1991. Identification of cis sequences controlling efficient position-independent tissue-specific expression of human major histocompatibility complex class I genes in transgenic mice. Mol. Cell. Biol. 11:3564–3572.
   PubMedGoogle Scholar
• Corneliussen, B., A. Thornell, B. Hallberg, and J. Grundstrom 1991. Helix-loop-helix transcriptional activators bind to a sequence in glucocorticoid response elements of retrovirus enhancers. J. Virol. 65:6084–6093.
   PubMedGoogle Scholar
• Dang, C. V., C. Dolde, M. L. Gillison, and J. Kato 1992. Discrimination between related DNA sites by a single amino acid residue of Myc-related basic-helix-loop-helix proteins. Proc. Natl. Acad. Sci. USA 89:599–602.
   PubMedGoogle Scholar
• Das, G., C. S. Hinkley, and J. Herr 1995. Basal promoter elements as a selective determinant of transcriptional activator function. Nature 374:657–660.
   PubMed Web of Science ®Google Scholar
• Davis, R. L., P.-F. Cheng, A. B. Lassar, and J. Weintraub 1990. The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation. Cell 60:733–746.
   PubMedGoogle Scholar
• Du, H., A. L. Roy, and J. Roeder 1993. Human transcription factor USF stimulates transcription through the initiator elements of the HIV-1 and the Ad-ML promoters. EMBO J. 12:501–511.
   PubMedGoogle Scholar
• Ehrlich, R., J. Maguire, and J. Singer 1988. Identification of negative and positive regulatory elements associated with a class I major histocompatibility complex gene. Mol. Cell. Biol. 8:695–703.
   PubMedGoogle Scholar
• Ferre-D’Amare, A. R., P. Pognonec, R. G. Roeder, and J. Burley 1994. Structure and function of the b/HLH/Z domain of USF. EMBO J. 13:180–189.
   PubMedGoogle Scholar
• Girardet, C., W. H. Walker, and J. Habener 1996. An alternatively spliced polycistronic mRNA encoding cyclic adenosine 3′,5′-monophosphate (cAMP)-responsive transcription factor CREB (cAMP response element-binding protein) in human testis extinguishes expression of an internally translated inhibitor CREB isoform. Mol. Endocrinol. 10:879–891.
   PubMedGoogle Scholar
• Gregor, P. D., M. Sawadogo, and J. Roeder 1990. The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer. Genes Dev. 4:1730–1740.
   PubMed Web of Science ®Google Scholar
• Howcroft, T. K., J. C. Richardson, and J. Singer 1992. MHC class I gene expression is negatively regulated by the proto-oncogene, c-jun. EMBO J. 12:3163–3169.
   Google Scholar
• Jones, N. 1990. Transcriptional regulation by dimerization: two sides to an incestuous relationship. Cell 61:9–11.
   PubMedGoogle Scholar
• Kim, J. B., G. D. Spotts, Y.-D. Halvorsen, H.-M. Shih, T. Ellenberger, H. C. Towle, and J. Spiegelman 1995. Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain. Mol. Cell. Biol. 15:2582–2588.
   PubMedGoogle Scholar
• LeBouteiller, P. 1994. HLA class I chromosomal region, genes, and products: facts and questions. Crit. Rev. Immunol. 14:89–129.
   PubMedGoogle Scholar
• Lin, Q., X. Luo, and J. Sawadogo 1994. Archaic structure of the gene encoding transcription factor USF. J. Biol. Chem. 269:23894–23903.
   PubMedGoogle Scholar
• Luo, X., and J. Sawadogo 1996. Functional domains of the transcription factor USF2: atypical nuclear localization signals and context-dependent transcriptional activation domains. Mol. Cell. Biol. 16:1367–1375.
   PubMedGoogle Scholar
• Luo, X., and J. Sawadogo 1996. Antiproliferative properties of the USF family of helix-loop-helix transcription factors. Proc. Natl. Acad. Sci. USA 93:1308–1313.
   PubMedGoogle Scholar
• Luo, X., and M. Sawadogo. Unpublished observation.
   Google Scholar
• Maguire, J. E., W. I. Frels, J. C. Richardson, J. D. Weissman, and J. Singer 1992. In vivo function of regulatory DNA sequence elements of a major histocompatibility complex class I gene. Mol. Cell. Biol. 12:3078–3086.
   PubMedGoogle Scholar
• Maniatis, T. 1991. Mechanisms of alternative pre-mRNA splicing. Science 251:33–34.
   PubMed Web of Science ®Google Scholar
• Mellor, J., W. Jiang, M. Funk, J. Rathjen, C. A. Barnes, T. Hinz, J. H. Hegemann, and J. Philippsen 1990. CPF1, a yeast protein which functions in centromeres and promoters. EMBO J. 9:4017–4026.
   PubMedGoogle Scholar
• Miyamoto, N. G., V. Moncollin, and J. Chambon 1985. Specific interaction between a transcription factor and the upstream element of the adenovirus-2 major late promoter. EMBO J. 4:3563–3570.
   PubMedGoogle Scholar
• Murphy, C., D. Nikodem, K. Howcroft, J. D. Weissman, and J. Singer 1996. Active repression of major histocompatibility complex class I genes in a human neuroblastoma cell line. J. Biol. Chem. 271:30992–30999.
   PubMedGoogle Scholar
• Murre, C., P. S. McCaw, and J. Baltimore 1989. A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell 56:777–783.
   PubMed Web of Science ®Google Scholar
• Murre, C., P. S. McCaw, H. Vaessin, M. Caudy, L. Y. Jan, Y. N. Jan, C. V. Cabrera, J. N. Buskin, S. D. Hauschka, A. B. Lassar, H. Weintraub, and J. Baltimore 1989. Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell 58:537–544.
   PubMed Web of Science ®Google Scholar
• Oettgen, P., Y. Akbarali, J. Boltax, J. Best, C. Kunsch, and J. Libermann 1996. Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1. Mol. Cell. Biol. 16:5091–5106.
   PubMedGoogle Scholar
• Sawadogo, M., and J. Roeder 1985. Interaction of a gene-specific transcription factor with the adenovirus major late promoter upstream of the TATA box region. Cell 43:165–175.
   PubMed Web of Science ®Google Scholar
• Sawadogo, M., M. W. VanDykes, P. D. Gregor, and J. Roeder 1988. Multiple forms of the human gene-specific transcription factor USF. J. Biol. Chem. 263:11985–11993.
   PubMed Web of Science ®Google Scholar
• Schmidt, C. M., R. G. Ehlenfeldt, M. C. Athanasiou, L. A. Duvick, H. Heinrichs, C. S. David, and J. Orr 1993. Extraembryonic expression of the human MHC class I gene HLA-G in transgenic mice. Evidence for a positive regulatory region located 1 kilobase 5′ to the start site of transcription. J. Immunol. 151:2633–2645.
   PubMedGoogle Scholar
• Singer, D., and J. Maguire 1990. Regulation of the expression of class I MHC genes. Crit. Rev. Immunol. 10:235–257.
   PubMedGoogle Scholar
• Sirito, M., S. Walker, Q. Lin, M. T. Kozlowski, W. H. Klein, and J. Sawadogo 1992. Members of the USF family of helix-loop-helix proteins bind DNA as homo- as well as heterodimers. Gene Expr. 2:231–240.
   PubMedGoogle Scholar
• Sirito, M., Q. Lin, T. Maity, and J. Sawadogo 1994. Ubiquitous expression of the 43- and 44-kDa forms of transcription factor USF in mammalian cells. Nucleic Acids Res. 22:427–433.
   PubMed Web of Science ®Google Scholar
• Ting, J. P.-Y., and J. Baldwin 1993. Regulation of MHC gene expression. Curr. Biol. 5:8–16.
   Google Scholar
• Viollet, B., A. M. Lefrancois-Martinez, A. Henrion, A. Kahn, M. Raymondjean, and J. Martinez 1996. Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms. J. Biol. Chem. 271:1405–1415.
   PubMedGoogle Scholar
• Weissman, J. D., and J. Singer 1991. A complex regulatory DNA element associated with a major histocompatibility complex class I gene consists of both a silencer and an enhancer. Mol. Cell. Biol. 11:4217–4227.
   PubMedGoogle Scholar