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Cell Growth and Development

Tyrosine Phosphorylation of the Proto-Oncoprotein Raf-1 Is Regulated by Raf-1 Itself and the Phosphatase Cdc25A

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Pages 4819-4824 | Received 14 Oct 1998, Accepted 15 Apr 1999, Published online: 28 Mar 2023

REFERENCES

  • Barber, D. L., C. N. Corless, K. Xia, T. M. Roberts, and J. D’Andrea 1997. Erythropoietin activates Raf1 by an Shc-independent pathway in CTLL-EPO-R cells. Blood 89:55–64.
  • Carroll, M. P., I. Clark-Lewis, U. R. Rapp, and J. May 1990. Interleukin-3 and granulocyte-macrophage colony-stimulating factor mediate rapid phosphorylation and activation of cytosolic c-raf. J. Biol. Chem. 265:19812–19817.
  • Conklin, D. S., K. Galaktionov, and J. Beach 1995. 14-3-3 proteins associate with cdc25 phosphatases. Proc. Natl. Acad. Sci. USA 92:7892–7896.
  • Dent, P., T. Jelinek, D. K. Morrison, M. J. Weber, and J. Sturgill 1995. Reversal of Raf-1 activation by purified and membrane-associated protein phosphatases. Science 268:1902–1906 (Erratum, 269:1657.)
  • Dent, P., D. B. Reardon, S. L. Wood, M. A. Lindorfer, S. G. Graber, J. C. Garrison, D. L. Brautigan, and J. Sturgill 1996. Inactivation of raf-1 by a protein-tyrosine phosphatase stimulated by GTP and reconstituted by Galphai/o subunits. J. Biol. Chem. 271:3119–3123.
  • Dunphy, W. G., and J. Kumagai 1991. The cdc25 protein contains an intrinsic phosphatase activity. Cell 67:189–196.
  • Fabian, J. R., I. O. Daar, and J. Morrison 1993. Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase. Mol. Cell. Biol. 13:7170–7179.
  • Galaktionov, K., and J. Beach 1991. Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. Cell 67:1181–1194.
  • Galaktionov, K., C. Jessus, and J. Beach 1995. Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation. Genes Dev. 9:1046–1058.
  • Gautier, J., M. J. Solomon, R. N. Booher, J. F. Bazan, and J. Kirschner 1991. cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2. Cell 67:197–211.
  • Jelinek, T., P. Dent, T. W. Sturgill, and J. Weber 1996. Ras-induced activation of Raf-1 is dependent on tyrosine phosphorylation. Mol. Cell. Biol. 16:1027–1034 (Erratum, 17:2971, 1997.)
  • Jinno, S., K. Suto, A. Nagata, M. Igarashi, Y. Kanaoka, H. Nojima, and J. Okayama 1994. Cdc25A is a novel phosphatase functioning early in the cell cycle. EMBO J. 13:1549–1556.
  • Kakizuka, A., B. Sebastian, U. Borgmeyer, I. Hermans-Borgmeyer, J. Bolado, T. Hunter, M. F. Hoekstra, and J. Evans 1992. A mouse cdc25 homolog is differentially and developmentally expressed. Genes Dev. 6:578–590.
  • Kasid, U., S. Suy, P. Dent, S. Ray, T. L. Whiteside, and J. Sturgill 1996. Activation of Raf by ionizing radiation. Nature 382:813–816.
  • Lee, M. S., S. Ogg, M. Xu, L. L. Parker, D. J. Donoghue, J. L. Maller, and J. Piwnica-Worms 1992. cdc25+ encodes a protein phosphatase that dephosphorylates p34cdc2. Mol. Biol. Cell 3:73–84.
  • Marais, R. Personal communication.
  • Marais, R., Y. Light, H. F. Paterson, and J. Marshall 1995. Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation. EMBO J. 14:3136–3145.
  • Marshall, C. J. 1995. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80:179–185 (Review.)
  • Morrison, D. K., and J. Cutler 1997. The complexity of Raf-1 regulation. Curr. Opin. Cell Biol. 9:174–179 (Review.)
  • Morrison, D. K., G. Heidecker, U. R. Rapp, and J. Copeland 1993. Identification of the major phosphorylation sites of the Raf-1 kinase. J. Biol. Chem. 268:17309–17316.
  • Morrison, D. K., D. R. Kaplan, J. A. Escobedo, U. R. Rapp, T. M. Roberts, and J. Williams 1989. Direct activation of the serine/threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF beta-receptor. Cell 58:649–657.
  • Muslin, A. J., J. W. Tanner, P. M. Allen, and J. Shaw 1996. Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine. Cell 84:889–897.
  • Park, R. K., Y. Liu, and J. Durden 1996. A role for Shc, Grb2, and Raf-1 in FcgammaRI signal relay. J. Biol. Chem. 271:13342–13348.
  • Roberts, T. M. 1992. Cell biology. A signal chain of events. Nature 360:534–535 (News; comment.)
  • Popik, W., and J. Pitha 1996. Binding of human immunodeficiency virus type 1 to CD4 induces association of Lck and Raf-1 and activates Raf-1 by a Ras-independent pathway. Mol. Cell. Biol. 16:6532–6541.
  • Sadhu, K., S. I. Reed, H. Richardson, and J. Russell 1990. Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2. Proc. Natl. Acad. Sci. USA 87:5139–5143.
  • Sakatsume, M., L. F. Stancato, M. David, O. Silvennoinen, P. Saharinen, J. Pierce, A. C. Larner, and J. Finbloom 1998. Interferon gamma activation of Raf-1 is Jak1-dependent and p21ras-independent. J. Biol. Chem. 273:3021–3026.
  • Sebastian, B., A. Kakizuka, and J. Hunter 1993. Cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine-15. Proc. Natl. Acad. Sci. USA 90:3521–3524.
  • Stancato, L. F., M. Sakatsume, M. David, P. Dent, F. Dong, E. F. Petricoin, J. J. Krolewski, O. Silvennoinen, P. Saharinen, J. Pierce, C. J. Marshall, T. Sturgill, D. S. Finbloom, and J. Larner 1997. Beta interferon and oncostatin M activate Raf-1 and mitogen-activated protein kinase through a JAK1-dependent pathway. Mol. Cell. Biol. 17:3833–3840.
  • Turner, B., U. Rapp, H. App, M. Greene, K. Dobashi, and J. Reed 1991. Interleukin 2 induces tyrosine phosphorylation and activation of p72-74 Raf-1 kinase in a T-cell line. Proc. Natl. Acad. Sci. USA 88:1227–1231.
  • Williams, N. G., and T. M. Roberts. Unpublished data.
  • Xia, K., N. K. Mukhopadhyay, R. C. Inhorn, D. L. Barber, P. E. Rose, R. S. Lee, R. P. Narsimhan, A. D. D’Andrea, J. D. Griffin, and J. Roberts 1996. The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21ras-dependent manner. Proc. Natl. Acad. Sci. USA 93:11681–11686.

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