Disordered T-Cell Development and T-Cell Malignancies in SCL LMO1 Double-Transgenic Mice: Parallels with E2A-Deficient Mice

REFERENCES

• Aplan, P. D., C. G. Begley, V. Bertness, M. Nussmeier, A. Ezquerra, J. Coligan, and J. Kirsch 1990. The SCL gene is formed from a transcriptionally complex locus. Mol. Cell. Biol. 10:6426–6435.
   PubMed Web of Science ®Google Scholar
• Aplan, P. D., C. A. Jones, D. S. Chervinsky, X. Zhao, M. Ellsworth, C. Wu, E. A. McGuire, and J. Gross 1997. An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice. EMBO J. 16:2408–2419.
   PubMed Web of Science ®Google Scholar
• Aplan, P. D., D. P. Lombardi, A. M. Ginsberg, J. Cossman, V. I. Bertness, and J. Kirsch 1990. Disruption of the human SCL locus by “illegitimate” V-(D)-J recombinase activity. Science 250:1426–1429.
   PubMed Web of Science ®Google Scholar
• Aplan, P. D., D. P. Lombardi, and J. Kirsch 1991. Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia. Mol. Cell. Biol. 11:5462–5469.
   PubMed Web of Science ®Google Scholar
• Bain, G., I. Engel, E. C. Robanus-Maandag, H. P. te Riele, J. R. Voland, L. I. Sharp, J. Chun, B. Huey, D. Pinkel, and J. Murre 1997. E2A deficiency leads to abnormalities in α/β T-cell development and to rapid development of T-cell lymphomas. Mol. Cell. Biol. 17:4782–4791.
   PubMed Web of Science ®Google Scholar
• Bash, R. O., W. M. Crist, J. J. Shuster, M. P. Link, M. Amylon, J. Pullen, A. J. Carroll, G. R. Buchanan, R. G. Smith, and J. Baer 1993. Clinical features and outcome of T-cell acute lymphoblastic leukemia in childhood with respect to alterations at the TAL1 locus: a Pediatric Oncology Group study. Blood 81:2110–2117.
   PubMed Web of Science ®Google Scholar
• Bash, R. O., S. Hall, C. F. Timmons, W. M. Crist, M. Amylon, R. G. Smith, and J. Baer 1995. Does activation of the TAL1 gene occur in a majority of patients with T-cell acute lymphoblastic leukemia? A Pediatric Oncology Group study. Blood 86:666–676.
   PubMed Web of Science ®Google Scholar
• Begley, C. G., P. D. Aplan, M. P. Davey, K. Nakahara, K. Tchorz, J. Kurtzberg, M. S. Hershfield, B. F. Haynes, D. I. Cohen, T. A. Waldmann, and J. Kirsch 1989. Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript. Proc. Natl. Acad. Sci. USA 86:2031–2035.
   PubMed Web of Science ®Google Scholar
• Begley, C. G., P. D. Aplan, S. M. Denning, B. F. Haynes, T. A. Waldmann, and J. Kirsch 1989. The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif. Proc. Natl. Acad. Sci. USA 86:10128–10132.
   PubMed Web of Science ®Google Scholar
• Brown, L., J. T. Cheng, Q. Chen, M. J. Siciliano, W. Crist, G. Buchanan, and J. Baer 1990. Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia. EMBO J. 9:3343–3351.
   PubMed Web of Science ®Google Scholar
• Burd, R., T. S. Dziedzic, Y. Xu, M. A. Caligiuri, J. R. Subjeck, and J. Repasky 1998. Tumor cell apoptosis, lymphocyte recruitment and tumor vascular changes are induced by low temperature, long duration (fever-like) whole body hyperthermia. J. Cell. Physiol. 177:137–147.
   PubMed Web of Science ®Google Scholar
• Chen, Q., J. T. Cheng, L. H. Tasi, N. Schneider, G. Buchanan, A. Carroll, W. Crist, B. Ozanne, M. J. Siciliano, and J. Baer 1990. The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein. EMBO J. 9:415–424.
   PubMed Web of Science ®Google Scholar
• Cheng, J. T., H. L. Hsu, L. Y. Hwang, and J. Baer 1993. Products of the TAL1 oncogene: basic helix-loop-helix proteins phosphorylated at serine residues. Oncogene 8:677–683.
   PubMed Web of Science ®Google Scholar
• Collazo-Garcia, N., P. Scherer, and J. Aplan 1995. Cloning and characterization of a murine SIL gene. Genomics 30:506–513.
   PubMedGoogle Scholar
• Condorelli, G. L., F. Facchiano, M. Valtieri, E. Proietti, L. Vitelli, V. Lulli, K. Huebner, C. Peschle, and J. Croce 1996. T-cell-directed TAL-1 expression induces T-cell malignancies in transgenic mice. Cancer Res. 56:5113–5119.
   PubMedGoogle Scholar
• Dedera, D. A., E. K. Waller, D. P. LeBrun, A. Sen-Majumdar, M. E. Stevens, G. S. Barsh, and J. Cleary 1993. Chimeric homeobox gene E2A-PBX1 induces proliferation, apoptosis, and malignant lymphomas in transgenic mice. Cell 74:833–843.
   PubMed Web of Science ®Google Scholar
• Elefanty, A. G., C. G. Begley, D. Metcalf, L. Barnett, F. Kontgen, and J. Robb 1997. Characterization of hematopoietic progenitor cells that express the transcription factor scl, using a lacZ knock-in strategy. Proc. Natl. Acad. Sci. USA 95:11897–11902.
   Google Scholar
• Finger, L. R., J. Kagan, G. Christopher, J. Kurtzberg, M. S. Hershfield, P. C. Nowell, and J. Croce 1989. Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma. Proc. Natl. Acad. Sci. USA 86:5039–5043.
   PubMed Web of Science ®Google Scholar
• Fitzgerald, T. J., G. A. Neale, S. C. Raimondi, and J. Goorha 1991. c-tal, a helix-loop-helix protein, is juxtaposed to the T-cell receptor-beta chain gene by a reciprocal chromosomal translocation: t(1;7)(p32;q35). Blood 78:2686–2695.
   PubMed Web of Science ®Google Scholar
• Gering, M., A. R. F. Rodaway, B. Gottgens, R. K. Patient, and J. Green 1998. The scl gene specifies haemangioblast development from early mesoderm. EMBO J. 17:4029–4045.
   PubMed Web of Science ®Google Scholar
• Goldfarb, A. N., S. Goueli, D. Mickelson, and J. Greenberg 1992. T-cell acute lymphoblastic leukemia—the associated gene SCL/tal codes for a 42-Kd nuclear phosphoprotein. Blood 80:2858–2866.
   PubMed Web of Science ®Google Scholar
• Goldfarb, A. N., K. Lewandowska, and J. Shoham 1996. Determinants of helix-loop-helix dimerization affinity. Random mutational analysis of SCL/tal. J. Biol. Chem. 271:2683–2688.
   PubMedGoogle Scholar
• Grutz, G. G., K. Bucher, I. Lavenir, T. Larson, R. Larson, and J. Rabbitts 1998. The oncogenic T cell LIM-protein LMO2 forms part of a DNA-binding complex specifically in immature T cells. EMBO J. 17:4594–4605.
   PubMedGoogle Scholar
• Hsu, H. L., J. T. Cheng, Q. Chen, and J. Baer 1991. Enhancer-binding activity of the tal-1 oncoprotein in association with the E47/E12 helix-loop-helix proteins. Mol. Cell. Biol. 11:3037–3042.
   PubMed Web of Science ®Google Scholar
• Hsu, H. L., L. Huang, J. T. Tsan, W. Funk, W. E. Wright, J. S. Hu, R. E. Kingston, and J. Baer 1994. Preferred sequences for DNA recognition by the TAL1 helix-loop-helix proteins. Mol. Cell. Biol. 14:1256–1265.
   PubMedGoogle Scholar
• Kelliher, M. A., D. C. Seldin, and J. Leder 1996. Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIalpha. EMBO J. 15:5160–5166.
   PubMedGoogle Scholar
• Larson, R. C., I. Lavenir, T. A. Larson, R. Baer, A. J. Warren, I. Wadman, K. Nottage, and J. Rabbitts 1996. Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice. EMBO J. 15:1021–1027.
   PubMed Web of Science ®Google Scholar
• Larson, R. C., H. Osada, T. A. Larson, I. Lavenir, and J. Rabbitts 1995. The oncogenic LIM protein Rbtn2 causes thymic developmental aberrations that precede malignancy in transgenic mice. Oncogene 11:853–862.
   PubMed Web of Science ®Google Scholar
• Lowsky, R., J. F. Decoteau, A. H. Reitmair, R. Ichinohasama, W. F. Dong, Y. Xu, T. W. Mak, M. E. Kadin, and J. Minden 1997. Defects of the mismatch repair gene Msh2 are implicated in the development of murine and human lymphoblastic lymphomas and are associated with the aberrant expression of rhombotin-2 (Lmo-2) and Tal-1 (Scl). Blood 89:2276–2282.
   PubMed Web of Science ®Google Scholar
• McGuire, E. A., C. E. Rintoul, G. M. Sclar, and J. Korsmeyer 1992. Thymic overexpression of Ttg-1 in transgenic mice results in T-cell acute lymphoblastic leukemia/lymphoma. Mol. Cell. Biol. 12:4186–4196.
   PubMed Web of Science ®Google Scholar
• Murre, C., P. S. McCaw, and J. Baltimore 1989. A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell 56:777–783.
   PubMed Web of Science ®Google Scholar
• Neale, G. A., J. E. Rehg, and J. Goorha 1995. Ectopic expression of rhombotin-2 causes selective expansion of CD4− CD8− lymphocytes in the thymus and T-cell tumors in transgenic mice. Blood 86:3060–3071.
   PubMedGoogle Scholar
• Ordentlich, P., A. Lin, C. P. Shen, C. Blaumueller, K. Matsuno, S. Artavanis-Tsakonas, and J. Kadesch 1998. Notch inhibition of E47 supports the existence of a novel signaling pathway. Mol. Cell. Biol. 18:2230–2239.
   PubMed Web of Science ®Google Scholar
• Park, S. T., and J. Sun 1998. The Tal1 oncoprotein inhibits E47-mediated transcription—mechanism of inhibition. J. Biol. Chem. 273:7030–7037.
   PubMedGoogle Scholar
• Rabbitts, T. H. 1994. Chromosomal translocations in human cancer. Nature 372:143–149.
   PubMed Web of Science ®Google Scholar
• Robb, L., I. Lyons, R. Li, L. Hartley, F. Kontgen, R. P. Harvey, D. Metcalf, and J. Begley 1995. Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene. Proc. Natl. Acad. Sci. USA 92:7075–7079.
   PubMedGoogle Scholar
• Robb, L., J. E. Rasko, M. L. Bath, A. Strasser, and J. Begley 1995. scl, a gene frequently activated in human T cell leukaemia, does not induce lymphomas in transgenic mice. Oncogene 10:205–209.
   PubMedGoogle Scholar
• Robey, E., D. Chang, A. Itano, D. Cado, H. Alexander, D. Lans, G. Weinmaster, and J. Salmon 1996. An activated form of Notch influences the choice between CD4 and CD8 T cell lineages. Cell 87:483–492.
   PubMed Web of Science ®Google Scholar
• Sanchez-Garcia, I., and J. Rabbitts 1994. Transcriptional activation by TAL1 and FUS-CHOP proteins expressed in acute malignancies as a result of chromosomal abnormalities. Proc. Natl. Acad. Sci. USA 91:7869–7873.
   PubMedGoogle Scholar
• Sawada, S., and J. Littman 1993. A heterodimer of Heb and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines. Mol. Cell. Biol. 13:5620–5628.
   PubMedGoogle Scholar
• Shivdasani, R. A., E. L. Mayer, and J. Orkin 1995. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature 373:432–434.
   PubMed Web of Science ®Google Scholar
• Stanulla, M., J. Wang, D. S. Chervinsky, S. Thandla, and J. Aplan 1997. DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of apoptosis. Mol. Cell. Biol. 17:4070–4079.
   PubMed Web of Science ®Google Scholar
• Thandla, S., and J. Aplan 1997. Molecular biology of acute lymphocytic leukemia. Semin. Oncol. 24:45–56.
   PubMedGoogle Scholar
• Visvader, J. E., Y. Fujiwara, and J. Orkin 1998. Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development. Genes Dev. 12:473–479.
   PubMed Web of Science ®Google Scholar
• Voronova, A. F., and J. Lee 1994. The E2A and tal-1 helix-loop-helix proteins associate in vivo and are modulated by Id proteins during interleukin 6-induced myeloid differentiation. Proc. Natl. Acad. Sci. USA 91:5952–5956.
   PubMedGoogle Scholar
• Wadman, I., J. Li, R. O. Bash, A. Forster, H. Osada, T. H. Rabbitts, and J. Baer 1994. Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia. EMBO J. 13:4831–4839.
   PubMedGoogle Scholar
• Wadman, I. A., H. Osada, G. G. Grutz, A. D. Agulnick, H. Westphal, A. Forster, and J. Rabbitts 1997. The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. EMBO J. 16:3145–3157.
   PubMed Web of Science ®Google Scholar
• Yan, W., A. Z. Young, V. C. Soares, R. Kelley, R. Benezra, and J. Zhuang 1997. High incidence of T-cell tumors in E2A-null mice and E2A/ld1 double-knockout mice. Mol. Cell. Biol. 17:7317–7327.
   PubMedGoogle Scholar
• Zhao, X.-F., and J. Aplan 1999. The hematopoietic transcription factor SCL binds the p44 subunit of TFIIH. J. Biol. Chem. 274:1388–1393.
   PubMedGoogle Scholar