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Transcriptional Regulation

The Linker Domain of Stat1 Is Required for Gamma Interferon-Driven Transcription

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Pages 5106-5112 | Received 17 Nov 1998, Accepted 05 Apr 1999, Published online: 28 Mar 2023

REFERENCES

  • Ausubel F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, K. Struhl 1994. Current protocols in molecular biology. John Wiley & Sons, Inc., New York, N.Y.
  • Becker, S., B. Groner, and J. Mueller 1998. Three-dimensional structure of the Stat3β homodimer bound to DNA. Nature 394:145–151.
  • Bhattacharya, S., R. Eckner, S. Grossman, E. Oldread, Z. Arany, A. D’Andrea, and J. Livingston 1996. Cooperation of Stat2 and p300/CBP in signalling induced by interferon-α. Nature 383:344–347.
  • Chen, X., U. Vinkemeier, Y. Zhao, D. Jeruzalmi, J. E. Darnell Jr., and J. Kuriyan 1998. Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA. Cell 93:827–839.
  • Darnell, J. E. Jr.. 1997. STATs and gene regulation. Science 277:1630–1635.
  • Erpel, T., G. Superti-Furga, and J. Courtneidge 1995. Mutational analysis of the Src SH3 domain: the same residues of the ligand binding surface are important for intra- and intermolecular interactions. EMBO J. 14:963–975.
  • Fu, X.-Y. 1992. A transcription factor with SH2 and SH3 domains is directly activated by an interferon α-induced cytoplasmic protein tyrosine kinase(s). Cell 70:323–335.
  • Haspel, R. L., M. Salditt-Georgieff, J. E. Darnell Jr.. 1996. The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase. EMBO J. 15:6262–6268.
  • Horvai, A. E., L. Xu, E. Korzus, G. Brard, D. Kalafus, T.-M. Mullen, D. W. Rose, M. G. Rosenfield, and J. Glass 1997. Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300. Proc. Natl. Acad. Sci. USA 94:1074–1079.
  • Horvath, C. M., J. E. Darnell Jr.. 1996. The antiviral state induced by alpha interferon and gamma interferon requires transcriptionally active Stat1 protein. J. Virol. 70:647–650.
  • Horvath, C. M., G. R. Stark, I. M. Kerr, J. E. Darnell Jr.. 1996. Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex. Mol. Cell. Biol. 16:6957–6964.
  • Horvath, C. M., Z. Wen, J. E. Darnell Jr.. 1995. A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain. Genes Dev. 9:984–994.
  • Kimura, T., K. Nakayama, J. Penninger, M. Kitagawa, H. Harada, T. Matsuyama, N. Tanaka, R. Kamijo, J. Vilcek, T. W. Mak, and J. Taniguchi 1994. Involvement of the IRF-1 transcription factor in antiviral responses to interferons. Science 264:1921–1924.
  • Kuriyan, J., and J. Cowburn 1997. Modular peptide recognition domains in eukaryotic signalling. Annu. Rev. Biophys. Biomol. Struct. 26:259–288.
  • Look, D. C., M. R. Pelletier, R. M. Tidwell, W. T. Roswit, and J. Holtzman 1995. Stat 1 depends on transcriptional synergy with Sp1. J. Biol. Chem. 270:30264–30267.
  • Lu, B., M. Reichel, D. Fisher, J. Smith, and J. Rothman 1997. Identification of a STAT6 domain required for IL-4 induced activation of transcription. J. Immunol. 159:1255–1264.
  • Moriggl, R., S. Berchtold, K. Friedrich, G. J. R. Standke, W. Kammer, M. Heim, M. Wissler, E. Stöcklin, F. Gouilleux, and J. Groner 1997. Comparison of the transactivation domains of Stat5 and Stat6 in lymphoid cells and mammary epithelial cells. Mol. Cell. Biol. 17:3663–3678.
  • Muhelthaler-Mottet, A., W. Di Berardino, L. A. Otten, and J. Mach 1998. Activation of the MHC class II transactivator CIITA by interferon-gamma requires cooperative interaction between Stat1 and USF-1. Immunity 8:157–166.
  • Schaefer, T. S., L. K. Sanders, and J. Nathans 1995. Cooperative transcriptional activity of Jun and Stat3β, a short form of Stat3. Proc. Natl. Acad. Sci. USA 92:9097–9101.
  • Schindler, C., K. Shuai, V. R. Prezioso, J. E. Darnell Jr.. 1992. Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science 257:809–813.
  • Seidel, H. M., L. H. Milocco, P. Lamb, J. E. Darnell Jr., R. B. Stein, and J. Rosen 1995. Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity. Proc. Natl. Acad. Sci. USA 92:3041–3045.
  • Shuai, K., C. M. Horvath, L. H. Tsai-Huang, S. Qureshi, D. Cowburn, J. E. Darnell Jr.. 1994. Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions. Cell 76:821–828.
  • Stark, G. R., I. M. Kerr, B. R. G. Williams, R. H. Silverman, and J. Schreiber 1998. How cells respond to interferons. Annu. Rev. Biochem. 67:227–264.
  • Stocklin, E., M. Wissler, F. Gouilleux, and J. Groner 1996. Functional interactions between Stat5 and the glucocorticoid receptor. Nature 383:726–728.
  • Transfac-Team. 1998, copyright date. Sequence alignment. [Online.] http://transfac.gbf.de/dbsearch/clustalw.html [19 May 1999, last date accessed.]
  • Vinkemeier, U., S. L. Cohen, I. Moarefi, B. T. Chait, J. Kuriyan, J. E. Darnell Jr.. 1996. DNA binding of in vitro activated Stat1α, Stat1β, and truncated Stat1: interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites. EMBO J. 15:5616–5626.
  • Vinkemeier, U., I. Moarefi, J. E. Darnell Jr., and J. Kuriyan 1998. Structure of the amino-terminal protein interaction domain of STAT-4. Science 279:1048–1052.
  • Wagner, B. J., T. E. Hayes, C. J. Hoban, and J. Cochran 1990. The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter. EMBO J. 9:4477–4484.
  • Wang, D., D. Stravopodis, S. Teglund, J. Kitazawa, and J. Ihle 1996. Naturally occurring dominant negative variants of Stat5. Mol. Cell. Biol. 16:6141–6148.
  • Wen, Z., Z. Zhong, J. E. Darnell Jr.. 1995. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 82:241–250.
  • Xu, X., Y.-L. Sun, and J. Hoey 1996. Cooperative DNA binding and sequence selective recognition conferred by the STAT amino-terminal domain. Science 273:794–797.
  • Yang, E., and J. E. Darnell. Unpublished observations.
  • Zhang, J. J., Y. Zhao, B. T. Chait, W. W. Lathem, M. Ritzi, R. Knippers, J. E. Darnell Jr.. 1998. Ser727-dependent recruitment of MCM5 by Stat1α in IFN-γ-induced transcriptional activation. EMBO J. 17:6963–6971.
  • Zhang, J. J., U. Vinkemeier, W. Gu, D. Chakravarti, J. E. Darnell Jr.. 1996. Two contact regions between Stat1 and CBP/p300 in interferon γ signalling. Proc. Natl. Acad. Sci. USA 93:15092–15096.
  • Zhu, M. H., S. John, M. Berg, and J. Leonard 1999. Functional association of Nmi with Stat5 and Stat1 in IL-2 and IFN-γ-mediated signalling. Cell 96:121–130.
  • Zhu, X., Z. Wen, L. Z. Xu, J. E. Darnell Jr.. 1997. Stat1 serine phosphorylation occurs independently of tyrosine phosphorylation and requires an activated Jak2 kinase. Mol. Cell. Biol. 17:6618–6623.

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