Mitogen-Activated Protein Kinase Kinase Kinase 1 Activates Androgen Receptor-Dependent Transcription and Apoptosis in Prostate Cancer

REFERENCES

• Abreu-Martin, M. T., and C. L. Sawyers. Unpublished data.
   Google Scholar
• Amati, B., and J. Land 1994. Myc-Max-Mad: a transcription factor network controlling cell cycle progression, differentiation and death. Curr. Opin. Genet. Dev. 4:102–108.
   PubMed Web of Science ®Google Scholar
• Brandstrom, A., P. Westin, A. Bergh, S. Cajander, and J. Damber 1994. Castration induces apoptosis in the ventral prostate but not in an androgen-sensitive prostatic adenocarcinoma in the rat. Cancer Res. 54:3594–3601.
   PubMed Web of Science ®Google Scholar
• Bubulya, A., S. C. Wise, X. Q. Shen, L. A. Burmeister, and J. Shemshedini 1996. c-Jun can mediate androgen receptor-induced transactivation. J. Biol. Chem. 271:24583–24589.
   PubMed Web of Science ®Google Scholar
• Bunone, G., P. A. Briand, R. J. Miksicek, and J. Picard 1996. Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation. EMBO J. 15:2174–2183.
   PubMed Web of Science ®Google Scholar
• Cardone, M. H., G. S. Salvesen, C. Widmann, G. Johnson, and J. Frisch 1997. The regulation of anoikis: MEKK-1 activation requires cleavage by caspases. Cell 90:315–323.
   PubMed Web of Science ®Google Scholar
• Chen, Y. R., X. Wang, D. Templeton, R. J. Davis, and J. Tan 1996. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation. J. Biol. Chem. 271:31929–31936.
   PubMed Web of Science ®Google Scholar
• Cleutjens, K. B., H. A. van der Korput, C. C. van Eekelen, H. C. J. van Rooij, P. W. Faber, and J. Trapman 1997. An androgen response element in a far upstream enhancer region is essential for high, androgen-regulated activity of the prostate-specific antigen promoter. Mol. Endocrinol. 11:148–161.
   PubMedGoogle Scholar
• Cleutjens, K. B., C. C. van Eekelen, H. A. van der Korput, A. O. Brinkmann, and J. Trapman 1996. Two androgen response regions cooperate in steroid hormone regulated activity of the prostate-specific antigen promoter. J. Biol. Chem. 271:6379–6388.
   PubMed Web of Science ®Google Scholar
• Colombel, M., S. Gil Diez, F. Radvanyi, R. Buttyan, J. P. Thiery, and J. Chopin 1996. Apoptosis in prostate cancer. Molecular basis to study hormone refractory mechanisms. Ann. N. Y. Acad. Sci. 784:63–69.
   PubMedGoogle Scholar
• Craft, N., Y. Shostak, M. Carey, and J. Sawyers 1999. A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase. Nat. Med. 5:280–285.
   PubMed Web of Science ®Google Scholar
• Culig, Z., A. Hobisch, M. V. Cronauer, C. Radmayr, J. Trapman, A. Hittmair, G. Bartsch, and J. Klocker 1994. Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor. Cancer Res. 54:5474–5478.
   PubMed Web of Science ®Google Scholar
• Deak, J. C., J. V. Cross, M. Lewis, Y. Qian, L. A. Parrott, C. W. Distelhorst, and J. Templeton 1998. Fas-induced proteolytic activation and intracellular redistribution of the stress-signaling kinase MEKK1. Proc. Natl. Acad. Sci. USA 95:5595–5600.
   PubMed Web of Science ®Google Scholar
• Derijard, B., M. Hibi, I. H. Wu, T. Barrett, B. Su, T. Deng, M. Karin, and J. Davis 1994. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76:1025–1037.
   PubMed Web of Science ®Google Scholar
• Dickens, M., J. S. Rogers, J. Cavanagh, A. Raitano, Z. Xia, J. R. Halpern, M. E. Greenberg, C. L. Sawyers, and J. Davis 1997. A cytoplasmic inhibitor of the JNK signal transduction pathway. Science 277:693–696.
   PubMed Web of Science ®Google Scholar
• Fanger, G. R., C. Widmann, A. C. Porter, S. Sather, G. L. Johnson, and J. Vaillancourt 1998. 14-3-3 proteins interact with specific MEK kinases. J. Biol. Chem. 273:3476–3483.
   PubMedGoogle Scholar
• Faris, M., N. Kokot, K. Latinis, S. Kasibhatla, D. R. Green, G. A. Koretzky, and J. Nel 1998. The c-Jun N-terminal kinase cascade plays a role in stress-induced apoptosis in Jurkat cells by upregulating Fas ligand expression. J. Immunol. 160:134–144.
   PubMed Web of Science ®Google Scholar
• Feng, Z., A. Marti, B. Jehn, H. J. Altermatt, G. Chicaiza, and J. Jaggi 1995. Glucocorticoid and progesterone inhibit involution and programmed cell death in the mouse mammary gland. J. Cell Biol. 131:1095–1103.
   PubMed Web of Science ®Google Scholar
• Frisch, S. M., K. Vuori, D. Kelaita, and J. Sicks 1996. A role for Jun-N-terminal kinase in anoikis; suppression by bcl-2 and crmA. J. Cell Biol. 135:1377–1382.
   PubMed Web of Science ®Google Scholar
• Gadducci, A., and J. Genazzani 1997. Steroid hormones in endometrial and breast cancer. Eur. J. Gynaecol. Oncol. 18:371–378 (Review.)
   PubMed Web of Science ®Google Scholar
• Garnick, M., and J. Fair 1996. Prostate cancer: emerging concepts. Part II. Ann. Intern. Med. 125:205–212.
   PubMed Web of Science ®Google Scholar
• Helmberg, A., N. Auphan, C. Caelles, and J. Karin 1995. Glucocorticoid-induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor. EMBO J. 14:452–460.
   PubMed Web of Science ®Google Scholar
• Hong, H., K. Kohli, A. Trivedi, D. L. Johnson, and J. Stallcup 1996. GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors. Proc. Natl. Acad. Sci. USA 93:4948–4952.
   PubMedGoogle Scholar
• Ikonen, T., J. J. Palvimo, P. J. Kallio, P. Reinikainen, and J. Janne 1994. Stimulation of androgen-regulated transactivation by modulators of protein phosphorylation. Endocrinology 135:1359–1366.
   PubMed Web of Science ®Google Scholar
• Jenster, G., P. E. de Ruiter, H. A. van der Korput, G. G. Kuiper, J. Trapman, and J. Brinkmann 1994. Changes in the abundance of androgen receptor isotypes: effects of ligand treatment, glutamine-stretch variation, and mutation of putative phosphorylation sites. Biochemistry 33:14064–14072.
   PubMed Web of Science ®Google Scholar
• Johnson, N. L., A. M. Gardner, K. M. Diener, C. A. Lange-Carter, J. Gleavy, M. B. Jarpe, A. Minden, M. Karin, L. I. Zon, and J. Johnson 1996. Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death. J. Biol. Chem. 271:3229–3237.
   PubMed Web of Science ®Google Scholar
• Karin, M. 1998. New twists in gene regulation by glucocorticoid receptor: is DNA binding dispensable? Cell 93:487–490.
   PubMed Web of Science ®Google Scholar
• Kato, S., H. Endoh, Y. Masuhiro, T. Kitamoto, S. Uchiyama, H. Sasaki, S. Masushige, Y. Gotoh, E. Nishida, H. Kawashima et al.. 1995. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science 270:1491–1494.
   PubMed Web of Science ®Google Scholar
• Kitsberg, D. I., and J. Leder 1996. Keratinocyte growth factor induces mammary and prostatic hyperplasia and mammary adenocarcinoma in transgenic mice. Oncogene 13:2507–2515.
   PubMed Web of Science ®Google Scholar
• Klein, K. A., R. E. Reiter, J. Redula, H. Moradi, X. L. Zhu, A. R. Brothman, D. J. Lamb, M. Marcelli, A. Belldegrun, O. N. Witte, and J. Sawyers 1997. Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice. Nat. Med. 3:402–408.
   PubMed Web of Science ®Google Scholar
• Lee, F. S., J. Hagler, Z. J. Chen, and J. Maniatis 1997. Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway. Cell 88:213–222.
   PubMed Web of Science ®Google Scholar
• Lehman, A. M., K. B. Ellwood, B. E. Middleton, and J. Carey 1998. Compensatory energetic relationships between upstream activators and the RNA polymerase II general transcription machinery. J. Biol. Chem. 273:932–939.
   PubMedGoogle Scholar
• Lim, D. J., X. L. Liu, D. M. Sutkowski, E. J. Braun, C. Lee, and J. Kozlowski 1993. Growth of an androgen-sensitive human prostate cancer cell line, LNCaP, in nude mice. Prostate 22:109–118.
   PubMedGoogle Scholar
• Marcelli, M., S. J. Haidacher, S. R. Plymate, and J. Birnbaum 1995. Altered growth and insulin-like growth factor-binding protein-3 production in PC3 prostate carcinoma cells stably transfected with a constitutively active androgen receptor complementary deoxyribonucleic acid. Endocrinology 136:1040–1048.
   PubMedGoogle Scholar
• Marcelli, M., W. Tilley, C. Wilson, J. Griffin, J. Wilson, and J. McPhaul 1990. Definition of the human androgen receptor gene structure permits the identification of mutations that cause androgen resistance: premature termination of the receptor protein at amino acid residue 588 causes complete androgen resistance. Mol. Endocrinol. 4:1105–1116.
   PubMed Web of Science ®Google Scholar
• McConkey, D. J., G. Greene, and J. Pettaway 1996. Apoptosis resistance increases with metastatic potential in cells of the human LNCaP prostate carcinoma line. Cancer Res. 56:5594–5599.
   PubMedGoogle Scholar
• Minden, A., A. Lin, M. McMahon, C. Lange-Carter, B. Derijard, R. J. Davis, G. L. Johnson, and J. Karin 1994. Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science 266:1719–1723.
   PubMed Web of Science ®Google Scholar
• Nakano, H., M. Shindo, S. Sakon, S. Nishinaka, M. Mihara, H. Yagita, and J. Okumura 1998. Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1. Proc. Natl. Acad. Sci. USA 95:3537–3542.
   PubMed Web of Science ®Google Scholar
• Nazareth, L. V., and J. Weigel 1996. Activation of the human androgen receptor through a protein kinase A signaling pathway. J. Biol. Chem. 271:19900–19907.
   PubMed Web of Science ®Google Scholar
• Pang, S., J. Dannull, R. Kaboo, Y. Xie, C.-L. Tso, K. Michel, J. B. deKernion, and J. Belldegrun 1997. Identification of a positive regulatory element responsible for tissue-specific expression of prostate-specific antigen. Cancer Res. 57:495–499.
   PubMed Web of Science ®Google Scholar
• Prins, G. S., R. J. Sklarew, and J. Pertschuk 1998. Image analysis of androgen receptor immunostaining in prostate cancer accurately predicts response to hormonal therapy. J. Urol. 159:641–649.
   PubMedGoogle Scholar
• Raitano, A. B., J. R. Halpern, T. M. Hambuch, and J. Sawyers 1995. The Bcr-Abl leukemia oncogene activates Jun kinase and requires Jun for transformation. Proc. Natl. Acad. Sci. USA 92:11746–11750.
   PubMed Web of Science ®Google Scholar
• Reinikainen, P., J. J. Palvimo, and J. Janne 1996. Effects of mitogens on androgen receptor-mediated transactivation. Endocrinology 137:4351–4357.
   PubMedGoogle Scholar
• Sato, N., M. D. Sadar, N. Bruchovsky, F. Saatcioglu, P. S. Rennie, S. Sato, P. H. Lange, and J. Gleave 1997. Androgenic induction of prostate-specific antigen gene is repressed by protein-protein interaction between the androgen receptor and AP-1/c-Jun in the human prostate cancer cell line LNCaP. J. Biol. Chem. 272:17485–17494.
   PubMed Web of Science ®Google Scholar
• Schurr, E. R., G. A. Henderson, L. A. Kmetec, J. D. Miller, H. G. Lamparski, and J. Henderson 1996. Prostate-specific antigen expression is regulated by an upstream enhancer. J. Biol. Chem. 271:7043–7051.
   PubMedGoogle Scholar
• Shi, Y., J. M. Glynn, L. J. Guilbert, T. G. Cotter, R. P. Bissonnette, and J. Green 1992. Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas. Science 257:212–214.
   PubMed Web of Science ®Google Scholar
• Sun, Z., J. Pan, and J. Balk 1997. Androgen receptor-associated protein complex binds upstream of the androgen-responsive elements in the promoters of human prostate-specific antigen and kallikrein 2 genes. Nucleic Acids Res. 25:3318–3325.
   PubMed Web of Science ®Google Scholar
• Tang, D. G., and J. Porter 1997. Target to apoptosis: a hopeful weapon for prostate cancer. Prostate 32:284–293.
   PubMed Web of Science ®Google Scholar
• van Steenbrugge, G., C. van Uffelen, J. Bolt, and J. Schroder 1991. The human prostatic cancer cell line LNCaP and its derived sublines: an in vitro model for the study of androgen sensitivity. J. Steroid Biochem. Mol. Biol. 40:207–214.
   PubMed Web of Science ®Google Scholar
• Veldscholte, J., C. Berrevoets, C. Ris-Stalpers, G. Kuiper, G. Jenster, J. Trapman, A. Brinkmann, and J. Mulder 1992. The androgen receptor in LNCaP cells contains a mutation in the ligand binding domain which affects steroid binding characteristics and response to anti-androgens. J. Steroid Biochem. Mol. Biol. 41:665–669.
   PubMed Web of Science ®Google Scholar
• Widmann, C., S. Gibson, and J. Johnson 1998. Caspase-dependent cleavage of signaling proteins during apoptosis. A turn-off mechanism for anti-apoptotic signals. J. Biol. Chem. 273:7141–7147.
   PubMed Web of Science ®Google Scholar
• Widmann, C., N. L. Johnson, A. M. Gardner, R. J. Smith, and J. Johnson 1997. Potentiation of apoptosis by low dose stress stimuli in cells expressing activated MEK kinase 1. Oncogene 15:2439–2447.
   PubMed Web of Science ®Google Scholar
• Wise, S. C., L. A. Burmeister, X.-F. Zhou, A. Bubulya, J. L. Oberfield, M. J. Birrer, and J. Shemshedini 1998. Identification of domains of c-jun mediating androgen receptor transactivation. Oncogene 16:2001–2009.
   PubMedGoogle Scholar
• Xia, Z., M. Dickens, J. Raingeaud, R. J. Davis, and J. Greenberg 1995. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270:1326–1331.
   PubMed Web of Science ®Google Scholar
• Xu, S., and J. Cobb 1997. MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases. J. Biol. Chem. 272:32056–32060.
   PubMed Web of Science ®Google Scholar
• Yeh, S., and J. Chang 1996. Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells. Proc. Natl. Acad. Sci. USA 93:5517–5521.
   PubMed Web of Science ®Google Scholar
• Yin, M. J., L. B. Christerson, Y. Yamamoto, Y. T. Kwak, S. Xu, F. Mercurio, M. Barbosa, M. H. Cobb, and J. Gaynor 1998. HTLV-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation. Cell 93:875–884.
   PubMed Web of Science ®Google Scholar
• Zhou, Q., J. F. Krebs, S. J. Snipas, A. Price, E. S. Alnemri, K. J. Tomaselli, and J. Salvesen 1998. Interaction of the baculovirus anti-apoptotic protein p35 with caspases. Specificity, kinetics, and characterization of the caspase/p35 complex. Biochemistry 37:10757–10765.
   PubMedGoogle Scholar
• Zhu, X., and J. Liu 1997. Steroid-independent activation of androgen receptor in androgen-independent prostate cancer: a possible role for the MAP kinase signal transduction pathway? Mol. Cell. Endocrinol. 134:9–14.
   PubMed Web of Science ®Google Scholar