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Gene Expression

PER and TIM Inhibit the DNA Binding Activity of a Drosophila CLOCK-CYC/dBMAL1 Heterodimer without Disrupting Formation of the Heterodimer: a Basis for Circadian Transcription

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Pages 5316-5325 | Received 09 Dec 1998, Accepted 12 May 1999, Published online: 28 Mar 2023

REFERENCES

  • Allada, R., N. E. White, W. V. So, J. C. Hall, and J. Rosbash 1998. A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless. Cell 93:791–804.
  • Bae, K., C. Lee, D. Sidote, K. Chuang, and J. Edery 1998. Circadian regulation of a Drosophila homolog of the mammalian clock gene: PER and TIM function as positive regulators. Mol. Cell. Biol. 18:6142–6151.
  • Baldwin, A. S. Jr.. 1996. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649–683.
  • Chen, Y., M. Hunter-Ensor, P. Schotland, and J. Sehgal 1998. Alterations of per RNA in noncoding regions affect periodicity of circadian behavioral rhythms. J. Biol. Rhythms 13:364–379.
  • Cheng, Y., B. Gvakharia, and J. Hardin 1998. Two alternatively spliced transcripts from the Drosophila period gene rescue rhythms having different molecular and behavioral characteristics. Mol. Cell. Biol. 18:6505–6514.
  • Citri, Y., H. V. Colot, A. C. Jacquier, Q. Yu, J. C. Hall, D. Baltimore, and J. Rosbash 1987. A family of unusually spliced biologically active transcripts encoded by a Drosophila clock gene. Nature 326:42–47.
  • Crews, S. T. 1998. Control of cell lineage-specific development and transcription by bHLH-PAS proteins. Genes Dev. 12:607–620.
  • Darlington, T. K., K. Wager-Smith, M. F. Ceriani, D. Staknis, N. Gekakis, T. D. L. Steeves, C. J. Weitz, J. S. Takahashi, and J. Kay 1998. Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim. Science 280:1599–1603.
  • Dembinska, M. E., R. Stanewsky, J. C. Hall, and J. Rosbash 1997. Circadian cycling of a PERIOD-beta-galactosidase fusion protein in Drosophila: evidence for cyclical degradation. J. Biol. Rhythms 12:157–172.
  • Dunlap, J. C. 1999. Molecular bases for circadian clocks. Cell 96:271–290.
  • Dushay, M. S., R. J. Konopka, D. Orr, M. L. Greenacre, C. P. Kyriacou, M. Rosbash, and J. Hall 1990. Phenotypic and genetic analysis of Clock, a new circadian rhythm mutant in Drosophila melanogaster. Genetics 125:557–578.
  • Edery, I., L. J. Zwiebel, M. E. Dembinska, and J. Rosbash 1994. Temporal phosphorylation of the Drosophila period protein. Proc. Natl. Acad. Sci. USA 91:2260–2264.
  • Fukunaga, B. N., M. R. Probst, S. Reisz-Porszasz, and J. Hankinson 1995. Identification of functional domains of the aryl hydrocarbon receptor. J. Biol. Chem. 270:29270–29278.
  • Gekakis, N., L. Saez, A. M. Delahaye-Brown, M. P. Myers, A. Sehgal, M. W. Young, and J. Weitz 1995. Isolation of timeless by PER protein interaction: defective interaction between timeless protein and long-period mutant PERL. Science 270:811–815.
  • Gekakis, N., D. Staknis, H. B. Nguyen, F. C. Davis, L. D. Wilsbacher, D. P. King, J. S. Takahashi, and J. Weitz 1998. Role of the CLOCK protein in the mammalian circadian mechanism. Science 280:1564–1569.
  • Gradin, K., J. McGuire, R. H. Wenger, I. Kvietikova, M. L. Whitelaw, R. Toftgard, L. Tora, M. Gassmann, and J. Poellinger 1996. Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor. Mol. Cell. Biol. 16:5221–5231.
  • Hall, J. C. 1998. Genetics of biological rhythms in drosophila. Adv. Genet. 38:135–184.
  • Hamblen, M. J., N. E. White, P. T. Emery, K. Kaiser, and J. Hall 1998. Molecular and behavioral analysis of four period mutants in Drosophila melanogaster encompassing extreme short, novel long, and unorthodox arrhythmic types. Genetics 149:165–178.
  • Hankinson, O. 1995. The aryl hydrocarbon receptor complex. Annu. Rev. Pharmacol. Toxicol. 35:307–340.
  • Hao, H., D. L. Allen, and J. Hardin 1997. A circadian enhancer mediates PER-dependent mRNA cycling in Drosophila melanogaster. Mol. Cell. Biol. 17:3687–3693.
  • Hao, H., N. R. Glossop, L. Lyons, J. Qiu, B. Morrish, Y. Cheng, C. Helfrich-Forster, and J. Hardin 1999. The 69 bp circadian regulatory sequence (CRS) mediates per-like developmental, spatial, and circadian expression and behavioral rescue in Drosophila. J. Neurosci. 19:987–994.
  • Hardin, P. E. 1998. Activating inhibitors and inhibiting activators: a day in the life of a fly. Curr. Opin. Neurobiol. 8:642–647.
  • Hardin, P. E., J. C. Hall, and J. Rosbash 1992. Circadian oscillations in period gene mRNA levels are transcriptionally regulated. Proc. Natl. Acad. Sci. USA 89:11711–11715.
  • Hardin, P. E., J. C. Hall, and J. Rosbash 1990. Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels. Nature 343:536–540.
  • Hastings, J. W., B. Rusak, Z. Boulos 1991. Circadian rhythms: the physiology of biological timing, p. 435–546. In C. L. Prosser (ed.), Neural and integrative animal physiology. Wiley-Liss, Inc., New York, N.Y.
  • Hogenesch, J. B., W. K. Chan, V. H. Jackiw, R. C. Brown, Y. Z. Gu, M. Pray-Grant, G. H. Perdew, and J. Bradfield 1997. Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. J. Biol. Chem. 272:8581–8593.
  • Hogenesch, J. B., Y. Z. Gu, S. Jain, and J. Bradfield 1998. The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proc. Natl. Acad. Sci. USA 95:5474–5479.
  • Huang, Z. J., I. Edery, and J. Rosbash 1993. PAS is a dimerization domain common to Drosophila period and several transcription factors. Nature 364:259–262.
  • Hunter-Ensor, M., A. Ousley, and J. Sehgal 1996. Regulation of the Drosophila protein timeless suggests a mechanism for resetting the circadian clock by light. Cell 84:677–685.
  • Kloss, B., J. L. Price, L. Saez, J. Blau, A. Rothenfluh, C. S. Wesley, and J. Young 1998. The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iε. Cell 94:97–107.
  • Konopka, R. J., and J. Benzer 1971. Clock mutants of Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 68:2112–2116.
  • Konopka, R. J., M. J. Hamblen-Coyle, C. F. Jamison, and J. Hall 1994. An ultrashort clock mutation at the period locus of Drosophila melanogaster that reveals some new features of the fly’s circadian system. J. Biol. Rhythms 9:189–216.
  • Lee, C., K. Bae, and J. Edery 1998. The Drosophila CLOCK protein undergoes daily rhythms in abundance, phosphorylation, and interactions with the PER-TIM complex. Neuron 21:857–867.
  • Lee, C., V. Parikh, T. Itsukaichi, K. Bae, and J. Edery 1996. Resetting the Drosophila clock by photic regulation of PER and a PER-TIM complex. Science 271:1740–1744.
  • Lindebro, M. C., L. Poellinger, and J. Whitelaw 1995. Protein-protein interaction via PAS domains: role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex. EMBO J. 14:3528–3539.
  • Luque, I., and J. Gelinas 1998. Distinct domains of IκBα regulate c-Rel in the cytoplasm and in the nucleus. Mol. Cell. Biol. 18:1213–1224.
  • Malek, S., T. Huxford, and J. Ghosh 1998. IκBα functions through direct contacts with the nuclear localization signals and the DNA binding sequences of NF-κB. J. Biol. Chem. 273:25427–25435.
  • McGuire, J., P. Coumailleau, M. L. Whitelaw, J. Gustafsson, and J. Poellinger 1996. The basic helix-loop-helix/PAS factor Sim is associated with hsp90. J. Biol. Chem. 270:31353–31357.
  • Moffett, P., M. Reece, and J. Pelletier 1997. The murine Sim-2 gene product inhibits transcription by active repression and functional interference. Mol. Cell. Biol. 17:4933–4947.
  • Myers, M. P., K. Wager-Smith, A. Rothenfluh-Hilfiker, and J. Young 1996. Light-induced degradation of TIMELESS and entrainment of the Drosophila circadian clock. Science 271:1736–1740.
  • Myers, M. P., K. Wager-Smith, C. S. Wesley, M. W. Young, and J. Sehgal 1995. Positional cloning and sequence analysis of the Drosophila clock gene, timeless. Science 270:805–808.
  • Ousley, A., K. Zafarullah, Y. Chen, M. Emerson, L. Hickman, and J. Sehgal 1998. Conserved regions of the timeless (tim) clock gene in Drosophila analyzed through phylogenetic and functional studies. Genetics 148:815–825.
  • Price, J. L., J. Blau, A. Rothenfluh, M. Abodeely, B. Kloss, and J. Young 1998. double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation. Cell 94:83–95.
  • Price, J. L., M. E. Dembinska, M. W. Young, and J. Rosbash 1995. Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless. EMBO J. 14:4044–4049.
  • Reisz-Porszasz, S., M. R. Probst, B. N. Fukunaga, and J. Hankinson 1994. Identification of functional domains of the aryl hydrocarbon receptor nuclear translocator protein (ARNT). Mol. Cell. Biol. 14:6075–6086.
  • Reppert, S. M. 1998. A clockwork explosion! Neuron 21:1–4.
  • Rosato, E., A. Piccin, and J. Kyriacou 1997. Circadian rhythms: from behaviour to molecules. Bioessays 19:1075–1082.
  • Rosbash, M., R. Allada, M. Dembinska, W. Q. Guo, M. Le, S. Marrus, Z. Qian, J. Rutila, J. Yaglom, and J. Zeng 1996. A Drosophila circadian clock. Cold Spring Harbor Symp. Quant. Biol. 61:265–278.
  • Rutila, J. E., V. Suri, M. Le, W. V. So, M. Rosbash, and J. Hall 1998. CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless. Cell 93:805–814.
  • Rutila, J. E., H. Zeng, M. Le, K. D. Curtin, J. C. Hall, and J. Rosbash 1996. The timSL mutant of the Drosophila rhythm gene timeless manifests allele-specific interactions with period gene mutants. Neuron 17:921–929.
  • Saez, L., and J. Young 1996. Regulation of nuclear entry of the Drosophila clock proteins period and timeless. Neuron 17:911–920.
  • Sangoram, A. M., L. Saez, M. P. Antoch, N. Gekakis, D. Staknis, A. Whiteley, E. M. Fruechte, M. H. Vitaterna, K. Shimomura, D. P. King, M. W. Young, C. J. Weitz, and J. Takahashi 1998. Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription. Neuron 21:1101–1113.
  • Sehgal, A. 1995. Molecular genetic analysis of circadian rhythms in vertebrates and invertebrates. Curr. Opin. Neurobiol. 5:824–831.
  • Sehgal, A., J. L. Price, B. Man, and J. Young 1994. Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless. Science 263:1603–1606.
  • Sehgal, A., A. Rothenfluh-Hilfiker, M. Hunter-Ensor, Y. Chen, M. P. Myers, and J. Young 1995. Rhythmic expression of timeless: a basis for promoting circadian cycles in period gene autoregulation. Science 270:808–810.
  • Sidote, D., J. Majercak, V. Parikh, and J. Edery 1998. Differential effects of light and heat on the Drosophila circadian clock proteins PER and TIM. Mol. Cell. Biol. 18:2004–2013.
  • So, W. V., and J. Rosbash 1997. Post-transcriptional regulation contributes to Drosophila clock gene mRNA cycling. EMBO J. 16:7146–7155.
  • Sogawa, K., R. Nakano, A. Kobayashi, Y. Kikuchi, N. Ohe, N. Matsushita, and J. Fujii-Kuriyama 1995. Possible function of Ah receptor nuclear translocator (Arnt) homodimer in transcriptional regulation. Proc. Natl. Acad. Sci. USA 92:1936–1940.
  • Stanewsky, R., C. F. Jamison, J. D. Plautz, S. A. Kay, and J. Hall 1997. Multiple circadian-regulated elements contribute to cycling period gene expression in Drosophila. EMBO J. 16:5006–5018.
  • Swanson, H. I., W. K. Chan, and J. Bradfield 1995. DNA binding specificities and pairing rules of the Ah receptor, ARNT, and SIM proteins. J. Biol. Chem. 270:26292–26302.
  • Vosshall, L. B., J. L. Price, A. Sehgal, L. Saez, and J. Young 1994. Block in nuclear localization of period protein by a second clock mutation, timeless. Science 263:1606–1609.
  • Young, M. W. 1998. The molecular control of circadian behavioral rhythms and their entrainment in Drosophila. Annu. Rev. Biochem. 67:135–152.
  • Zelzer, E., P. Wappner, and J. Shilo 1997. The PAS domain confers target gene specificity of Drosophila bHLH/PAS proteins. Genes Dev. 11:2079–2089.
  • Zeng, H., Z. Qian, M. P. Myers, and J. Rosbash 1996. A light-entrainment mechanism for the Drosophila circadian clock. Nature 380:129–135.
  • Zerr, D. M., J. C. Hall, M. Rosbash, and J. Siwicki 1990. Circadian fluctuations of period protein immunoreactivity in the CNS and the visual system of Drosophila. J. Neurosci. 10:2749–2762.

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