54
Views
440
CrossRef citations to date
0
Altmetric
Transcriptional Regulation

Phenobarbital-Responsive Nuclear Translocation of the Receptor CAR in Induction of the CYP2B Gene

, , , , &
Pages 6318-6322 | Received 16 Apr 1999, Accepted 16 Jun 1999, Published online: 27 Mar 2023

REFERENCES

  • Baes, M., T. Gulick, H. S. Choi, M. G. Martinoli, D. Simha, and J. Moore 1994. A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements. Mol. Cell. Biol. 14:1544–1551.
  • Barsony, J., I. Renyi, and J. McKoy 1997. Subcellular distribution of normal and mutant vitamin D receptors in living cells. Studies with a novel fluorescent ligand. J. Biol. Chem. 272:5774–5782.
  • Conney, A. H. 1982. Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons. Cancer Res. 42:4875–4917.
  • DeFranco, D. B., M. Qi, K. C. Borror, M. J. Garabedian, and J. Brautigan 1991. Protein phosphatase types 1 and/or 2A regulate nucleocytoplasmic shuttling of glucocorticoid receptors. Mol. Endocrinol. 5:1215–1228.
  • Desai, R. K., A. J. van Wijnen, J. L. Stein, G. S. Stein, and J. Lian 1995. Control of 1,25-dihydroxyvitamin D3 receptor-mediated enhancement of osteocalcin gene transcription: effects of perturbing phosphorylation pathways by okadaic acid and staurosporine. Endocrinology 136:5685–5693.
  • Dignam, J. D., R. M. Lebovitz, and J. Roeder 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475–1489.
  • Forman, B. M., I. Tzameli, H. S. Choi, J. Chen, D. Simha, W. Seol, R. M. Evans, and J. Moore 1998. Androstane metabolites bind to and deactivate the nuclear receptor CAR-β. Nature 395:612–615.
  • Honkakoski, P., R. Moore, K. A. Washburn, and J. Negishi 1998. Activation by diverse xenochemicals of the 51-base pair phenobarbital-responsive enhancer module in the CYP2B10 gene. Mol. Pharmacol. 53:597–601.
  • Honkakoski, P., and J. Negishi 1998. Protein serine/threonine phosphatase inhibitors suppress phenobarbital-induced Cyp2b10 gene transcription in mouse primary hepatocytes. Biochem. J. 330:889–895.
  • Honkakoski, P., and J. Negishi 1998. Regulatory DNA elements of phenobarbital-responsive cytochrome P450 CYP2B genes. J. Biochem. Mol. Toxicol. 12:3–9.
  • Honkakoski, P., I. Zelko, T. Sueyoshi, and J. Negishi 1998. The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene. Mol. Cell. Biol. 18:5652–5658.
  • Htun, H., J. Barsony, I. Renyi, D. L. Gould, and J. Hager 1996. Visualization of glucocorticoid receptor translocation and intranuclear organization in living cells with a green fluorescent protein chimera. Proc. Natl. Acad. Sci. USA 93:4845–4850.
  • Kim, J., and J. Kemper 1997. Phenobarbital alters protein binding to the CYP2B1/2 phenobarbital-responsive unit in native chromatin. J. Biol. Chem. 272:29423–29425.
  • Kojima, H., T. Sueyoshi, K. Yoshinari, Q.-H. Gong, I. Owens, and M. Negishi. Unpublished data.
  • Lim-Tio, S. S., and J. Fuller 1998. Intracellular signaling pathways confer specificity of transactivation by mineralocorticoid and glucocorticoid receptors. Endocrinology 139:1653–1661.
  • Picard, D. 1998. Two orphans find a home. Nature 395:543–544.
  • Picard, D., and J. Yamamoto 1987. Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor. EMBO J. 6:3333–3340.
  • Sidhu, J. S., and J. Omiecinski 1997. An okadaic acid-sensitive pathway involved in the phenobarbital-mediated induction of CYP2B gene expression in primary rat hepatocyte cultures. J. Pharmacol. Exp. Ther. 282:1122–1129.
  • Stoltz, C., M. H. Vachon, E. Trottier, S. Dubois, Y. Paquet, and J. Anderson 1998. The CYP2B2 phenobarbital response unit contains an accessory factor element and a putative glucocorticoid response element essential for conferring maximal phenobarbital responsiveness. J. Biol. Chem. 273:8528–8536.
  • Sueyoshi, T., T. Kawamoto, I. Zelko, P. Honkakoski, and J. Negishi 1999. The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene. J. Biol. Chem. 274:6043–6046.
  • Waxman, D. J., and J. Azaroff 1992. Phenobarbital induction of cytochrome P-450 gene expression. Biochem. J. 281:577–592.
  • Weigel, N. L. 1996. Steroid hormone receptors and their regulation by phosphorylation. Biochem. J. 319:657–667.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.