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Cell Growth and Development

Disruption of Retinoblastoma Protein Family Function by Human Papillomavirus Type 16 E7 Oncoprotein Inhibits Lens Development in Part through E2F-1

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Pages 6458-6468 | Received 02 Apr 1999, Accepted 08 Jun 1999, Published online: 27 Mar 2023

REFERENCES

  • Adams, P., and J. Kaelin 1996. The cellular effects of E2F overexpression Transcriptional control of cell growth: the E2F gene family In P. Farnham (ed.), 208:79–94 Springer-Verlag, New York, N.Y.
  • Banks, L., C. Edmonds, and J. Vousden 1990. Ability of the HPV16 E7 protein to bind RB and induce DNA synthesis is not sufficient for efficient transforming activity in NIH3T3 cells. Oncogene 5:1383–1389.
  • Broekhuyse, R. M., E. D. Kuhlman, and J. Stols 1979. Lens membranes. VII. MIP is an immunologically specific component of lens fiber membranes and is identical with the 26K band protein. Exp. Eye Res. 29:303–313.
  • Chellappan, S., V. B. Kraus, B. Kroger, K. Munger, P. M. Howley, W. C. Phelps, and J. Nevins 1992. Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product. Proc. Natl. Acad. Sci. USA 89:4549–4553.
  • Chepelinsky, A. E. 1994. The MIP transmembrane channel family, p. 413–432 In C. Peracchia (ed.), Handbook of membrane channels: molecular and cellular physiology. Academic Press, New York, N.Y.
  • Cobrinik, D. 1996. Regulatory interactions among E2Fs and cell cycle control proteins Transcriptional control of cell growth: the E2F gene family In P. Farnham (ed.), 208:31–62 Springer-Verlag, New York, N.Y.
  • Cress, W., and J. Nevins 1996. Use of the E2F transcription factor by DNA tumor virus regulatory proteins. Curr. Top. Microbiol. Immunol. 208:63–78.
  • DeGregori, J., G. Leone, A. Miron, L. Jakoi, and J. Nevins 1997. Distinct roles for E2F proteins in cell growth control and apoptosis. Proc. Natl. Acad. Sci. USA 94:7245–7250.
  • Du, W., M. Vidal, J.-E. Xie, and J. Dyson 1996. RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Genes Dev. 10:1206–1218.
  • Du, W., J. Xie, and J. Dyson 1996. Ectopic expression of dE2F and dDP induces cell proliferation and death in the Drosophila eye. EMBO J. 15:3684–3692.
  • Duronio, R., P. O’Farrell, J.-E. Xie, A. Brook, and J. Dyson 1995. The transcription factor E2F is required for S phase during Drosophila embryogenesis. Genes Dev. 9:1445–1455.
  • Dynlacht, B., A. Brook, M. Dembski, L. Yenush, and J. Dyson 1994. DNA-binding and trans-activation properties of Drosophila E2F and DP proteins. Proc. Natl. Acad. Sci. USA 91:6359–6363.
  • Dyson, N., P. Guida, K. Munger, and J. Harlow 1992. Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins. J. Virol. 66:6893–6902.
  • Dyson, N., P. Howley, K. Munger, and J. Harlow 1989. The human papillomavirus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 243:934–937.
  • Field, S., F. Tsai, F. Kuo, A. Zubiaga, W. G. Kaelin Jr., D. Livingston, S. Orkin, and J. Greenberg 1996. E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell 85:549–561.
  • Fromm, L., W. Shawlot, K. Gunning, J. S. Butel, and J. Overbeek 1994. The retinoblastoma protein-binding region of simian virus 40 large T antigen alters cell cycle regulation in lenses of transgenic mice. Mol. Cell. Biol. 14:6743–6754.
  • Funk, J. O., S. Waga, J. B. Harry, E. Espling, B. Stillman, and J. Galloway 1997. Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein. Genes Dev. 11:2090–2100.
  • Garner, W. H., M. H. Garner, and J. Spector 1981. Gamma-crystallin, a major cytoplasmic polypeptide disulfide linked to membrane proteins in human cataract. Biochem. Biophys. Res. Commun. 98:439–447.
  • Graw, J. 1996. Cataract mutations as a tool for developmental genetics. Ophthalmic Res. 28 (Suppl. 1):8–18.
  • Griep, A., and J. Westphal 1990. Differentiation versus proliferation of transgenic mouse lens cells expressing polyoma large T antigen: evidence for regulation by endogenous growth factor. New Biol. 2:727–738.
  • Gu, W., J. W. Schneider, G. Condorelli, S. Kaushal, V. Mahdavi, and J. Nadal Ginard 1993. Interaction of myogenic factors and the retinoblastoma protein mediates muscle commitment and differentiation. Cell 72:309–324.
  • Herber, R., L. A., H. Pitot, and J. Lambert 1996. Squamous epithelial hyperplasia and carcinoma in mice transgenic for the human papillomavirus type 16 E7 oncogene. J. Virol. 70:1873–1881.
  • Herwig, S., and J. Strauss 1997. The retinoblastoma protein: a master regulator of cell cycle, differentiation and apoptosis. Eur. J. Biochem. 246:581–601.
  • Hsieh, J.-K., S. Fredersdorf, T. Kouzarides, K. Martin, and J. Lu 1997. E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction. Genes Dev. 11:1840–1852.
  • Johnson, D. G., J. K. Schwartz, W. D. Cress, and J. Nevins 1993. Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature 365:349–352.
  • Jones, D. L., R. M. Alani, and J. Munger 1997. The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2. Genes Dev. 11:2101–2111.
  • Jones, D. L., D. A. Thompson, and J. Munger 1997. Destabilization of the RB tumor suppressor protein and stabilization of p53 contribute to HPV type 16 E7-induced apoptosis. Virology 239:97–107.
  • Kowalik, T. F., J. DeGregori, J. K. Schwarz, and J. Nevins 1995. E2F1 overexpression in quiescent fibroblasts leads to an induction of cellular DNA synthesis and apoptosis. J. Virol. 69:2491–2500.
  • Lin, S.-C., S. Skapek, and J. Lee 1996. Genes in the RB pathway and their knockout in mice. Semin. Cancer Biol. 7:279–289.
  • MacLeod, K. F., Y. Hu, and J. Jacks 1996. Loss of RB activates both p53-dependent and independent cell death pathways in the developing mouse nervous system. EMBO J. 15:6178–6188.
  • Martin, K., D. Trouche, C. Hagemeier, T. S. Sorensen, N. B. L. Thangue, and J. Kouzarides 1995. Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein. Nature 375:691–697.
  • McAvoy, J. 1978. Cell division, cell elongation and distribution of α, β, and γ-crystallins in the rat lens. J. Embryol. Exp. Morphol. 44:149–165.
  • McAvoy, J. 1978. Cell division, cell elongation and the co-ordination of crystallin gene expression during lens morphogenesis in the rat. J. Embryol. Exp. Morphol. 45:271–281.
  • McAvoy, J. W. 1980. Induction of the eye lens. Differentiation 17:137–149.
  • Morgenbesser, S. D., A. N. Schreiber, M. Bidder, K. A. Mahon, P. A. Overbeek, J. Horner, and J. DePinho 1995. Contrasting roles for c-Myc and L-Myc in the regulation of cellular growth and differentiation in vivo. EMBO J. 14:743–756.
  • Morgenbesser, S. D., B. O. Williams, T. Jacks, and J. DePinho 1994. p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature 371:72–74.
  • Munger, K., W. C. Phelps, V. Bubb, P. M. Howley, and J. Schlegel 1989. The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes. J. Virol. 63:4417–4421.
  • Munger, K., B. A. Werness, N. Dyson, W. C. Phelps, E. Harlow, and J. Howley 1989. Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product. EMBO J. 8:4099–4105.
  • Nevins, J. R. 1992. E2F; a link between the Rb tumor suppressor protein and viral oncoproteins. Science 258:424–429.
  • Ohtani, K., and J. Nevins 1994. Functional properties of a Drosophila homolog of the E2F1 gene. Mol. Cell. Biol. 14:1603–1612.
  • Pan, H. 1995. Ph.D. thesis. University of Wisconsin, Madison
  • Pan, H., and J. Griep 1994. Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development. Genes Dev. 8:1285–1299.
  • Pan, H., and J. Griep 1995. Temporally distinct patterns of p53-dependent and p53-independent apoptosis during mouse lens development. Genes Dev. 9:2157–2169.
  • Pan, H., C. Yni, N. J. Dyson, E. Harlow, L. Yamasaki, and J. Van Dyke 1998. Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors. Mol. Cell 2:283–292.
  • Phillips, A. C., S. Bates, K. M. Ryan, K. Helin, and J. Vousden 1997. Induction of DNA synthesis and apoptosis are separable functions of E2F-1. Genes Dev. 11:1853–1863.
  • Piatigorsky, J. 1981. Lens differentiation in vertebrates. A review of cellular and molecular features. Differentiation 19:134–153.
  • Qin, X. Q., D. M. Livingston, W. G. J. Kaelin, and J. Adams 1994. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc. Natl. Acad. Sci. USA 91:10918–10922.
  • Rampalli, A. M., C. Y. Gao, V. M. Chauthaiwale, and J. Zelenka 1998. pRb and p107 regulate E2F activity during lens fiber cell differentiation. Oncogene 16:399–408.
  • Royzman, I., A. J. Whittaker, and J. Orr-Weaver 1997. Mutations in Drosophila DP and E2F distinguish G1-S progression from an associated transcriptional program. Genes Dev. 11:1999–2011.
  • Russell, P., S. G. Smith, D. A. Carper, and J. Kinoshita 1979. Age and cataract-related changes in the heavy molecular weight proteins and gamma crystallin composition of the mouse lens. Exp. Eye Res. 29:245–255.
  • Shan, B., and J. Lee 1994. Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol. Cell. Biol. 14:8166–8173.
  • Shiels, A., and J. Bassnett 1996. Mutations in the founder of the MIP family underlie cataract development in the mouse. Nat. Genet. 12:212–215.
  • Stolen, C. M., M. W. Jackson, and J. Griep 1997. Overexpression of FGF-2 modulates fiber cell differentiation and survival in the mouse lens. Development 124:4009–4017.
  • Symonds, H., L. Krall, L. Remington, M. Saenz-Robles, S. Lowe, T. Jacks, and J. van Dyke 1994. p53-dependent apoptosis suppresses tumor growth and progression in vivo. Cell 78:703–711.
  • Tsai, K. Y., Y. Hu, K. F. Macleod, D. Crowley, L. Yamasaki, and J. Jacks 1998. Mutation of E2F-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos. Mol. Cell 2:293–304.
  • Wu, X., and J. Levine 1994. p53 and E2F-1 cooperate to mediate apoptosis. Proc. Natl. Acad. Sci. USA 91:3602–3606.
  • Xiao, Z.-X., J. Chen, A. J. Levine, N. Modjtahedi, J. Xing, W. R. Sellers, and J. Livingston 1995. Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature 375:694–698.
  • Yamasaki, L., T. Jacks, R. Bronson, E. Goillot, E. Harlow, and J. Dyson 1996. Tumor induction and tissue atrophy in mice lacking E2F-1. Cell 85:537–548.
  • Zerfass-Thome, K., W. Zwerschke, B. Mannhardt, R. Tindle, J. W. Botz, and J. Jansen-Durr 1996. Inactivation of the cdk inhibitor p27KIP1 by the human papillomavirus type 16 E7 oncoprotein. Oncogene 13:2323–2330.

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