Interaction between PAK and Nck: a Template for Nck Targets and Role of PAK Autophosphorylation

REFERENCES

• Arold, S., O'Brien, R., Franken, P., Strub, M. P., Hoh, F., Dumas, C., and Ladbury, J. E.. 1998. RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef. Biochemistry 37:14683–14691
   PubMed Web of Science ®Google Scholar
• Bagrodia, S., Taylor, S. J., Creasy, C. L., Chernoff, J., and Cerione, R. A.. 1995. Identification of a mouse p21Cdc42/Rac activated kinase. J. Biol. Chem. 270:22731–22737
   PubMedGoogle Scholar
• Bagrodia, S., Taylor, S. J., Jordon, K. A., Van Aelst, L., and Cerione, R. A.. 1998. A novel regulator of p21-activated kinases. J. Biol. Chem. 273:23633–23636
   PubMed Web of Science ®Google Scholar
• Bagrodia, S., Bailey, D., Lenard, Z., Hart, M., Guan, J. L., Premont, R. T., Taylor, S. J., and Cerione, R. A.. 1999. A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins. J. Biol. Chem. 274:22393–22400
   PubMed Web of Science ®Google Scholar
• Bokoch, G. M., Wang, Y., Bohl, B. P., Sells, M. A., Quilliam, L. A., and Knaus, U. G.. 1996. Interaction of the Nck adapter protein with p21-activated kinase (PAK1). J. Biol. Chem. 271:25746–25749
   PubMed Web of Science ®Google Scholar
• Booker, G. W., Gout, I., Downing, A. K., Driscoll, P. C., Boyd, J., Waterfield, M. D., and Campbell, I. D.. 1993. Solution structure and ligand-binding site of the SH3 domain of the p85 alpha subunit of phosphatidylinositol 3-kinase. Cell 73:813–822
   PubMedGoogle Scholar
• Buday, L., and Downward, J.. 1993. Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor. Cell 73:611–620
   PubMed Web of Science ®Google Scholar
• Chou, M. M., Fajardo, J. E., and Hanafusa, H.. 1992. The SH2- and SH3-containing Nck protein transforms mammalian fibroblasts in the absence of elevated phosphotyrosine levels. Mol. Cell Biol. 12:5834–5842
   PubMedGoogle Scholar
• Cicchetti, P., Mayer, B. J., Thiel, G., and Baltimore, D.. 1992. Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho. Science 257:803–806
   PubMedGoogle Scholar
• Clemens, J. C., Ursuliak, Z., Clemens, K. K., Price, J. V., and Dixon, J. E.. 1996. A Drosophila protein-tyrosine phosphatase associates with an adapter protein required for axonal guidance. J. Biol. Chem. 271:17002–17005
   PubMedGoogle Scholar
• Corbalan-Garcia, S., Yang, S. S., Degenhardt, K. R., and Bar-Sagi, D.. 1996. Identification of the mitogen-activated protein kinase phosphorylation sites on human Sos1 that regulate interaction with Grb2. Mol. Cell. Biol. 16:5674–5682
   PubMed Web of Science ®Google Scholar
• Du, Y., Weed, S. A., Xiong, W. C., Marshall, T. D., and Parsons, J. T.. 1998. Identification of a novel cortactin SH3 domain-binding protein and its localization to growth cones of cultured neurons. Mol. Cell. Biol. 18:5838–5851
   PubMed Web of Science ®Google Scholar
• Feng, S., Chen, J. K., Yu, H., Simon, J. A., and Schreiber, S. L.. 1994. Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions. Science 266:1241–1247
   PubMed Web of Science ®Google Scholar
• Galisteo, M. L., Chernoff, J., Su, Y. C., Skolnik, E. Y., and Schlessinger, J.. 1996. The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1. J. Biol. Chem. 271:20997–21000
   PubMed Web of Science ®Google Scholar
• Garrity, P. A., Rao, Y., Salecker, L., McGlade, J., Pawson, T., and Zipursky, S. L.. 1996. Drosophila photoreceptor axon guidance and targeting requires the dreadlocks SH2/SH3 adapter protein. Cell 85:639–650
   PubMedGoogle Scholar
• Gout, I., Dhand, R., Hiles, L. D., Fry, M. J., Panayotou, G., Das, P., Truong, O., Totty, N. F., Hsuan, J., Booker, G. W., Campbell, I. D., and Waterfield, M. D.. 1993. The GTPase dynamin binds to and is activated by a subset of SH3 domains. Cell 75:25–36
   PubMed Web of Science ®Google Scholar
• Gregorieff, A., Cloutier, J. F., and Veillette, A.. 1998. Sequence requirements for association of protein-tyrosine phosphatase PEP with the Src homology 3 domain of inhibitory tyrosine protein kinase p50(csk). J. Biol. Chem. 273:13217–13222
   PubMedGoogle Scholar
• Harden, N., Lee, J., Loh, H. Y., Ong, Y. M., Tan, I., Leung, T., Manser, E., and Lim, L.. 1996. A Drosophila homolog of the Rac- and Cdc42-activated serine/threonine kinase PAK is a potential focal adhesion and focal complex protein that colocalizes with dynamic actin structures. Mol. Cell. Biol. 16:1896–1908
   PubMedGoogle Scholar
• Hing, H., Xiao, J., Harden, N., Lim, L., and Zipursky, S. L.. 1999. Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila. Cell 97:853–863
   PubMed Web of Science ®Google Scholar
• Koyama, S., Yu, H., Dalgarno, D. C., Shin, T. B., Zydowsky, L. D., and Schreiber, S. L.. 1993. Structure of the PI3K SH3 domain and analysis of the SH3 family. Cell 72:945–952
   PubMedGoogle Scholar
• Ladbury, J. E., Lemmon, M. A., Zhou, M., Green, J., Botfield, M. C., and Schlessinger, J.. 1995. Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal. Proc. Natl. Acad. Sci. USA 92:3199–3203
   PubMed Web of Science ®Google Scholar
• Lee, C. H., Leung, B., Lemmon, M. A., Zheng, J., Cowburn, D., Kuriyan, J., and Saksela, K.. 1995. A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein. EMBO J. 14:5006–5015
   PubMed Web of Science ®Google Scholar
• Lee, C. H., Saksela, K., Mirza, U. A., Chait, B. T., and Kuriyan, J.. 1996. Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain. Cell 85:931–942
   PubMed Web of Science ®Google Scholar
• Lemmon, M. A., Ladbury, J. E., Mandiyan, V., Zhou, M., and Schlessinger, J.. 1994. Independent binding of peptide ligands to the SH2 and SH3 domains of Grb2. J. Biol. Chem. 269:31653–31658
   PubMed Web of Science ®Google Scholar
• Li, W., Hu, P., Skolnik, E. Y., Ullrich, A., and Schlessinger, J.. 1992. The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors. Mol. Cell. Biol. 12:5824–5833
   PubMedGoogle Scholar
• Lim, W. A., Richards, F. M., and Fox, R. O.. 1994. Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains. Nature 372:375–379
   PubMed Web of Science ®Google Scholar
• Lu, W., Katz, S., Gupta, R., and Mayer, B. J.. 1997. Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck. Curr. Biol. 7:85–94
   PubMed Web of Science ®Google Scholar
• Lu, W., and Mayer, B. J.. 1999. Mechanism of activation of Pak1 kinase by membrane localization. Oncogene 18:797–806
   PubMed Web of Science ®Google Scholar
• Luttrell, L. M., Ferguson, S. S., Daaka, Y., Miller, W. E., Maudsley, S., Della Rocca, G. J., Lin, F., Kawakatsu, H., Owada, K., Luttrell, D. K., Caron, M. G., and Lefkowitz, R. J.. 1999. Beta-arrestin-dependent formation of β2 adrenergic receptor-Src protein kinase complexes. Science 283:655–661
   PubMed Web of Science ®Google Scholar
• Manser, E., Huang, H.-Y., Loo, T.-H., Chen, X.-Q., Dong, J.-M., Leung, T., and Lim, L.. 1997. Expression of constitutively active αPAK reveals effects of the kinase on actin and focal complexes. Mol. Cell. Biol. 17:1129–1143
   PubMed Web of Science ®Google Scholar
• Manser, E., Leung, T., Salihuddin, H., Zhao, Z.-S., and Lim, L.. 1994. A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature 367:40–46
   PubMed Web of Science ®Google Scholar
• Manser, E., Loo, T.-H., Koh, C.-G., Zhao, Z.-S., Chen, X. Q., Tan, L., Tan, I., Leung, T., and Lim, L.. 1998. PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. Mol. Cell 1:183–192
   PubMed Web of Science ®Google Scholar
• Matsuda, M., Ota, S., Tanimura, R., Nakamura, H., Matuoka, K., Takenawa, T., Nagashima, K., and Kurata, T.. 1996. Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins. J. Biol. Chem. 271:14468–14472
   PubMedGoogle Scholar
• Matuoka, K., Miki, H., Takahashi, K., and Takenawa, T.. 1997. A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs. Biochem. Biophys. Res. Commun. 239:488–492
   PubMed Web of Science ®Google Scholar
• Mayer, B. J.. 1997. Signal transduction: clamping down on Src activity. Curr. Biol. 7:295–298
   PubMed Web of Science ®Google Scholar
• McPherson, P. S., Czernik, A. J., Chilcote, T. J., Onofri, F., Benfenati, F., Greengard, P., Schlessinger, J., and De Camilli, P.. 1994. Interaction of Grb2 via its Src homology 3 domains with synaptic proteins including synapsin I. Proc. Natl. Acad. Sci. USA 91:6486–6490
   PubMed Web of Science ®Google Scholar
• Nemoto, Y., Arribas, M., Haffner, C., and DeCamilli, P.. 1997. Synaptojanin 2, a novel synaptojanin isoform with a distinct targeting domain and expression pattern. J. Biol. Chem. 272:30817–30821
   PubMedGoogle Scholar
• Nguyen, J. T., Turck, C. W., Cohen, F. E., Zuckermann, R. N., and Lim, W. A.. 1998. Exploiting the basis of proline-recognition by SH3 and WW domains: design of N-substituted inhibitors. Science 282:2088–2092
   PubMed Web of Science ®Google Scholar
• Obermeier, A., Ahmed, S., Manser, E., Yen, S. C., Hall, C., and Lim, L.. 1998. PAK promotes morphological changes by acting upstream of Rac. EMBO J. 17:4328–4339
   PubMed Web of Science ®Google Scholar
• Ohoka, Y., and Takai, Y.. 1998. Isolation and characterization of cortactin isoforms and a novel cortactin-binding protein, CBP90. Genes Cells 3:603–612
   PubMed Web of Science ®Google Scholar
• Pawson, T.. 1995. Protein modules and signalling networks. Nature 373:573–580
   PubMed Web of Science ®Google Scholar
• Premont, R. T., Claing, A., Vitale, N., Freeman, J. L., Pitcher, J. A., Patton, W. A., Moss, J., Vaughan, M., and Lefkowitz, R. J.. 1998. β2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. Proc. Natl. Acad. Sci. USA 95:14082–14087
   PubMed Web of Science ®Google Scholar
• Quilliam, L. A., Lambert, Q. T., Mickelson-Young, L. A., Westwick, J. K., Sparks, A. B., Kay, B. K., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., and Der, C. J.. 1996. Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling. J. Biol. Chem. 271:28772–28776
   PubMedGoogle Scholar
• Rao, Y., and Zipursky, S. L.. 1998. Domain requirements for the Dock adapter protein in growth-cone signaling. Proc. Natl. Acad. Sci. USA 95:2077–2082
   PubMedGoogle Scholar
• Ren, R., Mayer, B. J., Cicchetti, P., and Baltimore, D.. 1993. Identification of a ten-amino acid proline-rich SH3 binding site. Science 259:1157–1161
   PubMed Web of Science ®Google Scholar
• Rickles, R. J., Botfield, M. C., Zhou, X.-M., Henrey, P. A., Brugge, J. S., and Zoller, M. J.. 1995. Phage display selection of ligand residues important for Src homology domain binding specificity. Proc. Natl. Acad. Sci. USA 92:10909–10913
   PubMed Web of Science ®Google Scholar
• Sastry, L., Lin, W., Wong, W. T., Di Fiore, P. P., Scoppa, C. A., and King, C. R.. 1995. Quantitative analysis of Grb2-Sos1 interaction: the N-terminal SH3 domain of Grb2 mediates affinity. Oncogene 11:1107–1112
   PubMed Web of Science ®Google Scholar
• Schultz, J., Milpetz, F., Bork, P., and Ponting, C. P.. 1998. SMART, a simple modular architecture research tool: identification of signaling domains. Proc. Natl. Acad. Sci. USA 95:5857–5864
   PubMed Web of Science ®Google Scholar
• Sells, M. A., Knaus, U. G., Bagrodia, S., Ambrose, D. M., Bokoch, G. M., and Chernoff, J.. 1997. Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells. Curr. Biol. 7:202–210
   PubMed Web of Science ®Google Scholar
• Sells, M. A., Boyd, J. T., and Chernoff, J.. 1999. p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts. J. Cell Biol. 145:837–849
   PubMed Web of Science ®Google Scholar
• Shen, Y., Schneider, G., Cloutier, J. F., Veillette, A., and Schaller, M. D.. 1998. Direct association of protein-tyrosine phosphatase PTP-PEST with paxillin. J. Biol. Chem. 273:6474–6481
   PubMed Web of Science ®Google Scholar
• Sparks, A. B., Rider, J. E., Hoffman, N. G., Fowlkes, D. M., Quillam, L. A., and Kay, B. K.. 1996. Distinct ligand preferences of Src homology 3 domains from Src, Yes, Abl, Cortactin, p53bp2, PLCγ, Crk, and Grb2. Proc. Natl. Acad. Sci. USA 93:1540–1544
   PubMed Web of Science ®Google Scholar
• Su, Y. C., Han, J., Xu, S., Cobb, M., and Skolnik, E. Y.. 1997. NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain. EMBO J. 16:1279–1290
   PubMed Web of Science ®Google Scholar
• Tanaka, S., Morishita, T., Hashimoto, Y., Hattori, S., Nakamura, S., Shibuya, M., Matuoka, K., Takenawa, T., Kurata, T., Nagashima, K., and Matsuda, M.. 1994. C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins. Proc. Natl. Acad. Sci. USA 91:3443–3447
   PubMed Web of Science ®Google Scholar
• Wang, B., Mysliwiec, T., Feller, S. M., Knudsen, B., Hanafusa, H., and Kruh, G. D.. 1996. Proline-rich sequences mediate the interaction of the Arg protein tyrosine kinase with Crk. Oncogene 13:1379–1385
   PubMedGoogle Scholar
• Yu, H., Chen, J. K., Feng, S., Dalgarno, D. C., Brauer, A. W., and Schreiber, S. L.. 1994. Structural basis for the binding of proline-rich peptides to SH3 domains. Cell 76:933–945
   PubMed Web of Science ®Google Scholar
• Yu, H., Rosen, M. K., Shin, T. B., Seidel-Dugan, C., Brugge, J. S., and Schreiber, S. L.. 1992. Solution structure of the SH3 domain of Src and identification of its ligand-binding site. Science 258:1665–1668
   PubMed Web of Science ®Google Scholar
• Zhang, Z., Schaffer, A. A., Miller, W., Madden, T. L., Lipman, D. J., Koonin, E. V., and Altschul, S. F.. 1998. Protein sequence similarity searches using patterns as seeds. Nucleic Acids Res. 26:3986–3990
   PubMedGoogle Scholar
• Zhao, Z.-S., Manser, E., Chen, X.-Q., Chong, C., Leung, T., and Lim, L.. 1998. A conserved negative regulatory region in αPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1. Mol. Cell. Biol. 18:2153–2163
   PubMed Web of Science ®Google Scholar