12
Views
75
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Activation of MEK Kinase 1 by the c-Abl Protein Tyrosine Kinase in Response to DNA Damage

, , , , , , , , , , , & show all
Pages 4979-4989 | Received 23 Dec 1999, Accepted 12 Apr 2000, Published online: 28 Mar 2023

REFERENCES

  • Angel, P., Hattori, K., Smeal, T., and Karin, M.. 1988. The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1. Cell 55:875–885
  • Baskaran, R., Wood, L. D., Whitaker, L. L., Xu, Y., Barlow, C., Canman, C. E., Morgan, S. E., Baltimore, D., Wynshaw-Boris, A., Kastan, M. B., and Wang, J. Y. J.. 1997. Ataxia telangiectasia mutant protein activates c-abl tyrosine kinase in response to ionizing radiation. Nature 387:516–519
  • Ben-Neriah, Y., Bernards, A., Paskind, M., Daley, G. Q., and Baltimore, D.. 1986. Alternative 5′ exons in c-abl mRNA. Cell 44:577–586
  • Blank, J. L., Gerwins, P., Elliott, E. M., Sather, S., and Johnson, G.. 1996. Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase. J. Biol. Chem. 271:5361–5368
  • Chen, R. H., Sarnecki, C., and Blenis, J.. 1992. Nuclear localization and regulation of erk- and rsk-encoded protein kinases. Mol. Cell. Biol. 12:915–927
  • Chen, Y.-R., Meyer, C. F., and Tan, T.-H.. 1996. Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in γ radiation-induced apoptosis. J. Biol. Chem. 271:631–634
  • Chen, Y.-R., Wang, X., Templeton, D., Davis, R. J., and Tan, T.-H.. 1996. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and γ radiation. J. Biol. Chem. 271:31929–31936
  • Coso, O. A., Chiariello, M., Yu, J., Teramoto, H., Crespo, P., Xu, N., Miki, T., and Gutkind, J. S.. 1995. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81:1137–1146
  • Davis, R. J.. 1994. MAPKs: new JNK expands the group. Trends Biochem. Sci. 19:470–473
  • Derijard, B., Hibi, M., Wu, I. H., Barrett, T., Su, B., Deng, T., Karin, M., and Davis, R. J.. 1994. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76:1025–1037
  • Derijard, B., Raingeaud, J., Barrett, T., Wu, I.-H., Han, J., Ulevitch, R. J., and Davis, R. J.. 1995. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. Science 267:682–685
  • Devary, Y., Gottlieb, R. A., Smeal, T., and Karin, M.. 1992. The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases. Cell 71:1081–1091
  • Dikic, I., Tokiwa, G., Lev, S., Courtneidge, S. A., and Schlessinger, J.. 1996. A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature 383:547–550
  • Errede, B., and Levin, D. E.. 1993. A conserved kinase cascade for MAP kinase activation in yeast. Curr. Opin. Cell Biol. 5:254–260
  • Fanger, G. R., Johnson, N. L., and Johnson, G. L.. 1997. MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42. EMBO J. 16:4961–4972
  • Feller, S., Ren, R., Hanafusa, H., and Baltimore, D.. 1994. SH2 and SH3 domains as molecular adhesives: the interactions of Crk and Abl. Trends Biochem. Sci. 19:453–458
  • Georgiev, O., Bourquin, J. P., Gstaiger, M., Knoepfel, L., Schaffner, W., and Hovens, C.. 1996. Two versatile eukaryotic vectors permitting epitope tagging, radiolabelling and nuclear localisation of expressed proteins. Gene 168:165–167
  • Goga, A., Liu, X., Hambuch, T. M., Senechal, K., Major, E., Berk, A. J., Witte, O. N., and Sawyers, C. L.. 1995. p53 dependent growth suppression by the c-Abl nuclear tyrosine kinase. Oncogene 11:791–799
  • Herskowitz, I.. 1995. MAP kinase pathways in yeast: for mating and more. Cell 80:187–197
  • Hirai, S., Izawa, M., Osada, S., Spyrou, G., and Ohno, S.. 1996. Activation of the JNK pathway by distantly related protein kinases, MEKK and MLK. Oncogene 12:641–650
  • Hirano, M., Osada, S.-I., Aoki, T., Hirai, S.-I., Hosaka, M., Inoue, J.-I., and Ohno, S.. 1996. MEK kinase is involved in tumor necrosis factor α-induced NF-κB activation and degradation of IkBα. J. Biol. Chem. 271:13234–13238
  • Ichijo, H., Nishida, E., Irie, K., ten Dijke, P., Moriguchi, T., Takagi, M., Matsumoto, K., Miyazono, K., and Gotoh, Y.. 1997. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science 275:90–94
  • Johnson, N. L., Gardner, A. M., Diener, K. M., Lange-Carter, C. A., Gleavy, J., Jarpe, M. B., Minden, A., Karin, M., Zon, L. I., and Johnson, G. L.. 1996. Signal transduction pathways regulated by mitogen-activated/extracurricular response kinase kinase kinase induce cell death. J. Biol. Chem. 271:3229–3237
  • Kaneki, M., Kharbanda, S., Pandey, P., Liou, J.-R., Stone, R., and Kufe, D.. 1999. Functional role for protein kinase Cβ as a regulator of stress-activated protein kinase activation and monocytic differentiation of myeloid leukemia cells. Mol. Cell. Biol. 19:461–470
  • Karin, M.. 1995. The regulation of AP-1 activity by mitogen-activated protein kinases. J. Biol. Chem. 270:16483–16486
  • Katz, P., Whalen, G., and Kehrl, J. H.. 1994. Differential expression of a novel protein kinase in human B lymphocytes. Preferential localization in the germinal center. J. Biol. Chem. 269:16802–16809
  • Kharbanda, S., Bharti, A., Pei, D., Wang, J., Pandey, P., Ren, R., Weichselbaum, R., Walsh, C. T., and Kufe, D.. 1996. The stress response to ionizing radiation involves c-Abl-dependent phosphorylation of SHPTP1. Proc. Natl. Acad. Sci. USA 93:6898–6901
  • Kharbanda, S., Pandey, P., Jin, S., Inoue, S., Bharti, A., Yuan, Z.-M., Weichselbaum, R., Weaver, D., and Kufe, D.. 1997. Functional interaction of DNA-PK and c-Abl in response to DNA damage. Nature 386:732–735
  • Kharbanda, S., Pandey, P., Ren, R., Feller, S., Mayer, B., Zon, L., and Kufe, D.. 1995. c-Abl activation regulates induction of the SEK1/stress activated protein kinase pathway in the cellular response to 1-β-d-arabinofuranosylcytosine. J. Biol. Chem. 270:30278–30281
  • Kharbanda, S., Ren, R., Pandey, P., Shafman, T. D., Feller, S. M., Weichselbaum, R. R., and Kufe, D. W.. 1995. Activation of the c-Abl tyrosine kinase in the stress response to DNA-damaging agents. Nature 376:785–788
  • Kharbanda, S., Saleem, A., Shafman, T., Emoto, Y., Weichselbaum, R., Woodgett, J., Avruch, J., Kyriakis, J., and Kufe, D.. 1995. Ionizing radiation stimulates a Grb2-mediated association of the stress activated protein kinase with phosphatidylinositol 3-kinase. J. Biol. Chem. 270:18871–18874
  • Kharbanda, S., Sherman, M. L., and Kufe, D. W.. 1990. Transcriptional regulation of c-jun gene expression by arabinofuranosylcytosine in human myeloid leukemia cells. J. Clin. Investig. 86:1517–1523
  • Kiefer, F., Tibbles, L. A., Anafi, M., Janssen, A., Zanke, B. W., Lassam, N., Pawson, T., Woodgett, J. R., and Iscove, N. N.. 1996. HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway. EMBO J. 15:7013–7025
  • Kyriakis, J. M., and Avruch, J.. 1996. Sounding the alarm: protein kinase cascades activated by stress and inflammation. J. Biol. Chem. 271:24313–24316
  • Kyriakis, J. M., Banerjee, P., Nikolakaki, E., Dai, T., Rubie, E. A., Ahmad, M. F., Avruch, J., and Woodgett, J. R.. 1994. The stress-activated protein kinase subfamily of c-Jun kinases. Nature 369:156–160
  • Lallemand, D., Ham, J., Garbay, S., Bakiri, L., Traincard, F., Jeannequin, O., Pfarr, C. M., and Yaniv, M.. 1998. Stress-activated protein kinases are negatively regulated by cell density. EMBO J. 17:5615–5626
  • Lange-Carter, C. A., and Johnson, G. L.. 1994. Ras-dependent growth factor regulation of MEK kinase in PC12 cells. Science 265:1458–1461
  • Lange-Carter, C. A., Pleiman, C. M., Gardner, A. M., Blumer, K. J., and Johnson, G. J.. 1994. A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science 260:315–319
  • Lin, A., Minden, A., Martinetto, H., Claret, F.-X., Lange-Carter, C., Mercurio, F., Johnson, G. L., and Karin, M.. 1995. Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. Science 268:286–290
  • Liu, Z.-G., Baskaran, R., Lea-Chou, E. T., Wood, L., Chen, Y., Karin, M., and Wang, J. Y. J.. 1996. Three distinct signalling responses by murine fibroblasts to genotoxic stress. Nature 384:273–276
  • Liu, Z.-G., Baskaran, R., Lea-Chou, E. T., Wood, L., Chen, Y., Karin, M., and Wang, J. Y. J.. 1996. Three distinct signalling responses by murine fibroblasts to genotoxic stress. Nature 384:273–276
  • Manser, E., Leung, T., Salihuddin, H., Zhao, Z. S., and Lim, L.. 1994. A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature 367:40–46
  • Marshall, C. J.. 1995. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80:179–185
  • Mattioni, T., Jackson, P. K., Bchini-Hooft van Huijsduijnen, O., and Picard, D.. 1995. Cell cycle arrest by tyrosine kinase Abl involves altered early mitogenic response. Oncogene 10:1325–1333
  • Minden, A., and Karin, M.. 1997. Regulation and function of the JNK subgroup of MAP kinases. Biochim. Biophys. Acta 1333:F85–104
  • Minden, A., Lin, A., McMahon, M., Lange-Carter, C., Derijard, B., Davis, R. J., Johnson, G. L., and Karin, M.. 1994. Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science 266:1719–1723
  • Pandey, P., Avraham, S., Place, A., Kumar, V., Majumder, P., Cheng, K., Nakazawa, A., Saxena, S., and Kharbanda, S.. 1999. Bcl-xL blocks activation of related adhesion focal tyrosine kinase/proline-rich tyrosine kinase 2 and stress-activated protein kinase/c-Jun N-terminal protein kinase in the cellular response to methylmethane sulfonate. J. Biol. Chem. 274:8618–8623
  • Pandey, P., Raingeaud, J., Kaneki, M., Weichselbaum, R., Davis, R., Kufe, D., and Kharbanda, S.. 1996. Activation of p38 MAP kinase by c-Abl-dependent and -independent mechanisms. J. Biol. Chem. 271:23775–23779
  • Pombo, C. M., Kehrl, J. H., Sanchez, I., Katz, P., Avruch, J., Zon, L. I., Woodgett, J. R., Force, T., and Kyriakis, J. M.. 1995. Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase. Nature 377:750–754
  • Raitano, A. B., Halpern, J. R., Hambuch, T. M., and Sawyers, C. L.. 1995. The Bcr-Abl leukemia oncogene activates Jun kinase and requires Jun for transformation. Proc. Natl. Acad. Sci. USA 92:11746–11750
  • Rana, A., Gallo, K., Godowski, P., Hirai, S.-I., Ohno, S., Zon, L., Kyriakis, J. M., and Avruch, J.. 1996. The mixed lineage kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK-1. J. Biol. Chem. 271:19025–19028
  • Ren, R., Ye, Z.-S., and Baltimore, D.. 1994. Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites. Genes Dev. 8:783–795
  • Renshaw, M. W., Lea-Chou, E., and Wang, J. Y. J.. 1996. Rac is required for v-Abl tyrosine kinase to activate mitogenesis. Curr. Biol. 6:76–83
  • Rubin, E., Kharbanda, S., Gunji, H., and Kufe, D.. 1991. Activation of the c-jun protooncogene in human myeloid leukemia cells treated with etoposide. Mol. Pharmacol. 39:697–701
  • Russell, M., Lange-Carter, C. A., and Johnson, G. L.. 1995. Direct interaction between Ras and the kinase domain of mitogen-activated protein kinase kinase kinase (MEKK1). J. Biol. Chem. 270:11757–11760
  • Salmeron, A., Ahmad, T. B., Carlile, G. W., Pappin, D., Narsimhan, R. P., and Ley, S. C.. 1996. Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase. EMBO J. 15:817–826
  • Sanchez, I., Hughes, R. T., Mayer, B. J., Yee, K., Woodgett, J. R., Avruch, J., Kyriakis, J. M., and Zon, L. I.. 1994. Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature 372:794–798
  • Sawyers, C. L., McLaughlin, J., Goga, A., Havilik, M., and Witte, O.. 1994. The nuclear tyrosine kinase c-Abl negatively regulates cell growth. Cell 77:121–131
  • Schwartzberg, P. L., Stall, A. M., Hardin, J. D., Bowdish, K. S., Humaran, T., Boast, S., Harbison, M. L., Robertson, E. J., and Goff, S. P.. 1991. Mice homozygous for the ablTm1 mutation show poor viability and depletion of selected B and T cell populations. Cell 65:1165–1175
  • Shafman, T., Khanna, K. K., Kedar, P., Spring, K., Kozlov, S., Yen, T., Hobson, K., Gatei, M., Zhang, N., Watters, D., Egerton, M., Shiloh, Y., Kharbanda, S., Kufe, D., and Lavin, M. F.. 1997. Interaction between ATM protein and c-Abl in response to DNA damage. Nature 387:520–523
  • Sherman, M., Stone, R., Datta, R., Bernstein, S., and Kufe, D.. 1990. Transcriptional and post-transcriptional regulation of c-Jun expression during monocytic differentiation of human myeloid leukemic cells. J. Biol. Chem. 265:3320–3323
  • Sherman, S. E., and Lippard, S. J.. 1987. Structural aspects of platinum anticancer drug interaction with DNA. J. Chem. Rev. 87:1153–1181
  • Takekawa, M., Posas, F., and Saito, H.. 1997. A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways. EMBO J. 16:4973–4982
  • Takekawa, M., and Saito, H.. 1998. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. Cell 95:521–530
  • Tibbles, L. A., Ing, Y. L., Kiefer, F., Chan, J., Iscove, N., Woodgett, J. R., and Lassam, N. J.. 1996. MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6. EMBO J. 15:7026–7035
  • Tokiwa, G., Dikic, I., Lev, S., and Schlessinger, J.. 1996. Activation of Pyk2 by stress signals and coupling with JNK signaling pathway. Science 273:792–794
  • Tournier, C., Whitmarsh, A. J., Cavanagh, J., Barrett, T., and Davis, R. J.. 1997. Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase. Proc. Natl. Acad. Sci. USA 94:7337–7342
  • Tybulewicz, V. L. J., Crawford, C. E., Jackson, P. K., Bronson, R. T., and Mulligan, R. C.. 1991. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell 65:1153–1163
  • Verheij, M., Bose, R., Lin, X. H., Yhao, B., Jarvis, W. D., Grant, S., Birrer, M. J., Szabo, E., Zon, L. I., Kyriakis, J. M., Haimovitz-Friedman, A., Fuks, Z., and Kolesnick, R. N.. 1996. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 380:75–79
  • Widmann, C., Gerwins, P., Johnson, N. L., Jarpe, M. B., and Johnson, G. L.. 1998. MEK kinase 1, a substrate for DEVD-directed caspases, is involved in genotoxin-induced apoptosis. Mol. Cell. Biol. 18:2416–2429
  • Widmann, C., Gibson, S., and Johnson, G. L.. 1998. Caspase-dependent cleavage of signaling proteins during apoptosis. A turn-off mechanism for anti-apoptotic signals. J. Biol. Chem. 273:7141–7147
  • Wilhelm, D., Bender, K., Knebel, A., and Angel, P.. 1997. The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including Jun N-terminal protein kinases and p38 kinase by alkylating agents. Mol. Cell. Biol. 17:4792–4800
  • Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., and Greenberg, M. E.. 1995. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270:1326–1331
  • Xu, S., and Cobb, M. H.. 1997. MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases. J. Biol. Chem. 272:32056–32060
  • Xu, S., Robbins, D. J., Christerson, L. B., English, J. M., Vanderbilt, C. A., and Cobb, M. H.. 1996. Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain. Proc. Natl. Acad. Sci. USA 93:5291–5295
  • Yan, M., Dai, T., Deak, J. C., Kyriakis, J. M., Zon, L. I., Woodgett, J. R., and Templeton, D. J.. 1994. Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1. Nature 372:798–800
  • Yuan, Z. M., Huang, Y., Ishiko, T., Nakada, S., Utsugisawa, T., Kharbanda, S., Sung, P., Shinohara, A., Weichselbaum, R., and Kufe, D.. 1998. Regulation of Rad51 function by c-Abl in response to DNA damage. J. Biol. Chem. 273:3799–3802
  • Yuan, Z. M., Huang, Y., Whang, Y., Sawyers, C., Weichselbaum, R., Kharbanda, S., and Kufe, D.. 1996. Role for the c-Abl tyrosine kinase in the growth arrest response to DNA damage. Nature 382:272–274
  • Yuasa, T., Ohno, S., Kehrl, J. H., and Kyriakis, J. M.. 1998. Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38. J. Biol. Chem. 273:22681–22692
  • Zanke, B. W., Boudreau, K., Rubie, E., Winnett, E., Tibbles, L. A., Zon, L., Kyriakis, J., Liu, F.-F., and Woodgett, J. R.. 1996. The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat. Curr. Biol. 6:606–613
  • Zhang, S., Han, J., Sells, M. A., Chernoff, J., Knaus, U. G., Ulevitch, R. J., and Bokoch, G. M.. 1995. Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1. J. Biol. Chem. 270:23934–23936

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.