5
Views
94
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Role of the IκB Kinase Complex in Oncogenic Ras- and Raf-Mediated Transformation of Rat Liver Epithelial Cells

, , , &
Pages 5381-5391 | Received 17 Nov 1999, Accepted 10 Apr 2000, Published online: 28 Mar 2023

REFERENCES

  • Arsura, M., FitzGerald, M. J., Fausto, N., and Sonenshein, G. E.. 1997. NF-κB/Rel blocks transforming growth factor-β1-induced apoptosis of murine hepatocyte cell lines. Cell Growth Differ. 8:1049–1059
  • Arsura, M., Wu, M., and Sonenshein, G. E.. 1996. TGF-β1 inhibits NF-κB/Rel activity inducing apoptosis of B cells: transcriptional activation of IκB-α. Immunity 5:31–40
  • Baeuerle, P. A., and Henkel, T.. 1994. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12:141–179
  • Baldwin, A. S.Jr.. 1996. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649–681
  • Ballard, D., Dixon, E., Peffer, N., Bogard, H., Doerre, S., Stein, B., and Greene, W.. 1992. The 65-kDa subunit of human NF-κB functions as a potent transcriptional activator and a target for v-Rel-mediated repression. Proc. Natl. Acad. Sci. USA 85:1875–1880
  • Bargou, R. C., Emmerich, F., Krappmann, D., Mapara, M. Y., Arnold, W., Royer, H. D., Grinstein, E., Greiner, A., Scheidereit, C., and Dorken, B.. 1997. Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells. J. Clin. Investig. 100:2961–2969
  • Bedossa, P., Peltier, E., Terris, B., Franco, D., and Poynard, T.. 1995. Transforming growth factor β1 (TGF-β1) and TGF-β1 receptors in normal, cirrhotic, and neoplastic human livers. Hepatology 21:760–766
  • Beg, A., Sha, W., Bronson, R., Ghosh, S., and Baltimore, D.. 1995. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB. Nature 376:167–170
  • Beg, A., and Baltimore, D.. 1996. An essential role for NF-κB in preventing TNF-α induced cell death. Science 274:782–784
  • Bellas, R. E., FitzGerald, M. J., Fausto, N., and Sonenshein, G. E.. 1997. Inhibition of NF-κB activity induces apoptosis in murine hepatocytes. Am. J. Pathol. 152:891–896
  • Brown, K., Gerstenberger, S., Carlson, L., Franzoso, G., and Siebenlist, U.. 1995. Control of IκB-α proteolysis by site-specific signal-induced phosphorylation. Science 267:1485–1488
  • Chen, Z. J., Parent, L., and Maniatis, T.. 1996. Site-specific phosphorylation of IκB-α by a novel ubiquitination-dependent protein kinase activity. Cell 84:853–862
  • Cherrington, J. M., and Mocarski, E. S.. 1989. Human cytomegalovirus ie1 transactivates the alpha promoter-enhancer via an 18-base-pair repeat element. J. Virol. 63:1435–1440
  • Cui, W., Fowlis, D. J., Bryson, S., Duffic, E., Ireland, H., Balman, A., and Akhurst, R. J.. 1996. TGF-β I inhibits the formation of benign skin tumors but enhances progression to invasive spindle carcinomas in transgenic mice. Cell 86:531–542
  • Czaja, M. J., Weiner, F. R., Flanders, K. C., Giambrone, R., Wind, L., Biempica, L., and Zern, M. A.. 1989. In vitro and in vivo association of transforming growth factor β1 with hepatic fibrosis. J. Cell Biol. 108:2477–2482
  • Delhase, M., Hayakawa, M., Chen, Y., and Karin, M.. 1999. Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. Science 284:309–313
  • DiDonato, J., Mercurio, F., Rosette, C., Wu-Li, J., Suyang, H., Ghosh, S., and Karin, M.. 1996. Mapping of the inducible IκB phosphorylation sites that signal its ubiquitination and degradation. Mol. Cell. Biol. 16:1295–1304
  • DiDonato, J., Hayakawa, A., Rothwarf, D. M., Zandi, E., and Karin, M.. 1997. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature 388:548–554
  • Duprez, D., Bell, E. J., Richardson, M. K., Archer, C. W., Wolpert, L., Brickell, P. M., and Francis-West, P. H.. 1996. Overexpression of BMP-2 and BMP-4 alters the size and shape of developing skeletal elements in the chick limb. Mech. Dev. 57:145–157
  • Duyao, M. P., Buckler, A. J., and Sonenshein, G. E.. 1990. Interaction of an NF-κB-like factor with a site upstream of the c-myc promoter. Proc. Natl. Acad. Sci. USA 87:4727–4731
  • Evarts, R. P., Nagy, P., Nakatsukasa, H., Marsden, E., and Thorgeirsson, S. S.. 1989. In vivo differentiation of rat liver oval cells into hepatocytes. Cancer Res. 49:1541–1547
  • Fausto, N.. 1991. Growth factors in liver development, regeneration and carcinogenesis. Prog. Growth Factor Res. 3:219–234
  • Fausto, N., Mead, J. E., Gruppuso, P. A., and Braun, L.. 1990. TGF-β in liver development, regeneration, and carcinogenesis. Ann. N.Y. Acad. Sci. 593:231–242
  • Finco, T. S., Baldwin, A. S.Jr.. 1993. κB site-dependent induction of gene expression by diverse inducers of nuclear factor κB requires raf-1. J. Biol. Chem. 268:17676–17679
  • Finco, T. S., Westwick, J. K., Norris, J. L., Beg, A. A., Der, C. J., Baldwin, A. S.Jr.. 1997. Oncogenic Ha-Ras-induced signalling activates NF-κB transcriptional activity, which is required for cellular transformation. J. Biol. Chem. 272:24113–24116
  • Fynn, T. M., and Reiss, M.. 1993. Resistance to inhibition of cell growth by transforming growth factor A and its role in oncogenesis. Crit. Rev. Oncog. 4:493–540
  • Garfield, S., Huber, B. E., Nagy, P., Cordingley, M. G., and Thorgeirsson, S. S.. 1988. Neoplastic transformation and lineage switching of rat liver epithelial cells by retrovirus-associated oncogenes. Mol. Carcinog. 1:189–195
  • Geleziunas, R., Ferrell, S., Lin, X., Mu, Y., Cunningham, E. T.Jr., Grant, M., Connelly, M. A., Hambor, J. E., Marcu, K. B., and Greene, W. C.. 1998. Human T-cell leukemia virus type 1 Tax induction of NF-κB involves activation of the IκB kinase alpha (IKKα) and IKKβ cellular kinases. Mol. Cell. Biol. 18:5257–5265
  • Gilmore, T. D., Koedood, M., Piffat, K. A., and White, D. W.. 1996. Rel/NF-κB/IκB protein and cancer. Oncogene 13:1367–1378
  • Giri, D. K., and Aggarwal, B. B.. 1998. Constitutive activation of NF-kappaB causes resistance to apoptosis in human cutaneous T cell lymphoma HuT-78 cells: autocrine role of tumor necrosis factor and reactive oxygen intermediates. J. Biol. Chem. 273:14008–14014
  • Grisham, J. W., and Thorgeirsson, S. S.. 1997. Liver stem cells Stem cells. Potten, C. S. 233–282 Academic Press, London, United Kingdom
  • Hampton, L. L., Worland, P. J., Yu, B., Thorgeirsson, S. S., and Huggett, A. C.. 1990. Expression of growth-related genes during tumor progression in v-raf-transformed rat liver epithelial cells. Cancer Res. 50:7460–7467
  • Houck, K. A., Michalopoulos, G. K., and Strom, S. C.. 1989. Introduction of a Ha-ras oncogene into rat liver epithelial cells and parenchymal hepatocytes confers resistance to the growth inhibitory effects of TGF-β. Oncogene 4:19–25
  • Howe, P. H., Dobrowolski, S. F., Reddy, K. B., and Stacey, D. W.. 1993. Release from G1 growth arrest by transforming growth factor β1 requires cellular ras activity. J. Biol. Chem. 268:21448–21452
  • Hu, Y., Baud, V., Delhase, M., Zhang, P., Deerinck, T., Ellisman, M., Johnson, R., and Karin, M.. 1999. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase. Science 284:316–320
  • Huggett, A. C., Hampton, L. L., Ford, C. P., Wirth, P. J., and Thorgeirsson, S. S.. 1989. Altered responsiveness of rat liver epithelial cells to transforming growth factor beta 1 following their transformation with v-raf. Cancer Res. 50:7468–7465
  • Kalkuhl, A., Troppmair, J., Buchmann, A., Stinchcombe, S., Buenemann, C. L., Rapp, U. R., Kaestner, K., and Schwarz, M.. 1998. p21Ras downstream effectors are increased in activity or expression in mouse liver tumors but do not differ between ras-mutated and ras-wild-type lesions. Hepatology 27:1081–1088
  • Kim, D. W., Sovak, M. A., Zanieski, G., Nonet, G., Romieu-Mourez, R., Lau, A. W., Hafer, L. J., Yaswen, P., Stampfer, M., Rogers, A. E., Russo, J., and Sonenshein, G. E.. 2000. Activation of NF-κB/Rel occurs early during neoplastic transformation of mammary cells. Carcinogenesis 21:871–879
  • Kolch, W., Heidecker, G., Kochs, G., Hummel, R., Vahidi, H., Mischack, H., Finkenzeller, G., Marme, D., and Rapp, U. R.. 1993. Protein kinase C alpha activates Raf-1 by direct phosphorylation. Nature 364:249–252
  • Kotani, K., Yonezawa K., Hara K., Hueda H., Kitamura Y., Sakaue H., Ando A., Chavanieu A., Calas B., and Grigorescu F.. Involvement of phosphoinositide 3-kinase in insulin- or IGF-1-induced membrane ruffling. EMBO J. 13:2313–2321.
  • Krams, S. M., Egawa, H., Quinn, M. B., Villanueva, J. C., Garcia-Kennedy, R., and Martinez, O. M.. 1995. Apoptosis as a mechanism of cell death in liver allograft rejection. Transplantation 59:621–625
  • Li, Q., Van Antwerp, D., Mercurio, F., Lee, K. F., and Verma, I. M.. 1999. Severe liver degeneration in mice lacking the IkappaB kinase 2 gene. Science 284:321–325
  • Lucito, R., and Schneider, R. J.. 1992. Hepatitis B virus X protein activates transcription factor NF-κB without a requirement for protein kinase C. J. Virol. 66:983–991
  • Malinin, N. L., Boldin, M. P., Kovalenko, A. V., and Wallach, D.. 1997. MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1. Nature 385:540–544
  • Maronpot, R. R., Fox, T., Malarkey, D. E., and Goldsworthy, T. L.. 1995. Mutations in the ras proto-oncogenes: clues to etiology and molecular pathogenesis of mouse liver tumors. Toxicology 101:125–156
  • Massague, J.. 1996. TGF-β signaling: receptors, transducers, and Mad proteins. Cell 85:947–950
  • Massague, J.. 1990. The transforming growth factor-β family. Annu. Rev. Cell. Biol. 6:597–641
  • May, M. J., and Ghosh, S.. 1999. IkappaB kinases: kinsmen with different crafts. Science 284:271–273
  • Mayo, M. W., Wang, C.-Y., Cogswell, P. C., Rogers-Graham, K. S., Lowe, S. W., Der, C. J., Baldwin, A. S.Jr.. 1997. Requirement of NF-κB activation to suppress p53-independent apoptosis induced by oncogenic Ras. Science 278:1812–1815
  • McMahon, J. B., Richards, W. L., del Campo, A. A., Song, M.-K. H., and Thorgeirsson, S. S.. 1986. Differential effects of transforming growth factor-β on proliferation of normal and malignant rat liver epithelial cells in culture. Cancer Res. 46:4665–4671
  • Mercurio, F., Murray, B. W., Shevchenko, A., Bennett, B. L., Young, D. B., Li, J. W., Pascual, G., Motiwala, A., Zhu, H., Mann, M., and Manning, A. M.. 1999. IκB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex. Mol. Cell. Biol. 19:1526–1538
  • Mercurio, F., Zhu, H., Murray, B. W., Shevchenko, A., Bennett, B. L., Li, J. W., Young, D. B., Barbosa, M., Mann, M., Manning, A., and Rao, A.. 1997. IKK-1 and IKK-2: cytokine-activated IκB kinases essential for NF-κB activation. Science 278:860–865
  • Mori, N., Fujii, M., Ikeda, S., Yamada, Y., Tomonaga, M., Ballard, D. W., and Yamamoto, N.. 1999. Constitutive activation of NF-kappaB in primary adult T-cell leukemia cells. Blood 93:2360–2368
  • Oberhammer, F. A., Bursch, W., Parzefall, W., Breit, P., Erber, E., Stadler, M., and Schulte-Hermann, R.. 1991. Effect of transforming growth factor β on cell death of cultured rat hepatocytes. Cancer Res. 51:2478–2485
  • Oberhammer, F. A., Pavelka, M., Sharma, S., Tiefenbacher, R., Purchio, A. F., Bursch, W., and Schulte-Hermann, R.. 1992. Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor β1. Proc. Natl. Acad. Sci. USA 89:5408–5412
  • O'Farrell, P. H.. 1975. High resolution two-dimensional electrophoresis of proteins. J. Biol. Chem. 10:4007–4021
  • Oft, M., Peli, J., Rudaz, C., Schwarz, H., Beug, H., and Reichmann, E.. 1996. TGF-β1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells. Genes Dev. 10:2462–2477
  • Ozes, O. N., Mayo, L. D., Gustin, J. A., Pfeffer, S. R., Pfeffer, L. M., and Donner, D. B.. 1999. NF-κB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 401:82–85
  • Pierce, D. F.Jr., Gorska, A. E., Chytil, A., Meise, K. S., Page, D. L., Coffrey, R. J.Jr., and Moses, H. L.. 1995. Mammary tumor suppression by transforming growth factor β transgene expression. Proc. Natl. Acad. Sci. USA 92:4254–4258
  • Regnier, C. H., Song, H. Y., Gao, X., Goeddel, D. V., Cao, Z., and Rothe, M.. 1997. Identification and characterization of an IκB kinase. Cell 90:373–383
  • Roberts, A. B., and Sporn, M. B.. 1990. The transforming growth factor-betas Peptide growth factor and their receptors. Sporn, M. B., and Roberts, A. B. 419–472 Springer-Verlag, Heidelberg, Germany
  • Rodriguez-Viciana, P., Warne, P. H., Khwaya, A., Marte, B. M., Pappin, D., Das, P., Waterfield, M. D., Ridley, A., and Downward, J.. 1997. Role of phosphoinositode 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell 89:457–467
  • Romashkova, J. A., and Makarov, S. S.. 1999. NF-κB is a target of Akt in anti-apoptotic PDGF signalling. Nature 410:86–90
  • Rothwarf, D. M., Zandi, E., Natoli, G., and Karin, M.. 1998. IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex. Nature 395:297–300
  • Sanderson, N., Factor, V., Nagy, P., Kopp, J., Kondaiah, P., Wakefield, L., Roberts, A. B., Sporn, M. B., and Thorgeirsson, S. S.. 1995. Hepatic expression of mature transforming growth factor β1 in transgenic mice results in multiple tissue lesions. Proc. Natl. Acad. Sci. USA 92:2572–2576
  • Schulte-Hermann, R., Grasl-Kraupp, B., and Bursch, W.. 1995. Apoptosis and hepatocarcinogenesis Liver regeneration and carcinogenesis: molecular and cellular mechanisms. Jirtle, R. L. 141–177 Academic Press, San Diego, Calif
  • Shattuck, R. L., Wood, L. D., Jaffe, G. J., and Richmond, A.. 1994. MGSA/GRO transcription is differentially regulated in normal retinal pigment epithelial and melanoma cells. Mol. Cell. Biol. 14:791–802
  • Sovak, M. A., Bellas, R. E., Kim, D. W., Zanieski, G. J., Rogers, A. E., Traish, A. M., and Sonenshein, G. E.. 1997. Aberrant NF-κB/Rel expression in breast cancer: a role in protection from apoptosis. J. Clin. Investig. 100:2952–2960
  • Sumitomo, M., Tachibana, M., Ozu, C., Asakura, H., Murai, M., Hayakawa, M., Nakamura, H., Takayanagi, A., and Shimizu, N.. 1999. Induction of apoptosis of cytokine-producing bladder cancer cells by adenovirus-mediated IkappaBalpha overexpression. Hum. Gene Ther. 10:37–47
  • Sumitomo, M., Tachibana, M., Nakashima, J., Murai, M., Miyajima, A., Kimura, M., Hayakawa, M., and Nakamura, H.. 1999. An essential role for nuclear factor kappa B in preventing TNF-alpha-induced cell death in prostate cancer cells. J. Urol. 161:674–679
  • Takeda, K., Takeuchi, O., Tsujimura, T., Itami, S., Adachi, O., Kawai, T., Sanjo, H., Yoshikawa, K., Terada, N., and Akira, S.. 1999. Limb and skin abnormalities in mice lacking IKKalpha. Science 284:313–316
  • Teramoto, T., Kiss, A., and Thorgeirsson, S. S.. 1998. Induction of p53 and Bax during TGF-beta 1 initiated apoptosis in rat liver epithelial cells. Biochem. Biophys. Res. Commun. 251:56–60
  • Thorgeirsson, S. S.. 1995. Target cell populations in virus-associated hepatocarcinogenesis. Princess Takamatsu Symp. 25:163–170
  • Tsao, M. S., Smith, J. D., Nelson, K. G., and Grisham, J. W.. 1984. A diploid epithelial cell line from normal adult rat liver with phenotypic properties of “oval” cells. Exp. Cell Res. 154:38–52
  • Urban, M. B., Schreck, R., and Baeuerle, P.. 1991. NF-κB contacts DNA by a heterodimer of the p50 and p65 subunit. EMBO J. 10:1817–1826
  • Van Antwerp, D. J., Seamus, J. M., Kafri, T., Green, D., and Verma, I. M.. 1996. Suppression of TNF-α-induced apoptosis by NF-κB. Science 274:787–789
  • Verma, I. M., Stevenson, J. K., Schwarz, E. M., Van Antwerp, D., and Miyamoto, S.. 1995. Rel/NF-κB/IκB family: intimate tales of association and dissociation. Genes Dev. 9:2723–2735
  • Wang, C.-Y., Mayo, M. W., Baldwin, A. S.Jr.. 1996. TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB. Science 274:784–787
  • Wang, W., Abbruzzese, J. L., Evans, D. B., Larry, L., Cleary, K. R., and Chiao, P. J.. 1999. The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Clin. Cancer Res. 5:119–127
  • Woronicz, J. D., Gao, X., Cao, Z., Rothe, M., and Goeddel, D. V.. 1997. IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK. Science 278:866–869
  • Wu, M., Lee, H., Bellas, R. E., Schauer, S. L., Arsura, M., Katz, D., FitzGerald, M. J., Rothstein, T. L., Sherr, D. H., and Sonenshein, G. E.. 1996. Inhibition of NF-κB/Rel induces apoptosis of murine B cells. EMBO J. 15:4682–4690

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.