31
Views
69
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Identification of B-KSR1, a Novel Brain-Specific Isoform of KSR1 That Functions in Neuronal Signaling

, , , &
Pages 5529-5539 | Received 07 Feb 2000, Accepted 12 Apr 2000, Published online: 28 Mar 2023

REFERENCES

  • Barnier, J. V., Papin, C., Eychene, A., Lecoq, O., and Calothy, G.. 1995. The mouse B-raf gene encodes multiple protein isoforms with tissue specific expression. J. Biol. Chem. 270:23381–23389
  • Bell, B., Xing, H., Yan, H., Gautam, N., and Muslin, A. J.. 1999. KSR1 binds to G-protein βγ subunits and inhibits βγ-induced mitogen-activated protein kinase activation. J. Biol. Chem. 274:7982–7986
  • Cacace, A. M., Michaud, N. R., Therrien, M., Mathes, K., Copeland, T., Rubin, G. M., and Morrison, D. K.. 1999. Identification of constitutive and Ras-inducible phosphorylation sites of KSR: implication for 14-3-3 bindings, mitogen-activated protein kinase binding, and KSR overexpression. Mol. Cell. Biol. 19:229–240
  • Choi, K. Y., Satterberg, B., Lyons, D. M., and Elion, E. A.. 1994. Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae. Cell 78:499–512
  • Cowley, S., Paterson, H., Kemp, P., and Marshall, C. J.. 1994. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 77:841–852
  • Denouel-Galy, A., Douville, E. M., Warne, P. H., Papin, C., Laugier, D., Calothy, G., Downward, J., and Eychene, A.. 1997. Murine Ksr interacts with MEK and inhibits Ras-induced transformation. Curr. Biol. 8:46–55
  • Downward, J.. 1998. Ras signalling and apoptosis. Curr. Opin. Genet. Dev. 8:49–54
  • Greene, L. A., Sobeih, M. M., and Teng, K. K.. 1991. Methodologies for the culture and experimental use of the PC12 rat pheochromocytoma cell line. MIT Press, Cambridge, Mass
  • Hanks, S., and Hunter, T.. 1995. Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J. 9:576–596
  • Hannink, M., and Donoghue, D.. 1985. Lysine residue 121 in the proposed ATP-binding site of the v-mos protein is required for transformation. Proc. Natl. Acad. Sci. USA 82:7894–7898
  • He, T.-C., Zhou, S., da Costa, L. T., Yu, J., Kinzler, K. W., and Vogelstein, B.. 1998. A simplified system for generating recombinant adenoviruses. Proc. Natl. Acad. Sci. USA 95:2509–2514
  • Jacobs, D., Glossip, D., Xing, H., Muslin, A. J., and Kornfeld, K.. 1999. Multiple docking sites on substrate proteins forms a modular system that mediates the recognition by ERK MAP kinase. Genes Dev. 13:163–175
  • Joneson, T., and Bar-Sargi, D.. 1997. Ras effectors and their role in mitogenesis and oncogenesis. J. Mol. Med. 75:587–583
  • Joneson, T., Fulton, J. A., Volle, D. J., Chaika, O. V., Bar-Sagi, D., and Lewis, R. E.. 1998. Kinase suppressor of Ras inhibits the activation of extracellular ligand-regulated (ERK) mitogen-activated protein (MAP) kinase by growth factors, activated Ras, and Ras effectors. J. Biol. Chem. 273:7743–7748
  • Kamps, M., and Sefton, B.. 1986. Neither arginine nor histidine can carry out the function of lysine-295 in the ATP-binding site of p60src. Mol. Cell. Biol. 6:751–757
  • Kornfeld, K., Hom, D. B., and Horvitz, H. R.. 1995. The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans. Cell 83:903–913
  • Levy, J. B., Dorai, T., Wang, L. H., and Brugge, J. S.. 1987. The structurally distinct form of pp60csrc detected in neuronal cells is encoded by a unique c-src mRNA. Mol. Cell. Biol. 7:4142–4245
  • Marshall, C. J.. 1996. Ras effectors. Curr. Opin. Cell Biol. 2:197–204
  • McCormick, F.. 1994. Activators and effectors of ras p21 proteins. Curr. Opin. Genet. Dev. 4:71–76
  • Michaud, N. R., Therrien, M., Cacace, A., Edsall, L. C., Spiegel, S., Rubin, G. M., and Morrison, D. K.. 1997. KSR stimulates Raf-1 activity in a kinase-independent manner. Proc. Natl. Acad. Sci. USA 94:12792–12796
  • Posas, F., and Saito, H.. 1997. Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: scaffold role of Pbs2p MAPKK. Science 276:1702–1705
  • Sambrook, J., Fritsch, E. F., and Maniatis, T.. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y
  • Stewart, S., Sundaram, M., Zhang, Y., Lee, J., Han, M., and Guan, K.-L.. 1989. 1999. Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization. Mol. Cell. Biol. 19:5523–5534
  • Sugimoto, T., Stewart, S., Han, M., and Guan, K.-L.. 1997. The kinase suppressor of Ras (KSR) modulates growth factor and Ras signaling by uncoupling elk-1 phosphorylation from MAP kinase activation. EMBO J. 17:1717–1727
  • Sundaram, M., and Han, M.. 1995. The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction. Cell 83:889–901
  • Therrien, M., Chang, H. C., Solomon, N. M., Karim, F. D., Wassarman, D. A., and Rubin, G. M.. 1995. KSR, a novel protein kinase required for RAS signal transduction. Cell 83:879–888
  • Therrien, M., Michaud, N. R., Rubin, G. M., and Morrison, D. K.. 1996. KSR modulates signal propagation within the MAPK cascade. Genes Dev. 10:2684–2695
  • Traverse, S., Seedorf, K., Paterson, H., Marshall, C. J., Cohen, P., and Ullrich, A.. 1994. EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor. Curr. Biol. 4:694–701
  • Wassarman, D., Therrien, M., and Rubin, G. M.. 1995. The Ras signaling pathway in Drosophila. Curr. Opin. Gen. Dev. 5:44–50
  • Wittinghofer, A.. 1998. Signal transduction via Ras. Biol. Chem. 379:933–937
  • Xing, H., Kornfeld, K., and Muslin, A. J.. 1997. The protein kinase KSR interacts with 14-3-3 protein and Raf. Curr. Biol. 7:294–300
  • York, R. D., Yao, H., Dillon, T., Ellig, C. L., Eckert, S. P., McCleskey, E. W., and Stork, P. J. S.. 1998. Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature 392:622–626
  • Yu, W., Fantl, W. J., Harrowe, G., and Williams, L. T.. 1997. Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK. Curr. Biol. 8:56–64
  • Zhang, Y., Yao, B., Delikat, S., Bayoumy, S., Lin, X.-H., Basu, S., McGinley, M., Chan-Hui, P.-Y., Lichenstein, H., and Kolesnick, R.. 1997. Kinase suppressor of Ras is ceramide-activated protein kinase. Cell 89:63–72

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.