Establishment of Irreversible Growth Arrest in Myogenic Differentiation Requires the RB LXCXE-Binding Function

REFERENCES

• Bader, D., Masaki, T., and Fischman, D. A.. 1982. Immunochemical analysis of myosin heavy chain during avian myogenesis in vivo and in vitro. J. Cell Biol. 95:763–770
   PubMed Web of Science ®Google Scholar
• Brehm, A., and Kouzarides, T.. 1999. Retinoblastoma protein meets chromatin. Trends Biochem. Sci. 24:142–145
   PubMedGoogle Scholar
• Brehm, A., Miska, E. A., McCance, D. J., Reid, J. L., Bannister, A. J., and Kouzarides, T.. 1998. Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature 391:597–601
   PubMed Web of Science ®Google Scholar
• Brugarolas, J., Moberg, K., Boyd, S. D., Taya, Y., Jacks, T., and Lees, J. A.. 1999. Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation. Proc. Natl. Acad. Sci. USA 96:1002–1007
   PubMed Web of Science ®Google Scholar
• DeCaprio, J. A., Ludlow, J. W., Figge, J., Shew, J. Y., Huang, C. M., Lee, W. H., Marsilio, E., Paucha, E., and Livingston, D. M.. 1988. SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell 54:275–283
   PubMed Web of Science ®Google Scholar
• DeGregori, J., Kowalik, T., and Nevins, J. R.. 1995. Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes. Mol. Cell. Biol. 15:4215–4224 (Erratum, 15:5846–5847.)
   PubMed Web of Science ®Google Scholar
• Du, W., Vidal, M., Xie, J. E., and Dyson, N.. 1996. RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Genes Dev. 10:1206–1218
   PubMed Web of Science ®Google Scholar
• Dynlacht, B. D., Flores, O., Lees, J. A., and Harlow, E.. 1994. Differential regulation of E2F transactivation by cyclin/cdk2 complexes. Genes Dev. 8:1772–1786
   PubMed Web of Science ®Google Scholar
• Dyson, N.. 1998. The regulation of E2F by pRB-family proteins. Genes Dev. 12:2245–2262
   PubMed Web of Science ®Google Scholar
• Dyson, N., Howley, P. M., Munger, K., and Harlow, E.. 1989. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 243:934–937
   PubMed Web of Science ®Google Scholar
• Fattaey, A. R., Harlow, E., and Helin, K.. 1993. Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes. Mol. Cell. Biol. 13:7267–7277
   PubMed Web of Science ®Google Scholar
• Ferreira, R., Magnaghi-Jaulin, L., Robin, P., Harel-Bellan, A., and Trouche, D.. 1998. The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase. Proc. Natl. Acad. Sci. USA 95:10493–10498
   PubMed Web of Science ®Google Scholar
• Guan, K. L., Jenkins, C. W., Li, Y., Nichols, M. A., Wu, X., O'Keefe, C. L., Matera, A. G., and Xiong, Y.. 1994. Growth suppression by p18, a p16INK4/MTS1-and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev. 8:2939–2952
   PubMed Web of Science ®Google Scholar
• Guo, K., Wang, J., Andres, V., Smith, R. C., and Walsh, K.. 1995. MyoD-induced expression of p21 inhibits cyclin-dependent kinase activity upon myocyte terminal differentiation. Mol. Cell. Biol. 15:3823–3829
   PubMed Web of Science ®Google Scholar
• Halevy, O., Novitch, B. G., Spicer, D. B., Skapek, S. X., Rhee, J., Hannon, G. J., Beach, D., and Lassar, A. B.. 1995. Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science 267:1018–1021
   PubMed Web of Science ®Google Scholar
• Harrington, E. A., Bruce, J. L., Harlow, E., and Dyson, N.. 1998. pRB plays an essential role in cell cycle arrest induced by DNA damage. Proc. Natl. Acad. Sci. USA 95:11945–11950
   PubMed Web of Science ®Google Scholar
• Helin, K., Lees, J. A., Vidal, M., Dyson, N., Harlow, E., and Fattaey, A.. 1992. A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F. Cell 70:337–350
   PubMed Web of Science ®Google Scholar
• Hiebert, S. W., Chellappan, S. P., Horowitz, J. M., and Nevins, J. R.. 1992. The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F. Genes Dev. 6:177–185
   PubMed Web of Science ®Google Scholar
• Hofmann, F., Martelli, F., Livingston, D. M., and Wang, Z.. 1996. The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway. Genes Dev. 10:2949–2959
   PubMed Web of Science ®Google Scholar
• Hu, Q. J., Dyson, N., and Harlow, E.. 1990. The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations. EMBO J. 9:1147–1155
   PubMed Web of Science ®Google Scholar
• Huang, S., Wang, N. P., Tseng, B. Y., Lee, W. H., and Lee, E. H.. 1990. Two distinct and frequently mutated regions of retinoblastoma protein are required for binding to SV40 T antigen. EMBO J. 9:1815–1822
   PubMed Web of Science ®Google Scholar
• Ikeda, M. A., and Nevins, J. R.. 1993. Identification of distinct roles for separate E1A domains in disruption of E2F complexes. Mol. Cell. Biol. 13:7029–7035
   PubMedGoogle Scholar
• Kaelin, W. G.Jr., Ewen, M. E., and Livingston, D. M.. 1990. Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product. Mol. Cell. Biol. 10:3761–3769
   PubMed Web of Science ®Google Scholar
• Kanda, T., Sullivan, K. F., and Wahl, G. M.. 1998. Histone-GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells. Curr. Biol. 8:377–385
   PubMed Web of Science ®Google Scholar
• Knudsen, E. S., Buckmaster, C., Chen, T. T., Feramisco, J. R., and Wang, J. Y.. 1998. Inhibition of DNA synthesis by RB: effects on G1/S transition and S-phase progression. Genes Dev. 12:2278–2292
   PubMed Web of Science ®Google Scholar
• Knudsen, E. S., and Wang, J. Y.. 1996. Differential regulation of retinoblastoma protein function by specific Cdk phosphorylation sites. J. Biol. Chem. 271:8313–8320
   PubMed Web of Science ®Google Scholar
• Knudsen, E. S., and Wang, J. Y.. 1997. Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation. Mol. Cell. Biol. 17:5771–5783
   PubMed Web of Science ®Google Scholar
• Koh, J., Enders, G. H., Dynlacht, B. D., and Harlow, E.. 1995. Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition. Nature 375:506–510
   PubMed Web of Science ®Google Scholar
• Lee, J. O., Russo, A. A., and Pavletich, N. P.. 1998. Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7. Nature 391:859–865
   PubMed Web of Science ®Google Scholar
• Leone, G., DeGregori, J., Yan, Z., Jakoi, L., Ishida, S., Williams, R. S., and Nevins, J. R.. 1998. E2F3 activity is regulated during the cell cycle and is required for the induction of S phase. Genes Dev. 12:2120–2130
   PubMed Web of Science ®Google Scholar
• Lu, X., and Horvitz, H. R.. 1998. lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48. Cell 95:981–991
   PubMedGoogle Scholar
• Lukas, J., Parry, D., Aagaard, L., Mann, D. J., Bartkova, J., Strauss, M., Peters, G., and Bartek, J.. 1995. Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16. Nature 375:503–506
   PubMed Web of Science ®Google Scholar
• Lukas, J., Petersen, B. O., Holm, K., Bartek, J., and Helin, K.. 1996. Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression. Mol. Cell. Biol. 16:1047–1057
   PubMed Web of Science ®Google Scholar
• Luo, R. X., Postigo, A. A., and Dean, D. C.. 1998. Rb interacts with histone deacetylase to repress transcription. Cell 92:463–473
   PubMed Web of Science ®Google Scholar
• Magnaghi-Jaulin, L., Groisman, R., Naguibneva, I., Robin, P., Lorain, S., Le Villain, J. P., Troalen, F., Trouche, D., and Harel-Bellan, A.. 1998. Retinoblastoma protein represses transcription by recruiting a histone deacetylase. Nature 391:601–605
   PubMed Web of Science ®Google Scholar
• Meloni, A. R., Smith, E. J., and Nevins, J. R.. 1999. A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor. Proc. Natl. Acad. Sci. USA 96:9574–9579
   PubMedGoogle Scholar
• Novitch, B. G., Mulligan, G. J., Jacks, T., and Lassar, A. B.. 1996. Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle. J. Cell Biol. 135:441–456
   PubMed Web of Science ®Google Scholar
• Parker, S. B., Eichele, G., Zhang, P., Rawls, A., Sands, A. T., Bradley, A., Olson, E. N., Harper, J. W., and Elledge, S. J.. 1995. p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells. Science 267:1024–1027
   PubMed Web of Science ®Google Scholar
• Patrick, D. R., Oliff, A., and Heimbrook, D. C.. 1994. Identification of a novel retinoblastoma gene product binding site on human papillomavirus type 16 E7 protein. J. Biol. Chem. 269:6842–6850
   PubMedGoogle Scholar
• Puri, P. L., Sartorelli, V., Yang, X. J., Hamamori, Y., Ogryzko, V. V., Howard, B. H., Kedes, L., Wang, J. Y., Graessmann, A., Nakatani, Y., and Levrero, M.. 1997. Differential roles of p300 and PCAF acetyltransferases in muscle differentiation. Mol. Cell 1:35–45
   PubMed Web of Science ®Google Scholar
• Ross, J. F., Liu, X., and Dynlacht, B. D.. 1999. Mechanism of transcriptional repression of E2F by the retinoblastoma tumor suppressor protein. Mol. Cell 3:195–205
   PubMedGoogle Scholar
• Schneider, J. W., Gu, W., Zhu, L., Mahdavi, V., and Nadal-Ginard, B.. 1994. Reversal of terminal differentiation mediated by p107 in Rb−/− muscle cells. Science 264:1467–1471
   PubMed Web of Science ®Google Scholar
• Sellers, W. R., Novitch, B. G., Miyake, S., Heith, A., Otterson, G. A., Kaye, F. J., Lassar, A. B., Kaelin, W. G.Jr.. 1998. Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth. Genes Dev. 12:95–106
   PubMed Web of Science ®Google Scholar
• Slansky, J. E., and Farnham, P. J.. 1996. Introduction to the E2F family: protein structure and gene regulation. Curr. Top. Microbiol. Immunol. 208:1–30
   PubMed Web of Science ®Google Scholar
• Tanaka, E. M., Gann, A. A., Gates, P. B., and Brockes, J. P.. 1997. Newt myotubes reenter the cell cycle by phosphorylation of the retinoblastoma protein. J. Cell Biol. 136:155–165
   PubMedGoogle Scholar
• Trouche, D., Le Chalony, C., Muchardt, C., Yaniv, M., and Kouzarides, T.. 1997. RB and hbrm cooperate to repress the activation functions of E2F1. Proc. Natl. Acad. Sci. USA 94:11268–11273
   PubMed Web of Science ®Google Scholar
• Walsh, K., and Perlman, H.. 1997. Cell cycle exit upon myogenic differentiation. Curr. Opin. Genet. Dev. 7:597–602
   PubMed Web of Science ®Google Scholar
• Wang, J., Guo, K., Wills, K. N., and Walsh, K.. 1997. Rb functions to inhibit apoptosis during myocyte differentiation. Cancer Res. 57:351–354
   PubMed Web of Science ®Google Scholar
• Wang, J. Y., Knudsen, E. S., and Welch, P. J.. 1994. The retinoblastoma tumor suppressor protein. Adv. Cancer Res. 64:25–85
   PubMed Web of Science ®Google Scholar
• Welch, P. J., and Wang, J. Y.. 1993. A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle. Cell 75:779–790
   PubMed Web of Science ®Google Scholar
• Welch, P. J., and Wang, J. Y.. 1995. Disruption of retinoblastoma protein function by coexpression of its C pocket fragment. Genes Dev. 9:31–46
   PubMedGoogle Scholar
• Whitaker, L. L., Su, H., Baskaran, R., Knudsen, E. S., and Wang, J. Y.. 1998. Growth suppression by an E2F-binding-defective retinoblastoma protein (RB): contribution from the RB C pocket. Mol. Cell. Biol. 18:4032–4042
   PubMed Web of Science ®Google Scholar
• Whyte, P., Buchkovich, K. J., Horowitz, J. M., Friend, S. H., Raybuck, M., Weinberg, R. A., and Harlow, E.. 1988. Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product. Nature 334:124–129
   PubMed Web of Science ®Google Scholar
• Xie, Q., Sanz-Burgos, A. P., Hannon, G. J., and Gutierrez, C.. 1996. Plant cells contain a novel member of the retinoblastoma family of growth regulatory proteins. EMBO J. 15:4900–4908
   PubMedGoogle Scholar
• Zacksenhaus, E., Jiang, Z., Chung, D., Marth, J. D., Phillips, R. A., and Gallie, B. L.. 1996. pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis. Genes Dev. 10:3051–3064
   PubMed Web of Science ®Google Scholar
• Zhang, H. S., Postigo, A. A., and Dean, D. C.. 1999. Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p16INK4a, TGFbeta, and contact inhibition. Cell 97:53–61
   PubMed Web of Science ®Google Scholar