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Gene Expression

Identification of a Methylation Imprint Mark within the Mouse Gnas Locus

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Pages 5808-5817 | Received 10 Mar 2000, Accepted 22 May 2000, Published online: 28 Mar 2023

REFERENCES

  • Barlow, D. P.. 1993. Methylation and imprinting: from host defense to gene regulation? Science 260:309–310
  • Barlow, D. P.. 1998. Competition—a common motif for the imprinting mechanism? EMBO J. 16:6899–6905
  • Bartolomei, M. S., and Tilghman, S. M.. 1997. Genomic imprinting in mammals. Annu. Rev. Genet. 31:493–525
  • Bird, A. P.. 1986. CpG-rich islands and the function of DNA methylation. Nature 321:209–213
  • Birger, Y., Shemer, R., Perk, J., and Razin, A.. 1999. The imprinting box of the mouse Igf2r gene. Nature 397:84–88
  • Brandeis, M., Frank, D., Keshet, I., Siegfried, Z., Mendelsohn, M., Nemes, A., Temper, V., Razin, A., and Cedar, H.. 1994. Sp1 elements protect a CpG island from de novo methylation. Nature 371:435–438
  • Brinster, H. L., Chen, N. Y., Trumbauer, M. E., Yagle, M. K., and Palmiter, R. D.. 1985. Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs. Proc. Natl. Acad. Sci. USA 82:4438–4442
  • Buiting, K., Saitoh, S., Gross, S., Dittrich, B., Schwartz, S., Nicholls, R. D., and Horsthemke, B.. 1995. Inherited microdeletions in the Angelman and Prader-Willi syndromes define an imprinting centre on human chromosome 15. Nat. Genet. 9:395–400
  • Campbell, R., Gosden, C. M., and Bonthron, D. T.. 1994. Parental origin of transcription from the human GNAS1 gene. J. Med. Genet. 31:607–614
  • Clark, S. J., Harrison, J., Paul, C. L., and Frommer, M.. 1994. High sensitivity mapping of methylated cytosines. Nucleic Acids Res. 22:2990–2997
  • Clemson, C. M., McNeil, J. A., Willard, H. F., and Lawrence, J. B.. 1996. Xist RNA paints the inactive X chromosome at interphase: evidence for a novel RNA involved in nuclear/chromosome structure. J. Cell Biol. 132:259–275
  • Constancia, M., Pickard, B., Kelsey, G., and Reik, W.. 1998. Imprinting mechanisms. Genome Res. 8:881–900
  • Davies, S. J., and Hughes, H. E.. 1993. Imprinting in Albright's hereditary osteodystrophy. J. Med. Genet. 30:101–103
  • Dittrich, B., Buiting, K., Korn, B., Rickard, S., Buxton, J., Saitoh, S., Nicholls, R. D., Poustka, A., Winterpacht, A., Zabel, B., and Horsthemke, B.. 1996. Imprint switching on human chromosome 15 may involve alternative transcripts of the SNRPN gene. Nat. Genet. 14:163–170
  • Gardiner-Garden, M., and Frommer, M.. 1987. CpG islands in vertebrate genomes. J. Mol. Biol. 196:261–282
  • Hayward, B. E., and Bonthron, D. T.. 2000. An imprinted antisense transcript at the human GNAS1 locus. Hum. Mol. Genet. 9:835–841
  • Hayward, B. E., Kamiya, M., Strain, L., Moran, V., Campbell, R., Hayashizaki, Y., and Bonthron, D. T.. 1998. The human GNAS1 gene is imprinted and encodes distinct paternally and biallelically expressed G proteins. Proc. Natl. Acad. Sci. USA 95:10038–10043
  • Hayward, B. E., Moran, V., Strain, L., and Bonthron, D. T.. 1998. Bidirectional imprinting of a single gene: GNAS1 encodes maternally, paternally, and biallelically derived proteins. Proc. Natl. Acad. Sci. USA 95:15475–15480
  • Howell, C. Y., Steptoe, A. L., Miller, M. W., and Chaillet, J. R.. 1998. cis-acting signal for inheritance of imprinted DNA methylation patterns in the preimplantation mouse embryo. Mol. Cell. Biol. 18:4147–4156
  • Hu, J. F., Oruganti, H., Yu, T. H., and Hoffman, A. R.. 1998. Tissue-specific imprinting of the mouse insulin-like growth factor II receptor gene correlates with differential allele-specific DNA methylation. Mol. Endocrinol. 12:220–232
  • Ischia, R., Lovisetti-Scamihorn, P., Hogue-Angeletti, R., Wolkersdorfer, M., Winkler, H., and Fischer-Colbrie, R.. 1997. Molecular cloning and characterization of NESP55, a novel chromogranin-like precursor of a peptide with 5-HT1B receptor antagonist activity. J. Biol. Chem. 272:11657–11662
  • Ishikawa, Y., Bianchi, C., Nadal-Ginard, B., and Homcy, C. J.. 1990. Alternative promoter and 5′ exon generate a novel GSα mRNA. J. Biol. Chem. 265:8458–8462
  • Jones, P. A., and Laird, P. W.. 1999. Cancer epigenetics come of age. Nat. Genet. 21:163–167
  • Juppner, H., Schipani, E., Bastepe, M., Cole, D. E., Lawson, M. L., Mannstadt, M., Hendy, G. N., Plotkin, H., Koshiyama, H., Koh, T., Crawford, J. D., Olsen, B. R., and Vikkula, M.. 1998. The gene responsible for pseudohypoparathyroidism type Ib is paternally imprinted and maps in four unrelated kindreds to chromosome 20q13.3. Proc. Natl. Acad. Sci. USA 95:11798–11803
  • Kehlenbach, R. H., Matthey, J., and Huttner, W. B.. 1994. XLαs is a new type of G protein. Nature 372:804–809
  • Kelsey, G., Bodle, D., Miller, H. J., Beechey, C. V., Coombes, C., Peters, J., and Williamson, C. M.. 1999. Identification of imprinted loci by methylation-sensitive representational difference analysis: application to mouse distal chromosome 2. Genomics 62:129–138
  • Kozasa, T., Itoh, H., Tsukamoto, T., and Kaziro, Y.. 1988. Isolation and characterization of the human Gs alpha gene. Proc. Natl. Acad. Sci. USA 85:2081–2085
  • Li, E., Beard, C., and Jaenisch, R.. 1993. Role of DNA methylation in genomic imprinting. Nature 366:362–365
  • Li, E., Bestor, T. H., and Jaenisch, R.. 1992. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69:915–926
  • Macleod, D., Charlton, J., Mullins, J., and Bird, A. P.. 1994. Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island. Genes Dev. 8:2282–2292
  • Moore, T., Constancia, M., Zubair, M., Bailleul, B., Feil, R., Sasaki, H., and Reik, W.. 1997. Multiple imprinted sense and antisense transcripts, differential methylation and tandem repeats in a putative imprinting control region upstream of mouse Igf2. Proc. Natl. Acad. Sci. USA 94:12509–12514
  • Neumann, B., Kubicka, P., and Barlow, D. P.. 1995. Characteristics of imprinted genes. Nat. Genet. 9:12–13
  • Olek, A., and Walter, J.. 1997. The pre-implantation ontogeny of the H19 methylation imprint. Nat. Genet. 17:275–276
  • Peters, J., Wroe, S. F., Wells, C. A., Miller, H. J., Bodle, D., Beechey, C. V., Williamson, C. M., and Kelsey, G.. 1999. A cluster of oppositely imprinted transcripts at the Gnas locus in the distal imprinting region of mouse chromosome 2. Proc. Natl. Acad. Sci. USA 96:3830–3835
  • Schmidt, J. V., Levorse, J. M., and Tilghman, S. M.. 1999. Enhancer competition between H19 and Igf2 does not mediate their imprinting. Proc. Natl. Acad. Sci. USA 96:9733–9738
  • Swaroop, A., Agarwal, N., Gruen, J. R., Bick, D., and Weissman, S. M.. 1991. Differential expression of novel Gsα signal transduction protein cDNA species. Nucleic Acids Res. 19:4725–4729
  • Thorvaldsen, J. L., Duran, K. L., and Bartolomei, M. S.. 1998. Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2. Genes Dev. 12:3693–3702
  • Tilghman, S. M.. 1999. The sins of the fathers and mothers: genomic imprinting in mammalian development. Cell 96:185–193
  • Tokunaga, K., Taniguchi, H., Yoda, K., Shimizu, M., and Sakiyama, S.. 1986. Nucleotide sequence of a full-length cDNA for mouse cytoskeletal β-actin mRNA. Nucleic Acids Res. 14: 2829
  • Tremblay, K. D., Duran, K. L., and Bartolomei, M. S.. 1997. A 5′ 2-kilobase-pair region of the imprinted H19 gene exhibits exclusive paternal methylation throughout development. Mol. Cell. Biol. 17:4322–4329
  • Warner, D. R., Gejman, P. V., Collins, R. M., and Weinstein, L. S.. 1997. A novel mutation adjacent to the switch III domain of GSα in a patient with pseudohypoparathyroidism. Mol. Endocrinol. 11:1718–1727
  • Weinstein, L. S.. 1998. Albright hereditary osteodystrophy, pseudohypoparathyroidism and GS deficiency G proteins, receptors, and disease. Spiegel, A. M. 23–56 Humana Press, Totowa, N.J
  • Weinstein, L. S., Yu, S., and Ecelbarger, C. A.. 2000. Variable imprinting of the heterotrimeric G protein GS α-subunit within different segments of the nephron. Am. J. Physiol. 278:F507–F514
  • Wroe, S. F., Kelsey, G., Skinner, J. A., Bodle, D., Ball, S. T., Beechey, C. V., Peters, J., and Williamson, C. M.. 2000. An imprinted transcript, antisense to Nesp, adds complexity to the cluster of imprinted genes at the mouse Gnas locus. Proc. Natl. Acad. Sci. USA 97:3342–3346
  • Wutz, A., Smrzka, O. W., Schweifer, N., Schellander, K., Wagner, E. F., and Barlow, D. P.. 1997. Imprinted expression of the Igf2r gene depends on an intronic CpG island. Nature 389:745–749
  • Yang, T., Adamson, T. E., Resnick, J. L., Leff, S., Wevrick, R., Francke, U., Jenkins, N. A., Copeland, N. G., and Brannan, C. I.. 1998. A mouse model for Prader-Willi syndrome imprinting-centre mutations. Nat. Genet. 19:25–31
  • Yu, S., Gavrilova, O., Chen, H., Lee, R., Liu, J., Pacak, K., Parlow, A. F., Quon, M. J., Reitman, M. L., and Weinstein, L. S.. 2000. Paternal versus maternal transmission of a stimulatory G protein α subunit knockout produces opposite effects on energy metabolism. J. Clin. Investig. 105:615–623
  • Yu, S., Yu, D., Lee, E., Eckhaus, M., Lee, R., Corria, Z., Accili, D., Westphal, H., and Weinstein, L. S.. 1998. Variable and tissue-specific hormone resistance in heterotrimeric GS protein α-subunit (GSα) knockout mice is due to tissue-specific imprinting of the GSα gene. Proc. Natl. Acad. Sci. USA 95:8715–8720
  • Zeschnigk, M., Schmitz, B., Dittrich, K., Horsthemke, B., and Doerfler, W.. 1997. Imprinted segments in the human genome: different DNA methylation patterns in the Prader-Willi/Angelman syndrome region as determined by the genomic sequencing method. Hum. Mol. Genet. 6:387–395

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