Transcriptional Scaffold: CIITA Interacts with NF-Y, RFX, and CREB To Cause Stereospecific Regulation of the Class II Major Histocompatibility Complex Promoter

REFERENCES

• Baxevanis, A. D., Arents, G., Moudrianakis, E. N., and Landsman, D.. 1995. A variety of DNA-binding and multimeric proteins contain the histone fold motif. Nucleic Acids Res. 23:2685–2691
   PubMed Web of Science ®Google Scholar
• Benoist, C., and Mathis, D.. 1990. Regulation of major histocompatibility complex class-II genes: X, Y, and other letters of the alphabet. Annu. Rev. Immunol. 8:681–715
   PubMed Web of Science ®Google Scholar
• Brickey, W. J., Wright, K. L., Zhu, X., and Ting, J. P.. 1999. Analysis of the defect in IFN-γ induction of MHC class II genes in G1B cells: identification of a novel and functionally critical leucine-rich motif (62-LYLYLQL-68) in the regulatory factor X5 transcription factor. J. Immunol. 163:6622–6630
   PubMedGoogle Scholar
• Chang, C. H., Fontes, J. D., Peterlin, M., and Flavell, R. A.. 1994. Class II transactivator (CIITA) is sufficient for the inducible expression of major histocompatibility complex class II genes. J. Exp. Med. 180:1367–1374
   PubMedGoogle Scholar
• Chin, K.-C., Mao, C., Skinner, C., Riley, J. L., Wright, K. L., Moreno, C. S., Stark, G. R., Boss, J. M., and Ting, J. P. Y.. 1994. Molecular analysis of G1B and G3A IFN gamma mutants reveals that defects in CIITA or RFX result in defective class II MHC and Ii gene induction. Immunity 1:687–697
   PubMedGoogle Scholar
• Chin, K.-C., Li, G. X., and Ting, J. P. Y.. 1997. Importance of acidic, proline/serine/threonine-rich, and GTP-binding regions in the major histocompatibility complex class II transactivator: generation of transdominant-negative mutants. Proc. Natl. Acad. Sci. USA 94:2501–2506
   PubMedGoogle Scholar
• Chin, K.-C., Li, G. X., and Ting, J. P. Y.. 1997. Activation and transdominant suppression of MHC class II and HLA-DMB promoters by a series of C-terminal CIITA deletion mutants. J. Immunol. 159:2789–2794
   PubMedGoogle Scholar
• Coustry, F., Maity, S. N., Sinha, S., and de Crombrugghe, B.. 1996. The transcriptional activity of the CCAAT-binding factor CBF is mediated by two distinct activation domains, one in the CBF-B subunit and the other in the CBF-C subunit. J. Biol. Chem. 271:14485–14491
   PubMedGoogle Scholar
• Cressman, D. E., Chin, K. C., Taxman, D. J., and Ting, J. P.. 1999. A defect in the nuclear translocation of CIITA causes a form of type II bare lymphocyte syndrome. Immunity 10:163–171
   PubMed Web of Science ®Google Scholar
• Currie, R. A.. 1998. NF-Y is associated with the histone acetyltransferases GCN5 and P/CAF. J. Biol. Chem. 273:1430–1434
   PubMedGoogle Scholar
• Dickens, M., Rogers, J. S., Cavanagh, J., Raitano, A., Xia, Z., Halpern, J. R., Greenberg, M. E., Sawyers, C. L., and Davis, R. J.. 1997. A cytoplasmic inhibitor of the JNK signal transduction pathway. Science 277:693–696
   PubMed Web of Science ®Google Scholar
• Durand, B., Sperisen, P., Emery, P., Barras, E., Zufferey, M., Mach, B., and Reith, W.. 1997. RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency. EMBO J. 16:1045–1055
   PubMedGoogle Scholar
• Faniello, M. C., Bevilacqua, M. A., Condorelli, G., de Crombrugghe, B., Maity, S. N., Avvedimento, V. E., Cimino, F., and Costanzo, F.. 1999. The B subunit of the CAAT-binding factor NFY binds the central segment of the co-activator p300. J. Biol. Chem. 274:7623–7626
   PubMed Web of Science ®Google Scholar
• Fontes, J. D., Kanazawa, S., Jean, D., and Peterlin, B. M.. 1999. Interactions between the class II transactivator and CREB binding protein increase transcription of major histocompatibility complex class II genes. Mol. Cell. Biol. 19:941–947
   PubMedGoogle Scholar
• Gaur, L. K., Heise, E. R., and Ting, J. P.. 1992. Conservation of the promoter region of DRA-like genes from nonhuman primates. Immunogenetics 35:136–139
   PubMedGoogle Scholar
• Gustin, M. C., Albertyn, J., Alexander, M., and Davenport, K.. 1998. MAP kinase pathways in the yeast Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 62:1264–1300
   PubMed Web of Science ®Google Scholar
• Harton, J. A., Cressman, D. E., Chin, K. C., Der, C. J., and Ting, J. P.. 1999. GTP binding by class II transactivator: role in nuclear import. Science 285:1402–1405
   PubMedGoogle Scholar
• Itoh-Lindstrom, Y., Piskurich, J. F., Felix, N. J., Wang, Y., Brickey, W. J., Platt, J. L., Koller, B. H., and Ting, J. P.. 1999. Reduced IL-4-, lipopolysaccharide-, and IFN-gamma-induced MHC class II expression in mice lacking class II transactivator due to targeted deletion of the GTP-binding domain. J. Immunol. 163:2425–2431
   PubMedGoogle Scholar
• Jin, S., and Scotto, K. W.. 1998. Transcriptional regulation of the MDR1 gene by histone acetyltransferase and deacetylase is mediated by NF-Y. Mol. Cell. Biol. 18:4377–4384
   PubMed Web of Science ®Google Scholar
• Kara, C. J., and Glimcher, L. H.. 1991. In vivo footprinting of MHC class II genes: bare promoter in the bare lymphocyte syndrome. Science 252:709–712
   PubMedGoogle Scholar
• Kretsovali, A.. 1998. Involvement of CREB binding protein in expression of major histocompatibility complex class II genes via interaction with the class II transactivator. Mol. Cell. Biol. 18:6777–6783
   PubMed Web of Science ®Google Scholar
• Levin, D. E., and Errede, B.. 1995. The proliferation of MAP kinase signaling pathways in yeast. Curr. Opin. Cell Biol. 7:197–202
   PubMed Web of Science ®Google Scholar
• Li, Q., Herrler, M., Landsberger, N., Kaludov, N., Ogryzko, V. V., Nakatani, Y., and Wolffe, A. P.. 1998. Xenopus NF-Y pre-sets chromatin to potentiate p300 and acetylation-responsive transcription from the Xenopus hsp70 promoter in vivo. EMBO J. 17:6300–6315
   PubMedGoogle Scholar
• Linhoff, M. W., Wright, K. L., and Ting, J. P. Y.. 1997. CCAAT-binding factor NF-Y and RFX are required for in vivo assembly of a nucleoprotein complex that spans 250 base pairs: the invariant chain promoter as a model. Mol. Cell. Biol. 17:4589–4596
   PubMedGoogle Scholar
• Maity, S. N., Vuorio, T., and de Crombrugghe, B.. 1990. The B subunit of a rat heteromeric CCAAT-binding transcription factor shows a striking sequence identity with the yeast Hap2 transcription factor. Proc. Natl. Acad. Sci. USA 87:5378–5382
   PubMedGoogle Scholar
• Maity, S. N., Sinha, S., Ruteshouser, E. C., and de Crombrugghe, B.. 1992. Three different polypeptides are necessary for DNA binding of mammalian heteromeric CCAAT binding factor. J. Biol. Chem. 267:16574–16580
   PubMedGoogle Scholar
• Mantovani, R., Pessara, U., Tronche, F., Li, X. Y., Knapp, A. M., Pasquali, J. L., Benoist, C., and Mathis, D.. 1992. Monoclonal antibodies to NF-Y define its function in MHC class II and albumin gene transcription. EMBO J. 11:3315–3322
   PubMedGoogle Scholar
• Masternak, K., Barras, E., Zufferey, M., Conrad, B., Corthals, G., Aebersold, R., Sanchez, J. C., Hochstrasser, D. F., Mach, B., and Reith, W.. 1998. A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients. Nat. Genet. 20:273–277
   PubMedGoogle Scholar
• Moreno, C. S., Beresford, G. W., Louis-Plence, P., Morris, A. C., and Boss, J. M.. 1999. CREB regulates MHC class II expression in a CIITA-dependent manner. Immunity 10:143–151
   PubMedGoogle Scholar
• Moses, H., Panek, R. B., Benveniste, E. N., and Ting, J. P.. 1992. Usage of primary cells to delineate IFN-gamma-responsive DNA elements in the HLA-DRA promoter and to identify a novel IFN-gamma-enhanced nuclear factor. J. Immunol. 148:3643–3651
   PubMed Web of Science ®Google Scholar
• Nagarajan, U. M., Louis-Plence, P., DeSandro, A., Nilsen, R., Bushey, A., and Boss, J. M.. 1999. RFX-B is the gene responsible for the most common cause of the bare lymphocyte syndrome, an MHC class II immunodeficiency. Immunity 10:153–162 (Erratum, 10:399.
   PubMedGoogle Scholar
• O'Keefe, G. M., Nguyen, V. T., and Benveniste, E. N.. 1999. Class II transactivator and class II MHC gene expression in microglia: modulation by the cytokines TGF-beta, IL-4, IL-13 and IL-10. Eur. J. Immunol. 29:1275–1285
   PubMed Web of Science ®Google Scholar
• Posas, F., Takekawa, M., and Saito, H.. 1998. Signal transduction by MAP kinase cascades in budding yeast. Curr. Opin. Microbiol. 1:175–182
   PubMed Web of Science ®Google Scholar
• Reith, W., Siegrist, C. A., Durand, B., Barras, E., and Mach, B.. 1994. Function of major histocompatibility complex class II promoters requires cooperative binding between factors RFX and NF-Y. Proc. Natl. Acad. Sci. USA 91:554–558
   PubMedGoogle Scholar
• Reith, W., Kobr, M., Emery, P., Durand, B., Siegrist, C. A., and Mach, B.. 1994. Cooperative binding between factors RFX and X2bp to the X and X2 boxes of MHC class II promoters. J. Biol. Chem. 269:20020–20025
   PubMedGoogle Scholar
• Rigaud, G., De Lerma Barbaro, A., Nicolis, M., Cestari, T., Ramarli, D., Riviera, A. P., and Accolla, R. S.. 1996. Induction of CIITA and modification of in vivo HLA-DR promoter occupancy in normal thymic epithelial cells treated with IFN-gamma: similarities and distinctions with respect to HLA-DR-constitutive B cells. J. Immunol. 156:4254–4258
   PubMed Web of Science ®Google Scholar
• Riley, J. L., Westerheide, S. D., Price, J. A., Brown, J. A., and Boss, J. M.. 1995. Activation of class II MHC genes requires both the X box region and the class II transactivator (CIITA). Immunity 2:533–543
   PubMedGoogle Scholar
• Sambrook, J., Fritsch, E. F., and Maniatis, T.. 1989. Molecular cloning: a laboratory manual, 2nd ed. 18.1–18.74J Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y
   Google Scholar
• Scholl, T., Mahanta, S. K., and Strominger, J. L.. 1997. Specific complex formation between the type II bare lymphocyte syndrome-associated transactivators CIITA and RFX5. Proc. Natl. Acad. Sci. USA 94:6330–6334
   PubMedGoogle Scholar
• Sefton, B. M.. 1999. Analysis of protein phosphorylation Current protocols in molecular biology. Ausubel, F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, J. A., and Struhl, K. 18.2.1–18.2.8 John Wiley & Sons, Inc., New York, N.Y
   Google Scholar
• Sinha, S., Maity, S. N., Lu, J., and de Crombrugghe, B.. 1995. Recombinant rat CBF-C, the third subunit of CBF/NFY, allows formation of a protein-DNA complex with CBF-A and CBF-B and with yeast HAP2 and HAP3. Proc. Natl. Acad. Sci. USA 92:1624–1628
   PubMed Web of Science ®Google Scholar
• Springer, T. A.. 1999. Analysis of protein Current protocols in molecular biology. Ausubel, M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, J. A., and Struhl, K. 10.16.1–10.16.11 John Wiley & Sons, Inc., New York, N.Y
   Google Scholar
• Steimle, V., Otten, L. A., Zufferey, M., and Mach, B.. 1993. Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome). Cell 75:135–146
   PubMed Web of Science ®Google Scholar
• Steimle, V., Siegrist, C. A., Mottet, A., Lisowska-Grospierre, B., and Mach, B.. 1994. Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA. Science 265:106–109
   PubMed Web of Science ®Google Scholar
• Steimle, V., Durand, B., Barras, E., Zufferey, M., Hadam, M. R., Mach, B., and Reith, W.. 1995. A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome). Genes Dev. 9:1021–1032
   PubMedGoogle Scholar
• Steimle, V., Reith, W., and Mach, B.. 1996. Major histocompatibility complex class II deficiency: a disease of gene regulation. Adv. Immunol. 61:327–340
   PubMedGoogle Scholar
• Ting, J. P., and Zhu, X.. 1999. Class II MHC genes: a model gene regulatory system with great biologic consequences. Microbes Infect. 1:855–861
   PubMed Web of Science ®Google Scholar
• Vilen, B. J., Cogswell, J. P., and Ting, J. P.. 1991. Stereospecific alignment of the X and Y elements is required for major histocompatibility complex class II DRA promoter function. Mol. Cell. Biol. 11:2406–2415
   PubMedGoogle Scholar
• Vilen, B. J., Penta, J. F., and Ting, J. P. Y.. 1992. Structural constraints within a trimeric transcriptional regulatory region: constitutive and interferon-gamma inducible expression of the HLA-DRA gene. J. Biol. Chem. 267:23728–23734
   PubMedGoogle Scholar
• Vuorio, T., Maity, S. N., and de Crombrugghe, B.. 1990. Purification and molecular cloning of the “A” chain of a rat heteromeric CCAAT-binding protein. Sequence identity with the yeast HAP3 transcription factor. J. Biol. Chem. 265:22480–22486
   PubMed Web of Science ®Google Scholar
• Whitmarsh, A. J., and Davis, R. J.. 1998. Structural organization of MAP-kinase signaling modules by scaffold. Trends Biochem. Sci. 23:481–485
   PubMed Web of Science ®Google Scholar
• Widmann, C., Gibson, S., Jarpe, M. B., and Johnson, G. L.. 1999. Mitogen-activated protein kinase: conservation of a three-kinase module. Physiol. Rev. 79:143–180
   PubMed Web of Science ®Google Scholar
• Wright, K. L., and Ting, J. P.. 1992. In vivo footprint analysis of the HLA-DRA gene promoter: cell-specific interaction at the octamer site and up-regulation of X box binding by interferon gamma. Proc. Natl. Acad. Sci. USA 89:7601–7605
   PubMedGoogle Scholar
• Wright, K. L., Vilen, B. J., Itoh-Lindstrom, Y., Moore, T. L., Li, G., Criscitiello, M., Cogswell, P., Clarke, J. B., and Ting, J. P. Y.. 1994. CCAAT box binding protein NF-Y facilitates in vivo recruitment of upstream DNA binding transcription factors. EMBO J. 13:4042–4053
   PubMedGoogle Scholar
• Wright, K. L., Chin, K.-C., Linhoff, M., Skinner, C., Brown, J. A., Boss, J. M., Stark, G. R., and Ting, J. P. Y.. 1998. CIITA stimulation of transcription factor binding to MHC class II and associated promoters in vivo. Proc. Natl. Acad. Sci. USA 95:6267–6272
   PubMedGoogle Scholar
• Yasuda, J., Whitmarsh, A. J., Cavanagh, J., Sharma, M., and Davis, R. J.. 1999. The JIP group of mitogen-activated protein kinase scaffold proteins. Mol. Cell. Biol. 19:7245–7254
   PubMed Web of Science ®Google Scholar
• Zeleznik-Le, N., Azizkhan, J. C., and Ting, J. P. Y.. 1991. Affinity-purified CCAAT-box-binding protein (YEBP) functionally regulates expression of a human class II major histocompatibility complex gene and the herpes simplex virus thymidine kinase gene. Proc. Natl. Acad. Sci. USA 88:1873–1877
   PubMedGoogle Scholar
• Zhou, H., and Glimcher, L. H.. 1995. Human MHC class II gene transcription directed by the carboxyl terminus of CIITA, one of the defective genes in type II MHC combined immune deficiency. Immunity 2:545–553
   PubMedGoogle Scholar