A Bromodomain Protein, MCAP, Associates with Mitotic Chromosomes and Affects G₂-to-M Transition

REFERENCES

• Abney, J. R., Cutler, B., Fillbach, M. L., Axelrod, D., and Scalettar, B. A.. 1997. Chromatin dynamics in interphase nuclei and its implications for nuclear structure. J. Cell Biol. 137:1459–1468
   PubMed Web of Science ®Google Scholar
• Beck, S., Hanson, I., Kelly, A., Pappin, D. J., and Trowsdale, J.. 1992. A homologue of the Drosophila female sterile homeotic (fsh) gene in the class II region of the human MHC. DNA Seq. 2:203–210
   PubMedGoogle Scholar
• Chua, P., and Roeder, G. S.. 1995. Bdf1, a yeast chromosomal protein required for sporulation. Mol. Cell. Biol. 15:3685–3696
   PubMedGoogle Scholar
• Coligan, J., Kruisbeek, A., Shevach, E., and Margulies, D.. 1997. Current protocols in immunology. John Wiley & Sons, New York, N.Y
   Google Scholar
• Coverley, D., and Laskey, R. A.. 1994. Regulation of eukaryotic DNA replication. Annu. Rev. Biochem. 63:745–776
   PubMed Web of Science ®Google Scholar
• Denis, G. V., and Green, M. R.. 1996. A novel, mitogen-activated nuclear kinase is related to a Drosophila developmental regulator. Genes Dev. 10:261–271
   PubMedGoogle Scholar
• Dey, A., Minucci, S., and Ozato, K.. 1994. Ligand-dependent occupancy of the retinoic acid receptor beta 2 promoter in vivo. Mol. Cell. Biol. 14:8191–8201
   PubMedGoogle Scholar
• Dhalluin, C., Carlson, J. E., Zeng, L., He, C., Aggarwal, A. K., and Zhou, M. M.. 1999. Structure and ligand of a histone acetyltransferase bromodomain. Nature 399:491–496
   PubMed Web of Science ®Google Scholar
• Digan, M. E., Haynes, S. R., Mozer, B. A., Dawid, I. B., Forquignon, F., and Gans, M.. 1986. Genetic and molecular analysis of fs(1)h, a maternal effect homeotic gene in Drosophila. Dev. Biol. 114:161–169
   PubMed Web of Science ®Google Scholar
• Ellenberg, J., Siggia, E. D., Moreira, J. E., Smith, C. L., Presley, J. F., Worman, H. J., and Lippincott-Schwartz, J.. 1997. Nuclear membrane dynamics and reassembly in living cells: targeting of an inner nuclear membrane protein in interphase and mitosis. J. Cell Biol. 138:1193–1206
   PubMed Web of Science ®Google Scholar
• Field, C., Li, R., and Oegema, K.. 1999. Cytokinesis in eukaryotes: a mechanistic comparison. Curr. Opin. Cell Biol. 11:68–80
   PubMedGoogle Scholar
• Gottesfeld, J. M., Wolf, V. J., Dang, T., Forbes, D. J., and Hartl, P.. 1994. Mitotic repression of RNA polymerase III transcription in vitro mediated by phosphorylation of a TFIIIB component. Science 263:81–84
   PubMed Web of Science ®Google Scholar
• Guacci, V., Koshland, D., and Strunnikov, A.. 1997. A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae. Cell 91:47–57
   PubMed Web of Science ®Google Scholar
• Haynes, S. R., Dollard, C., Winston, F., Beck, S., Trowsdale, J., and Dawid, I. B.. 1992. The bromodomain: a conserved sequence found in human, Drosophila and yeast proteins. Nucleic Acids Res 20:2603
   PubMed Web of Science ®Google Scholar
• Haynes, S. R., Mozer, B. A., Bhatia-Dey, N., and Dawid, I. B.. 1989. The Drosophila fsh locus, a maternal effect homeotic gene, encodes apparent membrane proteins. Dev. Biol. 134:246–257
   PubMedGoogle Scholar
• Hendzel, M. J., Wei, Y., Mancini, M. A., Van Hooser, A., Ranalli, T., Brinkley, B. R., Bazett-Jones, D. P., and Allis, C. D.. 1997. Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation. Chromosoma 106:348–360
   PubMed Web of Science ®Google Scholar
• Hershkovitz, M., and Riggs, A. D.. 1995. Metaphase chromosome analysis by ligation-mediated PCR: heritable chromatin structure and a comparison of active and inactive X chromosomes. Proc. Natl. Acad. Sci. USA 92:2379–2383
   PubMedGoogle Scholar
• Hirano, T.. 1999. SMC-mediated chromosome mechanics: a conserved scheme from bacteria to vertebrates? Genes Dev. 13:11–19
   PubMed Web of Science ®Google Scholar
• Horn, V., Minucci, S., Ogryzko, V. V., Adamson, E. D., Howard, B. H., Levin, A. A., and Ozato, K.. 1996. RAR and RXR selective ligands cooperatively induce apoptosis and neuronal differentiation in P19 embryonal carcinoma cells. FASEB J. 10:1071–1077
   PubMedGoogle Scholar
• Isaacs, R. J., Davies, S. L., Sandri, M. I., Redwood, C., Wells, N. J., and Hickson, I. D.. 1998. Physiological regulation of eukaryotic topoisomerase II. Biochim. Biophys. Acta 1400:121–137
   PubMed Web of Science ®Google Scholar
• Jeanmougin, F., Wurtz, J. M., Le Douarin, B., Chambon, P., and Losson, R.. 1997. The bromodomain revisited. Trends Biochem. Sci. 22:151–153
   PubMed Web of Science ®Google Scholar
• Jessberger, R., Frei, C., and Gasser, S. M.. 1998. Chromosome dynamics: the SMC protein family. Curr. Opin. Genet. Dev. 8:254–259
   PubMedGoogle Scholar
• Jiang, Y. W., Veschambre, P., Erdjument-Bromage, H., Tempst, P., Conaway, J. W., Conaway, R. C., and Kornberg, R. D.. 1998. Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways. Proc. Natl. Acad. Sci. USA 95:8538–8543
   PubMed Web of Science ®Google Scholar
• Jones, M. H., Numata, M., and Shimane, M.. 1997. Identification and characterization of BRDT: a testis-specific gene related to the bromodomain genes RING3 and Drosophila fsh. Genomics 45:529–534
   PubMed Web of Science ®Google Scholar
• Koepp, D., Harper, J., and Elledge, S. J.. 1999. how the cyclin became a cyclin: regulated proleolysis in the cell cycle. Cell 97:431–434
   PubMed Web of Science ®Google Scholar
• Lygerou, Z., Conesa, C., Lesage, P., Swanson, R. N., Ruet, A., Carlson, M., Sentenac, A., and Seraphin, B.. 1994. The yeast BDF1 gene encodes a transcription factor involved in the expression of a broad class of genes including snRNAs. Nucleic Acids Res. 22:5332–5340
   PubMedGoogle Scholar
• MacGregor, H., and Varley, J.. 1988. Chromosome banding. John Wiley & Sons, New York, N.Y
   Google Scholar
• Marshall, W. F., Straight, A., Marko, J. F., Swedlow, J., Dernburg, A., Belmont, A., Murray, A. W., Agard, D. A., and Sedat, J. W.. 1997. Interphase chromosomes undergo constrained diffusional motion in living cells. Curr. Biol. 7:930–939
   PubMed Web of Science ®Google Scholar
• Martinez-Balbas, M. A., Dey, A., Rabindran, S. K., Ozato, K., and Wu, C.. 1995. Displacement of sequence-specific transcription factors from mitotic chromatin. Cell 83:29–38
   PubMed Web of Science ®Google Scholar
• Matangkasombut, O., Buratowski, R. M., Swilling, N. W., and Buratowski, S.. 2000. Bromodomain factor 1 corresponds to a missing piece of yeast TFIID. Genes Dev. 14:951–962
   PubMed Web of Science ®Google Scholar
• McNally, J. G., Muller, W. G., Walker, D., Wolford, R., and Hager, G. L.. 2000. The glucocorticoid receptor: rapid exchange with regulatory sites in living cells. Science 287:1262–1265
   PubMed Web of Science ®Google Scholar
• Michelotti, E. F., Sanford, S., and Levens, D.. 1997. Marking of active genes on mitotic chromosomes. Nature 388:895–899
   PubMed Web of Science ®Google Scholar
• Muchardt, C., Reyes, J. C., Bourachot, B., Leguoy, E., and Yaniv, M.. 1996. The hbrm and BRG-1 proteins, components of the human SNF/SWI complex, are phosphorylated and excluded from the condensed chromosomes during mitosis. EMBO J. 15:3394–3402
   PubMedGoogle Scholar
• Murphy, T. D., and Karpen, G. H.. 1998. Centromeres take flight: alpha satellite and the quest for the human centromere. Cell 93:317–320
   PubMedGoogle Scholar
• Nasmyth, K.. 1999. Separating sister chromatids. Trends Biochem. Sci. 24:98–104
   PubMedGoogle Scholar
• Nurse, P., Masui, Y., and Hartwell, L.. 1998. Understanding the cell cycle. Nat. Med. 4:1103–1106
   PubMed Web of Science ®Google Scholar
• Ohi, R., and Gould, K. L.. 1999. Regulating the onset of mitosis. Curr. Opin. Cell Biol. 11:267–273
   PubMed Web of Science ®Google Scholar
• Parsons, G. G., and Spencer, C. A.. 1997. Mitotic repression of RNA polymerase II transcription is accompanied by release of transcription elongation complexes. Mol. Cell. Biol. 17:5791–5802
   PubMed Web of Science ®Google Scholar
• Phair, R. D., and Misteli, T.. 2000. High mobility of proteins in the mammalian cell nucleus. Nature 404:604–609
   PubMed Web of Science ®Google Scholar
• Pines, J., and Hunter, T.. 1991. Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport. J. Cell Biol. 115:1–17
   PubMed Web of Science ®Google Scholar
• Prescott, D., and Bender, M.. 1962. Synthesis of RNA and protein during mitosis of mammalian tissue culture cells. Exp. Cell Res. 26:260–268
   PubMed Web of Science ®Google Scholar
• Qi, C. F., Coleman A. E., Torrey T. A., Taddesse-Heath L., Ye B. H., Ohta Y., Chattopadhyay S. K., Hatrley J. W., and Morse I. H. C.. Genomic organization and expression of BCL6 in murine B cell lymphomas. Cancer Res., in press.
   Google Scholar
• Rhee, K., Brunori, M., Besset, V., Trousdale, R., and Wolgemuth, D. J.. 1998. Expression and potential role of Fsrg1, a murine bromodomain-containing homologue of the Drosophila gene female sterile homeotic. J. Cell Sci. 111:3541–3550
   PubMedGoogle Scholar
• Saurin, A. J., Shiels, C., Williamson, J., Satijn, D. P., Otte, A. P., Sheer, D., and Freemont, P. S.. 1998. The human polycomb group complex associates with pericentromeric heterochromatin to form a novel nuclear domain. J. Cell Biol. 142:887–898
   PubMed Web of Science ®Google Scholar
• Segil, N., Guermah, M., Hoffmann, A., Roeder, R. G., and Heintz, N.. 1996. Mitotic regulation of TFIID: inhibition of activator-dependent transcription and changes in subcellular localization. Genes Dev. 10:2389–2400
   PubMed Web of Science ®Google Scholar
• Sif, S., Stukenberg, P. T., Kirschner, M. W., and Kingston, R. E.. 1998. Mitotic inactivation of a human SWI/SNF chromatin remodeling complex. Genes Dev. 12:2842–2851
   PubMed Web of Science ®Google Scholar
• Soddu, S., Blandino, G., Scardigli, R., Martinelli, R., Rizzo, M. G., Crescenzi, M., and Sacchi, A.. 1996. Wild-type p53 induces diverse effects in 32D cells expressing different oncogenes. Mol. Cell. Biol. 16:487–495
   PubMedGoogle Scholar
• Stein, G., and Stein, J. L.. 1989. Cell synchronization. IRL Press, New York, N.Y
   Google Scholar
• Taniguchi, Y., Matsuzaka, Y., Fujimoto, H., Miyado, K., Kohda, A., Okumura, K., Kimura, M., and Inoko, H.. 1998. Nucleotide sequence of the ring3 gene in the class II region of the mouse MHC and its abundant expression in testicular germ cells. Genomics 51:114–123
   PubMedGoogle Scholar
• Thorpe, K. L., Abdulla, S., Kaufman, J., Trowsdale, J., and Beck, S.. 1996. Phylogeny and structure of the RING3 gene. Immunogenetics 44:391–396
   PubMedGoogle Scholar
• Thorpe, K. L., Gorman, P., Thomas, C., Sheer, D., Trowsdale, J., and Beck, S.. 1997. Chromosomal localization, gene structure and transcription pattern of the ORFX gene, a homologue of the MHC-linked RING3 gene. Gene 200:177–183
   PubMedGoogle Scholar
• Toyoshima, F., Moriguchi, T., Wada, A., Fukuda, M., and Nishida, E.. 1998. Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G2 checkpoint. EMBO J. 17:2728–2735
   PubMed Web of Science ®Google Scholar
• Van Hooser, A., Goodrich, D. W., Allis, C. D., Brinkley, B. R., and Mancini, M. A.. 1998. Histone H3 phosphorylation is required for the initiation, but not maintenance, of mammalian chromosome condensation. J. Cell Sci. 111:3497–3506
   PubMed Web of Science ®Google Scholar
• Wang, A., and Mark, D.. 1990. PCR protocols. Academic Press, New York, N.Y
   Google Scholar
• Wei, Y., Yu, L., Bowen, J., Gorovsky, M. A., and Allis, C. D.. 1999. Phosphorylation of histone H3 is required for proper chromosome condensation and segregation. Cell 97:99–109
   PubMed Web of Science ®Google Scholar
• Wiens, G. R., and Sorger, P. K.. 1998. Centromeric chromatin and epigenetic effects in kinetochore assembly. Cell 93:313–316
   PubMedGoogle Scholar
• Winston, F., and Allis, C. D.. 1999. The bromodomain: a chromatin-targeting module? Nat. Struct. Biol. 6:601–604
   PubMedGoogle Scholar
• Zachariae, W., and Nasmyth, K.. 1999. Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev. 13:2039–2058
   PubMed Web of Science ®Google Scholar