54
Views
137
CrossRef citations to date
0
Altmetric
Cell Growth and Development

A Novel Form of DAP5 Protein Accumulates in Apoptotic Cells as a Result of Caspase Cleavage and Internal Ribosome Entry Site-Mediated Translation

, , &
Pages 496-506 | Received 01 Jun 1999, Accepted 19 Oct 1999, Published online: 28 Mar 2023

REFERENCES

  • Akiri, G., Nahari, D., Finkelstein, Y., Le, S. Y., Elroy-Stein, O., and Levi, B. Z.. 1998. Regulation of vascular endothelial growth factor (VEGF) expression is mediated by internal initiation of translation and alternative initiation of transcription. Oncogene 17:227–236
  • Ashkenazi, A., and Dixit, V. M.. 1998. Death receptors: signaling and modulation. Science 281:1305–1308
  • Bernstein, J., Sella, O., Le, S. Y., and Elroy-Stein, O.. 1997. PDGF2/c-sis mRNA leader contains a differentiation-linked internal ribosomal entry site (D-IRES). J. Biol. Chem. 272:9356–9362
  • Boldin, M. P., Varfolomeev, E. E., Pancer, Z., Mett, I. L., Camonis, J. H., and Wallach, D.. 1995. A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain. J. Biol. Chem. 270:7795–7798
  • Borman, A. M., Kirchweger, R., Ziegler, E., Rhoads, R. E., Skern, T., and Kean, K. M.. 1997. eIF4G and its proteolytic cleavage products: effect on initiation of protein synthesis from capped, uncapped, and IRES-containing mRNAs. RNA 3:186–196
  • Bushell, M., McKendrick, L., Janicke, R. U., Clemens, M. J., and Morley, S. J.. 1999. Caspase-3 is necessary and sufficient for cleavage of protein synthesis eukaryotic initiation factor 4G during apoptosis. FEBS Lett. 451:332–336
  • Clemens, M. J., Bushell, M., and Morley, S. J.. 1998. Degradation of eukaryotic polypeptide chain initiation factor (eIF) 4G in response to induction of apoptosis in human lymphoma cell lines. Oncogene 17:2921–2931
  • Craig, A. W., Haghighat, A., Yu, A. T., and Sonenberg, N.. 1998. Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation. Nature 392:520–523
  • Deckwerth, T. L., Johnson, E. M.Jr.. 1993. Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor. J. Cell Biol. 123:1207–1222
  • Deiss, L. P., and Kimchi, A.. 1991. A genetic tool used to identify thioredoxin as a mediator of a growth inhibitory signal. Science 252:117–120
  • Duncan, R. F.. 1996. Translational control during heat shock Translational control. Hershey, J. W. B., Mathews, M. B., and Sonenberg, N. 271–293 CSHL Press, Cold Spring Harbor, N.Y
  • Gradi, A., Imataka, H., Svitkin, Y. V., Rom, E., Raught, B., Morino, S., and Sonenberg, N.. 1998. A novel functional human eukaryotic translation initiation factor 4G. Mol. Cell. Biol. 18:334–342
  • Gradi, A., Svitkin, Y. V., Imataka, H., and Sonenberg, N.. 1998. Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection. Proc. Natl. Acad. Sci. USA 95:11089–11094
  • Holcik, M., Lefebvre, C., Yeh, C., Chow, T., and Korneluk, R. G.. 1999. A new internal-ribosome-entry-site motif potentiates XIAP-mediated cytoprotection. Nat. Cell Biol. 1:190–192
  • Imataka, H., Olsen, H. S., and Sonenberg, N.. 1997. A new translational regulator with homology to eukaryotic translation initiation factor 4G. EMBO J. 16:817–825
  • Imataka, H., and Sonenberg, N.. 1997. Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A. Mol. Cell. Biol. 17:6940–6947
  • Kimchi, A.. 1998. DAP genes: novel apoptotic genes isolated by a functional approach to gene cloning. Biochim. Biophys. Acta 1377:F13–F33
  • Kissil, J. L., Cohen, O., Raveh, T., and Kimchi, A.. 1999. Structure-function analysis of an evolutionary conserved protein, DAP3, which mediates TNF-alpha- and Fas-induced cell death. EMBO J. 18:353–362
  • Kraggerud, S. M., Sandvik, J. A., and Pettersen, E. O.. 1995. Regulation of protein synthesis in human cells exposed to extreme hypoxia. Anticancer Res. 15:683–686
  • Lamphear, B. J., Kirchweger, R., Skern, T., and Rhoads, R. E.. 1995. Mapping of functional domains in eukaryotic protein synthesis initiation factor 4G (eIF4G) with picornaviral proteases. Implications for cap-dependent and cap-independent translational initiation. J. Biol. Chem. 270:21975–21983
  • Levy-Strumpf, N., Deiss, L. P., Berissi, H., and Kimchi, A.. 1997. DAP-5, a novel homolog of eukaryotic translation initiation factor 4G isolated as a putative modulator of gamma interferon-induced programmed cell death. Mol. Cell. Biol. 17:1615–1625
  • Marissen, W. E., and Lloyd, R. E.. 1998. Eukaryotic translation initiation factor 4G is targeted for proteolytic cleavage by caspase 3 during inhibition of translation in apoptotic cells. Mol. Cell. Biol. 18:7565–7574
  • Martin, D. P., Schmidt, R. E., DiStefano, P. S., Lowry, O. H., Carter, J. G., Johnson, E. M.Jr.. 1988. Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation. J. Cell Biol. 106:829–844
  • McCall, K., and Steller, H.. 1997. Facing death in the fly: genetic analysis of apoptosis in Drosophila. Trends Genet. 13:222–226
  • Methot, N., Rom, E., Olsen, H., and Sonenberg, N.. 1997. The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170. J. Biol. Chem. 272:1110–1116
  • Morley, S. J., Curtis, P. S., and Pain, V. M.. 1997. eIF4G: translation's mystery factor begins to yield its secrets. RNA 3:1085–1104
  • Morley, S. J., McKendrick, L., and Bushell, M.. 1998. Cleavage of translation initiation factor 4G (eIF4G) during anti-Fas IgM-induced apoptosis does not require signalling through the p38 mitogen-activated protein (MAP) kinase. FEBS Lett. 438:41–48
  • Nicholson, D. W., and Thornberry, N. A.. 1997. Caspases: killer proteases. Trends Biochem. Sci. 22:299–306
  • Ohlmann, T., Rau, M., Pain, V. M., and Morley, S. J.. 1996. The C-terminal domain of eukaryotic protein synthesis initiation factor (eIF) 4G is sufficient to support cap-independent translation in the absence of eIF4E. EMBO J. 15:1371–1382
  • Pestova, T. V., Shatsky, I. N., and Hellen, C. U.. 1996. Functional dissection of eukaryotic initiation factor 4F: the 4A subunit and the central domain of the 4G subunit are sufficient to mediate internal entry of 43S preinitiation complexes. Mol. Cell. Biol. 16:6870–6878
  • Porter, A. G., Ng, P., and Janicke, R. U.. 1997. Death substrates come alive. Bioessays 19:501–507
  • Pyronnet, S., Imataka, H., Gingras, A. C., Fukunaga, R., Hunter, T., and Sonenberg, N.. 1999. Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. EMBO J. 18:270–279
  • Shaughnessy, J. D.Jr., Jenkins, N. A., and Copeland, N. G.. 1997. cDNA cloning, expression analysis, and chromosomal localization of a gene with high homology to wheat eIF-(iso)4F and mammalian eIF-4G. Genomics 39:192–197
  • Stein, I., Itin, A., Einat, P., Skaliter, R., Grossman, Z., and Keshet, E.. 1998. Translation of vascular endothelial growth factor mRNA by internal ribosome entry: implications for translation under hypoxia. Mol. Cell. Biol. 18:3112–3119
  • Svitkin, Y. V., Gradi, A., Imataka, H., Morino, S., and Sonenberg, N.. 1999. Eukaryotic initiation factor 4GII (eIF4GII), but not eIF4GI, cleavage correlates with inhibition of host cell protein synthesis after human rhinovirus infection. J. Virol. 73:3467–3472
  • Thornberry, N. A., and Lazebnik, Y.. 1998. Caspases: enemies within. Science 281:1312–1316
  • Vagner, S., Gensac, M. C., Maret, A., Bayard, F., Amalric, F., Prats, H., and Prats, A.. 1995. Alternative translation of human fibroblast growth factor 2 mRNA occurs by internal entry of ribosomes. Mol. Cell. Biol. 15:35–44
  • Wang, C. Y., Mayo, M. W., Korneluk, R. G., Goeddel, D. V., Baldwin, A. S.Jr.. 1998. NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 281:1680–1683
  • Waskiewicz, A. J., Johnson, J. C., Penn, B., Mahalingam, M., Kimball, S. R., and Cooper, J. A.. 1999. Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo. Mol. Cell. Biol. 19:1871–1880
  • Yamanaka, S., Poksay, K. S., Arnold, K. S., and Innerarity, T. L.. 1997. A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme. Genes Dev. 11:321–333
  • Yonish-Rouach, E., Resnitzky, D., Lotem, J., Sachs, L., Kimchi, A., and Oren, M.. 1991. Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature 352:345–347

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.