7
Views
43
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Role of the Distal Half of the c-Mpl Intracellular Domain in Control of Platelet Production by Thrombopoietin In Vivo

, , , , , , & show all
Pages 507-515 | Received 17 Aug 1999, Accepted 21 Oct 1999, Published online: 28 Mar 2023

REFERENCES

  • Alexander, W. S., Roberts, A. W., Nicola, N. A., Li, L., and Metcalf, D.. 1996. Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietin receptor c-Mpl. Blood 87:2162–2170
  • Arnold, J. T., Daw, N. C., Stenberg, P. E., Jayawardene, D., Srivastava, D. K., and Jackson, C. W.. 1997. A single injection of pegylated murine megakaryocyte growth and development factor (MGDF) into mice is sufficient to produce a profound stimulation of megakaryocyte frequency, size, and ploidization. Blood 89:823–833
  • Bartley, T., Bogenberger, J., Hunt, P., Li, Y., Lu, H., Martin, F., Chang, M., Samal, B., Nichol, J., Swift, S., Johnson, M., Hsu, R., Parker, V., Suggs, S., Skrine, J., Merewether, L., Clogston, C., Hsu, E., Hokom, M., Hornkohl, A., Choi, E., Pangelian, M., Sun, Y., Mar, V., McNinch, J., Simonet, L., Jacobsen, F., Xie, C., Shutter, J., Chute, H., Basu, R., Selander, L., Trollinger, R., Sieu, L., Padilla, D., Trail, G., Elliott, G., Izumi, R., Covey, T., Crouse, J., Garcia, A., Xu, W., Del Castillo, J., Biron, J., Cole, S., Hu, M., Pacifici, R., Ponting, I., Saris, C., Wen, D., Yung, Y., Lin, H., and Bosselman, R.. 1994. Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell 77:1117–1124
  • Broudy, V. C., Lin, N. L., and Kaushansky, K.. 1995. Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro. Blood 85:1719–1726
  • Bunting, S., Widmer, R., Lipari, T., Rangell, L., Steinmetz, H., Carver-Moore, K., Moore, M. W., Keller, G. A., and de Sauvage, F. J.. 1997. Normal platelets and megakaryocytes are produced in vivo in the absence of thrombopoietin. Blood 90:3423–3429
  • Carver-Moore, K., Broxmeyer, H. E., Luoh, S.-M., Cooper, S., Peng, J., Burstein, S. A., Moore, M. W., and de Sauvage, F. J.. 1996. Low levels of erythroid and myeloid progenitors in thrombopoietin- and c-mpl-deficient mice. Blood 88:803–808
  • Choi, E. S., Nichol, J. L., Hokom, M. M., Hornkohl, A. C., and Hunt, P.. 1995. Platelets generated in vitro from proplatelet-displaying human megakaryocytes are functional. Blood 85:402–413
  • de Sauvage, F., Carver-Moore, K., Luoh, S., Ryan, A., Dowd, M., Eaton, D., and Moore, M.. 1996. Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin. J. Exp. Med. 183:651–656
  • de Sauvage, F., Hass, P., Spencer, S., Malloy, B., Gurney, A., Spencer, S., Darbonne, W., Henzel, W., Wong, S., Kuang, W., Oles, K., Hultgren, B., Solberg, L., Goeddel, D., and Eaton, D.. 1994. Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-mpl ligand. Nature 369:533–538
  • Drachman, J. G., and Kaushansky, K.. 1997. Dissecting the thrombopoietin receptor: functional elements of the Mpl cytoplasmic domain. Proc. Natl. Acad. Sci. USA 94:2350–2355
  • Drachman, J. G., Rojnuckarin, P., and Kaushansky, K.. 1999. Thrombopoietin signal transduction: studies from cell lines and primary cells. Methods 17:238–249
  • Fielder, P., Gurney, A., Stefanich, E., Marian, M., Moore, M., Carver-Moore, K., and de Sauvage, F.. 1996. Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets. Blood 87:2154–2161
  • Fukunaga, R., Ishizaka-Ikeda, E., and Nagata, S.. 1993. Growth and differentiation signals mediated by different regions in the cytoplasmic domain of granulocyte colony-stimulating factor receptor. Cell 74:1079–1087
  • Gurney, A. L., Carver Moore, K., de Sauvage, F. J., and Moore, M. W.. 1994. Thrombocytopenia in c-mpl-deficient mice. Science 265:1445–1447
  • Gurney, A. L., Wong, S. C., Henzel, W. J., and de Sauvage, F. J.. 1995. Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylation. Proc. Natl. Acad. Sci. USA 92:5292–5296
  • Hanks, M., Wurst, W., Anson-Cartwright, L., Auerbach, A. B., and Joyner, A. L.. 1995. Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2. Science 269:679–682
  • Hill, R. J., Zozulya, S., Lu, Y. L., Hollenbach, P. W., Joyce-Shaikh, B., Bogenberger, J., and Gishizky, M. L.. 1996. Differentiation induced by the c-Mpl cytokine receptor is blocked by mutant Shc adaptor protein. Cell Growth Differ. 7:1125–1134
  • Jackson, C. W.. 1973. Cholinesterase as a possible marker for early cells of the megakaryocytic series. Blood 42:413–421
  • Jackson, C. W., Brown, L. K., Somerville, B. C., Lyles, S. A., and Look, A. T.. 1984. Two-color flow cytometric measurement of DNA distributions of rat megakaryocytes in unfixed, unfractionated marrow cell suspensions. Blood 63:768–778
  • Kaushansky, K., Broudy, V. C., Lin, N., Jorgensen, M. J., McCarty, J., Fox, N., Zucker Franklin, D., and Lofton Day, C.. 1995. Thrombopoietin, the Mp1 ligand, is essential for full megakaryocyte development. Proc. Natl. Acad. Sci. USA 92:3234–3238
  • Kaushansky, K., Lok, S., Holly, R., Broudy, V., Lin, N., Bailey, M., Forstrom, J., Buddle, M., Oort, P., Hagen, F., Roth, G., Papayannopoulou, T., and Foster, D.. 1994. Promotion of megakaryocyte progenitor expansion and differentiation by the c-mpl ligand thrombopoietin. Nature 369: 568
  • Kuter, D. J., Beeler, D. L., and Rosenberg, R. D.. 1994. The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet production. Proc. Natl. Acad. Sci. USA 91:11104–11108
  • Levin, J., Peng, J.-P., Baker, R., Villeval, J.-L., Lecine, P., Burstein, S. A., and Shivdasani, R. A.. 1999. Pathophysiology of thrombocytopenia and anemia in mice lacking transcription factor NF-E2. Blood 94:1–12
  • Lieschke, G. J., Grail, D., Hodgson, G., Metcalf, D., Stanley, E., Cheers, C., Fowler, K. J., Basu, S., Zhan, Y. F., and Dunn, A. R.. 1994. Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization. Blood 84:1737–1746
  • Liu, F., Poursine-Laurent, J., Wu, H. Y., and Link, D. C.. 1997. Interleukin-6 and the granulocyte colony-stimulating factor receptor are major independent regulators of granulopoiesis in vivo but are not required for lineage commitment or terminal differentiation. Blood 90:2583–2590
  • Lok, S., Kaushansky, K., Holly, R., Kuljper, J., Lofton-Day, C., Oort, P., Grant, F., Helpel, M., Burkhead, S., Kramer, J., Bell, L., Sprecher, C., Blumberg, H., Johnson, R., Prunkard, D., Ching, A., Mathewes, S., Balley, M., Forstom, J., Buddle, M., Osborn, S., Evans, S., Sheppard, P., Presnell, S., O'Hara, P., Hagen, F., Roth, G., and Foster, D.. 1994. Cloning and sequencing of murine thrombopoietin and stimulation of platelet production in vivo. Nature 369:565–568
  • Methia, N., Louache, F., Vainchenker, W., and Wendling, F.. 1993. Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis. Blood 82:1395–1401
  • Montrucchio, G., Brizzi, M. F., Calosso, G., Marengo, S., Pegoraro, L., and Camussi, G.. 1996. Effects of recombinant MGDF on platelet activation. Blood 87:2762–2768
  • Morita, H., Tahara, T., Matsumoto, A., Kato, T., Miyazaki, H., and Ohashi, H.. 1996. Functional analysis of the cytoplasmic domain of the human Mpl receptor for tyrosine-phosphorylation of the signaling molecules, proliferation and differentiation. FEBS Lett. 395:228–234
  • Oda, A., Miyakawa, Y., Druker, B., Ozaki, K., Yabusaki, K., Shirasawa, Y., Handa, M., Kato, T., Miyazaki, H., Shimosaka, A., and Ikeda, Y.. 1996. Thrombopoietin primes human platelet aggregation induced by sheer stress and by multiple agonist. Blood 87:4664–4670
  • Pallard, C., Gouilleux, F., Benit, L., Cocault, L., Souyri, M., Levy, D., Groner, B., Gisselbrecht, S., and Dusanter-Fourt, I.. 1995. Thrombopoietin activates a STAT5-like factor in hematopoietic cells. EMBO J. 14:2847–2856
  • Rouyez, M. C., Boucheron, C., Gisselbrecht, S., Dusanter-Fourt, I., and Porteu, F.. 1997. Control of thrombopoietin-induced megakaryocytic differentiation by the mitogen-activated protein kinase pathway. Mol. Cell. Biol. 17:4991–5000
  • Sasaki, K., Odai, H., Hanazono, Y., Ueno, H., Ogawa, S., Langdon, W. Y., Tanaka, T., Miyagawa, K., Mitani, K., Yazaki, Y. et al. 1995. TPO/c-mpl ligand induces tyrosine phosphorylation of multiple cellular proteins including proto-oncogene products, Vav and c-Cbl, and Ras signaling molecules. Biochem. Biophys. Res. Commun. 216:338–347
  • Sattler, M., Durstin, M. A., Frank, D. A., Okuda, K., Kaushansky, K., Salgia, R., and Griffin, J. D.. 1995. The thrombopoietin receptor c-MPL activates JAK2 and TYK2 tyrosine kinases. Exp. Hematol. 23:1040–1048
  • Solar, G. P., Kerr, W. G., Zeigler, F. C., Hess, D., Donahue, C., de Sauvage, F. J., and Eaton, D. L.. 1998. Role of c-mpl in early hematopoiesis. Blood 92:4–10
  • Souyri, M., Vigon, I., Penciolelli, J.-F., Heard, J.-M., Tamboruin, P., and Wendling, F.. 1990. A putative truncated cytokine receptor gene tranduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors. Cell 63:1137–1147
  • Stoffel, R., Ziegler, S., Ghilardi, N., Ledermann, B., de Sauvage, F. J., and Skoda, R. C.. 1999. Permissive role of thrombopoietin and granulocyte colony-stimulating factor receptors in hematopoietic cell fate decisions in vivo. Proc. Natl. Acad. Sci. USA 96:698–702
  • Vignon, I., Dreyfus, F., Melle, J., Viguie, F., Ribrag, V., Soyri, C. L. M., and Gisselbrecht, S.. 1993. Expression of the c-mpl proto-oncogene in human hematologic malignancies. Blood 82:877–883
  • Wendling, F., Maraskovsky, E., Debili, N., Florindo, C., Teepe, M., Titeux, M., Methia, N., Breton-Gorius, J., Cosman, D., and Vainchenker, W.. 1994. cMpl ligand is a humoral regulator of megakaryocytopoiesis. Nature 369:571–574
  • Zauli, G., Bassini, A., Vitale, M., Gibellini, D., Celeghini, C., Caramelli, E., Pierpaoli, S., Guidotti, L., and Capitani, S.. 1997. Thrombopoietin enhances the alpha IIb beta 3-dependent adhesion of megakaryocytic cells to fibrinogen or fibronectin through PI 3 kinase. Blood 89:883–895
  • Zeigler, F. C., de Sauvage, F., Widmer, H. R., Keller, G. A., Donahue, C., Schreiber, R. D., Malloy, B., Hass, P., Eaton, D., and Matthews, W.. 1994. In vitro megakaryocytopoietic and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells. Blood 84:4045–4052

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.